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ClinicalTrials.gov public records Last synced Oct 29, 2026, 11:58 AM EDT

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Showing 1273–1296 of 10,293 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Pain Clear all
Completed Phase 2 Interventional Results available

PREMIX vs PREMED Intranasal Lidocaine and Midazolam

NCT03054844
View directory record Official record
Conditions
Pain
Interventions
Lidocaine, Lidocaine and midazolam (PREMIX), Midazolam
Drug
Lead sponsor
Columbia University
Other
Eligibility
6 Months to 7 Years
Enrollment
55 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Sep 11, 2019 · Synced Oct 29, 2026, 11:58 AM EDT
Not listed Not applicable Interventional

Caffeine Study for Pain Control Following Total Joint Replacement

NCT04280263
View directory record Official record
Conditions
Pain, Postoperative
Interventions
Caffeine, Placebo oral tablet
Drug
Lead sponsor
Rothman Institute Orthopaedics
Other
Eligibility
18 Years and older
Enrollment
70 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
1
States / cities
Egg Harbor, New Jersey
Source: ClinicalTrials.gov public record
Updated Oct 19, 2020 · Synced Oct 29, 2026, 11:58 AM EDT
Completed No phase listed Observational

Contemporary Pain Science Education and Physician Assistant Students

NCT07735663
View directory record Official record
Conditions
Focus of Study Pain Knowledge
Interventions
Pain education
Other
Lead sponsor
Belmont University
Other
Eligibility
18 Years and older
Enrollment
40 participants
Timeline
2019 – 2021
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Jul 30, 2026 · Synced Oct 29, 2026, 11:58 AM EDT
Completed Not applicable Interventional Results available

Adjunct VR Pain Management in Acute Brain Injury

NCT04356963
View directory record Official record
Conditions
Traumatic Brain Injury, Headaches Posttraumatic, Trauma, Pain, Acute
Interventions
Virtual Reality Session (VR Blu), Tablet-based Session (Tablet Blu), Use of Virtual Reality Head Mounted Display without Content (VR Blank)
Behavioral
Lead sponsor
University of Maryland, Baltimore
Other
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
2
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Apr 24, 2023 · Synced Oct 29, 2026, 11:58 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers

Evaluate the Depth and Duration of Anesthesia

NCT00891163
View directory record Official record
Conditions
Pain
Interventions
Synera™ Topical Patch (70 mg lidocaine/70 mg tetracaine), Placebo Patch
Drug
Lead sponsor
ZARS Pharma Inc.
Industry
Eligibility
18 Years to 60 Years
Enrollment
25 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2007
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated May 1, 2009 · Synced Oct 29, 2026, 11:58 AM EDT
Completed Not applicable Interventional

Comparison of Acetaminophen With Codeine and Ibuprofen for Children With Injuries

NCT00474721
View directory record Official record
Conditions
Pain
Interventions
ibuprofen, acetaminophen with codeine
Drug
Lead sponsor
University of California, San Diego
Other
Eligibility
5 Years to 18 Years
Enrollment
68 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2002 – 2004
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated May 17, 2007 · Synced Oct 29, 2026, 11:58 AM EDT
Withdrawn No phase listed Observational

Staged Bilateral Carpal Tunnel Release: Which Side Hurts More?

NCT02198521
View directory record Official record
Conditions
Carpal Tunnel Syndrome, Pain
Interventions
Not listed
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Feb 3, 2017 · Synced Oct 29, 2026, 11:58 AM EDT
Completed Phase 3 Interventional

The Safety and Efficacy of the Buprenorphine Transdermal Delivery System in Subjects With Osteoarthritis Pain.

NCT00315848
View directory record Official record
Conditions
Osteoarthritis
Interventions
Buprenorphine transdermal delivery system
Drug
Lead sponsor
Purdue Pharma LP
Industry
Eligibility
18 Years and older
Enrollment
225 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
1996 – 1999
U.S. locations
10
States / cities
Huntsville, Alabama • Phoenix, Arizona • Westminster, Colorado + 6 more
Source: ClinicalTrials.gov public record
Updated May 3, 2006 · Synced Oct 29, 2026, 11:58 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Subacute Low Back Pain in Active Duty

NCT03502187
View directory record Official record
Conditions
Subacute Low Back Pain
Interventions
Progressive Exercise Plan, NeuromuscularElectricalStimulation(NMES), Primary Care Management (PCM)
Behavioral · Device
Lead sponsor
University of Tennessee
Other
Eligibility
18 Years to 45 Years
Enrollment
133 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2020
U.S. locations
1
States / cities
Fort Campbell North, Kentucky
Source: ClinicalTrials.gov public record
Updated Jan 25, 2022 · Synced Oct 29, 2026, 11:58 AM EDT
Active, not recruiting Phase 4 Interventional

Pain Self-Management and Patient-Oriented Dosing for Pain and in Retention Opioid Treatment

