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ClinicalTrials.gov public records Last synced Oct 16, 2026, 4:04 AM EDT

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Showing 721–744 of 1,212 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Osteoarthritis, Knee Clear all
Terminated Phase 3 Interventional Results available

Long-Term Analgesic Efficacy And Safety Of Tanezumab Alone Or In Combination With Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) Versus NSAIDs Alone In Patients With Osteoarthritis Of The Knee Or Hip

NCT00809354
View directory record Official record
Conditions
Osteoarthritis, Arthritis
Interventions
NSAID, tanezumab
Drug · Biological
Lead sponsor
Pfizer
Industry
Eligibility
18 Years to 99 Years
Enrollment
2,720 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2011
U.S. locations
250
States / cities
Birmingham, Alabama • Huntsville, Alabama • Mobile, Alabama + 161 more
Source: ClinicalTrials.gov public record
Updated Jun 24, 2021 · Synced Oct 16, 2026, 4:04 AM EDT
Terminated Phase 4 Interventional

Effectiveness Study of the Ivivi SofPulse for Pain Amelioration in Adults With Mild to Moderate Knee Osteoarthritis

NCT01457742
View directory record Official record
Conditions
Knee Osteoarthritis
Interventions
Ivivi SofPulse
Device
Lead sponsor
Amp Orthopedics, Inc.
Industry
Eligibility
40 Years to 80 Years
Enrollment
45 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2012
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Jul 10, 2012 · Synced Oct 16, 2026, 4:04 AM EDT
Recruiting Phase 4 Interventional

Systemic Oral Glucocorticoids for the Treatment of Acute Osteoarthritis Pain in the Emergency Department

NCT06603662
View directory record Official record
Conditions
Osteoarthritis, Osteoarthritis (OA) of the Knee, Osteoarthritis (OA) of the Shoulder, Osteoarthritis (OA) of the Hip
Interventions
Prednisone, Dexamethasone, Placebo
Drug
Lead sponsor
WellSpan Health
Other
Eligibility
18 Years and older
Enrollment
192 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
York, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Aug 19, 2026 · Synced Oct 16, 2026, 4:04 AM EDT
Terminated Not applicable Interventional Results available

Efficacy of Cooled and Monopolar Radiofrequency Ablation of the Geniculate Nerves for the Treatment of Chronic Osteoarthritic Knee Pain

NCT02260869
View directory record Official record
Conditions
Osteoarthritis, Knee
Interventions
Genicular nerve radiofrequency ablation, Pain Management Radiofrequency Kit
Procedure · Device
Lead sponsor
Millennium Pain Center
Other
Eligibility
18 Years to 100 Years
Enrollment
79 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2019
U.S. locations
3
States / cities
Bloomington, Illinois • Decatur, Illinois • Peoria, Illinois
Source: ClinicalTrials.gov public record
Updated Apr 26, 2022 · Synced Oct 16, 2026, 4:04 AM EDT
Completed Phase 1Phase 2 Interventional Accepts healthy volunteers

Effects of Aquamin F on NSAID Dose Reduction in Osteoarthritis of the Knee

NCT00755482
View directory record Official record
Conditions
Osteoarthritis of the Knee
Interventions
Aquamin F, Placebo (maltodextran)
Drug
Lead sponsor
Marigot Ltd.
Industry
Eligibility
35 Years to 75 Years
Enrollment
29 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006
U.S. locations
1
States / cities
Edina, Minnesota
Source: ClinicalTrials.gov public record
Updated Sep 19, 2008 · Synced Oct 16, 2026, 4:04 AM EDT
Terminated Phase 3 Interventional Results available

Evaluate the Efficacy and Safety of Fasinumab in Patients With Moderate-to-Severe Chronic Low Back Pain and Osteoarthritis of the Hip or Knee

NCT03285646
View directory record Official record
Conditions
Chronic Low Back Pain, Osteoarthritis
Interventions
Fasinumab, Placebo
Drug
Lead sponsor
Regeneron Pharmaceuticals
Industry
Eligibility
18 Years and older
Enrollment
63 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
56
States / cities
Phoenix, Arizona • Tucson, Arizona • Anaheim, California + 47 more
Source: ClinicalTrials.gov public record
Updated Jun 30, 2021 · Synced Oct 16, 2026, 4:04 AM EDT
Completed Phase 3 Interventional Results available

Duloxetine Versus Placebo for Osteoarthritis Knee Pain

NCT00408421
View directory record Official record
Conditions
Osteoarthritis Knee Pain
Interventions
Duloxetine, placebo
Drug
Lead sponsor
Eli Lilly and Company
Industry
Eligibility
40 Years and older
Enrollment
231 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2007
U.S. locations
21
States / cities
Chandler, Arizona • Beverly Hills, California • Northridge, California + 18 more
Source: ClinicalTrials.gov public record
Updated Aug 19, 2009 · Synced Oct 16, 2026, 4:04 AM EDT
Completed Not applicable Interventional Results available

