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ClinicalTrials.gov public records Last synced Oct 22, 2026, 10:58 PM EDT

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Showing 1–24 of 10,279 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Pain Clear all
Recruiting Not applicable Interventional

Embolization for the Treatment of Heel Pain Secondary to Plantar Fasciitis

NCT06805942
View directory record Official record
Conditions
Plantar Fasciitis of Both Feet
Interventions
Lipiodol (ethiodized oil) injection
Device
Lead sponsor
IR Centers
Other
Eligibility
22 Years to 100 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025
U.S. locations
1
States / cities
Falls Church, Virginia
Source: ClinicalTrials.gov public record
Updated Feb 3, 2025 · Synced Oct 22, 2026, 10:58 PM EDT
Completed Not applicable Interventional Results available

Methadone in Pediatric Anesthesiology II

NCT01990573
View directory record Official record
Conditions
Pain
Interventions
0.3mg/kg IV methadone HCl, 0.4mg/kg IV methadon HCl, control no methadone
Drug · Other
Lead sponsor
Washington University School of Medicine
Other
Eligibility
11 Years to 18 Years
Enrollment
51 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2018
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Jan 28, 2020 · Synced Oct 22, 2026, 10:58 PM EDT
Completed Not applicable Interventional Results available

Managing Pain and Cognitions in Older Adults With Mild Cognitive Impairment or Memory Related Problems and Chronic Pain

NCT04044183
View directory record Official record
Conditions
Chronic Pain, Mild Cognitive Impairment, Older Adults, Physical Activity
Interventions
Active Brains 1, Active Brains 2
Behavioral
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
60 Years and older
Enrollment
21 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 20, 2023 · Synced Oct 22, 2026, 10:58 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Bupivacaine for Post-operative Pain in Mohs

NCT04362566
View directory record Official record
Conditions
Pain, Postoperative, Narcotic Use
Interventions
Bupivacaine, Placebo Saline
Drug · Other
Lead sponsor
University of Missouri-Columbia
Other
Eligibility
18 Years and older
Enrollment
174 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2021
U.S. locations
1
States / cities
Columbia, Missouri
Source: ClinicalTrials.gov public record
Updated Oct 14, 2026 · Synced Oct 22, 2026, 10:58 PM EDT
Completed Phase 2 Interventional Results available

Comparing Five Oral Analgesics for Treatment of Acute Pain in the Emergency Department (ED)

NCT03173456
View directory record Official record
Conditions
Musculoskeletal Pain
Interventions
oxycodone/APAP, hydrocodone/APAP, codeine/APAP, 400 ibuprofen/APAP, 800 ibuprofen/APAP
Drug
Lead sponsor
Albert Einstein College of Medicine
Other
Eligibility
21 Years to 64 Years
Enrollment
600 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
1
States / cities
The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Feb 1, 2022 · Synced Oct 22, 2026, 10:58 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Oklahoma Study of Native American Pain Risk IV: Smoking Cessation and Pain

NCT07080788
View directory record Official record
Conditions
Smoking Cessation Intervention, Pain, Smoking (Tobacco) Addiction
Interventions
Smoking Cessation
Behavioral
Lead sponsor
University of Oklahoma
Other
Eligibility
18 Years and older
Enrollment
150 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2028
U.S. locations
1
States / cities
Tulsa, Oklahoma
Source: ClinicalTrials.gov public record
Updated Mar 2, 2026 · Synced Oct 22, 2026, 10:58 PM EDT
Completed No phase listed Observational

Living With Sickle Cell Disease in the COVID-19 Pandemic

NCT04417673
View directory record Official record
Conditions
Isolation, Anxiety, Health Care Utilization, Sickle Cell Disease, Pain
Interventions
Not listed
Lead sponsor
National Human Genome Research Institute (NHGRI)
NIH
Eligibility
18 Years to 100 Years
Enrollment
186 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Jun 10, 2026 · Synced Oct 22, 2026, 10:58 PM EDT
Recruiting Phase 4 Interventional

Tirzepatide in Idiopathic Intracranial Hypertension Trial

NCT07191873
View directory record Official record
Conditions
Idiopathic Intracranial Hypertension (IIH)
Interventions
Tirzepatide, Tirzepatide Placebo
Drug
Lead sponsor
Duke University
Other
Eligibility
18 Years to 60 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Sep 15, 2026 · Synced Oct 22, 2026, 10:58 PM EDT
Recruiting Not applicable Interventional

