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ClinicalTrials.gov public records Last synced Oct 30, 2026, 3:50 PM EDT

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Showing 1–24 of 10,293 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: PAIN Clear all
Completed Not applicable Interventional

Adductor Canal Blocks With Bupivacaine and Magnesium After Same-day Discharge Total Knee Arthroplasty Improve Post-operative Pain Relief and Decrease Opioid Consumption: a Prospective Randomized Controlled Trial

NCT05004636
View directory record Official record
Conditions
Post-operative Pain, Acute
Interventions
Adding Magnesium as an adjuvant to the adductor canal Block (ACB) for same-day discharge total knee arthroplasty
Drug
Lead sponsor
Wayne State University
Other
Eligibility
18 Years to 100 Years
Enrollment
119 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
1
States / cities
Pontiac, Michigan
Source: ClinicalTrials.gov public record
Updated Aug 13, 2021 · Synced Oct 30, 2026, 3:50 PM EDT
Completed Phase 2 Interventional Results available

Prophylactic Topical Agents in Reducing Radiation-Induced Dermatitis in Patients With Non-inflammatory Breast Cancer

NCT02556632
View directory record Official record
Conditions
Breast Carcinoma, Pain, Radiation-Induced Dermatitis, Stage 0 Breast Cancer
Interventions
Curcumin-based Gel, Dermatologic Complications Management, Laboratory Biomarker Analysis, Placebo, Questionnaire Administration
Drug · Procedure · Other
Lead sponsor
Gary Morrow
Other
Eligibility
21 Years and older · Female only
Enrollment
191 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
6
States / cities
Newark, Delaware • Decatur, Illinois • Minneapolis, Minnesota + 3 more
Source: ClinicalTrials.gov public record
Updated Nov 6, 2017 · Synced Oct 30, 2026, 3:50 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Soft Active Back Exosuit to Reduce Workplace Back Pain

NCT05802914
View directory record Official record
Conditions
Low Back Pain, Musculoskeletal Pain, Low Back Injury
Interventions
Back Exosuit
Device
Lead sponsor
Wyss Institute at Harvard University
Other
Eligibility
18 Years to 65 Years
Enrollment
97 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2025
U.S. locations
1
States / cities
Louisville, Kentucky
Source: ClinicalTrials.gov public record
Updated Oct 14, 2026 · Synced Oct 30, 2026, 3:50 PM EDT
Completed Phase 3 Interventional

Study of Efficacy, Safety of Fulranumab Monotherapy for OA of Hip or Knee, PAI3003

NCT02289716
View directory record Official record
Conditions
Osteoarthritis, Pain
Interventions
Placebo, Fulranumab 1 mg, Fulranumab 3 mg
Drug
Lead sponsor
Janssen Research & Development, LLC
Industry
Eligibility
18 Years to 99 Years
Enrollment
41 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
7
States / cities
El Cajon, California • Sherman Oaks, California • Miami, Florida + 4 more
Source: ClinicalTrials.gov public record
Updated Apr 29, 2025 · Synced Oct 30, 2026, 3:50 PM EDT
Completed Not applicable Interventional Results available

N-of-1 Trials Using mHealth in Chronic Pain

NCT02116621
View directory record Official record
Conditions
Musculoskeletal Pain, Chronic Pain
Interventions
Trialist Intervention, smartphone
Behavioral · Device
Lead sponsor
University of California, Davis
Other
Eligibility
18 Years to 75 Years
Enrollment
215 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2017
U.S. locations
2
States / cities
Mather, California • Sacramento, California
Source: ClinicalTrials.gov public record
Updated May 25, 2018 · Synced Oct 30, 2026, 3:50 PM EDT
Completed No phase listed Observational

Psychological, Psychophysical and Epigenetic Determinants of Chronic Pain After Cytoreductive - Hyperthermic Intraoperative Chemotherapy

NCT05083338
View directory record Official record
Conditions
Appendix Carcinoma, Carcinomatosis, Colorectal Carcinoma, Gastric Carcinoma, Malignant Peritoneal Neoplasm, Malignant Solid Neoplasm
Interventions
Biospecimen Collection, Pain Assessment, Questionnaire Administration
Procedure · Other
Lead sponsor
M.D. Anderson Cancer Center
Other
Eligibility
18 Years and older
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Feb 13, 2024 · Synced Oct 30, 2026, 3:50 PM EDT
Completed Phase 2 Interventional Results available

Glucosamine and Chondroitin for Aromatase Inhibitor Induced Joint Symptoms in Women With Breast Cancer

