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ClinicalTrials.gov public records Last synced Oct 20, 2026, 8:51 AM EDT

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Showing 1–24 of 95 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Periodontal Therapy Clear all
Completed Not applicable Interventional Results available

Study to Compare Laser Assisted New Attachment Procedure (LANAP) to Traditional Treatments of Chronic Periodontitis

NCT01282229
View directory record Official record
Conditions
Chronic Periodontitis
Interventions
LANAP
Device
Lead sponsor
Institute for Advanced Laser Dentistry
Other
Eligibility
25 Years to 75 Years
Enrollment
59 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2014
U.S. locations
1
States / cities
Denver, Colorado
Source: ClinicalTrials.gov public record
Updated Oct 14, 2015 · Synced Oct 20, 2026, 8:51 AM EDT
Completed Phase 2 Interventional Accepts healthy volunteers

Study Comparing Two Different Methods of Treating Periodontal Disease

NCT00127244
View directory record Official record
Conditions
Periodontal Diseases
Interventions
Periodontal Treatment
Procedure
Lead sponsor
The Forsyth Institute
Other
Eligibility
18 Years and older
Enrollment
400 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2000 – 2004
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Dec 2, 2010 · Synced Oct 20, 2026, 8:51 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Mechanisms and Treatment Response of Aggressive Periodontitis in Children

NCT01330719
View directory record Official record
Conditions
Aggressive Periodontitis
Interventions
Diseased periodontal treatment, Conventional periodontal treatment
Procedure
Lead sponsor
University of Florida
Other
Eligibility
5 Years to 90 Years
Enrollment
514 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2022
U.S. locations
10
States / cities
Brooker, Florida • Fort Lauderdale, Florida • Gainesville, Florida + 6 more
Source: ClinicalTrials.gov public record
Updated Mar 12, 2024 · Synced Oct 20, 2026, 8:51 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Perio. Maint. With Diode LBR

NCT05276817
View directory record Official record
Conditions
Chronic Periodontitis
Interventions
Epic Diode, HP, Sham
Device · Drug
Lead sponsor
Biolase Inc
Industry
Eligibility
30 Years and older
Enrollment
14 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022
U.S. locations
1
States / cities
San Mateo, California
Source: ClinicalTrials.gov public record
Updated May 3, 2023 · Synced Oct 20, 2026, 8:51 AM EDT
Completed Phase 2 Interventional

Treating Periodontal Infection: Effects on Glycemic

NCT00016835
View directory record Official record
Conditions
Periodontal Disease, Diabetes Mellitus, Type 2
Interventions
Supra-gingival scaling and placebo, Subgingival scaling and metronidazole, Subgingival scaling and doxycycline
Procedure
Lead sponsor
University of Michigan
Other
Eligibility
18 Years and older
Enrollment
46 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2001 – 2004
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Jul 19, 2017 · Synced Oct 20, 2026, 8:51 AM EDT
Completed No phase listed Observational

Systemic Markers of Inflammation: 9- and 12-Month Follow-Up Post Non-Surgical Periodontal Therapy

NCT04312542
View directory record Official record
Conditions
SRP, Minocycline HCl Microspheres, Biomarkers
Interventions
Measurement of Biomarkers
Procedure
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Sep 23, 2022 · Synced Oct 20, 2026, 8:51 AM EDT
Completed Phase 4 Interventional Results available

Clinical and Microbiologic Outcomes of aPDT in the Non-surgical Treatment of Implant Inflammation

NCT04187053
View directory record Official record
Conditions
DENT IMPLANTS, LASER
Interventions
Conventional mechanical therapy, Saline, Methylene Blue, Light emitting laser, Non-light emitting laser
Procedure · Drug · Device
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
18 Years and older
Enrollment
56 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Feb 21, 2024 · Synced Oct 20, 2026, 8:51 AM EDT
Completed No phase listed Observational

The Impact of Oral Health in HIV Patients on Antiretroviral Therapy

NCT04645693
View directory record Official record
Conditions
HIV, Periodontal Diseases, Caries, Non-communicable Disease, Xerostomia
Interventions
Not listed
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years and older
Enrollment
227 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2026
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 5, 2026 · Synced Oct 20, 2026, 8:51 AM EDT
Active, not recruiting Phase 4 Interventional Accepts healthy volunteers

