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ClinicalTrials.gov public records Last synced Nov 14, 2026, 12:28 PM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 1–23 of 23 matching trials from the live ClinicalTrials.gov search.

Filters: Condition: Periorbital Clear all

Conditions: Wrinkles
Interventions: Laser treatment, High-intensity focused ultrasound; Procedure · Device
Lead sponsor: Northwestern University; Other
Eligibility: 35 Years to 60 Years
Enrollment: 20 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2012 – 2024
U.S. locations: 1
States / cities: Chicago, Illinois

Conditions: Peri-orbital Wrinkles, Peri-oral Wrinkles
Interventions: Illuiminage ® Diode Laser; Device
Lead sponsor: Cynosure, Inc.; Industry
Eligibility: 35 Years to 60 Years · Female only
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2013
U.S. locations: 1
States / cities: Westford, Massachusetts

Conditions: Lower Eyelid Steatoblepharon (Excess Eyelid Fat)
Interventions: XOPH5 Ointment, Placebo; Drug
Lead sponsor: Topokine Therapeutics, Inc.; Industry
Eligibility: 40 Years to 70 Years
Enrollment: 90 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Wrinkle
Interventions: Tixel, Laser; Device
Lead sponsor: Novoxel Ltd.; Industry
Eligibility: 40 Years to 70 Years
Enrollment: 68 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018 – 2020
U.S. locations: 1
States / cities: New York, New York

Conditions: Wrinkle, Periorbital, Tixel 2, Fractional, Resurfacing
Interventions: Tixel 2; Device
Lead sponsor: Novoxel Ltd.; Industry
Eligibility: 35 Years to 70 Years
Enrollment: 51 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2022
U.S. locations: 2
States / cities: Chicago, Illinois • New York, New York

Conditions: Periorbital Hyperpigmentation, Periorbital Edema, Fine Lines, Wrinkle
Interventions: Gentle Cleansing Lotion, Facial Moisturizer, Sunscreen SPF 30; Other
Lead sponsor: Revision Skincare; Industry
Eligibility: 35 Years to 60 Years · Female only
Enrollment: 40 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022
U.S. locations: 1
States / cities: Teaneck, New Jersey

Conditions: Periorbital Edema
Interventions: AccuTite, AccuTite + Morpheus 8; Device
Lead sponsor: InMode MD Ltd.; Industry
Eligibility: 29 Years to 75 Years
Enrollment: 12 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2021
U.S. locations: 2
States / cities: Sarasota, Florida • Youngstown, Ohio

Conditions: Periorbital Hyperpigmentation
Interventions: Skin imaging, Facial cleanser; Device · Other
Lead sponsor: Allergan; Industry
Eligibility: 25 Years to 50 Years
Enrollment: 44 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018
U.S. locations: 1
States / cities: Irvine, California

Conditions: Mild to Moderate Temporal Atrophy, Moderate to Severe Glabellar Rhytids, Moderate to Severe Periorbital Rhytids
Interventions: Dysport, Perlane L; Drug · Device
Lead sponsor: Beer, Kenneth R., M.D., PA; Individual
Eligibility: 40 Years to 75 Years
Enrollment: 20 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2010 – 2012
U.S. locations: 1
States / cities: West Palm Beach, Florida

Conditions: Ocular Hypertension, Open Angle Glaucoma
Interventions: JV-GL1, Latanoprost 0.005% Ophthalmic Solution; Drug
Lead sponsor: JeniVision, Inc.; Industry
Eligibility: 18 Years and older
Enrollment: 70 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2025
U.S. locations: 1
States / cities: Newport Beach, California

Conditions: Intracranial Pressure, Intracranial Pressure Changes
Interventions: CPMX3; Device
Lead sponsor: Compremium AG; Industry
Eligibility: 18 Years and older
Enrollment: 15 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2026
U.S. locations: 1
States / cities: Houston, Texas

Conditions: Intracranial Pressure
Interventions: CPMX3 measurement; Device
Lead sponsor: Compremium AG; Industry
Eligibility: 8 Years to 21 Years
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2026
U.S. locations: 1
States / cities: Washington D.C., District of Columbia

Conditions: Skin Health
Interventions: Experimental: Sahajan Golden Glow Balm; Dietary Supplement
Lead sponsor: Sahajan; Industry
Eligibility: 35 Years and older · Female only
Enrollment: 35 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024
U.S. locations: 1
States / cities: Santa Monica, California

Conditions: Periorbital Wrinkles, Periorbital Area, Under-eyes Dark Circles, Crows Feet
Interventions: Treatment with BTL-785 with the applicator BTL-785-7-11; Device
Lead sponsor: BTL Industries Ltd.; Industry
Eligibility: 21 Years and older
Enrollment: 30 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024 – 2025
U.S. locations: 3
States / cities: Sacramento, California • Solana Beach, California • Youngstown, Ohio

Conditions: Brow Ptosis, Lid Ptosis
Interventions: Dysport; Drug
Lead sponsor: Kenneth Beer; Individual
Eligibility: 25 Years to 75 Years
Enrollment: 24 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2011 – 2012
U.S. locations: 1
States / cities: West Palm Beach, Florida

