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ClinicalTrials.gov public records Last synced Oct 2, 2026, 7:41 PM EDT

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Showing 25–48 of 229 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Pelvic Organ Prolapse Clear all
Not listed Not applicable Interventional

Prospective Analysis of Restorelle in the Treatment of Uterine Prolapse

NCT02921451
View directory record Official record
Conditions
Uterine Prolapse
Interventions
Restorelle Smartmesh
Device
Lead sponsor
Michigan Institution of Women's Health PC
Other
Eligibility
18 Years to 90 Years · Female only
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2020
U.S. locations
1
States / cities
Dearborn, Michigan
Source: ClinicalTrials.gov public record
Updated Aug 14, 2019 · Synced Oct 2, 2026, 7:41 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Affixing Polypropylene Mesh Using Barbed Suture (Quill™ Srs) During Laparoscopic Sacrocolpopexy Randomized Controlled Trial (Quill Lsc)

NCT01551992
View directory record Official record
Conditions
Prolapse
Interventions
Quill suture vs. Interrupted suture
Procedure
Lead sponsor
Kaiser Permanente
Other
Eligibility
18 Years and older · Female only
Enrollment
32 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2014
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Sep 16, 2014 · Synced Oct 2, 2026, 7:41 PM EDT
Completed Not applicable Interventional Results available

A Randomized Controlled Trial of Permanent vs Absorbable Suture for Uterosacral Ligament Suspension

NCT02888093
View directory record Official record
Conditions
Pelvic Organ Prolapse, Cystocele, Uterine Prolapse
Interventions
Absorbent suture (polydioxanone) and Permanent suture (Gore-Tex CV2)
Device
Lead sponsor
Joseph Kowalski
Other
Eligibility
18 Years to 99 Years · Female only
Enrollment
44 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2018
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Dec 2, 2019 · Synced Oct 2, 2026, 7:41 PM EDT
Not listed No phase listed Observational Accepts healthy volunteers

Feasibility and Safety of Single Port Robot in Colorectal Procedures

NCT03700593
View directory record Official record
Conditions
Colon Cancer, Colon Polyp, Rectal Cancer, Diverticulitis, Prolapse, Rectal, Rectal Polyp, Inflammatory Bowel Diseases
Interventions
Single Port Robotic Colorectal Surgery
Device
Lead sponsor
Marks Colorectal Surgical Associates
Other
Eligibility
18 Years to 95 Years
Enrollment
200 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2020
U.S. locations
1
States / cities
Wynnewood, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Feb 19, 2020 · Synced Oct 2, 2026, 7:41 PM EDT
Completed Not applicable Interventional

EASE: The Materna Prep Pivotal Study

NCT03973281
View directory record Official record
Conditions
Vaginal Delivery, Pelvic Organ Prolapse
Interventions
Materna Prep Device, Standard of Care (SOC)
Device · Other
Lead sponsor
Materna Medical
Industry
Eligibility
18 Years and older · Female only
Enrollment
420 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2026
U.S. locations
22
States / cities
Birmingham, Alabama • Greenbrae, California • Los Angeles, California + 18 more
Source: ClinicalTrials.gov public record
Updated Aug 31, 2026 · Synced Oct 2, 2026, 7:41 PM EDT
Completed Not applicable Interventional Results available

Efficacy Study of Vaginal Mesh for Prolapse

NCT00475540
View directory record Official record
Conditions
Pelvic Organ Prolapse, Uterine Prolapse, Vaginal Prolapse, Cystocele, Rectocele
Interventions
synthetic monofilament polypropylene mesh
Device
Lead sponsor
Medstar Health Research Institute
Other
Eligibility
21 Years and older · Female only
Enrollment
65 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2013
U.S. locations
1
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated Oct 12, 2022 · Synced Oct 2, 2026, 7:41 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Predictors of Post Operative Morbidity in Older Women With Pelvic Organ Prolapse

NCT01967446
View directory record Official record
Conditions
Pelvic Organ Prolapse
Interventions
Not listed
Lead sponsor
University of Pennsylvania
Other
Eligibility
60 Years and older · Female only
Enrollment
132 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2013
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Dec 10, 2014 · Synced Oct 2, 2026, 7:41 PM EDT
Recruiting Not applicable Interventional

Sequence of Midurethral Sling Placement During Robotic Sacrocolpopexy

NCT07008898
View directory record Official record
Conditions
Stress Incontinence Female, Pelvic Organ Prolapse
Interventions
Midurethral sling placed before robotic sacrocolpopexy, Midurethral sling placed after robotic sacrocolpopexy
Procedure
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
18 Years and older · Female only
Enrollment
110 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
2
States / cities
Birmingham, Alabama • Albany, New York
Source: ClinicalTrials.gov public record
Updated Feb 17, 2026 · Synced Oct 2, 2026, 7:41 PM EDT
Completed Not applicable Interventional

