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Showing 1–24 of 663 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Oxygen Therapy Clear all
Completed Early Phase 1 Interventional

Hyperbaric Oxygen and Manipulative Therapies to Regain Function Post Stroke

NCT03352232
View directory record Official record
Conditions
Stroke, Motor Dysfunction, Chronic Stroke, Ischemic Stroke
Interventions
HBOT and OMT
Combination Product
Lead sponsor
Abington Memorial Hospital
Other
Eligibility
18 Years to 80 Years
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2021
U.S. locations
1
States / cities
Abington, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Dec 20, 2021 · Synced Sep 28, 2026, 6:56 AM EDT
Completed No phase listed Observational

Hyperbaric Oxygen Treatment in Patients With White Matter Hyperintensities

NCT00497432
View directory record Official record
Conditions
Neurological Impairments, Leukoencephalopathies
Interventions
Not listed
Lead sponsor
St. Luke's Hospital, Chesterfield, Missouri
Other
Eligibility
50 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2012
U.S. locations
2
States / cities
Chesterfield, Missouri • St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated May 30, 2013 · Synced Sep 28, 2026, 6:56 AM EDT
Completed No phase listed Observational

Validation of Fore-Sight Cerebral & Tissue Oximeter Saturation Measurements on Neonates ≤ 5 kg

NCT02017652
View directory record Official record
Conditions
Bowel Motility
Interventions
Not listed
Lead sponsor
Sharp HealthCare
Other
Eligibility
Up to 7 Days
Enrollment
19 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2014
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Oct 8, 2017 · Synced Sep 28, 2026, 6:56 AM EDT
Enrolling by invitation No phase listed Observational

Liquid Biopsy in Glioblastoma Treated With Chemoradiation and an Oxygen Therapeutic

NCT07417774
View directory record Official record
Conditions
Glioblastoma (GBM)
Interventions
Not listed
Lead sponsor
NuvOx LLC
Industry
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2030
U.S. locations
4
States / cities
Tucson, Arizona • New Haven, Connecticut • Kansas City, Missouri + 1 more
Source: ClinicalTrials.gov public record
Updated Feb 17, 2026 · Synced Sep 28, 2026, 6:56 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effects of Pre-dive Ketone Food Products on Latency to CNS Oxygen Toxicity (Aim 1)

NCT05801120
View directory record Official record
Conditions
Oxygen Toxicity
Interventions
Ketogenic food products
Dietary Supplement
Lead sponsor
Duke University
Other
Eligibility
18 Years to 39 Years
Enrollment
15 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated May 30, 2025 · Synced Sep 28, 2026, 6:56 AM EDT
Enrolling by invitation Not applicable Interventional Accepts healthy volunteers

The Effect of Respiratory Challenge on the BOLD Signal

NCT04258774
View directory record Official record
Conditions
Hypoxia, Brain, Hyperoxia, Hypercapnia, Hypocapnia
Interventions
Carbon Dioxide
Other
Lead sponsor
Washington University School of Medicine
Other
Eligibility
18 Years and older
Enrollment
48 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2027
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Jan 15, 2026 · Synced Sep 28, 2026, 6:56 AM EDT
Completed Not applicable Interventional Results available

Transnasal Humidified Rapid-Insufflation Ventilatory Exchange (THRIVE) and Laser Laryngeal Surgery

NCT03086265
View directory record Official record
Conditions
Otorhinolaryngologic Surgical Procedures, Laser Therapy
Interventions
THRIVE, Endotracheal tube
Device
Lead sponsor
Stanford University
Other
Eligibility
18 Years to 80 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
1
States / cities
Stanford, California
Source: ClinicalTrials.gov public record
Updated Mar 16, 2020 · Synced Sep 28, 2026, 6:56 AM EDT
Terminated Phase 1 Interventional

Trans Sodium Crocetinate (TSC) Study of Intra-tumoral Oxygen Concentration, Safety, and Pharmacokinetics in Patients With High Grade Glioma

NCT00826930
View directory record Official record
Conditions
High Grade Glioma
Interventions
Trans Sodium Crocetinate (TSC)
Drug
Lead sponsor
Diffusion Pharmaceuticals Inc
Industry
Eligibility
18 Years and older
Enrollment
1 participant
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Aug 11, 2010 · Synced Sep 28, 2026, 6:56 AM EDT
Active, not recruiting Not applicable Interventional

