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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Pain Threshold Clear all
Completed Early Phase 1 Interventional

Cognitive Function and Pain Threshold in People Who Are Methadone Maintained

NCT04027166
View directory record Official record
Conditions
Pain
Interventions
Methadone
Drug
Lead sponsor
Yale University
Other
Eligibility
18 Years and older
Enrollment
27 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
1
States / cities
West Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Jul 19, 2021 · Synced Sep 4, 2026, 11:19 AM EDT
Completed Not applicable Interventional

Effects of Vagus Nerve Stimulation on Central Pain Sensitivity & Parasympathetic Function in Knee Osteoarthritis

NCT05625178
View directory record Official record
Conditions
Knee Osteoarthritis, Central Pain Syndrome
Interventions
Transcutaneous vagus nerve stimulation
Device
Lead sponsor
University of Texas, El Paso
Other
Eligibility
45 Years to 90 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
El Paso, Texas
Source: ClinicalTrials.gov public record
Updated Apr 1, 2025 · Synced Sep 4, 2026, 11:19 AM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

Study on the Effect of a Beta Blocker on Increased Sensitivity to Pain in Humans Caused by Opioids

NCT01222091
View directory record Official record
Conditions
Hyperalgesia
Interventions
Propranolol, Placebo to Match Propranolol, Remifentanil
Drug
Lead sponsor
Stanford University
Other
Eligibility
18 Years to 45 Years · Male only
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2011
U.S. locations
1
States / cities
Stanford, California
Source: ClinicalTrials.gov public record
Updated Jun 14, 2018 · Synced Sep 4, 2026, 11:19 AM EDT
Not listed Not applicable Interventional

The Effects of Thoracic Spine Manipulation in Individuals With Non-traumatic Cervical Pain

NCT01760590
View directory record Official record
Conditions
Neck Pain, Cervical Pain
Interventions
Manual Manipulation, Mobilization
Procedure
Lead sponsor
Keystone Rehabilitation Systems
Other
Eligibility
18 Years to 60 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2013
U.S. locations
2
States / cities
Bridgeville, Pennsylvania • Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jan 3, 2013 · Synced Sep 4, 2026, 11:19 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Pain Inhibition With Neuromuscular Electrical Stimulation

NCT05280522
View directory record Official record
Conditions
Healthy Participants
Interventions
Volitional Contractions (VOL), Neuromuscular Electrical Stimulation (NMES), Noxious Electrical Stimulation (NXES)
Other · Device
Lead sponsor
University of New England
Other
Eligibility
18 Years to 30 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
1
States / cities
Portland, Maine
Source: ClinicalTrials.gov public record
Updated Mar 14, 2022 · Synced Sep 4, 2026, 11:19 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Ice Immersion Using Virtual Reality & Augmented Reality

NCT04196686
View directory record Official record
Conditions
Pain, Neuropathic, Pain, Acute
Interventions
VR/AR, Ice Bath
Device · Other
Lead sponsor
Stanford University
Other
Eligibility
18 Years and older
Enrollment
185 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2021
U.S. locations
1
States / cities
Stanford, California
Source: ClinicalTrials.gov public record
Updated Mar 24, 2022 · Synced Sep 4, 2026, 11:19 AM EDT
Not listed Phase 1 Interventional Accepts healthy volunteers

Effect of Electroacupuncture on Pain Threshold

NCT00802165
View directory record Official record
Conditions
Pain
Interventions
Electroacupuncture, Sham electroacupuncture
Device
Lead sponsor
Logan College of Chiropractic
Other
Eligibility
10 Years to 70 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2009
U.S. locations
1
States / cities
Chesterfield, Missouri
Source: ClinicalTrials.gov public record
Updated Dec 3, 2008 · Synced Sep 4, 2026, 11:19 AM EDT
Completed No phase listed Observational Results available

Pilot Study to Evaluate the Effect of Aromatase Inhibitor Therapy on Pain Threshold in Breast Cancer Patients