A Prospective Study Evaluating the Treatment of Knee Osteoarthritis With the Cryo-Touch III Device

NCT01704157
View directory record Official record
Conditions
Osteoarthritis of the Knee
Interventions
Cryo-Touch III
Device
Lead sponsor
Pacira Pharmaceuticals, Inc
Industry
Eligibility
18 Years and older
Enrollment
33 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2013
U.S. locations
2
States / cities
Napa, California • Boise, Idaho
Source: ClinicalTrials.gov public record
Updated Jan 24, 2024 · Synced Oct 16, 2026, 4:04 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Study to Evaluate the Iovera° Device for Temporary Relief From Knee Pain

NCT02260921
View directory record Official record
Conditions
Knee Osteoarthritis
Interventions
iovera°, Sham Comparator
Device
Lead sponsor
Pacira Pharmaceuticals, Inc
Industry
Eligibility
35 Years to 75 Years
Enrollment
180 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2016
U.S. locations
17
States / cities
Covina, California • Sacramento, California • Bradenton, Florida + 14 more
Source: ClinicalTrials.gov public record
Updated Jan 24, 2024 · Synced Oct 16, 2026, 4:04 AM EDT
Terminated Not applicable Interventional Accepts healthy volunteers Results available

A Prospective Study to Evaluate Robot Assisted Total Knee Replacement Outcomes

NCT03523897
View directory record Official record
Conditions
Primary Osteoarthritis of Knee Nos
Interventions
Robot Assisted Total Knee Replacement, Traditional Total Knee Replacement
Procedure
Lead sponsor
Virtua Health, Inc.
Other
Eligibility
18 Years and older
Enrollment
92 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2022
U.S. locations
1
States / cities
Voorhees Township, New Jersey
Source: ClinicalTrials.gov public record
Updated Jun 6, 2025 · Synced Oct 16, 2026, 4:04 AM EDT
Completed Not applicable Interventional

Validation of a Low-cost Platelet-Rich Plasma (PRP)

NCT06184048
View directory record Official record
Conditions
Platelet-Rich Plasma (PRP), Knee Osteoarthritis (OA)
Interventions
Intra-Articular knee injection of LC-PRP
Procedure
Lead sponsor
University of Utah
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Nov 17, 2025 · Synced Oct 16, 2026, 4:04 AM EDT
Completed Phase 4 Interventional Results available

The Use of Evicel to Reduce Blood Loss in Total Knee Replacement Surgery

NCT01235715
View directory record Official record
Conditions
Osteoarthritis
Interventions
Evicel fibrin sealant
Drug
Lead sponsor
Hospital for Special Surgery, New York
Other
Eligibility
20 Years to 90 Years
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2012
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Oct 29, 2013 · Synced Oct 16, 2026, 4:04 AM EDT
Not listed No phase listed Observational

Outcomes of MAKOplasty Patellofemoral Arthroplasty in Younger Active Patients

NCT02738476
View directory record Official record
Conditions
Osteoarthritis, Knee
Interventions
Patellofemoral arthroplasty
Procedure
Lead sponsor
Cincinnati Sportsmedicine Research and Education Foundation
Other
Eligibility
20 Years to 65 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2022
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Oct 8, 2020 · Synced Oct 16, 2026, 4:04 AM EDT
Completed Phase 4 Interventional Results available

Effect of Topical and Intravenous Tranexamic Acid (TXA) on Thrombogenic Markers in Patients Undergoing Knee Replacement

NCT02540226
View directory record Official record
Conditions
Osteoarthritis, Knee
Interventions
Intravenous tranexamic acid, Topical tranexamic acid, Intravenous saline, Topical saline
Drug
Lead sponsor
Hospital for Special Surgery, New York
Other
Eligibility
18 Years to 80 Years
Enrollment
76 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2019
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Mar 25, 2020 · Synced Oct 16, 2026, 4:04 AM EDT
Completed Phase 3 Interventional Results available

A Study to Compare the Effectiveness of Adductor Canal Pain Catheters Following Total Knee Arthroplasty

NCT05053087
View directory record Official record
Conditions
Osteoarthritis, Knee
Interventions
Ropivacaine Continuous Infusion, Ropivacaine Intermittent Bolus, Placebo
Drug
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years to 89 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
Jacksonville, Florida
Source: ClinicalTrials.gov public record
Updated Feb 22, 2024 · Synced Oct 16, 2026, 4:04 AM EDT
Recruiting Not applicable Interventional

ROAM OA: Functional and Patient Reported Outcomes Wearing a Knee Brace for Unicompartmental OA

NCT07224958
View directory record Official record
Conditions
Knee Osteoarthritis
Interventions
ROAM OA Single Upright Knee Brace, Ossur Unloader One Knee Brace or Standard of Care
Device
Lead sponsor
Rush University Medical Center
Other
Eligibility
40 Years to 85 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated May 12, 2026 · Synced Oct 16, 2026, 4:04 AM EDT
Completed Not applicable Interventional

