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ClinicalTrials.gov public records Last synced Oct 5, 2026, 9:36 PM EDT

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Showing 97–120 of 566 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Overweight and Obese Adults Clear all
Recruiting Phase 1 Interventional

A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of MBX 4291 in Adult Participants With Obesity

NCT07142707
View directory record Official record
Conditions
Obesity
Interventions
MBX 4291, Placebo
Drug
Lead sponsor
MBX Biosciences
Industry
Eligibility
18 Years to 65 Years
Enrollment
124 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
4
States / cities
Doral, Florida • Lexington, Kentucky • Kansas City, Missouri + 1 more
Source: ClinicalTrials.gov public record
Updated Jun 9, 2026 · Synced Oct 5, 2026, 9:36 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

National Survey of Young Adult Nutrition

NCT06096636
View directory record Official record
Conditions
Overweight or Obesity
Interventions
Study participants
Other
Lead sponsor
USDA Grand Forks Human Nutrition Research Center
Federal
Eligibility
18 Years to 24 Years
Enrollment
1,123 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
Grand Forks, North Dakota
Source: ClinicalTrials.gov public record
Updated Apr 22, 2025 · Synced Oct 5, 2026, 9:36 PM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Time-restricted Eating Versus Daily Continuous Calorie Restriction on Body Weight and Colorectal Cancer Risk Markers

NCT05114798
View directory record Official record
Conditions
Time Restricted Eating, Obesity, Weight Loss, Colorectal Cancer
Interventions
Time restricted eating, Calorie Restriction
Behavioral
Lead sponsor
University of Illinois at Chicago
Other
Eligibility
45 Years to 70 Years
Enrollment
194 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2027
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Jul 21, 2026 · Synced Oct 5, 2026, 9:36 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

This Study Assessed the Impact of Diet on Gastric Emptying Time and Metabolic Flexibility

NCT03630263
View directory record Official record
Conditions
Obesity, Diabetes Mellitus, Type 2, Appetitive Behavior
Interventions
Raw Corn Starch, No Raw Corn Starch
Other
Lead sponsor
Purdue University
Other
Eligibility
18 Years to 50 Years
Enrollment
32 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2022
U.S. locations
1
States / cities
West Lafayette, Indiana
Source: ClinicalTrials.gov public record
Updated Nov 16, 2022 · Synced Oct 5, 2026, 9:36 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Fiber-rich Foods, Weight Status, and the Gut Microbiota in NH Hispanic Adults at Risk for Food Insecurity

NCT05488912
View directory record Official record
Conditions
Food Insecurity, Overweight and Obesity
Interventions
Not listed
Lead sponsor
University of New Hampshire
Other
Eligibility
18 Years to 55 Years
Enrollment
61 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2024
U.S. locations
1
States / cities
Durham, New Hampshire
Source: ClinicalTrials.gov public record
Updated Mar 28, 2025 · Synced Oct 5, 2026, 9:36 PM EDT
Recruiting Phase 1Phase 2 Interventional

A Study to Evaluate ALN-CIDEB in Adult Participants With Metabolic Dysfunction-Associated Steatotic Liver Disease or With Metabolic Dysfunction-Associated Steatohepatitis (MASLD/MASH)

NCT06836609
View directory record Official record
Conditions
Metabolic Dysfunction-Associated Steatotic Liver Disease, Metabolic Dysfunction-Associated Steatohepatitis
Interventions
ALN-CIDEB, Placebo
Drug
Lead sponsor
Regeneron Pharmaceuticals
Industry
Eligibility
18 Years to 65 Years
Enrollment
132 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
2
States / cities
Chandler, Arizona • Tucson, Arizona
Source: ClinicalTrials.gov public record
Updated Jul 8, 2026 · Synced Oct 5, 2026, 9:36 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Walnut Consumption and Gut Microbiota

NCT05441748
View directory record Official record
Conditions
Obesity, Inflammation
Interventions
Walnuts, Walnut Oil, Control
Other
Lead sponsor
University of Illinois at Urbana-Champaign
Other
Eligibility
25 Years to 75 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2024
U.S. locations
1
States / cities
Urbana, Illinois
Source: ClinicalTrials.gov public record
Updated Jun 18, 2023 · Synced Oct 5, 2026, 9:36 PM EDT
Recruiting Not applicable Interventional

Plant-Based Online Weight Loss Through Education and Resources Program and Study

NCT07095543
View directory record Official record
Conditions
Type 2 Diabetes, Overweight and Obese Adults
Interventions
Low-fat, vegan diet
Behavioral
Lead sponsor
Physicians Committee for Responsible Medicine
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated Sep 17, 2026 · Synced Oct 5, 2026, 9:36 PM EDT
Recruiting Phase 3 Interventional