NCT06367387
View directory record Official record
Conditions
Opioid Use Disorder, Chronic Pain
Interventions
Patient-Oriented Dosing (POD), Pain Self-Management (PSM), Usual Care, Standard Buprenorphine Dosing Condition
Drug · Behavioral
Lead sponsor
Erin Winstanley
Other
Eligibility
18 Years and older
Enrollment
273 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
13
States / cities
Baltimore, Maryland • Dundalk, Maryland • Hagerstown, Maryland + 6 more
Source: ClinicalTrials.gov public record
Updated Aug 18, 2026 · Synced Oct 29, 2026, 11:58 AM EDT
Completed Not applicable Interventional

VRH Pain Reduction During Burn Wound Care and Physical Therapy

NCT00260221
View directory record Official record
Conditions
Burn
Interventions
using VR hypnosis/distraction and audio hypnosis
Behavioral
Lead sponsor
National Institute of General Medical Sciences (NIGMS)
NIH
Eligibility
7 Years to 85 Years
Enrollment
77 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2002 – 2011
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated May 8, 2013 · Synced Oct 29, 2026, 11:58 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Efficacy of IV Lidocaine at Alleviating Pain Associated With Propofol Infusion in Pediatric Patients Undergoing Sedation

NCT00786916
View directory record Official record
Conditions
Pain
Interventions
normal saline, lidocaine
Drug
Lead sponsor
Akron Children's Hospital
Other
Eligibility
2 Years to 7 Years
Enrollment
109 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2011
U.S. locations
1
States / cities
Akron, Ohio
Source: ClinicalTrials.gov public record
Updated Feb 27, 2015 · Synced Oct 29, 2026, 11:58 AM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

Pharmacokinetics, Pharmacodynamics, and Safety Profile of Understudied Drugs Administered to Children Per Standard of Care (POPS)

NCT04278404
View directory record Official record
Conditions
Coronavirus Infection (COVID-19), Pulmonary Arterial Hypertension, Urinary Tract Infections in Children, Hypertension, Pain, Hyperphosphatemia, Primary Hyperaldosteronism, Edema, Hypokalemia, Heart Failure, Hemophilia, Menorrhagia, Insomnia, Pneumonia, Skin Infection, Arrythmia, Asthma in Children, Bronchopulmonary Dysplasia, Adrenal Insufficiency, Fibrinolysis; Hemorrhage, Attention Deficit Hyperactivity Disorder, Multisystem Inflammatory Syndrome in Children (MIS-C), Kawasaki Disease, Coagulation Disorder, Down Syndrome
Interventions
The POP02 study is collecting bodily fluid samples (i.e., whole blood, effluent samples) of children prescribed the following drugs of interest per standard of care:
Drug
Lead sponsor
Duke University
Other
Eligibility
0 Years to 20 Years
Enrollment
5,000 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2026
U.S. locations
49
States / cities
Phoenix, Arizona • Little Rock, Arkansas • Los Angeles, California + 40 more
Source: ClinicalTrials.gov public record
Updated Aug 21, 2026 · Synced Oct 29, 2026, 11:58 AM EDT
Terminated Phase 2 Interventional Results available

Dosing of Methadone for Spine Surgery

NCT03605901
View directory record Official record
Conditions
Pain, Postoperative
Interventions
Standard dosing of methadone, Aliquots of methadone titrated to apnea
Drug
Lead sponsor
University of Florida
Other
Eligibility
18 Years to 75 Years
Enrollment
21 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2025
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Jun 23, 2026 · Synced Oct 29, 2026, 11:58 AM EDT
Recruiting Not applicable Interventional

Dose-Response Effects of a Brief Audio-Guided Mindfulness Intervention for Acute Pain

NCT07562412
View directory record Official record
Conditions
Pain, Pain Management, Mindfulness, Orthopedic, Acute Pain, Chronic Pain
Interventions
1-Minute Mindfulness Intervention, 2-Minute Mindfulness Intervention, 3-Minute Mindfulness Intervention
Behavioral
Lead sponsor
Florida State University
Other
Eligibility
18 Years and older
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Tallahassee, Florida
Source: ClinicalTrials.gov public record
Updated Jul 13, 2026 · Synced Oct 29, 2026, 11:58 AM EDT
Completed Phase 4 Interventional Results available

Efficacy of Intercostal CryoAnalgesia in Robotic Lung Resection

NCT05144828
View directory record Official record
Conditions
Pain, Postoperative, Lung Diseases
Interventions
Intercostal Nerve Cryoablation, Patient-controlled analgesia (PCA)
Device · Drug
Lead sponsor
Medical College of Wisconsin
Other
Eligibility
18 Years to 85 Years
Enrollment
33 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
1
States / cities
Milwaukee, Wisconsin
Source: ClinicalTrials.gov public record
Updated Apr 15, 2026 · Synced Oct 29, 2026, 11:58 AM EDT
Terminated Not applicable Interventional

Nerve Burial for Preventing Neuralgia After Total Knee Arthroplasty

NCT02885467
View directory record Official record
Conditions
Neuralgia, Osteoarthritis of the Knee
Interventions
Total knee arthroplasty with Saphenous nerve burial, Standard total knee arthroplasty
Procedure
Lead sponsor
Medstar Health Research Institute
Other
Eligibility
18 Years to 80 Years
Enrollment
58 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2018
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated May 21, 2018 · Synced Oct 29, 2026, 11:58 AM EDT
Completed Not applicable Interventional Results available