NCT00691678
View directory record Official record
Conditions
Breast Cancer, Joint Pain
Interventions
Chondroitin, Glucosamine
Drug
Lead sponsor
Dawn L. Hershman
Other
Eligibility
21 Years and older · Female only
Enrollment
53 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2012
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Nov 8, 2022 · Synced Oct 30, 2026, 3:50 PM EDT
Recruiting Not applicable Interventional

Impact of Virtual Reality on Anxiety in Patients Undergoing Interventional Procedures

NCT05744336
View directory record Official record
Conditions
Anxiety
Interventions
Group 1 Immersive Virtual Reality (VR), Group 2 Control Group
Other
Lead sponsor
Northwestern University
Other
Eligibility
18 Years to 80 Years
Enrollment
64 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Oct 29, 2026 · Synced Oct 30, 2026, 3:50 PM EDT
Completed Not applicable Interventional Results available

Use of Dermabond in Mitigation of Spinal Cord Stimulation (SCS) Trial Lead Migration

NCT05914311
View directory record Official record
Conditions
Chronic Pain
Interventions
Suture, Suture and Dermabond
Device
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years and older
Enrollment
57 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Jun 9, 2026 · Synced Oct 30, 2026, 3:50 PM EDT
Completed Phase 2 Interventional Results available

A Chronic Pain Master Protocol (CPMP): A Study of LY3857210 In Participants With Osteoarthritis Pain

NCT05620563
View directory record Official record
Conditions
Osteoarthritis
Interventions
LY3857210, Placebo
Drug
Lead sponsor
Eli Lilly and Company
Industry
Eligibility
40 Years and older
Enrollment
147 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
28
States / cities
Chandler, Arizona • Phoenix, Arizona • Riverside, California + 23 more
Source: ClinicalTrials.gov public record
Updated Jun 26, 2024 · Synced Oct 30, 2026, 3:50 PM EDT
Completed Not applicable Interventional Results available

Patient-Driven Analgesic Protocol Selection for Post-Cesarean Pain Management

NCT02605187
View directory record Official record
Conditions
Postoperative Pain
Interventions
No choice given, Choice given, Ibuprofen, Acetaminophen, Gabapentin, Morphine (low), Morphine (med), Morphine (high)
Other · Drug
Lead sponsor
Stanford University
Other
Eligibility
18 Years to 50 Years · Female only
Enrollment
160 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2017
U.S. locations
1
States / cities
Palo Alto, California
Source: ClinicalTrials.gov public record
Updated Oct 16, 2018 · Synced Oct 30, 2026, 3:50 PM EDT
Not listed Phase 3 Interventional

Wallis Stabilization System for Low Back Pain

NCT00484458
View directory record Official record
Conditions
Low Back Pain
Interventions
Interspinous process and dynamic stabilization (Wallis System), Total Disc Replacement
Device
Lead sponsor
Zimmer Spine
Industry
Eligibility
18 Years to 60 Years
Enrollment
340 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2014
U.S. locations
11
States / cities
Beverly Hills, California • Encinitas, California • Boulder, Colorado + 8 more
Source: ClinicalTrials.gov public record
Updated Oct 4, 2011 · Synced Oct 30, 2026, 3:50 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Boston Migraine and Contraception Study

NCT01216358
View directory record Official record
Conditions
Headache
Interventions
Not listed
Lead sponsor
Planned Parenthood League of Massachusetts
Other
Eligibility
18 Years to 65 Years · Female only
Enrollment
171 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2011
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated May 10, 2012 · Synced Oct 30, 2026, 3:50 PM EDT
Recruiting Early Phase 1 Interventional

Psilocybin as a Treatment for Chronic Pain in Smokers

NCT07118332
View directory record Official record
Conditions
Smokers With Chronic Pain
Interventions
Psilocybin (drug)
Drug
Lead sponsor
Yale University
Other
Eligibility
21 Years to 65 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
West Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Aug 3, 2026 · Synced Oct 30, 2026, 3:50 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Muscle Activation Characteristics During Spinal Manipulation in Healthy and Low Back Pain Participants

NCT03483714
View directory record Official record
Conditions
Back Pain
Interventions
Spinal Manipulation
Procedure
Lead sponsor
University of Denver
Other
Eligibility
18 Years to 55 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2015
U.S. locations
1
States / cities
Denver, Colorado
Source: ClinicalTrials.gov public record
Updated Mar 30, 2018 · Synced Oct 30, 2026, 3:50 PM EDT
Withdrawn Phase 1 Interventional

Pharmacokinetics and Safety of MNK-155 in Postsurgical Adolescent Subjects With Moderate to Severe Acute Pain

NCT02767349
View directory record Official record
Conditions
Acute Pain
Interventions
MNK-155
Drug
Lead sponsor
Mallinckrodt
Industry
Eligibility
12 Years to 17 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2017
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Apr 5, 2017 · Synced Oct 30, 2026, 3:50 PM EDT
Terminated Not applicable Interventional Results available

