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Showing 1–22 of 22 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Penicillin Allergy Clear all
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Inpatient Penicillin Allergy Delabeling Study

NCT05020327
View directory record Official record
Conditions
Penicillin Allergy, Penicillin Sensitivity, Penicillin Reaction, Penicillin Intolerance
Interventions
Graded Oral Amoxicillin Challenge, De-labelling in electronic medical record, Referral to Allergy Immunology/Retention of Allergy Label
Drug · Other
Lead sponsor
University Hospitals Cleveland Medical Center
Other
Eligibility
3 Years to 18 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Jul 19, 2023 · Synced Jul 22, 2026, 3:10 AM EDT
Completed Phase 4 Interventional Results available

Penicillin De-labeling in the Pediatric Primary Care Setting

NCT05010304
View directory record Official record
Conditions
Penicillin Allergy, Penicillin Reaction
Interventions
Amoxicillin
Drug
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
2 Years to 18 Years
Enrollment
23 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Aug 13, 2024 · Synced Jul 22, 2026, 3:10 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

The Effect of Providing Stratification of Low Risk Penicillin Allergies on Penicillin Allergy Label Removal

NCT03702270
View directory record Official record
Conditions
Penicillin Allergy
Interventions
Penicillin Allergic Risk Stratification Best Practice Alert
Other
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
18 Years and older
Enrollment
2,052 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2023
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Dec 17, 2024 · Synced Jul 22, 2026, 3:10 AM EDT
Recruiting Phase 4 Interventional

Allergy Delabeling in Antibiotic Stewardship - Intervention

NCT07133074
View directory record Official record
Conditions
Beta Lactam Allergy, Hematologic Malignancy
Interventions
RENEW-IN Algorithm for assessment of a beta-lactam intervention, EMR Review
Diagnostic Test · Other
Lead sponsor
Abramson Cancer Center at Penn Medicine
Other
Eligibility
18 Years and older
Enrollment
3,800 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jun 16, 2026 · Synced Jul 22, 2026, 3:10 AM EDT
Completed Phase 3 Interventional Accepts healthy volunteers Results available

Evaluation of Skin Testing Reagents for Penicillin Allergy

NCT01818336
View directory record Official record
Conditions
History of IgE Dependent Reaction to a Penicillin Product
Interventions
Penicillin skin test kit
Drug
Lead sponsor
AllerQuest LLC
Industry
Eligibility
18 Years and older
Enrollment
481 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2013
U.S. locations
13
States / cities
Homewood, Alabama • Tucson, Arizona • Walnut Creek, California + 10 more
Source: ClinicalTrials.gov public record
Updated Jan 3, 2017 · Synced Jul 22, 2026, 3:10 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Effect of Providing Stratification of Low Risk Penicillin Allergies on Penicillin Allergy Label Removal in ICU Setting

NCT03702283
View directory record Official record
Conditions
Penicillin Allergy
Interventions
Penicillin Allergic Risk Stratification Best Practice Alert
Other
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
18 Years to 99 Years
Enrollment
240 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2021
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated May 12, 2022 · Synced Jul 22, 2026, 3:10 AM EDT
Completed No phase listed Observational Results available

Perioperative Antibiotic Choices for Surgical Prophylaxis in Penicillin-allergic Pediatric Patients

NCT02036840
View directory record Official record
Conditions
Penicillin Allergy
Interventions
Antibiotic
Drug
Lead sponsor
Joseph D. Tobias
Other
Eligibility
Not listed
Enrollment
513 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2014
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Apr 21, 2015 · Synced Jul 22, 2026, 3:10 AM EDT
Completed Not applicable Interventional

Negative Predictive Value and NIC of Beta-Lactam Antibiotics.