Impact of Defecation Posture on Ease of First Bowel Movement Following Posterior Repair

NCT06253689
View directory record Official record
Conditions
Postoperative Constipation, Pelvic Organ Prolapse Vaginal Surgery, Defecation Function
Interventions
Defecation Posture Modification Device
Device
Lead sponsor
TriHealth Inc.
Other
Eligibility
18 Years and older · Female only
Enrollment
160 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
3
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Apr 18, 2025 · Synced Oct 2, 2026, 7:41 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers Results available

Nitrofurantoin and Urinary Tract Infections (UTIs)

NCT00678041
View directory record Official record
Conditions
Urinary Tract Infections
Interventions
Nitrofurantoin, Placebo
Drug
Lead sponsor
University of Pittsburgh
Other
Eligibility
18 Years and older · Female only
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2009
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Sep 27, 2016 · Synced Oct 2, 2026, 7:41 PM EDT
Terminated Phase 4 Interventional Results available

Hormonal Status on Blood Flow and Tissue in Pelvic Organ Prolapse

NCT01886794
View directory record Official record
Conditions
Pelvic Floor Disorders
Interventions
Postmenopausal, topical vaginal estrogen cream, Placebo Comparator: Postmenopausal, topical placebo cream
Drug
Lead sponsor
The University of Texas Medical Branch, Galveston
Other
Eligibility
21 Years to 70 Years · Female only
Enrollment
7 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2023
U.S. locations
1
States / cities
Galveston, Texas
Source: ClinicalTrials.gov public record
Updated Oct 29, 2025 · Synced Oct 2, 2026, 7:41 PM EDT
Completed Phase 4 Interventional Results available

Preoperative Gabapentin vs Placebo for Vaginal Prolapse Surgery

NCT05658887
View directory record Official record
Conditions
Pelvic Organ Prolapse, Perioperative/Postoperative Complications
Interventions
Gabapentin, Gabapentin Placebo
Drug
Lead sponsor
Joseph Kowalski
Other
Eligibility
18 Years and older · Female only
Enrollment
110 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Aug 12, 2025 · Synced Oct 2, 2026, 7:41 PM EDT
Terminated Not applicable Interventional Results available

Vaginal Estrogen and Pelvic Floor Physical Therapy in Women With Symptomatic Mild Prolapse

NCT01648751
View directory record Official record
Conditions
Pelvic Organ Prolapse
Interventions
Vaginal estrogen, Placebo
Drug
Lead sponsor
Pamela Moalli
Other
Eligibility
40 Years to 80 Years · Female only
Enrollment
21 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2023
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Sep 19, 2024 · Synced Oct 2, 2026, 7:41 PM EDT
Not listed Not applicable Interventional

Effect of Local Anesthesia on Postoperative Pain Following Sacrospinous Ligament Fixation

NCT02890199
View directory record Official record
Conditions
Pelvic Organ Prolapse
Interventions
Bupivacaine liposomal, Lidocaine
Drug
Lead sponsor
Hartford Hospital
Other
Eligibility
18 Years to 95 Years · Female only
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2017
U.S. locations
1
States / cities
Hartford, Connecticut
Source: ClinicalTrials.gov public record
Updated Oct 12, 2016 · Synced Oct 2, 2026, 7:41 PM EDT
Completed Not applicable Interventional

Impact of Defecation Posture on Ease of Bowel Movements in Patients With a Rectocele

NCT06252714
View directory record Official record
Conditions
Pelvic Organ Prolapse, Rectocele, Bowel Dysfunction
Interventions
Defecation Posture Modification Device
Device
Lead sponsor
TriHealth Inc.
Other
Eligibility
18 Years and older · Female only
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
3
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Jan 29, 2026 · Synced Oct 2, 2026, 7:41 PM EDT
Completed Phase 4 Interventional Results available

IV Acetaminophen for Postoperative Pain After Pelvic Organ Prolapse Repair

NCT02155738
View directory record Official record
Conditions
Pelvic Organ Prolapse
Interventions
IV Acetaminophen, IV normal saline
Drug
Lead sponsor
Halina M Zyczynski, MD
Other
Eligibility
18 Years and older · Female only
Enrollment
204 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2017
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Nov 19, 2018 · Synced Oct 2, 2026, 7:41 PM EDT
Completed No phase listed Observational

