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ClinicalTrials.gov public records Last synced Oct 2, 2026, 5:52 AM EDT

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Showing 25–48 of 1,424 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Parkinsons Disease Clear all
Withdrawn Not applicable Interventional

Concurrent DBS Local Field Potential Analysis and Stimulation in a Closed-Loop Neuromodulation Device

NCT02731365
View directory record Official record
Conditions
Parkinson's Disease
Interventions
Activa PC+S
Device
Lead sponsor
Vibhor Krishna
Other
Eligibility
22 Years to 90 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Nov 17, 2016 · Synced Oct 2, 2026, 5:52 AM EDT
Recruiting Not applicable Interventional

Optimizing Adaptive DBS for Parkinson's Disease

NCT07798271
View directory record Official record
Conditions
PARKINSON DISEASE (Disorder)
Interventions
aDBS-Extended (Medtronic Percept™), aDBS-Standard (Medtronic Percept™), Continuous DBS (cDBS) - Active Control (Medtronic Percept™)
Device
Lead sponsor
University of California, Davis
Other
Eligibility
18 Years and older
Enrollment
35 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2032
U.S. locations
1
States / cities
Davis, California
Source: ClinicalTrials.gov public record
Updated Sep 1, 2026 · Synced Oct 2, 2026, 5:52 AM EDT
Completed Phase 2 Interventional Results available

Repeated-Dose Oral N-acetylcysteine for the Treatment of Parkinson's Disease

NCT02212678
View directory record Official record
Conditions
Parkinson Disease
Interventions
N-acetylcysteine capsule
Drug
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years and older
Enrollment
8 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated May 16, 2019 · Synced Oct 2, 2026, 5:52 AM EDT
Completed Not applicable Interventional

The Effects of Nicotine Chewing Gum in Parkinson's Disease

NCT02452125
View directory record Official record
Conditions
Low Blood Pressure, Parkinsons Disease
Interventions
Nicotine gum
Dietary Supplement
Lead sponsor
New York Institute of Technology
Other
Eligibility
Not listed
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2017
U.S. locations
1
States / cities
Old Westbury, New York
Source: ClinicalTrials.gov public record
Updated Jul 28, 2017 · Synced Oct 2, 2026, 5:52 AM EDT
Completed Phase 1 Interventional

A Study of the Pharmacokinetics, Pharmacodynamics, and Safety of Opicapone in Subjects With Parkinson's Disease Taking Levodopa.

NCT03496870
View directory record Official record
Conditions
Parkinson Disease
Interventions
Opicapone, Carbidopa Levodopa
Drug
Lead sponsor
Neurocrine Biosciences
Industry
Eligibility
18 Years to 85 Years
Enrollment
16 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018
U.S. locations
3
States / cities
Glendale, California • Long Beach, California • Farmington Hills, Michigan
Source: ClinicalTrials.gov public record
Updated Mar 22, 2019 · Synced Oct 2, 2026, 5:52 AM EDT
Completed Phase 3 Interventional

Long Term Safety and Efficacy of SC Apomorphine in Treatment of "Off" Episodes in Late-Stage Parkinson's Disease

NCT00142545
View directory record Official record
Conditions
Parkinson Disease
Interventions
apomorphine HCl injection
Drug
Lead sponsor
Mylan Bertek Pharmaceuticals
Industry
Eligibility
18 Years and older
Enrollment
800 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
1999 – 2005
U.S. locations
1
States / cities
Morgantown, West Virginia
Source: ClinicalTrials.gov public record
Updated Sep 2, 2005 · Synced Oct 2, 2026, 5:52 AM EDT
Recruiting Not applicable Interventional

Slow-SPEED: Slowing Parkinson's Early Through Exercise Dosage

NCT06993142
View directory record Official record
Conditions
Parkinson Disease, Prodromal Stage, Neurodegenerative Diseases, Basal Ganglia Diseases, Central Nervous System Diseases, Synucleinopathies, Nervous System Diseases, Cerebral Disorder, Brain Diseases, Parkinsonian Disorders, Genetic Predisposition
Interventions
Increase of physical activity volume and intensity with the use of a motivational smartphone application
Behavioral
Lead sponsor
Radboud University Medical Center
Other
Eligibility
50 Years and older
Enrollment
600 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2029
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Aug 27, 2026 · Synced Oct 2, 2026, 5:52 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Randomized Study of the Effects of Glucose on Cognition in Healthy Young and Elderly People and Parkinson's Disease Patients