NCT04126096
View directory record Official record
Conditions
Allergy
Interventions
Skin Testing beta-lactams
Diagnostic Test
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
747 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2023
U.S. locations
2
States / cities
Jacksonville, Florida
Source: ClinicalTrials.gov public record
Updated Jun 21, 2023 · Synced Jul 22, 2026, 3:10 AM EDT
Enrolling by invitation No phase listed Observational

Allergy Delabeling in Antibiotic Stewardship - Evaluations

NCT06967467
View directory record Official record
Conditions
Beta Lactam Allergy in Patients With a Hematologic Malignancy
Interventions
Semi-structured interview, Survey, Ethnographic observation
Behavioral
Lead sponsor
Abramson Cancer Center at Penn Medicine
Other
Eligibility
18 Years and older
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2029
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jun 4, 2026 · Synced Jul 22, 2026, 3:10 AM EDT
Not listed Phase 4 Interventional

Inpatient Penicillin Delabeling for Low-Risk Patients

NCT06414694
View directory record Official record
Conditions
Penicillin, Drug Allergy
Interventions
Direct Oral Challenge
Procedure
Lead sponsor
University of Tennessee
Other
Eligibility
2 Years to 30 Years
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Memphis, Tennessee
Source: ClinicalTrials.gov public record
Updated May 15, 2024 · Synced Jul 22, 2026, 3:10 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Penicillin Allergy Testing in STD Clinics

NCT04620746
View directory record Official record
Conditions
Penicillin Allergy
Interventions
Penicillin Major Determinant (PrePen) Skin Testing, Direct Oral challenge
Drug
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years and older
Enrollment
284 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
2
States / cities
New Orleans, Louisiana • Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Sep 20, 2023 · Synced Jul 22, 2026, 3:10 AM EDT
Terminated Phase 4 Interventional

Oral Penicillin Challenge and Allergy De-labeling in Children

NCT05563610
View directory record Official record
Conditions
Penicillin Allergy
Interventions
Amoxicillin 500mg
Drug
Lead sponsor
Phoenix Children's Hospital
Other
Eligibility
2 Years to 17 Years
Enrollment
31 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
1
States / cities
Phoenix, Arizona
Source: ClinicalTrials.gov public record
Updated Jun 13, 2024 · Synced Jul 22, 2026, 3:10 AM EDT
Recruiting Phase 2 Interventional

Optimizing the Diagnostic Approach to Cephalosporin Allergy Testing

NCT06406114
View directory record Official record
Conditions
Drug Allergy, Cephalosporin Allergy, Drug Hypersensitivity, Antibiotic Allergy, Beta Lactam Adverse Reaction, Drug-Induced Anaphylaxis, Cephalosporin Reaction
Interventions
Beta-lactam antibiotic (cefazolin, cefuroxime, cefotaxime, ceftazidime, ceftriaxone, cefepime, pre-pen, penicillin G, ampicillin, and histamine) double-blind skin testing, Culprit cephalosporin (cefazolin, ceftazidime, ceftriaxone, cefepime, cephalexin, cefaclor, cefadroxil, cefuroxime, cefpodoxime, cefdinir, or cefixime) double-blind placebo-controlled drug challenge, Similar cephalosporin (cefepime, ceftriaxone, cefaclor, cephalexin, cefixime, or cefdinir) antibiotic double-blind placebo-controlled drug challenge, Dissimilar cephalosporin (ceftriaxone or cefazolin) antibiotic double-blind placebo-controlled drug challenge, Amoxicillin double-blind placebo-controlled drug challenge
Drug
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 70 Years
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
6
States / cities
Scottsdale, Arizona • San Francisco, California • Boston, Massachusetts + 3 more
Source: ClinicalTrials.gov public record
Updated May 25, 2026 · Synced Jul 22, 2026, 3:10 AM EDT
Withdrawn Not applicable Interventional

Penicillin Allergy Risk-Stratification and Delabeling of Low-Risk Patients

NCT05561777
View directory record Official record
Conditions
Antibiotic Allergy
Interventions
Physician-targeted CDS tool for PCN allergy delabeling
Other
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
1 Year and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Mar 7, 2024 · Synced Jul 22, 2026, 3:10 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Feasibility Assessment of Risk Stratification and Oral Challenge in Hospitalized Children at Low Risk for Antibiotic Allergy

