Independent directory Public ClinicalTrials.gov records United States
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ClinicalTrials.gov public records Last synced Oct 13, 2026, 8:08 AM EDT

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Showing 193–216 of 1,212 matching trials from the live ClinicalTrials.gov search.
Conditions
Osteoarthritis, Knee
Interventions
High-dose/short-duration Fisetin, Low-dose/sustained-duration Fisetin, Oral placebo capsule
Drug · Other
Lead sponsor
Austin V Stone
Other
Eligibility
35 Years to 80 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
2
States / cities
Lexington, Kentucky
Conditions
Osteoarthritis, Knee
Interventions
Oxytocin
Drug
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years to 75 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2027
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Conditions
Chronic Knee Pain
Interventions
Photobiomodulation therapy (PBM) device, Sham PBM device
Device
Lead sponsor
University of Florida
Other
Eligibility
50 Years to 99 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Gainesville, Florida
Conditions
Muscle Atrophy
Interventions
IMM01-STEM
Drug
Lead sponsor
Immunis, Inc.
Industry
Eligibility
50 Years to 75 Years
Enrollment
13 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2026
U.S. locations
2
States / cities
Irvine, California • Orange, California
Conditions
Osteoarthritis
Interventions
Gait Training; Altered Foot Progression Angle, Gait Training; Consistent Foot Progression Angle
Other
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
68 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2020
U.S. locations
2
States / cities
Palo Alto, California • Stanford, California
Conditions
Rheumatoid Arthritis, Traumatic Arthritis, Joint Disease Secondary to Osteoarthritis
Interventions
Encore 3DKnee™ system, Encore MJS™ Knee System
Device
Lead sponsor
Encore Medical, L.P.
Industry
Eligibility
18 Years and older
Enrollment
27 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2009
U.S. locations
1
States / cities
Fresno, California
Conditions
Osteoarthritis of the Knee
Interventions
4 mL injection of Ampion, 4 mL injection of Placebo
Biological · Drug
Lead sponsor
Ampio Pharmaceuticals. Inc.
Industry
Eligibility
40 Years to 85 Years
Enrollment
47 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
1
States / cities
Englewood, Colorado
Conditions
Knee Replacement Surgery, Osteoarthritis, Knee
Interventions
Epidiolex oral solution, Placebo
Drug · Other
Lead sponsor
Chad Brummett
Other
Eligibility
18 Years to 80 Years
Enrollment
380 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2029
U.S. locations
2
States / cities
Ann Arbor, Michigan • Detroit, Michigan
Active, not recruiting No phase listed Observational Accepts healthy volunteers

Performance of MOTO Medial® Unicompartmental Knee Arthroplasty

NCT03211663
Conditions
Knee Osteoarthritis, Knee Arthritis, Knee Pain Chronic
Interventions
MOTO Medial® UKA
Device
Lead sponsor
Medacta USA
Industry
Eligibility
18 Years and older
Enrollment
269 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2025
U.S. locations
5
States / cities
Lady Lake, Florida • Louisville, Kentucky • Billings, Montana + 2 more
Conditions
Knee Osteoarthritis, Traumatic Arthritis of Knee, Avascular Necrosis, Degenerative Joint Disease of Knee, Rheumatoid Arthritis of Knee, Correction of Functional Deformity
Interventions
Primary Knee implants
Device
Lead sponsor
MicroPort Orthopedics Inc.
Industry
Eligibility
21 Years and older
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2032
U.S. locations
1
States / cities
Saginaw, Michigan
Completed Not applicable Interventional Results available

Educational Intervention for Knee Pain

NCT00324857
Conditions
Osteoarthritis
Interventions
Decision Aid Video, Motivational Interviewing, MI plus Decision aid, Attention control
Behavioral · Other
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
50 Years and older
Enrollment
663 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2011
U.S. locations
3
States / cities
Cleveland, Ohio • Philadelphia, Pennsylvania • Pittsburgh, Pennsylvania
Conditions
Osteoarthritis, Knee
Interventions
XT-150
Biological
Lead sponsor
Xalud Therapeutics, Inc.
Industry
Eligibility
18 Years to 90 Years
Enrollment
32 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
Napa, California
Conditions
Osteoarthritis
Interventions
synovial fluid biomarker concentrations
Biological
Lead sponsor
NYU Langone Health
Other
Eligibility
18 Years to 90 Years
Enrollment
75 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
1
States / cities
New York, New York
Conditions
Osteoarthritis, Knee, Knee Replacement
Interventions
Mindfulness-based Cognitive Behavioral Therapy
Behavioral
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
45 Years to 100 Years
Enrollment
44 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2023
U.S. locations
1
States / cities
Chestnut Hill, Massachusetts
Terminated Not applicable Interventional Accepts healthy volunteers Results available

