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ClinicalTrials.gov public records Last synced Oct 23, 2026, 10:06 AM EDT

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Showing 1–24 of 106 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Perinatal Depression Clear all
Recruiting Not applicable Interventional Accepts healthy volunteers

Fathers and Babies (FAB) Research Study

NCT07893210
View directory record Official record
Conditions
Perinatal Mental Health, Fathers, Stress Management
Interventions
Fathers and Babies Program, Mothers and Babies Program
Behavioral
Lead sponsor
Northwestern University
Other
Eligibility
18 Years and older
Enrollment
624 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2027
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Oct 23, 2026 · Synced Oct 23, 2026, 10:06 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Reducing Stress-Sensitive Problems Among Pregnant Black Women With Childhood Adversity

NCT05718479
View directory record Official record
Conditions
Maternal Psychological Distress, Perinatal Depression, Self-Regulation, Emotion
Interventions
Trauma Informed Prenatal Intervention (TPI), Prenatal Education Topics
Behavioral · Other
Lead sponsor
University of Illinois at Chicago
Other
Eligibility
18 Years and older · Female only
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Mar 20, 2025 · Synced Oct 23, 2026, 10:06 AM EDT
Completed Not applicable Interventional Results available

"Mamma Mia" for Perinatal Health and Wellness

NCT04300894
View directory record Official record
Conditions
Perinatal Depression
Interventions
Mamma Mia, Mamma Mia Plus
Device · Other
Lead sponsor
Virginia Commonwealth University
Other
Eligibility
18 Years and older · Female only
Enrollment
1,757 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2025
U.S. locations
1
States / cities
Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Jul 2, 2026 · Synced Oct 23, 2026, 10:06 AM EDT
Completed Phase 1 Interventional

Sober Network IPT for Perinatal Women With Comorbid Substance Use and Depression

NCT01550913
View directory record Official record
Conditions
Perinatal Depression, Substance Use
Interventions
Sober Network Interpersonal Psychotherapy (IPT), Treatment as Usual
Behavioral · Other
Lead sponsor
Women and Infants Hospital of Rhode Island
Other
Eligibility
18 Years to 50 Years · Female only
Enrollment
59 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2015
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Mar 30, 2016 · Synced Oct 23, 2026, 10:06 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Telehealth Group Intervention for Perinatal Depressive Symptoms

NCT03932760
View directory record Official record
Conditions
Perinatal Depression
Interventions
UPLIFT Program, Attention Control Group
Behavioral
Lead sponsor
University of Utah
Other
Eligibility
18 Years and older · Female only
Enrollment
99 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2023
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Jun 4, 2024 · Synced Oct 23, 2026, 10:06 AM EDT
Completed Not applicable Interventional

African-American Social Support Effectiveness Treatment

NCT05762133
View directory record Official record
Conditions
Maternal Perinatal Depression
Interventions
African-American Social Support Effectiveness Treatment-Partners alleviating Perinatal Depression (ASSET-PPD)
Behavioral
Lead sponsor
Northwestern University
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2024
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Mar 3, 2025 · Synced Oct 23, 2026, 10:06 AM EDT
Recruiting Not applicable Interventional

Pathways to Perinatal Mental Health Equity

NCT06790641
View directory record Official record
Conditions
Perinatal Anxiety, Perinatal Depression, Social Determinants of Health (SDOH), Peer Support, Obstetric Care, Substance Use Disorder (SUD), Perinatal Depression, Substance Use
Interventions
Program in Support of Moms (PRISM), PSI Peer Support
Behavioral
Lead sponsor
University of Massachusetts, Worcester
Other
Eligibility
18 Years to 70 Years
Enrollment
1,270 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2030
U.S. locations
1
States / cities
Shrewsbury, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 20, 2026 · Synced Oct 23, 2026, 10:06 AM EDT
Completed Not applicable Interventional

A Postpartum Adaptation Study of the Connecting and Reflecting Experience Parenting Program

NCT06042166
View directory record Official record
Conditions
Postpartum Depression, Postpartum Anxiety, Parenting Stress, Parent Child Relationships
Interventions
Connecting and Reflecting Experience (CARE) Program
Behavioral
Lead sponsor
Montefiore Medical Center
Other
Eligibility
18 Years to 70 Years · Female only
Enrollment
17 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Jul 22, 2026 · Synced Oct 23, 2026, 10:06 AM EDT
Not yet recruiting Not applicable Interventional