A Study of Once-daily Oral ASC30 to Evaluate the Efficacy and Safety in Adult Participants With Obesity or Overweight With Type 2 Diabetes

NCT07743450
View directory record Official record
Conditions
Obesity, Overweight, Chronic Weight Management, Type 2 Diabetes Mellitus
Interventions
ASC30 tablets A1, Placebo
Drug
Lead sponsor
Ascletis Pharma (China) Co., Limited
Industry
Eligibility
18 Years and older
Enrollment
1,560 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
84
States / cities
Birmingham, Alabama • Huntsville, Alabama • Peoria, Arizona + 80 more
Source: ClinicalTrials.gov public record
Updated Sep 16, 2026 · Synced Oct 5, 2026, 9:36 PM EDT
Recruiting Phase 3 Interventional Accepts healthy volunteers

A Study of Aleniglipron in Adults With Obesity or Overweight and Type 2 Diabetes Mellitus (ACCOMPLISH-2)

NCT07654374
View directory record Official record
Conditions
Obesity, Overweight, Chronic Weight Management, Type2 Diabetes Mellitus
Interventions
aleniglipron, Placebo
Drug
Lead sponsor
Gasherbrum Bio, Inc., a wholly owned subsidiary of Structure Therapeutics
Industry
Eligibility
18 Years to 79 Years
Enrollment
1,100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2028
U.S. locations
74
States / cities
Birmingham, Alabama • Chandler, Arizona • Phoenix, Arizona + 68 more
Source: ClinicalTrials.gov public record
Updated Sep 11, 2026 · Synced Oct 5, 2026, 9:36 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Postprandial Inflammation and Nuts (PIN) in Older Adults

NCT06348771
View directory record Official record
Conditions
Healthy Aging, Overweight and Obesity
Interventions
monounsaturated fatty acids (MUFA) peanut meal
Behavioral
Lead sponsor
Rutgers, The State University of New Jersey
Other
Eligibility
55 Years and older
Enrollment
17 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
2
States / cities
New Brunswick, New Jersey
Source: ClinicalTrials.gov public record
Updated May 13, 2026 · Synced Oct 5, 2026, 9:36 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Examining the Longitudinal Relationship Between Sleep and Weight Gain in College Students

NCT04100967
View directory record Official record
Conditions
Healthy, Overweight
Interventions
Not listed
Lead sponsor
Oakland University
Other
Eligibility
17 Years to 22 Years
Enrollment
116 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2021
U.S. locations
1
States / cities
Rochester, Michigan
Source: ClinicalTrials.gov public record
Updated Apr 27, 2022 · Synced Oct 5, 2026, 9:36 PM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Inspiratory Muscle Strength Training in Adults With Obesity

NCT05459636
View directory record Official record
Conditions
Obesity
Interventions
High-resistance inspiratory muscle strength training, Very-low-resistance inspiratory muscle strength training
Device
Lead sponsor
Florida State University
Other
Eligibility
18 Years to 45 Years
Enrollment
44 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2026
U.S. locations
1
States / cities
Tallahassee, Florida
Source: ClinicalTrials.gov public record
Updated Aug 27, 2026 · Synced Oct 5, 2026, 9:36 PM EDT
Active, not recruiting Phase 2 Interventional Accepts healthy volunteers

MIST (Metabolic Intervention With Semaglutide and THR-β Therapy) Trial

NCT07505303
View directory record Official record
Conditions
Adult Obesity, Weight Management
Interventions
ECC4703, Placebo, Semaglutide
Drug
Lead sponsor
Eccogene
Industry
Eligibility
18 Years to 75 Years
Enrollment
151 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026
U.S. locations
15
States / cities
Birmingham, Alabama • Anaheim, California • Los Alamitos, California + 11 more
Source: ClinicalTrials.gov public record
Updated Jun 25, 2026 · Synced Oct 5, 2026, 9:36 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Improving Muscle for Functional Independence Trial

NCT01049698
View directory record Official record
Conditions
Obesity
Interventions
Resistance Training, Resistance Training + Diet
Behavioral
Lead sponsor
Wake Forest University
Other
Eligibility
65 Years to 79 Years
Enrollment
126 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2014
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Aug 1, 2018 · Synced Oct 5, 2026, 9:36 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

A Study of the Safety, Tolerance and Assessment of HE3286 on Insulin Sensitivity and Hepatic Glucose Production

