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ClinicalTrials.gov public records Last synced Nov 14, 2026, 10:11 PM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 1–24 of 1,142 matching trials from the live ClinicalTrials.gov search.

Filters: Condition: Osteoarthritis of Knee Clear all

Conditions: Knee Osteoarthritis
Interventions: Sustained Acoustic Device with 2.5% Diclofenac Patch, 1% Diclofenac Topical Gel; Device · Drug
Lead sponsor: ZetrOZ, Inc.; Industry
Eligibility: 35 Years to 80 Years
Enrollment: 60 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2022
U.S. locations: 3
States / cities: Stamford, Connecticut • Trumbull, Connecticut • Dryden, New York

Conditions: Knee Arthritis, Knee Osteoarthritis
Interventions: Suzetrigine; Drug
Lead sponsor: Emory University; Other
Eligibility: 18 Years to 95 Years
Enrollment: 75 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2028
U.S. locations: 3
States / cities: Atlanta, Georgia

Conditions: Chronic Pain, Osteoarthritis
Interventions: Transcranial Direct Current Stimulation; Device
Lead sponsor: Spaulding Rehabilitation Hospital; Other
Eligibility: 18 Years to 64 Years
Enrollment: 38 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2014
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Osteoarthritis,Knee
Interventions: Not listed
Lead sponsor: University of California, San Francisco; Other
Eligibility: 45 Years to 79 Years
Enrollment: 4,185 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2003 – 2020
U.S. locations: 3
States / cities: Birmingham, Alabama • Iowa City, Iowa • Boston, Massachusetts

Conditions: Osteoarthritis, Hip, Osteoarthritis, Knee, Lower Back Pain, Pain
Interventions: Oxycodone CR, Tapentadol (CG5503) ER; Drug
Lead sponsor: Johnson & Johnson Pharmaceutical Research & Development, L.L.C.; Industry
Eligibility: 18 Years and older
Enrollment: 1,123 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2006 – 2008
U.S. locations: 40
States / cities: Mesa, Arizona • Tucson, Arizona • Anaheim, California + 37 more

Conditions: Osteoarthritis: Joint Replacement Surgery
Interventions: CLARIX FLO, Saline; Other
Lead sponsor: BioTissue Holdings, Inc; Industry
Eligibility: 18 Years and older
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019
U.S. locations: 1
States / cities: Orange Park, Florida

Conditions: Knee Osteoarthritis, Total Knee Arthroplasty (TKA)
Interventions: Pain Scale/Medication Log; Other
Lead sponsor: Endeavor Health; Other
Eligibility: 18 Years and older
Enrollment: 375 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2022
U.S. locations: 1
States / cities: Skokie, Illinois

Conditions: Knee Osteoarthritis
Interventions: Realigning knee brace and custom orthodic, Non realigning knee brace and flat orthodic; Device
Lead sponsor: Boston University; Other
Eligibility: 18 Years and older
Enrollment: 80 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Chronic Low Back Pain, Osteoarthritis
Interventions: Fasinumab, Placebo; Drug
Lead sponsor: Regeneron Pharmaceuticals; Industry
Eligibility: 18 Years and older
Enrollment: 63 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2019
U.S. locations: 56
States / cities: Phoenix, Arizona • Tucson, Arizona • Anaheim, California + 47 more

Conditions: Osteoarthritis, Knee
Interventions: Acupuncture; Other
Lead sponsor: Massachusetts General Hospital; Other
Eligibility: 40 Years to 70 Years
Enrollment: 144 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2016
U.S. locations: 1
States / cities: Charlestown, Massachusetts

Conditions: Osteoarthritis
Interventions: Active Device (Torino II), Sham Device (Torino II); Device
Lead sponsor: Center for Joint Surgery and Sports Medicine, Maryland; Other
Eligibility: 18 Years and older
Enrollment: 40 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: Started 2010
U.S. locations: 1
States / cities: Hagerstown, Maryland

Conditions: Osteoarthritis
Interventions: Dextrose Prolotherapy, Saline Prolotherapy, At-home physical therapy exercise group; Procedure · Other
Lead sponsor: University of Wisconsin, Madison; Other
Eligibility: 40 Years to 70 Years
Enrollment: 98 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2004 – 2016
U.S. locations: 2
States / cities: Madison, Wisconsin

Conditions: Knee Osteoarthritis, Arthritis
Interventions: Exercise Only, Brace Only, Bracing + Exercises; Other · Device
Lead sponsor: Orthopaedic Research Foundation; Other
Eligibility: 21 Years to 80 Years
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2016
U.S. locations: 1
States / cities: Greenwood, Indiana

Conditions: Post-traumatic Osteoarthritis of the Knee
Interventions: FX006 32 mg, TCA IR 40 mg; Drug
Lead sponsor: Pacira Pharmaceuticals, Inc; Industry
Eligibility: 20 Years to 50 Years
Enrollment: 6 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2016
U.S. locations: 1
States / cities: San Antonio, Texas

Conditions: Osteoarthritis of the Knee
Interventions: Diclofenac Sodium Active Topical Patch 1, Diclofenac Sodium Active Topical Patch 2, Placebo patch; Drug
Lead sponsor: Noven Pharmaceuticals, Inc.; Industry
Eligibility: 40 Years to 85 Years
Enrollment: 289 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2019
U.S. locations: 1
States / cities: Jersey City, New Jersey

Conditions: Osteoarthritis, Knee
Interventions: OM1 Dell Shared Decision Making Tool, Education material from OM1 Dell Shared Decision Making Tool; Other
Lead sponsor: University of Texas at Austin; Other
Eligibility: 45 Years to 89 Years
Enrollment: 145 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2020
U.S. locations: 1
States / cities: Austin, Texas