Comparative Effectiveness of an Activity-specific Monitoring Device- StepRite

NCT02900781
Conditions
Osteoarthritis, Degenerative Joint Disease
Interventions
Steprite™, Standard of care
Device · Other
Lead sponsor
Texas Tech University Health Sciences Center
Other
Eligibility
45 Years to 75 Years
Enrollment
9 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2017
U.S. locations
1
States / cities
Lubbock, Texas
Conditions
Knee Injuries, Knee Osteoarthritis, Patellofemoral Syndrome
Interventions
Limber Digital Application, Physical therapy Therapy
Device · Behavioral
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years to 75 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020
U.S. locations
1
States / cities
Rochester, Minnesota
Completed No phase listed Observational Accepts healthy volunteers

Osteoarthritis Initiative (OAI): A Knee Health Study

NCT00080171
Conditions
Osteoarthritis, Knee Osteoarthritis
Interventions
Not listed
Lead sponsor
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
NIH
Eligibility
45 Years to 79 Years
Enrollment
4,796 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2004 – 2015
U.S. locations
5
States / cities
Baltimore, Maryland • Columbus, Ohio • Pittsburgh, Pennsylvania + 1 more
Active, not recruiting Not applicable Interventional

Geniculate Artery Embolization for Osteoarthritis

NCT04456569
Conditions
Osteo Arthritis Knee, Arthritis, Osteoarthritis, Osteoarthritis, Knee
Interventions
Geniculate Artery Embolization
Device
Lead sponsor
University of Minnesota
Other
Eligibility
40 Years to 70 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2027
U.S. locations
1
States / cities
Minneapolis, Minnesota
Completed Not applicable Interventional Results available

TSolution One® Total Knee Arthroplasty

NCT03017261
Conditions
Osteoarthritis, Knee
Interventions
TSolution One®
Device
Lead sponsor
Think Surgical Inc.
Industry
Eligibility
21 Years and older
Enrollment
115 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
6
States / cities
Hackensack, New Jersey • New York, New York • Roslyn, New York + 3 more
Conditions
Osteoarthritis, Knee Infection, Prosthetic Joint Infection, Complications; Arthroplasty, Infection or Inflammation, Complications; Arthroplasty
Interventions
Static Spacer, Articulating Spacer
Procedure
Lead sponsor
Rush University Medical Center
Other
Eligibility
18 Years to 100 Years
Enrollment
68 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2020
U.S. locations
1
States / cities
Chicago, Illinois
Conditions
Osteoarthritis, Knee
Interventions
Gait retraining
Behavioral
Lead sponsor
Stanford University
Other
Eligibility
18 Years to 80 Years
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2012
U.S. locations
1
States / cities
Stanford, California
Conditions
Knee Osteoarthritis
Interventions
Mobility shoe, control shoe
Other
Lead sponsor
Rush University Medical Center
Other
Eligibility
Not listed
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2007
U.S. locations
1
States / cities
Chicago, Illinois
Conditions
Knee Osteoarthritis
Interventions
bariatric lap band surgery
Procedure
Lead sponsor
NYU Langone Health
Other
Eligibility
25 Years and older
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2018
U.S. locations
1
States / cities
New York, New York
Conditions
Osteoarthritis, Knee
Interventions
Diclofenac, topical
Drug
Lead sponsor
Nuvo Research Inc.
Industry
Eligibility
40 Years to 85 Years
Enrollment
750 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2005
U.S. locations
22
States / cities
Mobile, Alabama • Phoenix, Arizona • Beverly Hills, California + 19 more