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Showing 1–24 of 40 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Oxalate Urolithiasis Clear all
Enrolling by invitation Not applicable Interventional

Heterozygous Individuals for AGXT and Kidney Stones

NCT04430426
View directory record Official record
Conditions
Kidney Stone, Urolithiasis, Calcium Oxalate
Interventions
Controlled Diet
Other
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
18 Years and older
Enrollment
4 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2027 – 2032
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Aug 30, 2026 · Synced Sep 12, 2026, 6:45 PM EDT
Completed Phase 3 Interventional

Evaluate ALLN-177 in Patients With Enteric Hyperoxaluria

NCT03456830
View directory record Official record
Conditions
Enteric Hyperoxaluria
Interventions
ALLN-177, Placebo
Drug
Lead sponsor
Allena Pharmaceuticals
Industry
Eligibility
18 Years and older
Enrollment
115 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
39
States / cities
Birmingham, Alabama • Phoenix, Arizona • Tucson, Arizona + 34 more
Source: ClinicalTrials.gov public record
Updated Feb 26, 2020 · Synced Sep 12, 2026, 6:45 PM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Oxalate Formation From Ascorbic Acid

NCT04603898
View directory record Official record
Conditions
Kidney Stone
Interventions
Low Oxalate Diet, Carbon-13 Ascorbic Acid Oral Load
Dietary Supplement
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
19 Years and older
Enrollment
90 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2027
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Jun 8, 2026 · Synced Sep 12, 2026, 6:45 PM EDT
Completed Phase 1Phase 2 Interventional Results available

Use of an Herbal Preparation to Prevent and Dissolve Kidney Stones

NCT00381849
View directory record Official record
Conditions
Cystinuria, Nephrolithiasis, Calcium Oxalate
Interventions
Cystone, Sugar Pill (Placebo)
Drug
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years to 100 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2010
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Feb 3, 2016 · Synced Sep 12, 2026, 6:45 PM EDT
Not yet recruiting Phase 1Phase 2 Interventional

Sodium Bicarbonate as an Alternative to Potassium Citrate for Kidney Stones

NCT07408076
View directory record Official record
Conditions
Kidney Stones, Urolithiasis, Hypocitraturia, Nephrolithiasis
Interventions
Potassium Citrate, Sodium Bicarbonate
Drug
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
4
States / cities
Los Angeles, California • Sacramento, California • San Diego, California + 1 more
Source: ClinicalTrials.gov public record
Updated Feb 11, 2026 · Synced Sep 12, 2026, 6:45 PM EDT
Completed Phase 2 Interventional

Evaluate the Effect of ALLN-177 in Reducing Urinary Oxalate in Patients With Hyperoxaluria and Kidney Stones

NCT02503345
View directory record Official record
Conditions
Secondary Hyperoxaluria, Nephrolithiasis, Kidney Stones, Hyperoxaluria, Dietary Hyperoxaluria
Interventions
ALLN-177 low dose, ALLN-177 mid dose, ALLN-177 high dose, Placebo
Drug
Lead sponsor
Allena Pharmaceuticals
Industry
Eligibility
18 Years and older
Enrollment
32 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2017
U.S. locations
16
States / cities
Los Angeles, California • Daytona Beach, Florida • Jacksonville, Florida + 13 more
Source: ClinicalTrials.gov public record
Updated Jan 10, 2018 · Synced Sep 12, 2026, 6:45 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Oxalobacter Formigenes Colonization and Urinary Oxalate Excretion

NCT03752684
View directory record Official record
Conditions
Calcium Oxalate Urolithiasis
Interventions
Moderately high oxalate/low calcium diet non-colonized, Oxalobacter formigenes, Moderately high oxalate/low calcium diet colonized
Dietary Supplement
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
19 Years to 65 Years
Enrollment
26 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2025
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Jan 29, 2026 · Synced Sep 12, 2026, 6:45 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Endogenous Oxalate Synthesis in Idiopathic Calcium Oxalate Kidney Stone Disease

NCT06989320
View directory record Official record
Conditions
Kidney Stones, Kidney Calculi, Urolithiasis, Urolithiasis, Calcium Oxalate, Nephrolithiasis, Nephrolithiasis, Calcium Oxalate, Oxalate Urolithiasis, Healthy, Healthy Volunteer
Interventions
Low-oxalate diet and glycolate dosing, Oral glycolate dosing, Oral 13C- ascorbic acid dosing
Dietary Supplement
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
18 Years to 80 Years
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2031
U.S. locations
2
States / cities
Birmingham, Alabama • Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Aug 26, 2026 · Synced Sep 12, 2026, 6:45 PM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Influence of Obesity on Oxalate Metabolism and Handling in Calcium Oxalate Stone Formers

