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Showing 1–24 of 172 matching trials from the live ClinicalTrials.gov search.
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Filters: "deep brain stimulation" Condition: Parkinson's Disease Clear all
Recruiting Not applicable Interventional

Globus Pallidus Stimulation to Treat Insomnia

NCT04116996
View directory record Official record
Conditions
Parkinson Disease
Interventions
DEEP BRAIN STIMULATION
Device
Lead sponsor
Mayo Clinic
Other
Eligibility
40 Years to 80 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2029
U.S. locations
1
States / cities
Jacksonville, Florida
Source: ClinicalTrials.gov public record
Updated Nov 30, 2025 · Synced Jul 24, 2026, 1:45 AM EDT
Terminated Not applicable Interventional Results available

Burst-Type Deep Brain Stimulation of the Subthalamic Nucleus in Parkinson's Disease

NCT05753449
View directory record Official record
Conditions
Parkinson Disease, Deep Brain Stimulation
Interventions
Baseline (or standard of care) DBS programming, Burst-type DBS electrical stimulation programming
Device
Lead sponsor
Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute)
Other
Eligibility
18 Years to 85 Years
Enrollment
2 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 27, 2025 · Synced Jul 24, 2026, 1:45 AM EDT
Completed Phase 2 Interventional Results available

A Comparison of an Implanted Neuroprosthesis With Sensory Training for Improving Airway Protection in Chronic Dysphagia

NCT00376506
View directory record Official record
Conditions
Chronic Dysphagia, Multiple Sclerosis, Parkinson Disease
Interventions
Neurostimulation device for dysphagia, External vibrotactile device
Device
Lead sponsor
National Institute of Neurological Disorders and Stroke (NINDS)
NIH
Eligibility
18 Years to 90 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2011
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Oct 25, 2012 · Synced Jul 24, 2026, 1:45 AM EDT
Withdrawn No phase listed Observational

Optimizing DBS Electrode Placement and Programming

NCT01820390
View directory record Official record
Conditions
Parkinson's Disease, Essential Tremor
Interventions
Not listed
Lead sponsor
University of Colorado, Denver
Other
Eligibility
18 Years to 70 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2015
U.S. locations
2
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Feb 19, 2014 · Synced Jul 24, 2026, 1:45 AM EDT
Completed Not applicable Interventional

Mobile Decision Support System for Nurse Management of Neuromodulation Therapy

NCT02474459
View directory record Official record
Conditions
Parkinson's Disease
Interventions
iPad-Based Clinical Support Care, Standard Clinical Care
Device · Other
Lead sponsor
University of Utah
Other
Eligibility
30 Years to 75 Years
Enrollment
123 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2020
U.S. locations
6
States / cities
San Francisco, California • Gainesville, Florida • New York, New York + 3 more
Source: ClinicalTrials.gov public record
Updated Jun 4, 2020 · Synced Jul 24, 2026, 1:45 AM EDT
Completed No phase listed Observational

Deep Brain Stimulation of the Subthalamic Nucleus (STN) and Cognitive Control

NCT00917722
View directory record Official record
Conditions
Parkinson's Disease
Interventions
Not listed
Lead sponsor
Washington University School of Medicine
Other
Eligibility
Not listed
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2013
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Nov 9, 2016 · Synced Jul 24, 2026, 1:45 AM EDT
Recruiting Phase 4 Interventional

Personalized Real-Time DBS and PD Mechanisms

NCT06013956
View directory record Official record
Conditions
Parkinson Disease
Interventions
Neurostimulation, Carbidopa 25/Levodopa 100Mg Tab
Device · Drug
Lead sponsor
David Escobar
Other
Eligibility
18 Years to 80 Years
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2028
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated May 13, 2026 · Synced Jul 24, 2026, 1:45 AM EDT
Completed No phase listed Observational

Circuit-Based Deep Brain Stimulation for Parkinson's Disease; Udall Project 1 Aim 2 and 3

NCT03079037
View directory record Official record
Conditions
Parkinson Disease
Interventions
Stimulation
Device
Lead sponsor
University of Minnesota
Other
Eligibility
22 Years to 85 Years
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2023
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Apr 15, 2024 · Synced Jul 24, 2026, 1:45 AM EDT
Completed No phase listed Observational

