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ClinicalTrials.gov public records Last synced Oct 25, 2026, 7:40 AM EDT

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Showing 385–408 of 1,386 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Pain, Chronic Disease Clear all
Recruiting Not applicable Interventional

Effects of Non-invasive Brain Stimulation on Pain Avoidance Behavior in Chronic Pain Patients

NCT07791966
View directory record Official record
Conditions
Complex Regional Pain Syndrome (CRPS)
Interventions
transcranial alternating current stimulation (tACS)
Device
Lead sponsor
The Cleveland Clinic
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Aug 28, 2026 · Synced Oct 25, 2026, 7:40 AM EDT
Completed Phase 3 Interventional Results available

Ketamine Infusion for Comorbid PTSD and Chronic Pain

NCT04322968
View directory record Official record
Conditions
PTSD, Chronic Pain
Interventions
A single low dose ketamine infusion as compared to the IV infusion of active placebo - ketorolac on chronic pain and PTSD symptoms.
Drug
Lead sponsor
VA Ann Arbor Healthcare System
Federal
Eligibility
18 Years to 65 Years
Enrollment
41 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Dec 22, 2020 · Synced Oct 25, 2026, 7:40 AM EDT
Completed Not applicable Interventional

Autosomal Dominant Polycystic Kidney Disease (ADPKD) Pain Study

NCT00571909
View directory record Official record
Conditions
Kidney, Polycystic, Autosomal Dominant
Interventions
video thorascopic splanchnicectomy (VSPL)
Procedure
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
18 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2016
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Oct 20, 2017 · Synced Oct 25, 2026, 7:40 AM EDT
Completed Not applicable Interventional Results available

Virtual Reality Therapy for Chronic Low Back Pain

NCT04409353
View directory record Official record
Conditions
Chronic Low Back Pain
Interventions
Distraction-Based VR, Sham VR, Skills-Based VR, Activity Tracker
Device
Lead sponsor
Cedars-Sinai Medical Center
Other
Eligibility
13 Years and older
Enrollment
413 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2024
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Oct 31, 2025 · Synced Oct 25, 2026, 7:40 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Real-world Momentary Assessment of Kratom Use Accompanied by Product Assays: A Natural-history Study for Interdisciplinary Characterization of Kratom Use and Pharmacology

NCT05457803
View directory record Official record
Conditions
Chronic Pain, Fatigue, Substance Use Disorders
Interventions
Not listed
Lead sponsor
National Institute on Drug Abuse (NIDA)
NIH
Eligibility
18 Years and older
Enrollment
396 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Jul 4, 2025 · Synced Oct 25, 2026, 7:40 AM EDT
Completed Not applicable Interventional Results available

Optimizing Psychotherapy for Older Veterans With Chronic Pain

NCT03918642
View directory record Official record
Conditions
Musculoskeletal Pain
Interventions
Emotional Awareness and Expression Therapy, Cognitive Behavior Therapy
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
60 Years to 95 Years
Enrollment
126 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2023
U.S. locations
1
States / cities
West Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Nov 4, 2024 · Synced Oct 25, 2026, 7:40 AM EDT
Completed Not applicable Interventional

Behavioral Consultation for HIV+ Older Adults Prescribed Opioids for Chronic Pain

NCT02272829
View directory record Official record
Conditions
Opioid Misuse, Older Adults, HIV
Interventions
Choacot: Behavioral Intervention for Chronic Opioid Use, Health Education
Behavioral · Other
Lead sponsor
Butler Hospital
Other
Eligibility
50 Years and older
Enrollment
8 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2017
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Sep 18, 2017 · Synced Oct 25, 2026, 7:40 AM EDT
Terminated Phase 2 Interventional

A Trial Of [S,S]-Reboxetine In Patients With Chronic Painful Diabetic Peripheral Neuropathy.

NCT00625833
View directory record Official record
Conditions
Diabetic Neuropathies
Interventions
Placebo, [S,S]-Reboxetine
Drug
Lead sponsor
Pfizer
Industry
Eligibility
18 Years and older
Enrollment
330 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2008
U.S. locations
32
States / cities
Anniston, Alabama • Birmingham, Alabama • Mission Viejo, California + 24 more
Source: ClinicalTrials.gov public record
Updated Dec 13, 2019 · Synced Oct 25, 2026, 7:40 AM EDT
Not listed Phase 3 Interventional

CREATE-1: A Study to Assess the Efficacy and Safety of AXS-02 in Patients With CRPS-1