NCT00004451
View directory record Official record
Conditions
Parkinson Disease
Interventions
Glucose
Drug
Lead sponsor
National Institute of Mental Health (NIMH)
NIH
Eligibility
18 Years and older
Enrollment
120 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
Started 1998
U.S. locations
1
States / cities
Charlottesville, Virginia
Source: ClinicalTrials.gov public record
Updated Dec 1, 2005 · Synced Oct 2, 2026, 5:52 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Development of a Face Valid Executive Functioning Task

NCT00918112
View directory record Official record
Conditions
Parkinson's Disease
Interventions
Not listed
Lead sponsor
Washington University School of Medicine
Other
Eligibility
20 Years to 70 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2004 – 2016
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Mar 31, 2022 · Synced Oct 2, 2026, 5:52 AM EDT
Completed Phase 2 Interventional Results available

A Study of Tolerability and Efficacy of Cannabidiol on Motor Symptoms in Parkinson's Disease

NCT03582137
View directory record Official record
Conditions
Parkinson Disease
Interventions
Cannabidiol, Placebo
Drug · Other
Lead sponsor
University of Colorado, Denver
Other
Eligibility
40 Years to 85 Years
Enrollment
74 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2022
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Jul 23, 2024 · Synced Oct 2, 2026, 5:52 AM EDT
Completed Phase 2 Interventional

Parkinson's Disease Treatment With Coenzyme Q10

NCT00004731
View directory record Official record
Conditions
Parkinson's Disease
Interventions
Coenzyme Q10
Drug
Lead sponsor
National Institute of Neurological Disorders and Stroke (NINDS)
NIH
Eligibility
30 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
1998 – 2003
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Jun 24, 2005 · Synced Oct 2, 2026, 5:52 AM EDT
Terminated Not applicable Interventional Accepts healthy volunteers Results available

Trial Comparing Functional Outcomes of Awake vs. Asleep Deep Brain Stimulation (DBS) for Parkinson's Disease

NCT02401308
View directory record Official record
Conditions
Parkinson's Disease
Interventions
Deep Brain Stimulation surgery
Procedure
Lead sponsor
St. Joseph's Hospital and Medical Center, Phoenix
Other
Eligibility
18 Years to 85 Years
Enrollment
1 participant
Healthy volunteers
Accepts healthy volunteers
Timeline
2015
U.S. locations
1
States / cities
Phoenix, Arizona
Source: ClinicalTrials.gov public record
Updated Oct 26, 2021 · Synced Oct 2, 2026, 5:52 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

PET Scan to Study Brain Control of Human Movement

NCT00001324
View directory record Official record
Conditions
Ataxia, Cerebrovascular Accident, Healthy, Movement Disorder, Tremor
Interventions
Not listed
Lead sponsor
National Institute of Neurological Disorders and Stroke (NINDS)
NIH
Eligibility
Not listed
Enrollment
510 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
1992 – 2001
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Mar 16, 2021 · Synced Oct 2, 2026, 5:52 AM EDT
Recruiting Not applicable Interventional

Non-invasive VNS for Parkinson's Gait

NCT06562569
View directory record Official record
Conditions
Parkinson's Disease
Interventions
non-invasive cervical vagal nerve stimulation ncVNS
Device
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
50 Years to 88 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Hines, Illinois
Source: ClinicalTrials.gov public record
Updated Jul 9, 2026 · Synced Oct 2, 2026, 5:52 AM EDT
Terminated Not applicable Interventional Results available

Lubiprostone as a Treatment for Constipation in Parkinson's Disease

NCT00669461
View directory record Official record
Conditions
Constipation, Parkinson's Disease
Interventions
Lubiprostone
Drug
Lead sponsor
University of Arkansas
Other
Eligibility
50 Years to 85 Years
Enrollment
1 participant
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2010
U.S. locations
1
States / cities
Little Rock, Arkansas
Source: ClinicalTrials.gov public record
Updated Dec 30, 2016 · Synced Oct 2, 2026, 5:52 AM EDT
Completed Phase 1 Interventional

A 2-Part Trial of CVL-751 in Subjects With Parkinson's Disease

NCT04295642
View directory record Official record
Conditions
Parkinson Disease
Interventions
CVL-751
Drug
Lead sponsor
Cerevel Therapeutics, LLC
Industry
Eligibility
45 Years to 75 Years
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
2
States / cities
Long Beach, California • Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Aug 31, 2021 · Synced Oct 2, 2026, 5:52 AM EDT
Terminated Phase 3 Interventional Results available

