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ClinicalTrials.gov public records Last synced Oct 6, 2026, 10:29 PM EDT

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Showing 1–24 of 47 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Out-of-Hospital Cardiac Arrest Clear all
Active, not recruiting Not applicable Interventional

The PulsePoint Study

NCT04806958
View directory record Official record
Conditions
Out-Of-Hospital Cardiac Arrest, Heart Arrest, Heart Diseases, Cardiovascular Diseases
Interventions
PulsePoint notification
Other
Lead sponsor
Dr. Steven Brooks
Other
Eligibility
Not listed
Enrollment
340 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2026
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Apr 13, 2026 · Synced Oct 6, 2026, 10:29 PM EDT
Completed Phase 3 Interventional Results available

Amiodarone, Lidocaine or Neither for Out-Of-Hospital Cardiac Arrest Due to Ventricular Fibrillation or Tachycardia

NCT01401647
View directory record Official record
Conditions
Cardiac Arrest
Interventions
amiodarone, Lidocaine, Normal saline
Drug · Other
Lead sponsor
University of Washington
Other
Eligibility
18 Years and older
Enrollment
3,024 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2016
U.S. locations
7
States / cities
Birmingham, Alabama • San Diego, California • Portland, Oregon + 4 more
Source: ClinicalTrials.gov public record
Updated Apr 17, 2017 · Synced Oct 6, 2026, 10:29 PM EDT
Not yet recruiting Not applicable Interventional Accepts healthy volunteers

Gathering Evidence on Best Practices for Lay Rescuer CPR Training

NCT05908500
View directory record Official record
Conditions
Cardiac Arrest, Out-Of-Hospital
Interventions
CPR Training, CPR Manikin Type
Behavioral · Device
Lead sponsor
University of Nevada, Reno
Other
Eligibility
Not listed
Enrollment
2,100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2031
U.S. locations
1
States / cities
Reno, Nevada
Source: ClinicalTrials.gov public record
Updated Jun 4, 2025 · Synced Oct 6, 2026, 10:29 PM EDT
Terminated Phase 2 Interventional Results available

Inhaled Nitric Oxide After Out-of-Hospital Cardiac Arrest

NCT03079102
View directory record Official record
Conditions
Heart Arrest, Out-Of-Hospital
Interventions
Nitric Oxide, Nitrogen
Drug
Lead sponsor
Cameron Dezfulian
Other
Eligibility
18 Years and older
Enrollment
57 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2020
U.S. locations
5
States / cities
McKeesport, Pennsylvania • Monroeville, Pennsylvania • Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Apr 25, 2022 · Synced Oct 6, 2026, 10:29 PM EDT
Completed Phase 3 Interventional Results available

Therapeutic Hypothermia to Improve Survival After Cardiac Arrest in Pediatric Patients-THAPCA-OH [Out of Hospital] Trial

NCT00878644
View directory record Official record
Conditions
Cardiac Arrest
Interventions
Therapeutic Hypothermia, Therapeutic Normothermia
Procedure · Other
Lead sponsor
University of Michigan
Other
Eligibility
48 Hours to 18 Years
Enrollment
295 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2014
U.S. locations
33
States / cities
Birmingham, Alabama • Phoenix, Arizona • Tucson, Arizona + 29 more
Source: ClinicalTrials.gov public record
Updated Sep 29, 2017 · Synced Oct 6, 2026, 10:29 PM EDT
Recruiting Not applicable Interventional

Ventilation Performance and Feedback Simulation Trial

NCT07352709
View directory record Official record
Conditions
Out-of-hospital Cardiac Arrest (OHCA)
Interventions
Real-time feedback
Other
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
18 Years to 60 Years
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2031
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Sep 3, 2026 · Synced Oct 6, 2026, 10:29 PM EDT
Completed No phase listed Observational

Effect of Pre-imaging on Cardiopulmonary Resuscitation (CPR) Pause

NCT04248985
View directory record Official record
Conditions
Cardiac Arrest
Interventions
Pre-Imaging - an ultrasound technique of acquiring images
Other
Lead sponsor
University of Massachusetts, Worcester
Other
Eligibility
Not listed
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
Worcester, Massachusetts
Source: ClinicalTrials.gov public record
Updated Feb 8, 2022 · Synced Oct 6, 2026, 10:29 PM EDT
Completed Phase 1 Interventional

Phase 1 Clinical Trial of Sodium Nitrite for Out of Hospital Cardiac Arrest

NCT02987088
View directory record Official record
Conditions
Out-Of-Hospital Cardiac Arrest
Interventions
Sodium Nitrite
Drug
Lead sponsor
University of Washington
Other
Eligibility
18 Years and older
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2017
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated May 7, 2018 · Synced Oct 6, 2026, 10:29 PM EDT
Suspended Not applicable Interventional