Percutaneous Rectus Sheath Block Versus Intra-operative Rectus Sheath Block for Pediatric Umbilical Hernia Repair

NCT02341144
View directory record Official record
Conditions
Pain, Postoperative
Interventions
Pre-op percutaneous rectus sheath block, Intra-operative rectus sheath block, Ropivacaine
Procedure · Drug
Lead sponsor
Johns Hopkins All Children's Hospital
Other
Eligibility
3 Years to 18 Years
Enrollment
61 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
1
States / cities
St. Petersburg, Florida
Source: ClinicalTrials.gov public record
Updated Jul 3, 2023 · Synced Oct 29, 2026, 11:58 AM EDT
Recruiting Not applicable Interventional

Marginal Ulcer Healing With Low-Thermal Argon Plasma Endoscopic Treatment

NCT06543316
View directory record Official record
Conditions
Roux-en-y Anastomosis Site, Marginal Ulcer, Marginal Ulcer (Peptic) or Erosion, Ulcer, Ulcer, Gastric, Ulcer Gastrointestinal, Abdominal Pain, Nausea, Vomiting, GastroIntestinal Bleeding, Dysphagia, Ulcer Gastrojejunal
Interventions
Low Thermal Plasma (LTP) Treatment, Standard of Care Ulcer Treatment (typically PPI Administration)
Procedure · Other
Lead sponsor
Christopher C. Thompson, MD, MSc
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jun 25, 2026 · Synced Oct 29, 2026, 11:58 AM EDT
Completed Phase 4 Interventional Results available

Low-Dose Opiate Therapy for Discomfort in Dementia (L-DOT)

NCT00385684
View directory record Official record
Conditions
Alzheimer Disease, Dementia, Dementia, Vascular, Pain
Interventions
hydrocodone/APAP w placebo PRN, hydrocodone/APAP, placebo with hydrocodone/APAP PRN
Drug
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
55 Years and older
Enrollment
11 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2014
U.S. locations
3
States / cities
Tuscaloosa, Alabama
Source: ClinicalTrials.gov public record
Updated Nov 20, 2015 · Synced Oct 29, 2026, 11:58 AM EDT
Withdrawn Phase 4 Interventional

Post-Operative Pain Control in Opioid Tolerant Patients: Fentanyl Challenge Protocol Versus Standard of Care

NCT02324933
View directory record Official record
Conditions
Pain, Postoperative
Interventions
Fentanyl
Drug
Lead sponsor
Bassett Healthcare
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2014
U.S. locations
1
States / cities
Cooperstown, New York
Source: ClinicalTrials.gov public record
Updated Nov 2, 2015 · Synced Oct 29, 2026, 11:58 AM EDT
Completed Phase 3 Interventional Results available

Zoledronic Acid in Treating Patients With Metastatic Breast Cancer, Metastatic Prostate Cancer, or Multiple Myeloma With Bone Involvement

NCT00869206
View directory record Official record
Conditions
Breast Adenocarcinoma, DS Stage I Plasma Cell Myeloma, DS Stage II Plasma Cell Myeloma, Metastatic Malignant Neoplasm to the Bone, Pain, Musculoskeletal Complication, Urinary Complications
Interventions
zoledronic acid
Drug
Lead sponsor
Alliance for Clinical Trials in Oncology
Other
Eligibility
18 Years and older
Enrollment
1,822 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2017
U.S. locations
503
States / cities
Fairbanks, Alaska • Scottsdale, Arizona • Castro Valley, California + 353 more
Source: ClinicalTrials.gov public record
Updated Nov 7, 2018 · Synced Oct 29, 2026, 11:58 AM EDT
Recruiting Not applicable Interventional

Trans-Auricular Stimulation for Postoperative Inflammation in Spine Surgery

NCT07218133
View directory record Official record
Conditions
Spinal Fusion, Hyperglycemia, Postoperative Pain Management, Postoperative Care, Spine Disease, Neurologic Deficits, Neurological Disorder, Inflammation, Spine Condition, Spinal (Fusion) Surgery, Cytokine Levels, Spine Fusion
Interventions
Auricular vagus nerve stimulation, Sham Auricular Vagus nerve Stimulation
Device
Lead sponsor
Alexander T. Yahanda
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Aug 18, 2026 · Synced Oct 29, 2026, 11:58 AM EDT
Completed No phase listed Observational

Back in the Game: An Immediate Functional Progression Program in Athletes With a Spondylolysis.

NCT03237104
View directory record Official record
Conditions
Low Back Pain, Spondylosis
Interventions
Immediate PT
Other
Lead sponsor
Nationwide Children's Hospital
Other
Eligibility
10 Years to 19 Years
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2021
U.S. locations
5
States / cities
Columbus, Ohio • Dublin, Ohio • New Albany, Ohio + 1 more
Source: ClinicalTrials.gov public record
Updated Jan 11, 2021 · Synced Oct 29, 2026, 11:58 AM EDT