KAATSU Training to Enhance Physical Function of Older Adults With Osteoarthritis

NCT02132715
View directory record Official record
Conditions
Knee Osteoarthritis
Interventions
Resistance Exercise, KAATSU exercise
Behavioral
Lead sponsor
University of Florida
Other
Eligibility
60 Years and older
Enrollment
35 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Aug 23, 2016 · Synced Oct 16, 2026, 4:04 AM EDT
Completed Phase 3 Interventional Accepts healthy volunteers Results available

Research Study Looking at How Well Semaglutide Works in People Suffering From Obesity and Knee Osteoarthritis

NCT05064735
View directory record Official record
Conditions
Obesity
Interventions
semaglutide 2.4 mg, semaglutide 2.4 mg (placebo)
Drug
Lead sponsor
Novo Nordisk A/S
Industry
Eligibility
Not listed
Enrollment
407 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2023
U.S. locations
61
States / cities
Montgomery, Alabama • Phoenix, Arizona • Anaheim, California + 52 more
Source: ClinicalTrials.gov public record
Updated Nov 17, 2025 · Synced Oct 16, 2026, 4:04 AM EDT
Completed Phase 3 Interventional

Hymovis™ Versus Placebo in Knee Osteoarthritis

NCT01372475
View directory record Official record
Conditions
Knee Osteoarthritis
Interventions
Hymovis Intra-articular Injection, Phosphate Buffered Saline Injection
Device · Procedure
Lead sponsor
Fidia Farmaceutici s.p.a.
Industry
Eligibility
40 Years and older
Enrollment
800 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2013
U.S. locations
32
States / cities
Birmingham, Alabama • Tucson, Arizona • Encinitas, California + 28 more
Source: ClinicalTrials.gov public record
Updated Apr 8, 2014 · Synced Oct 16, 2026, 4:04 AM EDT
Completed Phase 1Phase 2 Interventional Results available

A Study to Evaluate Safety of Three Intra-articular Injections of Ampion in the Knee of Adults With Osteoarthritis Pain

NCT02184156
View directory record Official record
Conditions
Osteoarthritis of the Knee
Interventions
4 mL injection of Ampion, 4 mL injection of Placebo
Biological · Drug
Lead sponsor
Ampio Pharmaceuticals. Inc.
Industry
Eligibility
40 Years to 85 Years
Enrollment
47 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
1
States / cities
Englewood, Colorado
Source: ClinicalTrials.gov public record
Updated Sep 30, 2022 · Synced Oct 16, 2026, 4:04 AM EDT
Completed No phase listed Observational

VISIONAIRE™ Value Study

NCT01107769
View directory record Official record
Conditions
Osteoarthritis of the Knee
Interventions
Not listed
Lead sponsor
Smith & Nephew, Inc.
Industry
Eligibility
18 Years and older
Enrollment
38 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2011
U.S. locations
1
States / cities
Lake Charles, Louisiana
Source: ClinicalTrials.gov public record
Updated Nov 21, 2011 · Synced Oct 16, 2026, 4:04 AM EDT
Completed Not applicable Interventional

Moving Well for Total Knee Arthroplasty (TKA)

NCT05217420
View directory record Official record
Conditions
Osteoarthritis, Knee
Interventions
Moving Well, Staying Well
Behavioral
Lead sponsor
Weill Medical College of Cornell University
Other
Eligibility
50 Years and older
Enrollment
101 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Aug 3, 2026 · Synced Oct 16, 2026, 4:04 AM EDT
Withdrawn Phase 2 Interventional

Conventional Platelet-Rich Plasma Versus Concentrated Bone Marrow Stem Cell Injections for Osteoarthritis of the Knee

NCT03271229
View directory record Official record
Conditions
Osteo Arthritis Knee
Interventions
Concentrated Bone Marrow Aspirate (BMAC), Platelet-Rich Plasma (PRP)
Biological
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
1
States / cities
Jacksonville, Florida
Source: ClinicalTrials.gov public record
Updated Dec 24, 2019 · Synced Oct 16, 2026, 4:04 AM EDT
Completed Not applicable Interventional Results available

Nerve Ablation by Cooled Radiofrequency Compared to Corticosteroid Injection for Management of Knee Pain

NCT02343003
View directory record Official record
Conditions
Osteoarthritis of the Knee
Interventions
Cooled Radiofrequency, Corticosteroid injection
Device · Drug
Lead sponsor
Halyard Health
Industry
Eligibility
21 Years and older
Enrollment
151 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2017
U.S. locations
11
States / cities
Phoenix, Arizona • Scottsdale, Arizona • Santa Monica, California + 8 more
Source: ClinicalTrials.gov public record
Updated May 13, 2019 · Synced Oct 16, 2026, 4:04 AM EDT