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ClinicalTrials.gov public records Last synced Nov 11, 2026, 6:01 PM EST

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Showing 1–24 of 636 matching trials from the live ClinicalTrials.gov search.

Filters: Condition: Osteoarthritis Pain Clear all

Conditions: Lower-limb Orthoses, Osteoarthritic Knee Pain, Osteoarthritis (OA) of the Knee
Interventions: Modular powered orthosis; Device
Lead sponsor: University of Michigan; Other
Eligibility: 18 Years to 85 Years
Enrollment: 65 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025 – 2030
U.S. locations: 1
States / cities: Ann Arbor, Michigan

Conditions: Osteoarthritis, Knee
Interventions: Diet and Exercise; Behavioral
Lead sponsor: Wake Forest University; Other
Eligibility: 50 Years and older · Female only
Enrollment: 1,230 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024 – 2029
U.S. locations: 3
States / cities: Boston, Massachusetts • Chapel Hill, North Carolina • Winston-Salem, North Carolina

Conditions: Knee Osteoarthritis, Primary Total Knee Arthroplasty, Physical Therapy, Pain, Knee Extension
Interventions: Ropivacaine, Interspace Between the Popliteal Artery and Capsule of the Knee (iPACK) Block, Saline; Drug · Procedure
Lead sponsor: Duke University; Other
Eligibility: 18 Years to 75 Years
Enrollment: 50 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2021
U.S. locations: 1
States / cities: Durham, North Carolina

Conditions: Osteoarthritis of the Knee
Interventions: TLC599, DSP, Normal Saline; Drug · Other
Lead sponsor: Taiwan Liposome Company; Industry
Eligibility: 40 Years and older
Enrollment: 504 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2022
U.S. locations: 41
States / cities: Birmingham, Alabama • Sheffield, Alabama • Phoenix, Arizona + 33 more

Conditions: Knee Osteoarthritis
Interventions: Synvisc-One Injection, Sham Injection; Device · Other
Lead sponsor: Elaine Husni; Other
Eligibility: 21 Years and older
Enrollment: 42 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2015
U.S. locations: 1
States / cities: Weston, Florida

Conditions: Osteoarthritis (OA) of the Knee, Fear of Needles
Interventions: 25 gauge needle, 22 gauge needle, +/- Ethyl Chloride Topical Aerosol Anesthetic; Procedure
Lead sponsor: University of California, Davis; Other
Eligibility: 40 Years to 89 Years
Enrollment: 88 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026
U.S. locations: 1
States / cities: Sacramento, California

Conditions: Osteoarthritis, Pain, Postoperative
Interventions: Liposomal bupivacaine, Bupivacaine plus dexamethasone; Drug
Lead sponsor: Albany Medical College; Other
Eligibility: 40 Years to 70 Years
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2020
U.S. locations: 1
States / cities: Albany, New York

Conditions: Opioid Use, Opioid Dependence, Knee Pain Chronic, Knee Osteoarthritis
Interventions: Improved Opioid-Tapering Instructions, Clinical Patient Educator; Drug · Behavioral
Lead sponsor: Brigham and Women's Hospital; Other
Eligibility: 18 Years and older
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2024
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Osteoarthritis, Knee
Interventions: Cannabidiol (CBD) Extract, Placebo; Drug
Lead sponsor: University of Florida; Other
Eligibility: 40 Years to 75 Years
Enrollment: 30 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2026
U.S. locations: 1
States / cities: Gainesville, Florida

Conditions: Osteoarthritis, Knee
Interventions: Lidoderm, Placebo patch; Drug
Lead sponsor: Endo USA Inc., a Keenova Therapeutics Company; Industry
Eligibility: 18 Years and older
Enrollment: 224 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: Started 2004
U.S. locations: 24
States / cities: Birmingham, Alabama • Hueytown, Alabama • Tallassee, Alabama + 21 more

Conditions: Osteoarthritis Of Knee
Interventions: Geniculate Artery Embolization; Device
Lead sponsor: University of North Carolina, Chapel Hill; Other
Eligibility: 40 Years and older
Enrollment: 20 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2018
U.S. locations: 2
States / cities: Chapel Hill, North Carolina • Woodbridge, Virginia

Conditions: Degenerative Joint Disease, Osteoarthritis, Knee Injury, Trauma, Connective Tissue Disorder, Pain, Loss of Function
Interventions: Not listed
Lead sponsor: Loma Linda University; Other
Eligibility: 40 Years to 80 Years
Enrollment: 50 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2012 – 2016
U.S. locations: 1
States / cities: San Bernardino, California

Conditions: Osteoarthritis, Tendinitis, Sports Injury, Degenerative Disc Disease, Degenerative Arthritis, Ligament Injury, Neuropathy, Pelvic Pain
Interventions: Umbilical Allograft; Other
Lead sponsor: R3 Stem Cell; Industry
Eligibility: 18 Years and older
Enrollment: 200 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2030
U.S. locations: 1
States / cities: Encino, California

Conditions: Osteoarthritis, Knee
Interventions: UBX0101, Placebo; Drug · Other
Lead sponsor: Unity Biotechnology, Inc.; Industry
Eligibility: 40 Years to 85 Years
Enrollment: 78 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2019
U.S. locations: 7
States / cities: El Cajon, California • La Mesa, California • Miami, Florida + 4 more

Conditions: Osteoarthritis, Chronic Pain
Interventions: Phenotype assessment; Other
Lead sponsor: University of Michigan; Other
Eligibility: 50 Years and older
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2015
U.S. locations: 1
States / cities: Ann Arbor, Michigan