Pediatric Prehospital Airway Resuscitation Trial

NCT06364280
View directory record Official record
Conditions
Heart Arrest, Out-Of-Hospital, Wounds and Injuries, Respiratory Insufficiency in Children, Child, Only, Critical Illness
Interventions
BVM, SGA, ETI
Device
Lead sponsor
Ohio State University
Other
Eligibility
24 Hours to 17 Years
Enrollment
3,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2029
U.S. locations
10
States / cities
Tucson, Arizona • Los Angeles, California • Sacramento, California + 7 more
Source: ClinicalTrials.gov public record
Updated Apr 7, 2026 · Synced Oct 6, 2026, 10:29 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Out-of-hospital Cardiac Arrest (OHCA) Biomarkers

NCT03112486
View directory record Official record
Conditions
Neurological Outcome, Cardiac Arrest, Out-Of-Hospital Cardiac Arrest, Brain Anoxia Ischemia, Hypoxia, Brain, Hypoxia-Ischemia, Brain, Cardiac Arrest With Successful Resuscitation, Cardiac Arrest, Out-Of-Hospital, Brain Injuries
Interventions
blood draw
Procedure
Lead sponsor
University of Florida
Other
Eligibility
18 Years and older
Enrollment
32 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2020
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated May 8, 2020 · Synced Oct 6, 2026, 10:29 PM EDT
Not listed Phase 1 Interventional

Phase 1 Study of HBN-1

NCT04094857
View directory record Official record
Conditions
Cardiac Arrest
Interventions
HBN-1
Drug
Lead sponsor
Hibernaid, Inc
Industry
Eligibility
40 Years to 80 Years
Enrollment
18 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
2
States / cities
Portland, Maine • Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Oct 7, 2019 · Synced Oct 6, 2026, 10:29 PM EDT
Completed No phase listed Observational

COOL-ARREST Pilot Study to Assess Intravascular Temperature Management (IVTM) in the Treatment of Cardiac Arrest

NCT01818388
View directory record Official record
Conditions
Out of Hospital Cardiac Arrest
Interventions
ZOLL Intravascular Temperature Management System (IVTM)
Device
Lead sponsor
ZOLL Circulation, Inc., USA
Industry
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
9
States / cities
New Britain, Connecticut • Detroit, Michigan • Royal Oak, Michigan + 6 more
Source: ClinicalTrials.gov public record
Updated Jun 26, 2018 · Synced Oct 6, 2026, 10:29 PM EDT
Completed Not applicable Interventional Results available

Hemodynamic Effects of Standard Cardiopulmonary Resuscitation (CPR), Active Compression Decompression CPR With an Inspiratory Impedance Device, and Standard CPR With an Intrathoracic Pressure Regulator During Out-of-hospital Cardiac Arrest

NCT01325870
View directory record Official record
Conditions
Cardiac Arrest, Sudden Cardiac Death
Interventions
ACD-CPR, ITPR, S-CPR, Impedance Threshold Device (ITD)
Device · Procedure
Lead sponsor
Advanced Circulatory Systems
Industry
Eligibility
18 Years and older
Enrollment
48 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2012
U.S. locations
1
States / cities
Kalamazoo, Michigan
Source: ClinicalTrials.gov public record
Updated Aug 12, 2016 · Synced Oct 6, 2026, 10:29 PM EDT
Active, not recruiting Not applicable Interventional

RACE-CARS - RAndomized Cluster Evaluation of Cardiac ARrest Systems

NCT04660526
View directory record Official record
Conditions
Cardiac Arrest
Interventions
Rapid cardiac arrest recognition that triggers immediate priority EMS/first responder dispatch by 911 operators, Systematic bystander resuscitation instruction by 911 operators, Comprehensive community training of lay people in CPR and AED use., Optimized first responder performance including earlier use of AEDs.
Other
Lead sponsor
Duke University
Other
Eligibility
18 Years and older
Enrollment
20,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2027
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Jul 16, 2026 · Synced Oct 6, 2026, 10:29 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Arizona Prehospital CPR Quality Improvement Project

NCT01258244
View directory record Official record
Conditions
Out-of-Hospital Cardiac Arrest
Interventions
Audiovisual Feedback
Other
Lead sponsor
Valleywise Health
Other
Eligibility
24 Years to 55 Years
Enrollment
101 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2015
U.S. locations
2
States / cities
Flagstaff, Arizona • Mesa, Arizona
Source: ClinicalTrials.gov public record
Updated Jan 25, 2018 · Synced Oct 6, 2026, 10:29 PM EDT
Terminated Not applicable Interventional Results available

Advanced Reperfusion Strategies for Refractory Cardiac Arrest

NCT03880565
View directory record Official record
Conditions
Cardiac Arrest, Extracorporeal Membrane Oxygenation Complication, Ventricular Fibrillation, Pulseless Ventricular Tachycardia, Out-Of-Hospital Cardiac Arrest
Interventions
Early Extracorporeal Membrane Oxygenation (ECMO) Facilitated Resuscitation, Standard Advanced Cardiac Life Support (ACLS) Resuscitation
Device
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years to 75 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Mar 10, 2022 · Synced Oct 6, 2026, 10:29 PM EDT
Terminated Phase 2 Interventional Results available

Ceftriaxone to PRevent pneumOnia and inflammatTion aftEr Cardiac arresT (PROTECT)

