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ClinicalTrials.gov public records Last synced Oct 15, 2026, 2:28 AM EDT

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Showing 481–504 of 1,212 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Osteoarthritis, Knee Clear all
Completed Not applicable Interventional

An Exploratory Clinical Study to Investigate Biomarkers of Senescence in Patients With Osteoarthritis of the Knee

NCT03100799
View directory record Official record
Conditions
Osteoarthritis, Knee
Interventions
Arthroscopy, Arthrocentesis, MRI
Procedure · Diagnostic Test
Lead sponsor
Unity Biotechnology, Inc.
Industry
Eligibility
35 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017
U.S. locations
1
States / cities
Frederick, Maryland
Source: ClinicalTrials.gov public record
Updated Aug 1, 2017 · Synced Oct 15, 2026, 2:28 AM EDT
Completed Not applicable Interventional

Improving Walking in Older Adults With Knee Osteoarthritis

NCT00583245
View directory record Official record
Conditions
Knee Osteoarthritis
Interventions
Gait Training
Other
Lead sponsor
University of Iowa
Other
Eligibility
60 Years and older
Enrollment
27 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2009
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Mar 10, 2017 · Synced Oct 15, 2026, 2:28 AM EDT
Recruiting Not applicable Interventional

MISHA Post-Market Clinical Study

NCT06118892
View directory record Official record
Conditions
Osteo Arthritis Knee
Interventions
MISHA Knee System
Device
Lead sponsor
Moximed
Industry
Eligibility
25 Years to 65 Years
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2030
U.S. locations
4
States / cities
Sonoma, California • Raleigh, North Carolina • Portland, Oregon + 1 more
Source: ClinicalTrials.gov public record
Updated Jul 14, 2026 · Synced Oct 15, 2026, 2:28 AM EDT
Enrolling by invitation No phase listed Observational

Post Market Clinical Follow-Up Study for EVOLUTION® NitrX™ Keeled Tibia and EVOLUTION® NitrX™ CS/CR Femur With Cruciate Sacrificing Insert

NCT04816773
View directory record Official record
Conditions
Joint Diseases, Osteoarthritis, Arthritis Knee, Avascular Necrosis
Interventions
EVOLUTION® NitrX™
Device
Lead sponsor
MicroPort Orthopedics Inc.
Industry
Eligibility
21 Years and older
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2035
U.S. locations
1
States / cities
Fremont, California
Source: ClinicalTrials.gov public record
Updated Mar 20, 2024 · Synced Oct 15, 2026, 2:28 AM EDT
Completed Not applicable Interventional Results available

Delaware Physical Exercise and Activity for Knee Osteoarthritis

NCT04980300
View directory record Official record
Conditions
Knee Osteoarthritis
Interventions
Intervention, Control
Behavioral
Lead sponsor
University of Delaware
Other
Eligibility
45 Years and older
Enrollment
103 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Newark, Delaware
Source: ClinicalTrials.gov public record
Updated Jan 1, 2025 · Synced Oct 15, 2026, 2:28 AM EDT
Completed Not applicable Interventional Results available

Agili-C™ Implant Performance Evaluation

NCT03299959
View directory record Official record
Conditions
Cartilage or Osteochondral Defects in the Knee, Up to Moderate Osteoarthritis
Interventions
Agili-C implant, SSOC
Device · Procedure
Lead sponsor
Smith & Nephew, Inc.
Industry
Eligibility
21 Years to 75 Years
Enrollment
251 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2024
U.S. locations
11
States / cities
San Diego, California • New Orleans, Louisiana • Salisbury, Maryland + 7 more
Source: ClinicalTrials.gov public record
Updated Dec 5, 2025 · Synced Oct 15, 2026, 2:28 AM EDT
Completed Not applicable Interventional

Minimally Invasive Surgical Approaches In Total Knee Arthroplasty

NCT01461356
View directory record Official record
Conditions
Knee Osteoarthritis
Interventions
Minimally invasive total knee replacement, Standard approach total knee replacement
Procedure
Lead sponsor
Mayo Clinic
Other
Eligibility
45 Years to 75 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2011
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Oct 28, 2011 · Synced Oct 15, 2026, 2:28 AM EDT
Terminated Phase 4 Interventional

Celebrex Total Knee Arthroplasty Study

NCT00359151
View directory record Official record
Conditions
Osteoarthritis, Pain
Interventions
Celecoxib, Placebo
Drug
Lead sponsor
Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Industry
Eligibility
18 Years to 80 Years
Enrollment
22 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2007
U.S. locations
7
States / cities
Aurora, Colorado • Englewood, Colorado • Chicago, Illinois + 3 more
Source: ClinicalTrials.gov public record
Updated Mar 3, 2021 · Synced Oct 15, 2026, 2:28 AM EDT
Completed Phase 3 Interventional Results available