Inflammatory Pathways Modulated by Prenatal Mindfulness: A Route to Improve Maternal Child Emotional Well Being and Whole Person Health

NCT07892326
View directory record Official record
Conditions
Inflammation, Depression Disorder, Mindfulness, Emotional Well-being, Physical Health, Mental Health
Interventions
Mindfulness-based cognitive therapy for perinatal depression, Pregnancy Health Group
Behavioral
Lead sponsor
Oregon Health and Science University
Other
Eligibility
18 Years to 50 Years · Female only
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2030
U.S. locations
1
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Oct 23, 2026 · Synced Oct 23, 2026, 10:06 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

The Dream Team: Testing Implementation of a Sleep Intervention for Perinatal Women Delivered by Direct Care Workers

NCT06737055
View directory record Official record
Conditions
Sleep, Postpartum Depression, Pregnancy Related, Insomnia, Sleep Deprivation, Sleep Hygiene, Sleep Disturbance
Interventions
Education about behavioral strategies to improve sleep
Behavioral
Lead sponsor
Rhode Island Hospital
Other
Eligibility
18 Years to 99 Years
Enrollment
55 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2025
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Dec 27, 2024 · Synced Oct 23, 2026, 10:06 AM EDT
Completed Not applicable Interventional Results available

The Stony Brook University Calm-Mom Study

NCT04018625
View directory record Official record
Conditions
Pregnancy Related, Stress, Psychological, Anxiety, Perinatal Depression
Interventions
SMART Mom, Mama Support
Behavioral
Lead sponsor
Stony Brook University
Other
Eligibility
18 Years and older · Female only
Enrollment
63 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Stony Brook, New York
Source: ClinicalTrials.gov public record
Updated Aug 20, 2026 · Synced Oct 23, 2026, 10:06 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Development, Feasibility and Acceptability of Fathers and Babies (FAB): A Pilot Study

NCT03427528
View directory record Official record
Conditions
Perinatal Depression, Postpartum Depression, Depression
Interventions
Fathers and Babies (FAB), MB 1-on-1 plus TXT
Behavioral
Lead sponsor
Northwestern University
Other
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2020
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Jul 18, 2022 · Synced Oct 23, 2026, 10:06 AM EDT
Active, not recruiting Not applicable Interventional

Perinatal Research on Improving Sleep and Mental Health

NCT05596318
View directory record Official record
Conditions
Insomnia, Depression
Interventions
Digital CBT-I, Digital SHE
Device
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years and older · Female only
Enrollment
456 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2027
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Mar 11, 2026 · Synced Oct 23, 2026, 10:06 AM EDT
Completed Not applicable Interventional Results available

Minimum Intervention to Maintain a Postpartum Depression Prevention Program in Clinics Serving Low-income Women

NCT03267563
View directory record Official record
Conditions
Depression, Postpartum
Interventions
EIAU, LICF, HICF
Behavioral
Lead sponsor
Michigan State University
Other
Eligibility
18 Years and older
Enrollment
160 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2023
U.S. locations
1
States / cities
Flint, Michigan
Source: ClinicalTrials.gov public record
Updated Apr 15, 2026 · Synced Oct 23, 2026, 10:06 AM EDT
Terminated Not applicable Interventional Results available

Optimizing (Longer, Deeper) Cooling for Neonatal Hypoxic-Ischemic Encephalopathy(HIE)

NCT01192776
View directory record Official record
Conditions
Infant, Newborn, Hypoxia, Brain, Hypoxia-Ischemia, Brain, Encephalopathy, Hypoxic-Ischemic, Hypoxic-Ischemic Encephalopathy, Ischemic-Hypoxic Encephalopathy
Interventions
Whole-body Cooling
Procedure
Lead sponsor
NICHD Neonatal Research Network
Network
Eligibility
Up to 6 Hours
Enrollment
364 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2016
U.S. locations
19
States / cities
Birmingham, Alabama • Los Angeles, California • Palo Alto, California + 15 more
Source: ClinicalTrials.gov public record
Updated Jun 24, 2026 · Synced Oct 23, 2026, 10:06 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Testing "Doula Link", a Multi-Component Intervention to Improve Perinatal Mental Health