Histologic Comparison of Ablative Techniques for Endometriosis

NCT06414083
View directory record Official record
Conditions
Endometriosis, Endometriosis-related Pain, Endometriosis Pelvic, Endometriosis; Peritoneum
Interventions
Diathermy, CO2 Laser, Argon Beam Coagulator
Device
Lead sponsor
TriHealth Inc.
Other
Eligibility
18 Years and older · Female only
Enrollment
141 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated May 30, 2024 · Synced Oct 22, 2026, 10:58 PM EDT
Terminated Phase 2 Interventional

Safety and Efficacy Study of NTC-510 to Treat Pain Following Dental Surgery of Third Molars

NCT02161354
View directory record Official record
Conditions
Dental Pain
Interventions
NTC-510 capsules, Placebo Capsules, NTC-510A Capsules
Drug
Lead sponsor
NanoSHIFT LLC
Industry
Eligibility
18 Years to 45 Years
Enrollment
52 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
1
States / cities
Austin, Texas
Source: ClinicalTrials.gov public record
Updated Jun 23, 2017 · Synced Oct 22, 2026, 10:58 PM EDT
Completed Not applicable Interventional

MOBile Instruction for Low Back Pain (MOBIL)

NCT02777983
View directory record Official record
Conditions
Low Back Pain
Interventions
Educational Video App
Behavioral
Lead sponsor
Brooke Army Medical Center
Federal
Eligibility
18 Years to 50 Years
Enrollment
220 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2017
U.S. locations
1
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Oct 26, 2018 · Synced Oct 22, 2026, 10:58 PM EDT
Completed Phase 3 Interventional

Study of Two Digital Therapeutics for the Prevention of Episodic Migraine Receiving CGRP Therapy (ReMMiD-C)

NCT06004388
View directory record Official record
Conditions
Migraine, Episodic Migraine, Headache, Headache, Migraine
Interventions
Click Digital Therapeutic
Device
Lead sponsor
Click Therapeutics, Inc.
Industry
Eligibility
18 Years and older
Enrollment
110 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Dec 18, 2024 · Synced Oct 22, 2026, 10:58 PM EDT
Completed Phase 3 Interventional Results available

Study to Evaluate the Equivalence of Estradiol Vaginal Cream to Reference Standard in the Treatment of Vaginal Atrophy

NCT03332303
View directory record Official record
Conditions
Vulvar and Vaginal Atrophy
Interventions
Estrace® Cream, Estradiol Vaginal Cream, Vehicle Cream
Drug
Lead sponsor
Prasco LLC
Industry
Eligibility
30 Years to 75 Years · Female only
Enrollment
540 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
27
States / cities
Sacramento, California • San Diego, California • Denver, Colorado + 23 more
Source: ClinicalTrials.gov public record
Updated May 30, 2024 · Synced Oct 22, 2026, 10:58 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Virtual Reality as a Postoperative Pain Management Adjunct in Older Adults: An Acceptability and Feasibility Study

NCT06095661
View directory record Official record
Conditions
Aged, Surgery, Pain, Postoperative, Virtual Reality
Interventions
REAL System i-Series VR head-mounted display (HMD) from Penumbra, Inc.
Other
Lead sponsor
University of California, San Francisco
Other
Eligibility
65 Years and older
Enrollment
29 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Jun 18, 2024 · Synced Oct 22, 2026, 10:58 PM EDT
Completed Not applicable Interventional

University of Michigan / Wayne State Chronic Pain Study

NCT03391661
View directory record Official record
Conditions
Chronic Musculoskeletal Pain
Interventions
Pain neuroscience education patient exercise, Health behavior control intervention
Behavioral
Lead sponsor
Wayne State University
Other
Eligibility
18 Years and older
Enrollment
104 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Jul 25, 2019 · Synced Oct 22, 2026, 10:58 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

NSS-2-BRIDGE Study for Total Knee and Hip Arthroplasties, Bariatric, and Kidney Transplant Surgeries

NCT03834142
View directory record Official record
Conditions
Acute Pain, Arthropathy of Knee, Arthropathy of Hip, Pain, Postoperative, Kidney Transplant Donor, Bariatric Surgery Candidate
Interventions
NSS-2 Bridge
Device
Lead sponsor
Jacques E. Chelly
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2021
U.S. locations
3
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Aug 3, 2022 · Synced Oct 22, 2026, 10:58 PM EDT
Completed Phase 4 Interventional Results available