Efficacy And Safety Of Pregabalin For Pain Following Total Knee Replacement

NCT00442546
View directory record Official record
Conditions
Osteoarthritis, Postoperative Pain
Interventions
pregabalin, Placebo
Drug
Lead sponsor
Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Industry
Eligibility
18 Years to 80 Years
Enrollment
307 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2008
U.S. locations
27
States / cities
Northport, Alabama • Tuscaloosa, Alabama • Phoenix, Arizona + 21 more
Source: ClinicalTrials.gov public record
Updated Jan 22, 2021 · Synced Oct 15, 2026, 2:28 AM EDT
Completed Not applicable Interventional

A Powered Exoskeleton for Veterans With Knee OA

NCT04653896
View directory record Official record
Conditions
Knee Osteoarthritis
Interventions
Keeogo
Device
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
32 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2025
U.S. locations
1
States / cities
The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Jul 24, 2026 · Synced Oct 15, 2026, 2:28 AM EDT
Completed Not applicable Interventional

Adductor Canal Block With Posterior Capsular Injection for Total Knee Replacement

NCT01805661
View directory record Official record
Conditions
Pain, Osteoarthritis
Interventions
Canal Block and Capsular Injection, Femoral with Tibial Nerve Block
Procedure
Lead sponsor
Trinity Health Of New England
Other
Eligibility
18 Years to 80 Years
Enrollment
56 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013
U.S. locations
1
States / cities
Hartford, Connecticut
Source: ClinicalTrials.gov public record
Updated Mar 17, 2015 · Synced Oct 15, 2026, 2:28 AM EDT
Completed Phase 2 Interventional Results available

Early Neuromuscular Electrical Stimulation For Quadriceps Muscle Activation Deficits Following Total Knee Replacement

NCT00800254
View directory record Official record
Conditions
Osteoarthritis
Interventions
Neuromuscular Electrical Stimulation (NMES), Standard Rehabilitation Protocol
Device · Other
Lead sponsor
University of Colorado, Denver
Other
Eligibility
50 Years to 85 Years
Enrollment
66 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2011
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Aug 11, 2015 · Synced Oct 15, 2026, 2:28 AM EDT
Active, not recruiting Not applicable Interventional

Positive Minds Strong Joints for Knee Osteoarthritis

NCT06493903
View directory record Official record
Conditions
Osteoarthritis, Knee
Interventions
Positive Minds, Strong Joints
Behavioral
Lead sponsor
Boston University Charles River Campus
Other
Eligibility
50 Years and older
Enrollment
39 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Aug 11, 2026 · Synced Oct 15, 2026, 2:28 AM EDT
Active, not recruiting Not applicable Interventional

Maximizing Patient Goal Attainment

NCT05652270
View directory record Official record
Conditions
Knee Osteoarthritis, Knee Injuries, Knee Pain Chronic, Knee Injuries and Disorders
Interventions
Goal Attainment, Goal Development, Goal Tracking
Behavioral
Lead sponsor
Dartmouth-Hitchcock Medical Center
Other
Eligibility
21 Years and older
Enrollment
258 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
1
States / cities
Lebanon, New Hampshire
Source: ClinicalTrials.gov public record
Updated Aug 31, 2026 · Synced Oct 15, 2026, 2:28 AM EDT
Completed Phase 2 Interventional

Apitox, Honeybee Venom Treatment for Osteoarthritis Pain and Inflammation

NCT00949754
View directory record Official record
Conditions
Osteoarthritis of the Knee
Interventions
honeybee venom (Apitoxin (Korea) Apitox (USA))
Drug
Lead sponsor
Apimeds, Inc.
Industry
Eligibility
35 Years to 85 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2010
U.S. locations
4
States / cities
Pinellas Park, Florida • Chicago, Illinois • Columbus, Ohio + 1 more
Source: ClinicalTrials.gov public record
Updated May 5, 2010 · Synced Oct 15, 2026, 2:28 AM EDT
Not yet recruiting Phase 4 Interventional Accepts healthy volunteers

Zynrelef Versus Adductor Canal Block

NCT07216586
View directory record Official record
Conditions
Knee Osteoarthritis, Arthritis Knee
Interventions
ZYNRELEF 400Mg-12Mg Extended-Release Solution, Ultrasound-Guided Adductor Canal Block, Ropivacaine 0.5% Injectable Solution
Drug · Procedure
Lead sponsor
University of Miami
Other
Eligibility
18 Years and older
Enrollment
120 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2027 – 2028
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated Jun 12, 2026 · Synced Oct 15, 2026, 2:28 AM EDT
Not listed Phase 3 Interventional Accepts healthy volunteers