Delayed Cord Clamping With Oxygen In Extremely Low Gestation Infants

NCT04413097
View directory record Official record
Conditions
IVH- Intraventricular Hemorrhage, Extreme Prematurity, Hypoxia Neonatal, Hyperoxia, Respiratory Insufficiency
Interventions
Delayed Cord Clamping with Low Oxygen concentration, Delayed Cord Clamping with High Oxygen concentration
Procedure
Lead sponsor
Sharp HealthCare
Other
Eligibility
22 Weeks to 28 Weeks
Enrollment
140 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2026
U.S. locations
3
States / cities
Davis, California • San Diego, California
Source: ClinicalTrials.gov public record
Updated Jun 11, 2025 · Synced Sep 28, 2026, 6:56 AM EDT
Completed Phase 4 Interventional Results available

Oxygen Versus PAP for Sleep Apnea in Heart Failure

NCT01807897
View directory record Official record
Conditions
Heart Failure, Sleep Apnea Syndromes
Interventions
Continuous positive airway pressure, Nocturnal supplemental oxygen, Healthy Lifestyle and Sleep Education
Device · Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
74 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2020
U.S. locations
2
States / cities
West Haven, Connecticut • Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jan 24, 2023 · Synced Sep 28, 2026, 6:56 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Maternal Oxygen Supplementation for Intrauterine Resuscitation

NCT05681624
View directory record Official record
Conditions
Fetal Distress, Fetal Hypoxia, Labor and Delivery Complication
Interventions
Maternal oxygen supplementation, Room air
Other
Lead sponsor
Washington University School of Medicine
Other
Eligibility
Female only
Enrollment
2,252 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2028
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Aug 9, 2026 · Synced Sep 28, 2026, 6:56 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Cerebral Oxygen Metabolism in Children

NCT04157179
View directory record Official record
Conditions
Sickle Cell Disease, Cerebral Stroke
Interventions
Carbon Dioxide
Other
Lead sponsor
Washington University School of Medicine
Other
Eligibility
3 Years to 50 Years
Enrollment
350 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2027
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Sep 10, 2025 · Synced Sep 28, 2026, 6:56 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Study Effects of Intermittent Hypoxia on Restoring Hand Function Following SCI

NCT01272336
View directory record Official record
Conditions
Spinal Cord Injury
Interventions
Acute Intermittent Hypoxia (AIH), SHAM-Intermittent Room Air
Drug · Other
Lead sponsor
Emory University
Other
Eligibility
18 Years to 65 Years
Enrollment
53 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2015
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Jan 25, 2016 · Synced Sep 28, 2026, 6:56 AM EDT
Terminated No phase listed Observational

Effects of Oxygen on Lung Tissue During Anesthesia

NCT00715338
View directory record Official record
Conditions
Lung Injury, Acute
Interventions
Not listed
Lead sponsor
Vanderbilt University
Other
Eligibility
18 Years to 80 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Apr 19, 2017 · Synced Sep 28, 2026, 6:56 AM EDT
Terminated Phase 2Phase 3 Interventional

Effects of Cerebral Oxygen Saturation on Neuropsychological Outcomes

NCT00151307
View directory record Official record
Conditions
Cardiovascular Diseases, Postoperative Complications
Interventions
INVOS cerebral oximeter
Device
Lead sponsor
Weill Medical College of Cornell University
Other
Eligibility
18 Years to 80 Years
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2001 – 2007
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jun 5, 2008 · Synced Sep 28, 2026, 6:56 AM EDT
Completed Phase 2 Interventional Results available

High-Flow Oxygen for Dyspnea in Hospitalized Cancer Patients

NCT02932332
View directory record Official record
Conditions
Cancer
Interventions
High-flow Oxygen, Low-flow Oxygen, High-flow Air, Low-flow Air
Other
Lead sponsor
M.D. Anderson Cancer Center
Other
Eligibility
18 Years and older
Enrollment
26 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2023
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Apr 20, 2023 · Synced Sep 28, 2026, 6:56 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