Conditions: Osteoarthritis
Interventions: tanezumab 10 mg, tanezumab 5 mg, naproxen, placebo; Biological · Drug · Other
Lead sponsor: Pfizer; Industry
Eligibility: 18 Years and older
Enrollment: 849 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2010
U.S. locations: 95
States / cities: Birmingham, Alabama • Huntsville, Alabama • Mobile, Alabama + 69 more

Conditions: Osteoarthritis of the Knee
Interventions: Massage 30 min 2x/wk x4 wks then 1x/wk x4 wks, Massage 60 min 2x/wk for 4 wks then 1x/wk for 4 wks, Massage 30 min sessions 1x/wk for 8 wks, Massage 60 min session 1x/wk for 8 wks; Other
Lead sponsor: University of Medicine and Dentistry of New Jersey; Other
Eligibility: 35 Years and older
Enrollment: 125 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2011
U.S. locations: 2
States / cities: Derby, Connecticut • Livingston, New Jersey

Conditions: Osteoarthritis, Knee
Interventions: Patellofemoral arthroplasty; Procedure
Lead sponsor: Cincinnati Sportsmedicine Research and Education Foundation; Other
Eligibility: 20 Years to 65 Years
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2022
U.S. locations: 1
States / cities: Cincinnati, Ohio

Conditions: Osteoarthritis
Interventions: Standard of care for osteoarthritis treatment, Conjoint Analysis for Osteoarthritis; Behavioral
Lead sponsor: Baylor College of Medicine; Other
Eligibility: 65 Years to 95 Years
Enrollment: 182 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2007 – 2010
U.S. locations: 1
States / cities: Houston, Texas

Conditions: Osteoarthritis, Knee
Interventions: acupuncture; Device
Lead sponsor: Massachusetts General Hospital; Other
Eligibility: 40 Years to 70 Years
Enrollment: 44 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2014
U.S. locations: 1
States / cities: Charlestown, Massachusetts

Conditions: Knee Osteoarthritis
Interventions: Exparel, Ropivacaine; Drug
Lead sponsor: Monmouth Medical Center; Other
Eligibility: 18 Years and older
Enrollment: 200 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2015 – 2017
U.S. locations: 1
States / cities: Long Branch, New Jersey

Conditions: Osteoarthritis
Interventions: Buprenorphine transdermal patch, Placebo; Drug
Lead sponsor: Purdue Pharma LP; Industry
Eligibility: 40 Years to 75 Years
Enrollment: 529 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2003 – 2004
U.S. locations: 44
States / cities: Mesa, Arizona • Phoenix, Arizona • Tucson, Arizona + 38 more

Conditions: Knee Osteoarthritis (OA), Chronic Pain, Chronic Knee Pain
Interventions: Not listed
Lead sponsor: University of Pittsburgh; Other
Eligibility: 45 Years to 80 Years
Enrollment: 300 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2030
U.S. locations: 1
States / cities: Pittsburgh, Pennsylvania

Search by objective public record fields.

Comparative Usability Evaluation of Sustained Acoustic Medicine (SAM) Devices and Topical Gel for OA Knee Pain

Role of Suzetrigine as a Part of a Multimodal Regimen to Reduce Pain and Opioid Use After Total Knee Arthroplasty

Effects of Transcranial Direct Current Stimulation (tDCS) and Transcranial Ultrasound on Osteoarthritis Pain of the Knee

Multicenter Bone and Joint Health Study

A Study to Evaluate Long-Term Safety of Multiple Doses of Tapentadol (CG5503) Prolonged-Release (PR) and Oxycodone Controlled-Release (CR) in Patients With Chronic Pain

Amniotic Umbilical Cord Particulate During Total Knee Arthroplasty

How Variations in Pharmacogenomic Profiles Affect Pain and Narcotic Needs Following Total Knee Arthroplasty (TKA)

Trial of Realignment Therapy for Treatment of Medial Knee Osteoarthritis

Evaluate the Efficacy and Safety of Fasinumab in Patients With Moderate-to-Severe Chronic Low Back Pain and Osteoarthritis of the Hip or Knee

fMRI Study of Expectancy on Acupuncture Treatment Outcomes in Knee OA

Use of Pulsed Electromagnetic Fields for Postoperative Knee Pain

Joint Injections for Osteoarthritic Knee Pain

Energy Dispersive Bracing for Conservative Treatment of Knee Osteoarthritis

Proof of Concept Study Comparing FX006 to Kenalog®-40 in Patients With Post-Traumatic Osteoarthritis of the Knee

A 4-week Study to Evaluate the Efficacy and Safety of HP-5000 in Subjects With Knee Osteoarthritis

The Impact of a Technology-enabled Decision Aid, for Patients With Hip and Knee Osteoarthritis on Decision Quality, Level of Shared Decision-making, Patient Satisfaction and Magnitude of Limitations

Tanezumab in Osteoarthritis of the Hip or Knee (2)

Exploring Massage Benefits for Arthritis of the Knee

Outcomes of MAKOplasty Patellofemoral Arthroplasty in Younger Active Patients

Conjoint Analysis of Treatment Preferences for Osteoarthritis

An Acupuncture Functional Magnetic Resonance Imaging (fMRI) Study on Chronic Pain: Response Reliability and Dose Effect

Comparing Exparel & Ropivacaine for Pain Relief in Total Knee Arthroplasty

Safety and Efficacy of Buprenorphine Transdermal System in Subjects With Moderate to Severe Osteoarthritis of Hip or Knee

Individual Differences in Gait and Osteoarthritis Pain