NCT04333745
View directory record Official record
Conditions
Kidney Stone
Interventions
Controlled Diet, Carbon-13 Oxalate and Sucralose Ingestion
Other · Dietary Supplement
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
19 Years to 75 Years
Enrollment
22 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2027
U.S. locations
2
States / cities
Birmingham, Alabama • Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Aug 25, 2026 · Synced Sep 12, 2026, 6:45 PM EDT
Completed Phase 2 Interventional Results available

Febuxostat Versus Allopurinol or Placebo in Patients With Hyperuricosuria and Calcium Oxalate Stones

NCT01077284
View directory record Official record
Conditions
Hyperuricosuria, Kidney Stones
Interventions
Febuxostat, Allopurinol, Placebo
Drug
Lead sponsor
Takeda
Industry
Eligibility
18 Years and older
Enrollment
99 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2011
U.S. locations
28
States / cities
Birmingham, Alabama • Anchorage, Alaska • Tucson, Arizona + 25 more
Source: ClinicalTrials.gov public record
Updated Feb 14, 2013 · Synced Sep 12, 2026, 6:45 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

The Effects of Sports Drinks on Urinary Lithogenicity

NCT00381277
View directory record Official record
Conditions
Urolithiasis
Interventions
Gatorade, Performance
Drug
Lead sponsor
VA New York Harbor Healthcare System
Federal
Eligibility
18 Years to 80 Years
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Feb 20, 2011 · Synced Sep 12, 2026, 6:45 PM EDT
Completed Phase 1Phase 2 Interventional Results available

Use of Oral Probiotics to Reduce Urinary Oxalate Excretion

NCT00587041
View directory record Official record
Conditions
Nephrolithiasis, Hyperoxaluria, Crohn's Disease
Interventions
Oxadrop, Agri-King Synbiotic (AKSB), Placebo
Dietary Supplement · Other
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2009
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated May 30, 2012 · Synced Sep 12, 2026, 6:45 PM EDT
Recruiting Not applicable Interventional

O. Formigenes Colonization in Calcium Oxalate Kidney Stone Disease

NCT06330246
View directory record Official record
Conditions
Kidney Stone, Kidney Calculi, Urolithiasis, Urolithiasis, Calcium Oxalate, Nephrolithiasis, Nephrolithiasis, Calcium Oxalate, Oxalate Urolithiasis, Oxaluria
Interventions
Low oxalate fixed diets pre-colonization, Moderately high oxalate fixed diets pre-colonization, Colonization with Oxalobacter formigenes, Low oxalate fixed diets post-colonization, Moderately high oxalate fixed diets post-colonization
Dietary Supplement
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
18 Years to 70 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2031
U.S. locations
2
States / cities
Birmingham, Alabama • Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Aug 26, 2026 · Synced Sep 12, 2026, 6:45 PM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Renal Metabolism of Glycolate to Oxalate

NCT04437225
View directory record Official record
Conditions
Healthy
Interventions
Low oxalate controlled Diet, Primed, continuous intravenous infusion of 13C2-Glycolate, Bolus intravenous infusion of 13C2-Glycolate, Oral bolus administration of 13C2-Glycolate
Dietary Supplement · Other
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
18 Years to 75 Years
Enrollment
15 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2030
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Aug 26, 2026 · Synced Sep 12, 2026, 6:45 PM EDT
Terminated Phase 3 Interventional

Establishing the Safety and Efficacy of Reloxaliase in Patients With Enteric Hyperoxaluria

NCT03847090
View directory record Official record
Conditions
Enteric Hyperoxaluria
Interventions
Reloxaliase, Placebo
Drug
Lead sponsor
Allena Pharmaceuticals
Industry
Eligibility
18 Years and older
Enrollment
92 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
64
States / cities
Birmingham, Alabama • Mobile, Alabama • Mesa, Arizona + 57 more
Source: ClinicalTrials.gov public record
Updated Jun 9, 2022 · Synced Sep 12, 2026, 6:45 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Assessment of Endogenous Oxalate Synthesis

NCT05229952
View directory record Official record
Conditions
Healthy, Kidney Stone, Obesity
Interventions
Low-oxalate controlled diet, Primed, continuous intravenous infusion of 13C2-oxalate
Dietary Supplement · Other
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
18 Years to 75 Years
Enrollment
23 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2024
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated May 12, 2025 · Synced Sep 12, 2026, 6:45 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Gut Oxalate Absorption in Calcium Oxalate Stone Disease