Microderm for Root Coverage Procedures

NCT07203326
View directory record Official record
Conditions
Connective Tissue Graft, Gum Recession
Interventions
Alloderm, MicroDerm
Biological
Lead sponsor
Ohio State University
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Nov 26, 2025 · Synced Oct 20, 2026, 8:51 AM EDT
Terminated Not applicable Interventional

Dental Carotid Cognitive Study

NCT03755362
View directory record Official record
Conditions
Carotid Stenosis, Mild Cognitive Impairment, Periodontitis
Interventions
Standard Treatment, Intensive Treatment
Procedure
Lead sponsor
University of Maryland, Baltimore
Other
Eligibility
60 Years to 100 Years
Enrollment
26 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Feb 18, 2026 · Synced Oct 20, 2026, 8:51 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Laser-Assisted Regenerative Surgical Therapy for Peri-implantitis

NCT03127228
View directory record Official record
Conditions
Peri-Implantitis
Interventions
Standard mechanical debridement, Er:YAG laser-assisted debridement
Other · Device
Lead sponsor
University of Michigan
Other
Eligibility
18 Years to 85 Years
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Nov 15, 2019 · Synced Oct 20, 2026, 8:51 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Microsurgery and Periodontal Healing

NCT07054008
View directory record Official record
Conditions
Periodontal Diseases
Interventions
Microsurgical approach with Digital Microscope
Procedure
Lead sponsor
The University of Texas Health Science Center at San Antonio
Other
Eligibility
18 Years to 18 Years
Enrollment
25 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2027
U.S. locations
1
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Nov 12, 2025 · Synced Oct 20, 2026, 8:51 AM EDT
Recruiting Not applicable Interventional

MODERN-Dental: Pediatric Obesity, Cardiometabolic Risks, And Periodontal Disease

NCT07478653
View directory record Official record
Conditions
Obesity, Dental Care for Children
Interventions
Dental Cleaning and Oral Hygiene Instruction (OHI), Oral Hygiene Instruction (OHI)
Procedure · Behavioral
Lead sponsor
Oelisoa Andriankaja
Other
Eligibility
12 Years to 17 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Lexington, Kentucky
Source: ClinicalTrials.gov public record
Updated Oct 8, 2026 · Synced Oct 20, 2026, 8:51 AM EDT
Active, not recruiting No phase listed Observational Accepts healthy volunteers

Ultrasound for Socket Healing Evaluation

NCT06017193
View directory record Official record
Conditions
Healing Wound, Alveolar; Wound, Alveolar Bone Loss, Image, Dent Disease
Interventions
Not listed
Lead sponsor
University of Michigan
Other
Eligibility
18 Years and older
Enrollment
140 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2027
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Sep 14, 2026 · Synced Oct 20, 2026, 8:51 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Controlled Study Comparing REPaiR® and MIST Therapies for Treatment of Periodontitis

NCT04169139
View directory record Official record
Conditions
Periodontal Diseases
Interventions
MIST (minimally invasive surgical therapy)
Device
Lead sponsor
McGuire Institute
Industry
Eligibility
18 Years to 75 Years
Enrollment
54 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2020
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Mar 30, 2023 · Synced Oct 20, 2026, 8:51 AM EDT
Completed Not applicable Interventional Results available

Clinical and Microbiologic Outcomes of Adjunctive Antimicrobial Photodynamic Therapy in the Non-surgical and Surgical Treatment of Teeth With Periodontal Disease

NCT05252000
View directory record Official record
Conditions
Periodontal Diseases
Interventions
mechanical debridement, adjunctive aPDT, sham aPDT
Device
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Mar 12, 2026 · Synced Oct 20, 2026, 8:51 AM EDT
Completed No phase listed Observational

Therapeutic Peri-implant Maintenance with Laser Therapy

NCT04251793
View directory record Official record
Conditions
Peri-Implantitis
Interventions
Observation
Other
Lead sponsor
University of Michigan
Other
Eligibility
Not listed
Enrollment
16 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Nov 12, 2024 · Synced Oct 20, 2026, 8:51 AM EDT
Completed Phase 3 Interventional