NCT02504008
View directory record Official record
Conditions
Complex Regional Pain Syndrome, Reflex Sympathetic Dystrophy
Interventions
AXS-02 (oral zoledronate), Placebo
Drug
Lead sponsor
Axsome Therapeutics, Inc.
Industry
Eligibility
18 Years and older
Enrollment
190 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2019
U.S. locations
29
States / cities
Tucson, Arizona • Hot Springs, Arkansas • Encinitas, California + 26 more
Source: ClinicalTrials.gov public record
Updated Mar 23, 2018 · Synced Oct 25, 2026, 7:40 AM EDT
Completed Not applicable Interventional Results available

Establishing Efficacy of a Functional-Restoration Based CAM Pain Management Program in Post-9/11 Veterans

NCT02657317
View directory record Official record
Conditions
Chronic Pain, Traumatic Brain Injury, Posttraumatic Stress Disorder, Depression, Opioid Use Disorder
Interventions
FORT-A, VA Treatment as Usual
Behavioral · Other
Lead sponsor
The University of Texas Health Science Center at San Antonio
Other
Eligibility
18 Years to 72 Years
Enrollment
103 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2020
U.S. locations
1
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Jul 29, 2024 · Synced Oct 25, 2026, 7:40 AM EDT
Completed Not applicable Interventional

A Trial of a Positive Psychology Intervention for Older Adults (RESET)

NCT05451589
View directory record Official record
Conditions
Depressive Symptoms, Anxiety, Chronic Pain, Fatigue, Loneliness, Stress, Psychological
Interventions
RESET, Wellness Check Control
Behavioral
Lead sponsor
University of Michigan
Other
Eligibility
50 Years and older
Enrollment
457 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Aug 19, 2026 · Synced Oct 25, 2026, 7:40 AM EDT
Not yet recruiting Not applicable Interventional

Ultrasound for Peripheral Nerve Modulation

NCT07572591
View directory record Official record
Conditions
Neuropathic Pain, Chronic Pain
Interventions
Ultrasound, Sham (No Treatment)
Device
Lead sponsor
Stanford University
Other
Eligibility
18 Years and older
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Stanford, California
Source: ClinicalTrials.gov public record
Updated May 7, 2026 · Synced Oct 25, 2026, 7:40 AM EDT
Withdrawn Phase 4 Interventional

Pharmacokinetic,Safety and Exploratory Efficacy of RECTIV® in Adolescents With Chronic Anal Fissure

NCT01920074
View directory record Official record
Conditions
Anal Fissure
Interventions
Nitroglycerin Ointment 0.4%
Drug
Lead sponsor
Forest Laboratories
Industry
Eligibility
12 Years to 16 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2015
U.S. locations
6
States / cities
Los Angeles, California • Miami, Florida • Orlando, Florida + 3 more
Source: ClinicalTrials.gov public record
Updated May 4, 2015 · Synced Oct 25, 2026, 7:40 AM EDT
Recruiting Phase 1Phase 2 Interventional

Safety and Tolerability Study of ST-503 for Refractory Pain Due to Peripheral Neuropathy (Small Fiber Predominant, SFN)

NCT06980948
View directory record Official record
Conditions
Chronic Neuropathic Pain
Interventions
ST-503, Sham (No Treatment)
Genetic · Procedure
Lead sponsor
Sangamo Therapeutics
Industry
Eligibility
18 Years and older
Enrollment
27 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
11
States / cities
Scottsdale, Arizona • Little Rock, Arkansas • La Jolla, California + 8 more
Source: ClinicalTrials.gov public record
Updated Jun 1, 2026 · Synced Oct 25, 2026, 7:40 AM EDT
Completed Phase 2 Interventional Results available

Chronic Low Back Pain Research Project

NCT00108550
View directory record Official record
Conditions
Chronic Low Back Pain
Interventions
gabapentin, Inert placebo
Drug
Lead sponsor
US Department of Veterans Affairs
Federal
Eligibility
21 Years to 70 Years
Enrollment
108 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2009
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Feb 10, 2014 · Synced Oct 25, 2026, 7:40 AM EDT
Completed Not applicable Interventional

Telephone Intervention for Pain Study (TIPS)

NCT00663663
View directory record Official record
Conditions
Chronic Pain, Multiple Sclerosis, Amputation, Spinal Cord Injury
Interventions
Telephone-Delivered Intervention 1, Telephone-Delivered Intervention 2
Behavioral
Lead sponsor
University of Washington
Other
Eligibility
18 Years and older
Enrollment
207 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2013
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Aug 30, 2013 · Synced Oct 25, 2026, 7:40 AM EDT
Completed No phase listed Observational