NASA Exercise Prebreathe Study

NCT07702539
View directory record Official record
Conditions
Decompression Sickness
Interventions
Oxygen Prebreathe and Hypobaric Exposure
Procedure
Lead sponsor
Duke University
Other
Eligibility
30 Years to 60 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2027
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Sep 21, 2026 · Synced Sep 28, 2026, 6:56 AM EDT
Not yet recruiting Not applicable Interventional

Respiratory Oxygen Adherence Monitor for Chronic Obstructive Pulmonary Disease Patients

NCT06874101
View directory record Official record
Conditions
COPD, COPD - Chronic Obstructive Pulmonary Disease
Interventions
Activated ROAM System with User Feedback, Sham Comparator
Device
Lead sponsor
Barron Associates, Inc.
Industry
Eligibility
21 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Charlottesville, Virginia
Source: ClinicalTrials.gov public record
Updated Mar 12, 2025 · Synced Sep 28, 2026, 6:56 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Endothelial Progenitor Cells and Nitric Oxide in Cardiac Rehabilitation Program Participants

NCT00308633
View directory record Official record
Conditions
Coronary Artery Disease (CAD)
Interventions
Not listed
Lead sponsor
National Heart, Lung, and Blood Institute (NHLBI)
NIH
Eligibility
21 Years and older
Enrollment
55 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
Started 2006
U.S. locations
2
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Jul 1, 2017 · Synced Sep 28, 2026, 6:56 AM EDT
Not yet recruiting Not applicable Interventional

SpO2 Infant and Pediatric Study

NCT07615738
View directory record Official record
Conditions
SpO2 (Peripheral Oxygen Saturation) Measurement Validation, SpO2
Interventions
SpO2 Sensor
Device
Lead sponsor
GE Healthcare
Industry
Eligibility
29 Days to 12 Years
Enrollment
180 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Omaha, Nebraska
Source: ClinicalTrials.gov public record
Updated Jun 30, 2026 · Synced Sep 28, 2026, 6:56 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Adherence to Health Coaching with Wearable Devices: Enhancing Patient Engagement and Outcomes

NCT06525337
View directory record Official record
Conditions
Obstructive Sleep Apnea
Interventions
STANDARDCARE (STAND) group, CONTROL (CON) group
Behavioral · Other
Lead sponsor
Coastal Carolina University
Other
Eligibility
18 Years to 85 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
2
States / cities
Conway, South Carolina • Cordova, Tennessee
Source: ClinicalTrials.gov public record
Updated Dec 8, 2024 · Synced Sep 28, 2026, 6:56 AM EDT
Recruiting Phase 1Phase 2 Interventional

Intermittent Hypoxia-initiated Plasticity in Humans: A Multi-pronged Therapeutic Approach to Treat Sleep Apnea and Overlapping Co-morbidities

NCT05558501
View directory record Official record
Conditions
Obstructive Sleep Apnea
Interventions
Mild Intermittent Hypoxia, Sham MIH
Other
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
30 Years to 60 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
1
States / cities
Detroit, Michigan
Source: ClinicalTrials.gov public record
Updated Dec 3, 2025 · Synced Sep 28, 2026, 6:56 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Time Outside Target Oxygen Saturation Range in Preterm Infants and Long Term Outcomes and Preterm Infants

NCT00845624
View directory record Official record
Conditions
Retinopathy of Prematurity
Interventions
Not listed
Lead sponsor
University of Virginia
Other
Eligibility
1 Day to 12 Months
Enrollment
102 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2009
U.S. locations
1
States / cities
Charlottesville, Virginia
Source: ClinicalTrials.gov public record
Updated Jun 14, 2012 · Synced Sep 28, 2026, 6:56 AM EDT
Completed Phase 2 Interventional Results available

Brain Tissue Oxygen Monitoring in Traumatic Brain Injury (TBI)

NCT00974259
View directory record Official record
Conditions
Severe Traumatic Brain Injury
Interventions
Management protocol based on pBrO2 and ICP values., Management protocol based on ICP values only.
Device
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years to 70 Years
Enrollment
122 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2014
U.S. locations
10
States / cities
Miami, Florida • Durham, North Carolina • Cincinnati, Ohio + 5 more
Source: ClinicalTrials.gov public record
Updated Sep 25, 2019 · Synced Sep 28, 2026, 6:56 AM EDT