Diabetes and Periodontal Therapy Trial

NCT00997178
View directory record Official record
Conditions
Chronic Periodontitis, Type 2 Diabetes
Interventions
Non-surgical periodontal therapy, Delayed non-surgical periodontal therapy
Procedure · Other
Lead sponsor
Stony Brook University
Other
Eligibility
35 Years and older
Enrollment
514 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2012
U.S. locations
8
States / cities
Birmingham, Alabama • Minneapolis, Minnesota • Stony Brook, New York + 2 more
Source: ClinicalTrials.gov public record
Updated Jan 20, 2014 · Synced Oct 20, 2026, 8:51 AM EDT
Completed Phase 2 Interventional Results available

Safety, Efficacy and Treatment Regimen Study of ST266 in Subjects With Moderate to Severe Periodontitis

NCT02761993
View directory record Official record
Conditions
Periodontal Disease
Interventions
ST266, Saline (0.9% NaCl)
Biological · Drug
Lead sponsor
Noveome Biotherapeutics, formerly Stemnion
Industry
Eligibility
18 Years to 85 Years
Enrollment
151 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2017
U.S. locations
6
States / cities
Birmingham, Alabama • Indianapolis, Indiana • Cambridge, Massachusetts + 3 more
Source: ClinicalTrials.gov public record
Updated Jul 22, 2021 · Synced Oct 20, 2026, 8:51 AM EDT
Not yet recruiting Not applicable Interventional

Efficacy of Different Disinfection Technologies in Molar Non-Surgical Retreatment

NCT07469150
View directory record Official record
Conditions
Apical Periodontitis
Interventions
GentleWave System, Conventional rotary instrumentation with passive ultrasonic irrigation
Procedure
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
16 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2027 – 2030
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Apr 8, 2026 · Synced Oct 20, 2026, 8:51 AM EDT
Completed Phase 4 Interventional Results available

Long-term Safety of Minocycline in Patients With Gum Disease

NCT00668746
View directory record Official record
Conditions
Periodontitis
Interventions
Minocycline HCl microspheres
Drug
Lead sponsor
OraPharma
Industry
Eligibility
25 Years and older
Enrollment
35 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2009
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Dec 12, 2011 · Synced Oct 20, 2026, 8:51 AM EDT
Completed No phase listed Observational

Periodontal Treatment Response in Type II Diabetic Patients

NCT01881074
View directory record Official record
Conditions
Type II Diabetes, Periodontal Disease
Interventions
Triclosan containing toothpaste, Non-triclosan containing toothpaste
Drug
Lead sponsor
University of Florida
Other
Eligibility
18 Years to 70 Years
Enrollment
74 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2015
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Sep 17, 2018 · Synced Oct 20, 2026, 8:51 AM EDT
Recruiting Not applicable Interventional

An Evaluation of the Effect of the Erchonia FX-405 Laser as an Adjunctive Treatment of Periodontitis

NCT06656325
View directory record Official record
Conditions
Periodontal Diseases, Periodontitis, Gum Disease
Interventions
Erchonia® FX405, Placebo Laser
Device
Lead sponsor
Erchonia Corporation
Industry
Eligibility
22 Years to 75 Years
Enrollment
70 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
2
States / cities
Thousand Oaks, California • Acton, Massachusetts
Source: ClinicalTrials.gov public record
Updated May 18, 2026 · Synced Oct 20, 2026, 8:51 AM EDT
Completed Not applicable Interventional

Evaluation of Geistlich Fibro-Gide® + CAF in Comparison to CTG + CAF for the Treatment of Recession Defects at 6 Months

NCT04260152
View directory record Official record
Conditions
Gingival Recession
Interventions
Geistlich Fibro-Gide, Connective Tissue Graft (CTG
Device · Procedure
Lead sponsor
Geistlich Pharma AG
Industry
Eligibility
18 Years to 75 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
3
States / cities
Fenton, Michigan • Houston, Texas • Tacoma, Washington
Source: ClinicalTrials.gov public record
Updated Aug 10, 2021 · Synced Oct 20, 2026, 8:51 AM EDT