A Study to Assess if BIIB122 Tablets Are Safe and Can Slow Worsening of Early-Stage Parkinson's Disease in Participants With Specific LRRK2 Genetic Variants Between the Ages of 30 and 80 Using the Movement Disorder Society-Unified Parkinson's Disease Rating Scale

NCT05418673
View directory record Official record
Conditions
Parkinson Disease
Interventions
BIIB122, BIIB122-Matching Placebo
Drug
Lead sponsor
Biogen
Industry
Eligibility
30 Years to 80 Years
Enrollment
7 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
12
States / cities
San Francisco, California • Aurora, Colorado • Englewood, Colorado + 8 more
Source: ClinicalTrials.gov public record
Updated Jun 26, 2024 · Synced Oct 2, 2026, 5:52 AM EDT
Active, not recruiting Phase 3 Interventional

To Evaluate the Efficacy of CVN424 in Parkinson's Disease Participants With Motor Complications

NCT06553027
View directory record Official record
Conditions
Parkinson Disease
Interventions
CVN424 75 mg, CVN424 150 mg, Placebo
Drug
Lead sponsor
Cerevance
Industry
Eligibility
30 Years and older
Enrollment
330 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
53
States / cities
Birmingham, Alabama • Phoenix, Arizona • Aliso Viejo, California + 41 more
Source: ClinicalTrials.gov public record
Updated Apr 17, 2026 · Synced Oct 2, 2026, 5:52 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers

The Effect of Rasagiline on Cognition in Parkinson's Disease

NCT01382342
View directory record Official record
Conditions
Parkinson's Disease
Interventions
Rasagiline, Placebo
Drug
Lead sponsor
Brown University
Other
Eligibility
40 Years and older
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2014
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Feb 5, 2015 · Synced Oct 2, 2026, 5:52 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Cell Studies of Parkinson's Disease

NCT00076505
View directory record Official record
Conditions
Parkinson Disease
Interventions
Not listed
Lead sponsor
National Human Genome Research Institute (NHGRI)
NIH
Eligibility
18 Years and older
Enrollment
150 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2004 – 2006
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Jul 2, 2017 · Synced Oct 2, 2026, 5:52 AM EDT
Active, not recruiting No phase listed Observational

Noninterventional Study Evaluating Parkinson's Disease Diary Use

NCT05363046
View directory record Official record
Conditions
Parkinson's Disease
Interventions
Not listed
Lead sponsor
BlueRock Therapeutics
Industry
Eligibility
39 Years to 70 Years
Enrollment
194 participants
Timeline
2022 – 2026
U.S. locations
16
States / cities
Scottsdale, Arizona • Los Angeles, California • Orange, California + 12 more
Source: ClinicalTrials.gov public record
Updated Jul 31, 2024 · Synced Oct 2, 2026, 5:52 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Levodopa Response and Gut Microbiome in Patients With Parkinson's Disease

NCT04956939
View directory record Official record
Conditions
Parkinson Disease
Interventions
Low dose levodopa, High dose levodopa
Drug
Lead sponsor
Rush University Medical Center
Other
Eligibility
40 Years to 80 Years
Enrollment
38 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2021
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Nov 7, 2022 · Synced Oct 2, 2026, 5:52 AM EDT
Completed Phase 2 Interventional

Talampanel to Treat Parkinson's Disease

NCT00108667
View directory record Official record
Conditions
Parkinson Disease
Interventions
IV Levodopa, Talampanel
Drug
Lead sponsor
National Institute of Neurological Disorders and Stroke (NINDS)
NIH
Eligibility
Not listed
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2006
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Mar 4, 2008 · Synced Oct 2, 2026, 5:52 AM EDT
Terminated No phase listed Observational Accepts healthy volunteers

Characteristics of Parkinson s Disease Associated With the LRRK-2 Gene Mutation

NCT00467090
View directory record Official record
Conditions
Parkinson Disease
Interventions
Not listed
Lead sponsor
National Institute of Neurological Disorders and Stroke (NINDS)
NIH
Eligibility
18 Years and older
Enrollment
34 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2014
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Dec 17, 2019 · Synced Oct 2, 2026, 5:52 AM EDT