Parkinstep: Automated PD Gait and Balance Assessment for Optimizing DBS

NCT02080572
View directory record Official record
Conditions
Parkinson's Disease With Deep Brain Stimulation
Interventions
Not listed
Lead sponsor
Great Lakes NeuroTechnologies Inc.
Industry
Eligibility
21 Years and older
Enrollment
22 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2014
U.S. locations
2
States / cities
Cincinnati, Ohio • Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Feb 4, 2015 · Synced Jul 24, 2026, 1:45 AM EDT
Recruiting Not applicable Interventional

Investigating Inhibitory Control Networks in Parkinson's Disease

NCT04735458
View directory record Official record
Conditions
Parkinson Disease
Interventions
Procedure/Surgery: Response Inhibition and Deep Brain Stimulation in Parkinson's disease
Other
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
18 Years and older
Enrollment
140 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2028
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Dec 1, 2025 · Synced Jul 24, 2026, 1:45 AM EDT
Active, not recruiting No phase listed Observational Accepts healthy volunteers

Gait Analysis in Neurological Disease

NCT02994719
View directory record Official record
Conditions
Parkinson's Disease, Parkinsonian Disorders, Atypical Parkinson Disease, Progressive Supranuclear Palsy, Multiple System Atrophy, Corticobasal Degeneration, Gait, Frontal, Huntington Disease, Ataxia, Spinocerebellar
Interventions
Anti-Parkinson medication, Deep Brain Stimulation
Drug · Device
Lead sponsor
Beth Israel Deaconess Medical Center
Other
Eligibility
18 Years to 85 Years
Enrollment
120 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2027
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 7, 2026 · Synced Jul 24, 2026, 1:45 AM EDT
Completed No phase listed Observational

Effect of Deep Brain Stimulation on Depression and Quality of Life in Parkinson's Patients

NCT00179101
View directory record Official record
Conditions
Parkinson's Disease
Interventions
Deep Brain Stimulation
Procedure
Lead sponsor
Vanderbilt University
Other
Eligibility
50 Years to 85 Years
Enrollment
42 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2005
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Aug 14, 2006 · Synced Jul 24, 2026, 1:45 AM EDT
Recruiting No phase listed Observational

Circuit-Based Deep Brain Stimulation for Parkinson's Disease P1A2&3 Catalyst

NCT05658302
View directory record Official record
Conditions
Parkinson Disease
Interventions
Not listed
Lead sponsor
University of Minnesota
Other
Eligibility
21 Years and older · Female only
Enrollment
30 participants
Timeline
2023 – 2028
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Jan 25, 2026 · Synced Jul 24, 2026, 1:45 AM EDT
Not yet recruiting Not applicable Interventional

VC/VS for Apathy in PD

NCT06991335
View directory record Official record
Conditions
Parkinson Disease, Deep Brain Stimulation, Apathy
Interventions
Deep Brain Stimulation
Device
Lead sponsor
Nora Vanegas
Other
Eligibility
40 Years to 75 Years
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2032
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated May 30, 2025 · Synced Jul 24, 2026, 1:45 AM EDT
Recruiting Not applicable Interventional

Investigating Subcortical Contributions to Speech Sequencing in Deep Brain Stimulator Recipients

NCT07455760
View directory record Official record
Conditions
Parkinson's Disease (PD), Essential Tremor
Interventions
Phoneme sequence learning, Cessation and re-enabling of stimulation of the STN, Cessation and re-enabling of stimulation of the VIM thalamic nucleus, Multisyllabic sequence learning
Behavioral · Other
Lead sponsor
Boston University Charles River Campus
Other
Eligibility
18 Years and older
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2030
U.S. locations
2
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 8, 2026 · Synced Jul 24, 2026, 1:45 AM EDT
Completed Not applicable Interventional Results available

Low Frequency Subthalamic Nucleus Deep Brain Stimulation to Improve Verbal Fluency

NCT04383665
View directory record Official record
Conditions
Parkinson Disease
Interventions
STN DBS 10Hz, STN DBS 130Hz, STN DBS off
Device
Lead sponsor
University of Southern California
Other
Eligibility
18 Years and older
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Jul 14, 2021 · Synced Jul 24, 2026, 1:45 AM EDT
Withdrawn Phase 2Phase 3 Interventional