Assessing the Impact of Exercise Based Intensive Interdisciplinary Pain Treatment (IIPT) on Endogenous Pain Modulation in Youth With Chronic Pain Syndromes

NCT05491499
View directory record Official record
Conditions
Chronic Pain Syndrome, Fibromyalgia, Chronic Headache Disorder, Functional Abdominal Pain Syndrome, Complex Regional Pain Syndromes
Interventions
Not listed
Lead sponsor
Boston Children's Hospital
Other
Eligibility
10 Years to 17 Years
Enrollment
43 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
Waltham, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jun 26, 2024 · Synced Oct 25, 2026, 7:40 AM EDT
Not yet recruiting Phase 2 Interventional

Allopregnanolone in Chronic Complex Traumatic Brain Injury

NCT04003285
View directory record Official record
Conditions
Traumatic Brain Injury (TBI)
Interventions
Placebo, Allopregnanolone
Drug
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
21 Years to 62 Years
Enrollment
132 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Oct 19, 2026 · Synced Oct 25, 2026, 7:40 AM EDT
Terminated Not applicable Interventional

SCI Pain App Intervention Study

NCT04818814
View directory record Official record
Conditions
Spinal Cord Injuries, Chronic Pain
Interventions
Mindfulness Meditation App, Engagement and Distraction App
Behavioral
Lead sponsor
Baylor College of Medicine
Other
Eligibility
18 Years and older
Enrollment
11 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Apr 6, 2022 · Synced Oct 25, 2026, 7:40 AM EDT
Completed Not applicable Interventional

Improving Chronic Disease Care With PatientSite

NCT00130416
View directory record Official record
Conditions
Depression, Pain, Mobility Difficulty
Interventions
E-mail coaching to improve patient communication with doctor
Behavioral
Lead sponsor
Robert Wood Johnson Foundation
Other
Eligibility
18 Years and older
Enrollment
750 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2007
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 8, 2008 · Synced Oct 25, 2026, 7:40 AM EDT
Active, not recruiting No phase listed Observational

Chronic Pain in Rheumatoid Arthritis

NCT05038553
View directory record Official record
Conditions
Arthritis, Rheumatoid, Pain
Interventions
No intervention
Other
Lead sponsor
Northwestern University
Other
Eligibility
18 Years and older
Enrollment
125 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2027
U.S. locations
5
States / cities
Denver, Colorado • Chicago, Illinois • Baltimore, Maryland + 2 more
Source: ClinicalTrials.gov public record
Updated May 28, 2026 · Synced Oct 25, 2026, 7:40 AM EDT
Completed Not applicable Interventional Results available

Subchondroplasty® Knee RCT

NCT03112200
View directory record Official record
Conditions
Bone Marrow Edema, Knee Pain Chronic, Knee Osteoarthritis, Osteoarthritis, Knee, Osteoarthritis
Interventions
Subchondroplasty with Arthroscopy, Arthroscopy Alone
Procedure
Lead sponsor
Zimmer Biomet
Industry
Eligibility
30 Years to 75 Years
Enrollment
131 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2023
U.S. locations
12
States / cities
Encinitas, California • Loma Linda, California • Stanford, California + 9 more
Source: ClinicalTrials.gov public record
Updated May 14, 2026 · Synced Oct 25, 2026, 7:40 AM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Effects of Transcranial Direct Current Stimulation (tDCS) and Visual Illusion on Chronic Pain Due to Spinal Cord Injury

NCT01404065
View directory record Official record
Conditions
Chronic Pain, Spinal Cord Injury
Interventions
Transcranial Direct Current Stimulation (tDCS)
Procedure
Lead sponsor
Spaulding Rehabilitation Hospital
Other
Eligibility
18 Years to 64 Years
Enrollment
23 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2014
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 24, 2020 · Synced Oct 25, 2026, 7:40 AM EDT
Terminated No phase listed Observational

MDR SureLock All-Suture Anchor

NCT04093700
View directory record Official record
Conditions
Shoulder Pain, Shoulder Injuries, Shoulder Disease, Shoulder Pain Chronic, Shoulder Syndrome, Labral Tear, Glenoid
Interventions
SureLock All-Suture Anchor
Device
Lead sponsor
Zimmer Biomet
Industry
Eligibility
14 Years to 45 Years
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
1
States / cities
Lutherville, Maryland
Source: ClinicalTrials.gov public record
Updated Aug 14, 2023 · Synced Oct 25, 2026, 7:40 AM EDT