NCT06331546
View directory record Official record
Conditions
Kidney Stone, Kidney Calculi, Urolithiasis, Urolithiasis, Calcium Oxalate, Nephrolithiasis, Nephrolithiasis, Calcium Oxalate, Oxalate Urolithiasis, Oxaluria, Healthy
Interventions
Low-oxalate diet, High-oxalate diet, soluble oxalate gut absorption test
Dietary Supplement · Other
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
18 Years to 70 Years
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2031
U.S. locations
2
States / cities
Birmingham, Alabama • Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Aug 26, 2026 · Synced Sep 12, 2026, 6:45 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Obesity and Endogenous Oxalate Synthesis

NCT03808090
View directory record Official record
Conditions
Obesity
Interventions
Normal Individuals
Dietary Supplement
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
19 Years to 70 Years
Enrollment
58 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2024
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated May 31, 2026 · Synced Sep 12, 2026, 6:45 PM EDT
Completed Phase 2 Interventional

Study of ALLN-177 in Patients Aged 12 Years or Older With Enteric or Primary Hyperoxaluria and Hyperoxalemia

NCT03391804
View directory record Official record
Conditions
Enteric Hyperoxaluria, Primary Hyperoxaluria, Hyperoxalemia
Interventions
ALLN-177
Drug
Lead sponsor
Allena Pharmaceuticals
Industry
Eligibility
12 Years and older
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
4
States / cities
Scottsdale, Arizona • Little Rock, Arkansas • New Haven, Connecticut + 1 more
Source: ClinicalTrials.gov public record
Updated Dec 29, 2020 · Synced Sep 12, 2026, 6:45 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Oxalate and Citrate in Humans - Response to Citrate

NCT06944223
View directory record Official record
Conditions
Kidney Stone, Healthy
Interventions
Kidney stone formers, Control cohort
Other
Lead sponsor
University of Chicago
Other
Eligibility
18 Years to 70 Years
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2027
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Dec 15, 2025 · Synced Sep 12, 2026, 6:45 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Dietary Oxalate and Innate Immunity in Kidney Stone Disease

NCT04051346
View directory record Official record
Conditions
Kidney Stone
Interventions
Low Oxalate Diet, High Oxalate Diet
Dietary Supplement
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
18 Years to 60 Years
Enrollment
14 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2025
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Jun 25, 2026 · Synced Sep 12, 2026, 6:45 PM EDT
Completed Phase 2 Interventional Results available

Evaluating ALLN-177 for Reducing Urinary Oxalate Excretion in Calcium Oxalate Kidney Stone Formers With Hyperoxaluria

NCT02289755
View directory record Official record
Conditions
Hyperoxaluria, Nephrolithiasis
Interventions
ALLN-177
Drug
Lead sponsor
Allena Pharmaceuticals
Industry
Eligibility
Not listed
Enrollment
16 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
4
States / cities
Indianapolis, Indiana • Lake Success, New York • Cleveland, Ohio + 1 more
Source: ClinicalTrials.gov public record
Updated Jun 4, 2019 · Synced Sep 12, 2026, 6:45 PM EDT
Terminated Phase 1Phase 2 Interventional Accepts healthy volunteers

Safety, Tolerability, and Pharmacodynamics of NOV-001 in Adult Subjects

NCT04909723
View directory record Official record
Conditions
Healthy Volunteers, Enteric Hyperoxaluria
Interventions
NOV-001, NB1000S, NB2000P, Placebo
Combination Product · Biological · Drug
Lead sponsor
Novome Biotechnologies Inc
Industry
Eligibility
18 Years to 65 Years
Enrollment
153 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2023
U.S. locations
19
States / cities
Birmingham, Alabama • Scottsdale, Arizona • Daytona Beach, Florida + 15 more
Source: ClinicalTrials.gov public record
Updated May 16, 2023 · Synced Sep 12, 2026, 6:45 PM EDT
Enrolling by invitation No phase listed Observational Accepts healthy volunteers

Pilot Study to Evaluate the Contribution of Gene Variants to Idiopathic Urolithiasis

NCT01127854
View directory record Official record
Conditions
Kidney Stones, Urolithiasis, Calcium Oxalate Urolithiasis
Interventions
Not listed
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
2,900 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2027
U.S. locations
1
States / cities
Jacksonville, Florida
Source: ClinicalTrials.gov public record
Updated Jan 22, 2026 · Synced Sep 12, 2026, 6:45 PM EDT