Dexmedetomidine Effects on Microelectrode Recording in Deep Brain Stimulation

NCT00608231
View directory record Official record
Conditions
Parkinson's Disease, Essential Tremor, Dystonia
Interventions
Dexmedetomidine Hydrochloride Infusion, Normal Saline
Drug
Lead sponsor
Vanderbilt University
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2012
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Jun 30, 2014 · Synced Jul 24, 2026, 1:45 AM EDT
Recruiting Not applicable Interventional

Electrophysiology-based DBS Programming for PD

NCT07348705
View directory record Official record
Conditions
Parkinson's Disease (PD)
Interventions
Clinician-based DBS programming, Maximum Beta power-based DBS programming, Broad-band electrophysiology-based DBS programming
Device
Lead sponsor
University of Florida
Other
Eligibility
21 Years to 89 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2031
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Mar 29, 2026 · Synced Jul 24, 2026, 1:45 AM EDT
Completed No phase listed Observational Results available

Follow Up Study for Treatment of Parkinson's Disease With Deep Brain Stimulation

NCT01022073
View directory record Official record
Conditions
Parkinson Disease
Interventions
Not listed
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
21 Years to 95 Years
Enrollment
156 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2015
U.S. locations
12
States / cities
Los Angeles, California • San Francisco, California • West Los Angeles, California + 4 more
Source: ClinicalTrials.gov public record
Updated Jun 9, 2016 · Synced Jul 24, 2026, 1:45 AM EDT
Enrolling by invitation Not applicable Interventional

Vibrotactile Coordinated Reset for the Treatment of Advanced Parkinson's Disease

NCT05504902
View directory record Official record
Conditions
Parkinson Disease
Interventions
Vibrotactile coordinated reset
Device
Lead sponsor
Stanford University
Other
Eligibility
18 Years and older
Enrollment
35 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
1
States / cities
Stanford, California
Source: ClinicalTrials.gov public record
Updated Aug 18, 2024 · Synced Jul 24, 2026, 1:45 AM EDT
Completed Not applicable Interventional

Non-invasive Measurement of Brain Oxygen Levels in People With Subthalamic Deep Brain Stimulators

NCT02278406
View directory record Official record
Conditions
Parkinson's Disease
Interventions
Deep brain stimulator
Other
Lead sponsor
Beth Israel Deaconess Medical Center
Other
Eligibility
18 Years to 75 Years
Enrollment
8 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated May 7, 2017 · Synced Jul 24, 2026, 1:45 AM EDT
Completed Not applicable Interventional

Deep Brain Stimulation in Patients With Parkinson's Disease

NCT00586079
View directory record Official record
Conditions
Parkinson's Disease
Interventions
Deep brain stimulation surgery.
Procedure
Lead sponsor
Mayo Clinic
Other
Eligibility
40 Years to 82 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2011
U.S. locations
1
States / cities
Scottsdale, Arizona
Source: ClinicalTrials.gov public record
Updated Mar 17, 2016 · Synced Jul 24, 2026, 1:45 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Perceptual Decision Making Under Conditions of Visual Uncertainty

NCT01845883
View directory record Official record
Conditions
Parkinson's Disease, Dystonia, Ataxia
Interventions
Deep Brain Stimulation (DBS)
Procedure
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years to 80 Years
Enrollment
120 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2016
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Dec 17, 2015 · Synced Jul 24, 2026, 1:45 AM EDT
Completed Not applicable Interventional Results available

Evaluation of the Infinity Deep Brain Stimulation Electrode Screening Mode Tool

NCT03794661
View directory record Official record
Conditions
Essential Tremor, Parkinson's Disease
Interventions
Clinician programmer electrode screening mode tool
Device
Lead sponsor
Abbott Medical Devices
Industry
Eligibility
18 Years to 80 Years
Enrollment
8 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
3
States / cities
Albany, New York • San Antonio, Texas • Spokane, Washington
Source: ClinicalTrials.gov public record
Updated Mar 30, 2022 · Synced Jul 24, 2026, 1:45 AM EDT