NCT04441021
View directory record Official record
Conditions
Penicillin Allergy
Interventions
Penicillin Allergy Risk Stratification and Evaluation
Other
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
0 Years and older
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2021
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Jun 29, 2021 · Synced Jul 22, 2026, 3:10 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Allergy Testing of Patients Labeled as Penicillin Allergic

NCT02983630
View directory record Official record
Conditions
Drug Hypersensitivity
Interventions
Penicillin allergy testing
Other
Lead sponsor
Albany Medical College
Other
Eligibility
18 Years and older
Enrollment
37 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2017
U.S. locations
1
States / cities
Albany, New York
Source: ClinicalTrials.gov public record
Updated Jan 8, 2018 · Synced Jul 22, 2026, 3:10 AM EDT
Completed Not applicable Interventional

The Use of Penicillin Allergy Clinical Decision Rule to Enable Direct Oral Penicillin Challenge

NCT04454229
View directory record Official record
Conditions
Hypersensitivity, Immediate, Hypersensitivity, Delayed, Hypersensitivity Response
Interventions
Direct oral penicillin challenge, Standard of care
Other
Lead sponsor
Austin Health
Government
Eligibility
18 Years and older
Enrollment
382 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
2
States / cities
Durham, North Carolina • Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Mar 5, 2023 · Synced Jul 22, 2026, 3:10 AM EDT
Recruiting Phase 3 Interventional

Penicillin Allergy Delabeling After a One-Dose Versus Two-Dose Graded Direct Oral Challenge

NCT06303128
View directory record Official record
Conditions
Penicillin Allergy
Interventions
Amoxicillin 250 MG, Placebo, Amoxicillin 62.5mg, Amoxicillin 187.5mg
Drug
Lead sponsor
James Tarbox, MD
Other
Eligibility
18 Years to 89 Years
Enrollment
380 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Lubbock, Texas
Source: ClinicalTrials.gov public record
Updated Apr 30, 2025 · Synced Jul 22, 2026, 3:10 AM EDT
Terminated Early Phase 1 Interventional

Geisinger Antibiotic Allergy Pilot Program: Assess and Address

NCT05464615
View directory record Official record
Conditions
Penicillin Allergy
Interventions
Amoxicillin
Drug
Lead sponsor
Geisinger Clinic
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
4
States / cities
Danville, Pennsylvania • Lewiston, Pennsylvania • Scranton, Pennsylvania + 1 more
Source: ClinicalTrials.gov public record
Updated Jul 19, 2026 · Synced Jul 22, 2026, 3:10 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Desensitization of Human Mast Cells: Mechanisms and Potential Utility for Preventing Anaphylaxis

NCT00868842
View directory record Official record
Conditions
Anaphylaxis
Interventions
Not listed
Lead sponsor
Virginia Commonwealth University
Other
Eligibility
18 Years to 45 Years
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2012
U.S. locations
1
States / cities
Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Apr 13, 2014 · Synced Jul 22, 2026, 3:10 AM EDT
Completed Phase 4 Interventional Results available

Oral Challenge in the Pediatric ED

NCT03404804
View directory record Official record
Conditions
Penicillin Allergy, Pediatric Emergency Medicine
Interventions
Amoxicillin
Drug
Lead sponsor
Medical College of Wisconsin
Other
Eligibility
2 Years to 16 Years
Enrollment
116 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2022
U.S. locations
1
States / cities
Milwaukee, Wisconsin
Source: ClinicalTrials.gov public record
Updated May 15, 2024 · Synced Jul 22, 2026, 3:10 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Drug Challenges Without Prior Skin Testing

NCT03158831
View directory record Official record
Conditions
Drug Hypersensitivity, Penicillin Allergy, Antibiotic Allergy
Interventions
Placebo-Controlled Graded Drug Challenge
Drug
Lead sponsor
Montefiore Medical Center
Other
Eligibility
7 Years and older
Enrollment
166 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2021
U.S. locations
1
States / cities
The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Nov 15, 2021 · Synced Jul 22, 2026, 3:10 AM EDT