Composite Graft Use in Abdominal Sacrocolpopexy Reduces Erosion Rates

NCT00581412
View directory record Official record
Conditions
Pelvic Organ Prolapse
Interventions
Not listed
Lead sponsor
University of California, Irvine
Other
Eligibility
18 Years and older · Female only
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2008
U.S. locations
1
States / cities
Orange, California
Source: ClinicalTrials.gov public record
Updated Jan 11, 2010 · Synced Oct 2, 2026, 7:41 PM EDT
Completed No phase listed Observational

Restorelle® Mesh Versus Native Tissue Repair for Prolapse

NCT02162615
View directory record Official record
Conditions
Pelvic Organ Prolapse
Interventions
Restorelle Direct Fix A, Restorelle Direct Fix P, Native Tissue Repair Anterior, Native Tissue Repair Posterior
Device · Procedure
Lead sponsor
Coloplast A/S
Industry
Eligibility
18 Years and older · Female only
Enrollment
810 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2021
U.S. locations
33
States / cities
Agoura Hills, California • Stanford, California • Denver, Colorado + 30 more
Source: ClinicalTrials.gov public record
Updated Jan 27, 2022 · Synced Oct 2, 2026, 7:41 PM EDT
Terminated Not applicable Interventional Results available

Prospective Randomized Controlled Trial of Obstructed Defecation Surgery

NCT05747027
View directory record Official record
Conditions
Obstructed Defecation, Pelvic Organ Prolapse
Interventions
Laparoscopic abdominal ventral rectopexy, Transvaginal sacrospinous rectopexy
Procedure
Lead sponsor
Endeavor Health
Other
Eligibility
18 Years to 80 Years · Female only
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
2
States / cities
Skokie, Illinois • New York, New York
Source: ClinicalTrials.gov public record
Updated Jul 15, 2025 · Synced Oct 2, 2026, 7:41 PM EDT
Terminated Not applicable Interventional

Early Versus Late Voiding Trials After Prolapse Repair

NCT02739256
View directory record Official record
Conditions
Urinary Retention, Pelvic Organ Prolapse
Interventions
Retrograde voiding trial
Procedure
Lead sponsor
University of Pittsburgh
Other
Eligibility
21 Years and older · Female only
Enrollment
57 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2017
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jun 27, 2018 · Synced Oct 2, 2026, 7:41 PM EDT
Completed No phase listed Observational Accepts healthy volunteers Results available

Axis™ Allograft Dermis for Female Pelvic Floor Repair: a Prospective Post Market Study

NCT01541748
View directory record Official record
Conditions
Pelvic Organ Prolapse
Interventions
Axis
Other
Lead sponsor
Coloplast A/S
Industry
Eligibility
18 Years and older · Female only
Enrollment
74 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2018
U.S. locations
5
States / cities
Weston, Florida • Cambridge, Massachusetts • Grand Rapids, Michigan + 2 more
Source: ClinicalTrials.gov public record
Updated Jun 30, 2020 · Synced Oct 2, 2026, 7:41 PM EDT
Not listed Phase 4 Interventional Accepts healthy volunteers

Axis(TM) Solvent-dehydrate Dermal Allograft in the Treatment of Pelvic Organ Prolapse.

NCT06263985
View directory record Official record
Conditions
Pelvic Organ Prolapse
Interventions
Axis Dermis biologic mesh repair for pelvic organ prolapse
Device
Lead sponsor
Michigan Institution of Women's Health PC
Other
Eligibility
21 Years to 89 Years · Female only
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2025
U.S. locations
1
States / cities
Dearborn, Michigan
Source: ClinicalTrials.gov public record
Updated Feb 16, 2024 · Synced Oct 2, 2026, 7:41 PM EDT
Not yet recruiting Phase 4 Interventional

Suzetrigine for Opioid-Sparing Postoperative Analgesia Following Transvaginal Pelvic Reconstructive Surgery

NCT07600697
View directory record Official record
Conditions
Pelvic Organ Prolapse (POP), Stress Urinary Incontinence (SUI), Postoperative Pain
Interventions
Suzetrigine, Opioid Analgesics (Tramadol or Oxycodone), Scheduled Acetaminophen and Ibuprofen
Drug
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years and older · Female only
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Sep 15, 2026 · Synced Oct 2, 2026, 7:41 PM EDT
Completed Not applicable Interventional Results available

Barbed Suture Versus Non-Barbed Suture for Posterior Colporrhaphy

NCT04658784
View directory record Official record
Conditions
Rectocele
Interventions
2-0 dioxanone, glycolide and trimethylene carbonate, 2-0 polydioxanone
Device
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years and older · Female only
Enrollment
72 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
1
States / cities
Charlotte, North Carolina
Source: ClinicalTrials.gov public record
Updated May 6, 2023 · Synced Oct 2, 2026, 7:41 PM EDT