NCT01814397
View directory record Official record
Conditions
Breast Cancer, Pain, Arthralgia
Interventions
Anastrozole, exemestane, letrozole
Drug
Lead sponsor
University of Michigan Rogel Cancer Center
Other
Eligibility
21 Years and older · Female only
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2013
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Feb 6, 2024 · Synced Sep 4, 2026, 11:19 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Kettlebell Swings & Low Back Pressure Pain Threshold

NCT03696615
View directory record Official record
Conditions
Low Back Pain
Interventions
Tabata Kettlebell Swing Workout, Control
Other
Lead sponsor
University of Central Florida
Other
Eligibility
18 Years to 45 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014
U.S. locations
1
States / cities
Orlando, Florida
Source: ClinicalTrials.gov public record
Updated Oct 3, 2018 · Synced Sep 4, 2026, 11:19 AM EDT
Completed Phase 1 Interventional

Lubiprostone Effects on Visceral Pain Sensitivity

NCT01166789
View directory record Official record
Conditions
Irritable Bowel Syndrome
Interventions
Lubiprostone, Placebo
Drug
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years and older
Enrollment
62 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2010
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Sep 15, 2011 · Synced Sep 4, 2026, 11:19 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Effects of Two Different Dry-Needling Techniques for Low Back Pain

NCT03970486
View directory record Official record
Conditions
Low Back Pain
Interventions
Dry needling
Procedure
Lead sponsor
Texas Woman's University
Other
Eligibility
18 Years and older
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2019
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated May 30, 2019 · Synced Sep 4, 2026, 11:19 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

The Effects of Pain and the Memory of Pain on Autonomic and Neuromuscular Function

NCT02269384
View directory record Official record
Conditions
Pain
Interventions
Experimental Noxious Stimulus, Memory of Experimental Noxious Stimulus, Memory of Prior Significant Injury, Mental Challenge Test
Procedure · Behavioral
Lead sponsor
Mount St. Mary's College, Los Angeles, CA
Other
Eligibility
18 Years to 60 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2015
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Feb 17, 2015 · Synced Sep 4, 2026, 11:19 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Wearable Focused Ultrasound Stimulation for Peripheral Nerve Pain Management

NCT07160049
View directory record Official record
Conditions
Pain Management, Peripheral Neuropathic Pain
Interventions
Cold Pressor Task - Upper Limb, Algometry Pain Tests in the Upper Limb, Algometry Pain Tests in the Lower Limb
Device
Lead sponsor
Evan (Huiliang) Wang
Other
Eligibility
20 Years to 40 Years
Enrollment
8 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025
U.S. locations
1
States / cities
Austin, Texas
Source: ClinicalTrials.gov public record
Updated Jun 9, 2026 · Synced Sep 4, 2026, 11:19 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Lumbosacral Muscle Sensitivity & Pressure Pain Threshold After Kettlebell Swings

NCT05607212
View directory record Official record
Conditions
Muscle Soreness, Muscle Weakness, Muscle Tenderness
Interventions
Kettlebell Swing, Isometric Hold, Control
Other
Lead sponsor
University of Central Florida
Other
Eligibility
18 Years to 35 Years
Enrollment
90 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2024
U.S. locations
1
States / cities
Orlando, Florida
Source: ClinicalTrials.gov public record
Updated Jun 4, 2024 · Synced Sep 4, 2026, 11:19 AM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Puberty, Sex Hormones and Pain Sensitivity in Adolescents With Migraine

NCT05738213
View directory record Official record
Conditions
Migraine
Interventions
Thermal stimuli, Pressure stimuli, Pain ratings, Pressure pain thresholds (PPT), Conditioned pain modulation (CPM) response, PedMIDAS (Pediatric Migraine Disability Assessment), Hormonal assessment, Pubertal status
Device · Behavioral · Diagnostic Test + 1 more
Lead sponsor
Washington University School of Medicine
Other
Eligibility
11 Years to 15 Years
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2028
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Jul 12, 2026 · Synced Sep 4, 2026, 11:19 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

To Study the Mechanisms of Acupuncture Through Functional Magnetic Resonance Imaging and Peripheral Neurosensory Testing