NCT04999592
View directory record Official record
Conditions
Out-Of-Hospital Cardiac Arrest, Pneumonia
Interventions
Standard of care without prophylaxis, Antibiotic prophylaxis
Drug
Lead sponsor
David J. Gagnon
Other
Eligibility
18 Years and older
Enrollment
53 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
1
States / cities
Portland, Maine
Source: ClinicalTrials.gov public record
Updated Apr 17, 2025 · Synced Oct 6, 2026, 10:29 PM EDT
Terminated Not applicable Interventional

Early Coronary Angiography Versus Delayed Coronary Angiography

NCT02387398
View directory record Official record
Conditions
Out-of-Hospital Cardiac Arrest, Hypothermia, Cardiac Arrest
Interventions
Early Angiography
Procedure
Lead sponsor
University of Arizona
Other
Eligibility
18 Years and older
Enrollment
99 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2019
U.S. locations
4
States / cities
Tucson, Arizona • Portland, Maine • Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Jan 14, 2022 · Synced Oct 6, 2026, 10:29 PM EDT
Terminated Not applicable Interventional Results available

ACCESS to the Cardiac Cath Lab in Patients Without STEMI Resuscitated From Out-of-hospital VT/VF Cardiac Arrest

NCT03119571
View directory record Official record
Conditions
Cardiac Arrest Due to Underlying Cardiac Condition, Ventricular Fibrillation, Cardiopulmonary Arrest With Successful Resuscitation
Interventions
Initial CCL admission, Initial ICU admission
Procedure · Diagnostic Test
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years to 75 Years
Enrollment
65 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
21
States / cities
Atlanta, Georgia • Indianapolis, Indiana • Ann Arbor, Michigan + 14 more
Source: ClinicalTrials.gov public record
Updated Jan 27, 2021 · Synced Oct 6, 2026, 10:29 PM EDT
Completed Not applicable Interventional Results available

Circulation Improving Resuscitation Care (CIRC)

NCT00597207
View directory record Official record
Conditions
Cardiac Arrest, Cardiopulmonary Resuscitation
Interventions
AutoPulse, Manual
Device · Other
Lead sponsor
Zoll Medical Corporation
Industry
Eligibility
18 Years and older
Enrollment
4,231 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2013
U.S. locations
3
States / cities
Tampa, Florida • Houston, Texas • Menasha, Wisconsin
Source: ClinicalTrials.gov public record
Updated Jul 24, 2018 · Synced Oct 6, 2026, 10:29 PM EDT
Active, not recruiting No phase listed Observational

End-Tidal CO2 (ETCO2) Trends in Out-of-Hospital Cardiac Arrest

NCT07632430
View directory record Official record
Conditions
Prehospital Resuscitation, End-Tidal Carbon Dioxide, Cardiac Arrest, Out-Of-Hospital, Prehospital Emergency Medical Services
Interventions
Not listed
Lead sponsor
Office of the Medical Director for EMS in Oklahoma City and Tulsa
Other
Eligibility
18 Years and older
Enrollment
3,500 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Oklahoma City, Oklahoma
Source: ClinicalTrials.gov public record
Updated Jun 9, 2026 · Synced Oct 6, 2026, 10:29 PM EDT
Completed Not applicable Interventional

Targeted Hypothermia Versus Targeted Normothermia After Out-of-hospital Cardiac Arrest

NCT02908308
View directory record Official record
Conditions
Out-of-hospital Cardiac Arrest
Interventions
Targeted temperature management to 33°C, Standard care with early treatment of fever
Procedure
Lead sponsor
Helsingborgs Hospital
Other
Eligibility
18 Years and older
Enrollment
1,900 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2022
U.S. locations
2
States / cities
Rochester, New York • Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Apr 3, 2023 · Synced Oct 6, 2026, 10:29 PM EDT
Completed Not applicable Interventional

Influence of Cooling Duration on Efficacy in Cardiac Arrest Patients

NCT04217551
View directory record Official record
Conditions
Cardiac Arrest, Out-Of-Hospital, Hypothermia, Induced, Hypoxia-Ischemia, Brain
Interventions
Therapeutic Hypothermia
Device
Lead sponsor
University of Michigan
Other
Eligibility
18 Years and older
Enrollment
1,158 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2026
U.S. locations
76
States / cities
Birmingham, Alabama • Tucson, Arizona • Los Angeles, California + 57 more
Source: ClinicalTrials.gov public record
Updated Jul 15, 2026 · Synced Oct 6, 2026, 10:29 PM EDT
Completed Phase 1Phase 2 Interventional Results available

Washington Study of Hemofiltration After Out-of-Hospital Cardiac Arrest

NCT01509040
View directory record Official record
Conditions
Cardiac Arrest
Interventions
Standard Care, Low Volume Hemofiltration, High Volume Hemofiltration
Other · Device
Lead sponsor
University of Washington
Other
Eligibility
65 Years and older
Enrollment
2 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2014
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Jun 9, 2016 · Synced Oct 6, 2026, 10:29 PM EDT