Comprehensive Cardiothoracic Dual Source CT for the Early Triage of Patients With Acute Chest Pain

NCT01067456
View directory record Official record
Conditions
Chest Pain Syndrome
Interventions
Comprehensive Cardiothoracic CT arm
Radiation
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
30 Years and older
Enrollment
59 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2010
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Dec 22, 2017 · Synced Oct 22, 2026, 10:58 PM EDT
Completed Not applicable Interventional Results available

Digital Health Psychosocial Intervention for Adolescent Spine Surgery Preparation and Recovery

NCT04637802
View directory record Official record
Conditions
Juvenile; Scoliosis, Scoliosis Idiopathic, Scoliosis; Adolescence, Scoliosis;Congenital, Kyphosis, Spondylolisthesis
Interventions
CBT (SurgeryPal), Education
Behavioral
Lead sponsor
Seattle Children's Hospital
Other
Eligibility
12 Years to 18 Years
Enrollment
433 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2025
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Sep 24, 2026 · Synced Oct 22, 2026, 10:58 PM EDT
Recruiting Not applicable Interventional

Behavioral Economic & Staffing Strategies in the ICU

NCT06184945
View directory record Official record
Conditions
Implementation Science, Delirium, Critical Illness, Mechanical Ventilation Complication, ICU Acquired Weakness, Pain
Interventions
Realtime audit and feedback, RN Implementation Facilitator
Behavioral
Lead sponsor
University of Nebraska
Other
Eligibility
19 Years and older
Enrollment
16,500 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2028
U.S. locations
3
States / cities
Iowa City, Iowa • Omaha, Nebraska • Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Sep 29, 2026 · Synced Oct 22, 2026, 10:58 PM EDT
Recruiting Phase 4 Interventional

Dextenza in the Post-op Management of Vitreoretinal Surgeries

NCT04371445
View directory record Official record
Conditions
Vitreoretinal Surgery, Ocular Inflammation, Post-operative Pain, Post-Operative Inflammation
Interventions
Dexamethasone Ophthalmic Insert, Prednisolone Acetate 1% Oph Susp
Drug
Lead sponsor
The Cleveland Clinic
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2027
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Jul 29, 2026 · Synced Oct 22, 2026, 10:58 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Novel Technique for Botulinum Toxin Injection to Minimize Patient Discomfort

NCT00628472
View directory record Official record
Conditions
Pain
Interventions
botulinum type a
Drug
Lead sponsor
Henry Ford Health System
Other
Eligibility
25 Years to 55 Years · Female only
Enrollment
21 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007
U.S. locations
1
States / cities
Detroit, Michigan
Source: ClinicalTrials.gov public record
Updated Apr 30, 2024 · Synced Oct 22, 2026, 10:58 PM EDT
Completed Not applicable Interventional Results available

Effectiveness of Cervical Facet Joint Nerve Blocks

NCT00332722
View directory record Official record
Conditions
Neck Pain
Interventions
Cervical facet joint nerve blocks
Procedure
Lead sponsor
Pain Management Center of Paducah
Other
Eligibility
18 Years and older
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2007
U.S. locations
1
States / cities
Paducah, Kentucky
Source: ClinicalTrials.gov public record
Updated Oct 1, 2013 · Synced Oct 22, 2026, 10:58 PM EDT
Recruiting Not applicable Interventional

Brief Mindfulness Intervention for Pain Before an In-clinic Orthopedic Procedure

NCT06471075
View directory record Official record
Conditions
Pain, Chronic Pain, Acute Pain
Interventions
Mindful Pain Management, Pain Psychoeducation
Behavioral
Lead sponsor
Florida State University
Other
Eligibility
18 Years and older
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Tallahassee, Florida
Source: ClinicalTrials.gov public record
Updated Sep 15, 2026 · Synced Oct 22, 2026, 10:58 PM EDT
Completed Phase 2 Interventional

Bradykinin Receptors and Pain

NCT00083356
View directory record Official record
Conditions
Tooth, Impacted
Interventions
Wisdom tooth extraction
Procedure
Lead sponsor
National Institute of Nursing Research (NINR)
NIH
Eligibility
Not listed
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2006
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Mar 4, 2008 · Synced Oct 22, 2026, 10:58 PM EDT