NCT00991107
View directory record Official record
Conditions
Insulin Resistance
Interventions
HE3286
Drug
Lead sponsor
Harbor Therapeutics
Industry
Eligibility
18 Years to 65 Years
Enrollment
5 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2010
U.S. locations
1
States / cities
Baton Rouge, Louisiana
Source: ClinicalTrials.gov public record
Updated Mar 9, 2011 · Synced Oct 5, 2026, 9:36 PM EDT
Recruiting Phase 3 Interventional

A Study of Eloralintide (LY3841136) in Participants With Obesity or Overweight, and Type 2 Diabetes

NCT07282600
View directory record Official record
Conditions
Overweight, Obesity
Interventions
Eloralintide, Placebo
Drug
Lead sponsor
Eli Lilly and Company
Industry
Eligibility
18 Years and older
Enrollment
1,035 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
60
States / cities
Birmingham, Alabama • Cullman, Alabama • Tucson, Arizona + 56 more
Source: ClinicalTrials.gov public record
Updated Sep 22, 2026 · Synced Oct 5, 2026, 9:36 PM EDT
Recruiting Phase 2 Interventional Accepts healthy volunteers

Effect of Ketone Esters on Liver Fat Content and Metabolic Function

NCT07097506
View directory record Official record
Conditions
MASLD - Metabolic Dysfunction-Associated Steatotic Liver Disease, Obesity, Overweight (BMI > 25)
Interventions
bis-octanoyl (R)-1,3-butanediol (C8 ketone di-ester), Placebo
Drug · Other
Lead sponsor
Washington University School of Medicine
Other
Eligibility
18 Years to 40 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2027
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Jul 15, 2026 · Synced Oct 5, 2026, 9:36 PM EDT
Completed Not applicable Interventional

NUTRITION MATTERS: A Food is Medicine Intervention for African-American Adults With Multiple Chronic Conditions

NCT06933940
View directory record Official record
Conditions
Type 2 Diabetes, Hypertension, Obesity and Obesity-related Medical Conditions, Heart Disease
Interventions
Nutrition Matters
Behavioral
Lead sponsor
Winston Salem State University
Other
Eligibility
35 Years to 64 Years
Enrollment
26 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Jul 18, 2025 · Synced Oct 5, 2026, 9:36 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effects of Milk Protein Concentrate on Overall Health During Weight Loss in Overweight/Obese Adults

NCT01692860
View directory record Official record
Conditions
Sarcopenia, Metabolic Disease, High Blood Pressure
Interventions
Energy Restriction
Other
Lead sponsor
Purdue University
Other
Eligibility
35 Years to 65 Years
Enrollment
48 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2015
U.S. locations
1
States / cities
West Lafayette, Indiana
Source: ClinicalTrials.gov public record
Updated Nov 4, 2015 · Synced Oct 5, 2026, 9:36 PM EDT
Recruiting Phase 3 Interventional

Role of Semaglutide in Restoring Ovulation in Youth and Adults With Polycystic Ovary Syndrome

NCT05819853
View directory record Official record
Conditions
PCOS (Polycystic Ovary Syndrome) of Bilateral Ovaries, Obese
Interventions
Semaglutide Injectable Product (Wegovy and/or Ozempic)
Drug
Lead sponsor
University of Colorado, Denver
Other
Eligibility
12 Years to 35 Years · Female only
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2028
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Aug 31, 2026 · Synced Oct 5, 2026, 9:36 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Assessing Inherited Markers of Metabolic Syndrome in the Young

NCT00966407
View directory record Official record
Conditions
Metabolic Syndrome, Diabetes Mellitus, Type 2, Obesity
Interventions
Not listed
Lead sponsor
Eric Hoffman
Other
Eligibility
18 Years to 35 Years
Enrollment
700 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2016
U.S. locations
1
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated Feb 9, 2017 · Synced Oct 5, 2026, 9:36 PM EDT
Completed Not applicable Interventional

Time Restricted Feeding in Autosomal Dominant Polycystic Kidney Disease

NCT04534985
View directory record Official record
Conditions
Polycystic Kidney, Autosomal Dominant
Interventions
Dietary
Behavioral
Lead sponsor
University of Colorado, Denver
Other
Eligibility
18 Years to 65 Years
Enrollment
29 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Apr 10, 2023 · Synced Oct 5, 2026, 9:36 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Use of a Soy-based Meal Replacement Weight Loss Intervention to Impact Ectopic Fat

NCT01298817
View directory record Official record
Conditions
Abdominal Obesity
Interventions
Medifast meal replacement products
Dietary Supplement
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
60 Years to 79 Years
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2012
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Aug 15, 2018 · Synced Oct 5, 2026, 9:36 PM EDT