NCT07217561
View directory record Official record
Conditions
Perinatal Depression, Perinatal Anxiety
Interventions
Doula Link
Behavioral
Lead sponsor
Beth Israel Deaconess Medical Center
Other
Eligibility
Not listed
Enrollment
90 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2027
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Oct 22, 2025 · Synced Oct 23, 2026, 10:06 AM EDT
Recruiting Not applicable Interventional

Deconstructing Maternal Burdens: Doulas and the Community Unite for Health

NCT07799805
View directory record Official record
Conditions
Pregnancy, Post Partum, Doula Care, Postpartum Depression (PPD), Perinatal Depression, Perinatal Anxiety, Health Disparities, Pregnancy Complications, Maternal Adverse Outcomes
Interventions
Doula, Standard (non-enhanced) Medicaid doula support
Other
Lead sponsor
University of Florida
Other
Eligibility
15 Years to 49 Years · Female only
Enrollment
516 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Sep 28, 2026 · Synced Oct 23, 2026, 10:06 AM EDT
Completed Not applicable Interventional

Improving Negative Stressful Perseverations in Insomnia to Revitalize Expectant Moms

NCT04445805
View directory record Official record
Conditions
Insomnia
Interventions
Cognitive Behavioral Therapy for Insomnia (CBTI), Perinatal-enhanced Behavioral Therapy for Insomnia, Attention Control
Behavioral
Lead sponsor
Henry Ford Health System
Other
Eligibility
18 Years to 40 Years · Female only
Enrollment
64 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Novi, Michigan
Source: ClinicalTrials.gov public record
Updated Jan 19, 2024 · Synced Oct 23, 2026, 10:06 AM EDT
Recruiting Not applicable Interventional

The Development of PATH, a Program to Support NICU Parent Mental Health Through the Transition From Hospital to Home

NCT06467916
View directory record Official record
Conditions
Perinatal Mental Health
Interventions
Behavioral Treatment
Behavioral
Lead sponsor
University of Colorado, Denver
Other
Eligibility
Not listed
Enrollment
72 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
2
States / cities
Aurora, Colorado • Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Apr 24, 2025 · Synced Oct 23, 2026, 10:06 AM EDT
Completed Not applicable Interventional

Group Interpersonal Psychotherapy for Treatment of Major Depressive Disorder Following Perinatal Loss

NCT01867749
View directory record Official record
Conditions
Major Depressive Disorder, Miscarriage, Stillbirth, Neonatal Death
Interventions
Group Interpersonal Psychotherapy (IPT-G), Coping with Depression (CWD)
Behavioral
Lead sponsor
Brown University
Other
Eligibility
18 Years to 50 Years · Female only
Enrollment
62 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2014
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Jan 13, 2016 · Synced Oct 23, 2026, 10:06 AM EDT
Completed Not applicable Interventional

A Text Messaging Intervention to Reduce Perinatal Depression Risk

NCT06117397
View directory record Official record
Conditions
Major Depressive Episode
Interventions
Text Messaging Intervention
Other
Lead sponsor
University of Massachusetts, Worcester
Other
Eligibility
16 Years to 45 Years · Female only
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
Worcester, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jan 27, 2026 · Synced Oct 23, 2026, 10:06 AM EDT
Completed Not applicable Interventional Results available

Evaluating Technology Enabled Services in Perinatal Depression

NCT05525689
View directory record Official record
Conditions
Depression
Interventions
IntelliCare, COMPASS-Care
Behavioral · Other
Lead sponsor
Northwestern University
Other
Eligibility
18 Years and older · Female only
Enrollment
75 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Sep 12, 2025 · Synced Oct 23, 2026, 10:06 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Labor Pain and Postpartum Behavioral Health Outcomes Study

NCT02692404
View directory record Official record
Conditions
Depression, Postpartum, Pregnancy, Child Development, Pain, Labor Pain
Interventions
Not listed
Lead sponsor
University of Pittsburgh
Other
Eligibility
18 Years and older · Female only
Enrollment
199 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2017
U.S. locations
2
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jan 18, 2020 · Synced Oct 23, 2026, 10:06 AM EDT
Completed Not applicable Interventional

Perinatal Depression Treatment in a Pediatric Setting- Pilot Phase

NCT00804739
View directory record Official record
Conditions
Postpartum Depression
Interventions
Mother-Infant Treatment Team
Other
Lead sponsor
University of Rochester
Other
Eligibility
18 Years and older · Female only
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2012
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Feb 27, 2012 · Synced Oct 23, 2026, 10:06 AM EDT