Conditions: Osteoarthritis, Knee Pain
Interventions: SL-1002, Placebo; Drug
Lead sponsor: Saol Therapeutics Inc; Industry
Eligibility: 35 Years and older
Enrollment: 132 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2024
U.S. locations: 15
States / cities: Greenwood Village, Colorado • Washington D.C., District of Columbia • Coral Gables, Florida + 12 more

Conditions: Knee Osteoarthritis, Acute Pain, Anesthesia, Local, Regional Anesthesia
Interventions: ropivacaine 0.25% with epinephrine and 6mg dexamethasone, Saline; Drug
Lead sponsor: University of California, San Diego; Other
Eligibility: 18 Years and older
Enrollment: 14 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2022
U.S. locations: 1
States / cities: San Diego, California

Conditions: Osteoarthritis Pain of the Knee
Interventions: Diclofenac sodium active topical patch, Placebo patch; Drug
Lead sponsor: Noven Pharmaceuticals, Inc.; Industry
Eligibility: 40 Years to 85 Years
Enrollment: 370 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2022
U.S. locations: 10
States / cities: Little Rock, Arkansas • Clearwater, Florida • Doral, Florida + 7 more

Conditions: Osteoarthritis, Hip
Interventions: Cooled RFA treatment with COOLIEF* device, intra-articular corticosteroid injection; Procedure · Drug
Lead sponsor: Brigham and Women's Hospital; Other
Eligibility: 18 Years and older
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2022
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Osteoarthritis, Knee
Interventions: XT-150; Biological
Lead sponsor: Xalud Therapeutics, Inc.; Industry
Eligibility: 18 Years to 90 Years
Enrollment: 32 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2019
U.S. locations: 1
States / cities: Napa, California

Conditions: Osteoarthritis, Knee, Pain
Interventions: Knee Osteoarthritis, Healthy Control; Other
Lead sponsor: University of Colorado, Denver; Other
Eligibility: 50 Years to 85 Years
Enrollment: 187 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2013 – 2016
U.S. locations: 1
States / cities: Aurora, Colorado

Conditions: Knee Osteoarthritis
Interventions: Methylprednisolone acetate, taVNS; Drug · Device
Lead sponsor: VA Office of Research and Development; Federal
Eligibility: 45 Years to 75 Years
Enrollment: 40 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2028
U.S. locations: 1
States / cities: Decatur, Georgia

Conditions: Osteoarthritis, Arthroplasty
Interventions: Ropivacaine with NaCl, Epinephrine, Morphine, Ketorolac Tromethamine, Ropivacaine; Drug
Lead sponsor: Corewell Health East; Other
Eligibility: 18 Years and older
Enrollment: 100 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2017
U.S. locations: 1
States / cities: Royal Oak, Michigan

Conditions: Knee Arthroplasty, Total, Osteoarthritis, Radiologic Tibiofemoral Osteoarthritis
Interventions: Genicular Nerve RFA, Sham Genicular Nerve RFA; Procedure
Lead sponsor: Vanderbilt University Medical Center; Other
Eligibility: 45 Years to 79 Years
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2020
U.S. locations: 1
States / cities: Nashville, Tennessee

Search by objective public record fields.

Enhancing Voluntary Motion in Broad Patient Populations With Modular Powered Orthoses Renewal

The Osteoarthritis Prevention Study

Evaluation of Utility of Ultrasound Guided iPACK Block for Knee Extension After Total Knee Arthroplasty.

Extended and Controlled Release Liposomal Formulated Dexamethasone for Chronic Knee OA Pain

Optimization of Synvisc-One for Knee OA

Pain Perception During Intra-Articular Knee Joint Injection: What is the Effect of Needle Gauge and the Use of Ethyl Chloride?

Liposomal Bupivacaine Versus Standard Bupivacaine Plus Dexamethasone in Quadriceps Sparing Femoral Nerve Block and Wound Infiltration for Total Knee Arthroplasty

Can Simplified and More Detailed Instructions Affect Post-Operative Narcotic Consumption

CBD for Knee Osteoarthritis

Pilot Study of Lidocaine 5% Patch Versus Placebo in Patients With Osteoarthritis Pain of the Knee

Geniculate Artery Embolization for the Treatment of Knee Pain

Comparison of Clinical Outcomes and Performance of Total Knee Replacement Patients Before and After Surgery

Evaluation of Outcomes With Umbilical Cord Allograft for Musculoskeletal Conditions Musculoskeletal Conditions

A Safety and Tolerability Study of UBX0101 in Patients With Osteoarthritis of the Knee

OASIS: Osteoarthritis Sensitivity Integration Study

Phase II Study to Assess Safety and Efficacy of SL-1002 for Osteoarthritic Knee Pain

iPACK Block With Dexamethasone For Total Knee Replacement

A 12-week Study to Evaluate the Efficacy and Safety of HP-5000 in Subjects With Osteoarthritis Pain of the Knee

Use of Cooled Radiofrequency for the Treatment of Hip Pain Associated With Hip OA Compared to Intra-articular Steroid Injections

Safety, Tolerability, and Efficacy of XT-150 for the Treatment of Osteoarthritic Pain

Pain Phenotypes in Knee Osteoarthritis

taVNS in Veterans With Knee OA (AVAHCS)

Psoas Compartment Block Versus Periarticular Local Anesthetic for Total Hip Arthroplasty

Genicular Radiofrequency Ablation Efficacy in Achieving Total Knee Pain Reduction Trial