NCT00521547
View directory record Official record
Conditions
Healthy
Interventions
Electroacupuncture
Procedure
Lead sponsor
National Center for Complementary and Integrative Health (NCCIH)
NIH
Eligibility
18 Years to 80 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2003 – 2007
U.S. locations
1
States / cities
La Jolla, California
Source: ClinicalTrials.gov public record
Updated Aug 27, 2007 · Synced Sep 4, 2026, 11:19 AM EDT
Completed No phase listed Observational

Genetics and Pain Severity in Sickle Cell Disease

NCT01441141
View directory record Official record
Conditions
Genotype, Pain, Genetic Variation, Quantitative Sensory Testing (QST), GCH1
Interventions
Not listed
Lead sponsor
National Heart, Lung, and Blood Institute (NHLBI)
NIH
Eligibility
18 Years to 99 Years
Enrollment
67 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2020
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Dec 9, 2020 · Synced Sep 4, 2026, 11:19 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Comparing the Effects of Upper and Lower Body Resistance Training on Pain Sensitivity

NCT05985382
View directory record Official record
Conditions
Healthy
Interventions
Lower Body Resistance Exercise, Upper Body Resistance Exercise
Other
Lead sponsor
University of Central Florida
Other
Eligibility
18 Years to 60 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023
U.S. locations
1
States / cities
Orlando, Florida
Source: ClinicalTrials.gov public record
Updated Mar 3, 2025 · Synced Sep 4, 2026, 11:19 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Does Self-myofascial Release With a Foam Roll Change Pressure Pain Thresholds in Lower Extremity Muscles

NCT02924259
View directory record Official record
Conditions
Myofascial Pain Syndromes
Interventions
The GRID foam roll
Device
Lead sponsor
California State University, Dominguez Hills
Other
Eligibility
18 Years to 65 Years
Enrollment
45 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016
U.S. locations
1
States / cities
Carson, California
Source: ClinicalTrials.gov public record
Updated Nov 30, 2016 · Synced Sep 4, 2026, 11:19 AM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers Results available

The Influence of Testosterone on Experimental Pain Perception

NCT05781685
View directory record Official record
Conditions
Acute Pain
Interventions
Testosterone, Placebo Syrup
Drug · Other
Lead sponsor
University of New Mexico
Other
Eligibility
18 Years to 25 Years · Female only
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
1
States / cities
Albuquerque, New Mexico
Source: ClinicalTrials.gov public record
Updated Aug 4, 2024 · Synced Sep 4, 2026, 11:19 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Dry Needling and Shoulder Muscle Blood Flow, Motions, and Pain Sensitivity

NCT05467098
View directory record Official record
Conditions
Dry Needling, Shoulder Pain
Interventions
Dry Needling
Other
Lead sponsor
Texas Woman's University
Other
Eligibility
18 Years to 65 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2024
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Nov 18, 2024 · Synced Sep 4, 2026, 11:19 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Evaluating VR Therapy Using Cold Pressor Test

NCT03268863
View directory record Official record
Conditions
Pain
Interventions
Virtual Reality, Cold Pressor
Device · Other
Lead sponsor
Janet Vittone
Other
Eligibility
18 Years to 65 Years
Enrollment
48 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
2
States / cities
Scottsdale, Arizona • Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Jun 10, 2019 · Synced Sep 4, 2026, 11:19 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Characterization of Nociception Phenotype in Individuals With Intellectual Disability

NCT05473429
View directory record Official record
Conditions
Intellectual Disability
Interventions
TSA2 Thermosensory Stimulator
Device
Lead sponsor
National Institutes of Health Clinical Center (CC)
NIH
Eligibility
8 Years to 30 Years
Enrollment
215 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Aug 30, 2026 · Synced Sep 4, 2026, 11:19 AM EDT
Not yet recruiting Not applicable Interventional

Marine Lipids Ease Painful TMD

NCT07437313
View directory record Official record
Conditions
Temporomandibular Disorder (TMD)
Interventions
SPM Precursor-Enriched Marine Lipid Supplement, Medium-Chain Triglyceride Supplement
Dietary Supplement
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2030
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Aug 30, 2026 · Synced Sep 4, 2026, 11:19 AM EDT