Safety and Efficacy Study of Bee Venom to Treat Knee Osteoarthritis

NCT00253942
View directory record Official record
Conditions
Persons With Mild to Moderate Knee Osteoarthritis
Interventions
Injecting bee venom as a treatment for OA
Procedure
Lead sponsor
Rheumatology Therapeutics Medical Center
Other
Eligibility
35 Years and older
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
Started 2005
U.S. locations
2
States / cities
Encino, California • Tarzana, California
Source: ClinicalTrials.gov public record
Updated Nov 15, 2005 · Synced Oct 15, 2026, 2:28 AM EDT
Active, not recruiting Phase 2 Interventional

A Trial to Investigate the Safety and Efficacy of Intra-articular 4P004 Injection in Subjects With Knee Synovitis and Osteoarthritis

NCT07225829
View directory record Official record
Conditions
Knee Osteoarthritis, Synovitis of Knee
Interventions
4P004, Placebo (NaCl 0.9%)
Drug
Lead sponsor
4Moving Biotech
Industry
Eligibility
40 Years to 80 Years
Enrollment
129 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
3
States / cities
Tucson, Arizona • Chicago, Illinois • Burlington, Massachusetts
Source: ClinicalTrials.gov public record
Updated Sep 21, 2026 · Synced Oct 15, 2026, 2:28 AM EDT
Completed Not applicable Interventional Results available

Investigating Racial Differences in Diet Benefits for Knee Osteoarthritis

NCT04343716
View directory record Official record
Conditions
Knee Osteoarthritis
Interventions
Low-carbohydrate diet
Behavioral
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
65 Years to 75 Years · Female only
Enrollment
19 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2023
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Aug 13, 2026 · Synced Oct 15, 2026, 2:28 AM EDT
Recruiting Phase 3 Interventional

A Study to Evaluate the Efficacy and Safey of PTP-001 (MOTYS™) in Knee Osteoarthritis Patients

NCT07219771
View directory record Official record
Conditions
Knee Osteoarthritis
Interventions
PTP-01, Placebo control / saline vehicle
Biological · Other
Lead sponsor
Doron Therapeutics Inc.
Industry
Eligibility
40 Years to 80 Years
Enrollment
260 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
8
States / cities
Birmingham, Alabama • La Mesa, California • West Hills, California + 5 more
Source: ClinicalTrials.gov public record
Updated Apr 29, 2026 · Synced Oct 15, 2026, 2:28 AM EDT
Active, not recruiting Not applicable Interventional

Knee Arthroplasty Activity Trial

NCT04107649
View directory record Official record
Conditions
Knee Osteoarthritis, Total Knee Replacement
Interventions
Telephonic Active Coaching (Motivational Interviewing) + Financial Incentives, Wrist based activity tracker wear, Basic Study Activities
Behavioral · Other
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
40 Years to 85 Years
Enrollment
600 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2028
U.S. locations
5
States / cities
Chicago, Illinois • Kansas City, Kansas • Boston, Massachusetts + 2 more
Source: ClinicalTrials.gov public record
Updated Nov 24, 2025 · Synced Oct 15, 2026, 2:28 AM EDT
Recruiting No phase listed Observational

Creation of a Prospective Data Collecting Registry for Genicular Artery Embolization for Arthritis

NCT06781463
View directory record Official record
Conditions
Knee Osteoarthritis, Knee Osteoarthritis (Knee OA), Knee Osteoarthritis (OA)
Interventions
Registry (N/A)
Other
Lead sponsor
University of Chicago
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2028
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated May 13, 2026 · Synced Oct 15, 2026, 2:28 AM EDT
Completed Not applicable Interventional Results available

Self Transcranial Direct Current Stimulation for Pain in Older Adults With Knee Osteoarthritis

NCT03425019
View directory record Official record
Conditions
Knee Osteoarthritis, Chronic Pain
Interventions
Soterix 1x1 tDCS mini-CT Stimulator device
Device
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
50 Years to 80 Years
Enrollment
21 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Oct 15, 2021 · Synced Oct 15, 2026, 2:28 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

The Strong Brain Study

NCT02320864
View directory record Official record
Conditions
Osteoarthritis, Sarcopenia
Interventions
Total knee replacement surgery
Procedure
Lead sponsor
University of Florida
Other
Eligibility
60 Years and older
Enrollment
18 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2017
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Apr 5, 2018 · Synced Oct 15, 2026, 2:28 AM EDT