Subcutaneous Botulinum Toxin for Cutaneous Allodynia - Enriched Responder Trial

NCT00822926
View directory record Official record
Conditions
Pain
Interventions
Botulinum Toxin Type A, Saline
Drug
Lead sponsor
Stanford University
Other
Eligibility
18 Years to 100 Years
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2013
U.S. locations
1
States / cities
Stanford, California
Source: ClinicalTrials.gov public record
Updated Aug 15, 2017 · Synced Oct 30, 2026, 3:50 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

Intrathecal Hydromorphone for Labor Analgesia

NCT01598506
View directory record Official record
Conditions
Labor Pain
Interventions
Hydromorphone
Drug
Lead sponsor
Emory University
Other
Eligibility
18 Years to 40 Years · Female only
Enrollment
22 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2014
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Jan 12, 2018 · Synced Oct 30, 2026, 3:50 PM EDT
Completed Not applicable Interventional Results available

Effectiveness of Biofreeze® on Shoulder Pain and In-office Exercise Performance

NCT01827306
View directory record Official record
Conditions
Shoulder Pain
Interventions
Biofreeze
Drug
Lead sponsor
Sport and Spine Rehab Clinical Research Foundation
Other
Eligibility
18 Years to 64 Years
Enrollment
34 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2014
U.S. locations
1
States / cities
Rockville, Maryland
Source: ClinicalTrials.gov public record
Updated Feb 9, 2016 · Synced Oct 30, 2026, 3:50 PM EDT
Withdrawn Phase 4 Interventional Accepts healthy volunteers

Radiofrequency Ablation: Treatment for Posterior Element Pain From Vertebral Compression Fractures

NCT03651804
View directory record Official record
Conditions
Vertebral Compression Fracture, Facet Joint Pain
Interventions
Radiofrequency ablation of the medial branch nerves, Non-steroidal anti-inflammatory drugs, Bisphosphonates, Acetaminophen, Physical therapy, Opioids
Procedure · Drug · Behavioral
Lead sponsor
University of California, Davis
Other
Eligibility
18 Years to 90 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2023
U.S. locations
1
States / cities
Davis, California
Source: ClinicalTrials.gov public record
Updated Jul 16, 2025 · Synced Oct 30, 2026, 3:50 PM EDT
Completed Phase 1 Interventional

To Assess the Patients' Ability to Self-Administer Fasinumab

NCT03491904
View directory record Official record
Conditions
Osteoarthritis, Knee, Osteoarthritis, Hip
Interventions
Fasinumab AI, Fasinumab PFS
Drug
Lead sponsor
Regeneron Pharmaceuticals
Industry
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
23
States / cities
Gilbert, Arizona • Glendale, Arizona • Los Angeles, California + 17 more
Source: ClinicalTrials.gov public record
Updated Mar 3, 2021 · Synced Oct 30, 2026, 3:50 PM EDT
Withdrawn Not applicable Interventional

Pain Levels and Opioid Usage in Three Nerve Block Cohorts in Primary TKA

NCT04292392
View directory record Official record
Conditions
Knee Arthropathy
Interventions
preop ACB, followed by Intra-articular block during TKA surgery, preop ACB+IPACK block, preop ACB+IPACK block, followed by Intra-articular block during TKA surgery
Other
Lead sponsor
University of Louisville
Other
Eligibility
22 Years to 89 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020
U.S. locations
1
States / cities
Louisville, Kentucky
Source: ClinicalTrials.gov public record
Updated Nov 4, 2020 · Synced Oct 30, 2026, 3:50 PM EDT
Not listed Phase 3 Interventional

Liposomal Bupivacaine Use in Alveolar Bone Graft Patients

NCT06284434
View directory record Official record
Conditions
Cleft Lip and Palate
Interventions
Liposomal Bupivacaine, Bupivacain, Epinephrine
Drug
Lead sponsor
Kerry O'Rourke
Other
Eligibility
6 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Jul 3, 2024 · Synced Oct 30, 2026, 3:50 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Pain Outcomes During Rigid Cystoscopy in Females With and Without Cystoscopic Sheath Obturator

NCT05152199
View directory record Official record
Conditions
Dysuria
Interventions
Cystoscopy - with use of obturator sheath, Cystoscopy - without use of obturator sheath
Procedure
Lead sponsor
Todd Moyerbrailean DO FACOG
Other
Eligibility
18 Years to 100 Years · Female only
Enrollment
68 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
East Lansing, Michigan
Source: ClinicalTrials.gov public record
Updated Apr 7, 2022 · Synced Oct 30, 2026, 3:50 PM EDT