Conditions: Periorbital Wrinkles
Interventions: Ulthera® System treatment; Device
Lead sponsor: Ulthera, Inc; Industry
Eligibility: 30 Years to 65 Years
Enrollment: 68 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2011 – 2012
U.S. locations: 2
States / cities: Hunt Valley, Maryland • Nashville, Tennessee

Conditions: Wrinkle
Interventions: Tixel 2; Device
Lead sponsor: Physicians Laser and Dermatology Institute; Other
Eligibility: 35 Years to 75 Years
Enrollment: 20 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2022
U.S. locations: 1
States / cities: Chicago, Illinois

Conditions: Periorbital Wrinkles
Interventions: enhanced DefenAge 8-in-1 BioSerum; Drug
Lead sponsor: Goldman, Butterwick, Fitzpatrick and Groff; Other
Eligibility: 31 Years and older
Enrollment: 20 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2022
U.S. locations: 1
States / cities: San Diego, California

Conditions: Periorbital Wrinkles
Interventions: Ulthera™ System; Device
Lead sponsor: Ulthera, Inc; Industry
Eligibility: 40 Years to 70 Years
Enrollment: 100 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2008 – 2009
U.S. locations: 4
States / cities: San Diego, California • Chicago, Illinois • Chestnut Hill, Massachusetts + 1 more

Conditions: Skin Laxity, Meibomian Gland Dysfunction
Interventions: THERMIeyes® 20 RF System; Device
Lead sponsor: Ophthalmic Consultants of Long Island; Other
Eligibility: 40 Years to 70 Years
Enrollment: 30 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017 – 2019
U.S. locations: 1
States / cities: Lynbrook, New York

Conditions: Wrinkles, Photoaging, Fine Lines
Interventions: Onabotulinumtoxin A, Facial Cleanser, Facial Moisturizer, Sunscreen; Procedure · Combination Product
Lead sponsor: Revision Skincare; Industry
Eligibility: 35 Years to 60 Years · Female only
Enrollment: 29 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2020 – 2021
U.S. locations: 3
States / cities: Fort Lauderdale, Florida • Coralville, Iowa • Columbus, Ohio

Conditions: Skin Resurfacing
Interventions: Fraxel® FTX Laser System; Device
Lead sponsor: Bausch Health Americas, Inc.; Industry
Eligibility: 21 Years to 60 Years
Enrollment: 49 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025 – 2026
U.S. locations: 5
States / cities: La Jolla, California • Miami, Florida • Naperville, Illinois + 2 more

Conditions: Periorbital Area
Interventions: DIME Beauty Luminosity Eye Serum; Other
Lead sponsor: Dime Beauty Co.; Industry
Eligibility: 18 Years to 65 Years · Female only
Enrollment: 35 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023 – 2024
U.S. locations: 1
States / cities: Santa Monica, California

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Fractional Laser vs. Ultrasound for Periorbital Wrinkles

Treatment of Periorbital and Perioral Wrinkles With the Applications of the Iluminage Diode Laser

Phase 2 Study of XAF5 (XOPH5) Ointment for Reduction of Excess Eyelid Fat (Steatoblepharon)

A Safety and Effectiveness Study of the Tixel Device, (Fractional Peri-orbital Wrinkles Treatment ) Compared With Laser

Clinical Study Evaluating the Safety and Effectiveness of The Tixel Fractional System in The Treatment of Periorbital Wrinkles

A 12 Week Study to Evaluate the Efficacy of an Eye Cream

Energy-Based Lower Eyelid Rejuvenation - Proof of Concept for InMode AccuTite With or Without Morpheus8

Physiopathologic Aspects and Quality of Life in Participants With Eye Dark Circles

Upper Facial Remodeling With Perlane-L and Dysport

Safety and Efficacy Study of JV-GL1 in Patients With Open-Angle Glaucoma or Ocular Hypertension

Non-invasive Intracranial Pressure Estimation by Measurement of the Occlusion Pressure of the Isolated Periorbital Vein

Validation of Non-Invasive Intracranial Pressure Estimation Using CPMX3 in the Periorbital Vein: A Feasibility Study in Pediatric Patients

A Clinical Trial to Evaluate the Effects of a Skin Balm on the Appearance of the Eye Area

Non-invasive Rejuvenation of the Periorbital Area and Lower Eyelid

Brow Lifting With Dysport

Reducing Wrinkles Around the Eyes Using the Ulthera® System

A Prospective, Single Center, Single-Arm Clinical Study of 20 Participants to Reduce the Appearance of the Peri-orbital Wrinkles. Participants Will Receive up to Four Treatments With Tixel Every 4 Weeks. Follow-up Will Occur 1 Month and 3 Months Following Last Treatment.

Improvement in the Appearance of Periorbital Wrinkles

Evaluation of the Effectiveness and Safety of the Ulthera™ System for the Treatment of Wrinkles Around the Eyes

Evaluation of Ocular Surface Changes Following RF Electrocoagulation Treatment of the Periorbital Region

Investigation of the Efficacy and Tolerability of a Cosmetic Product With Onabotulinumtoxin A in the Treatment of Facial Lines

A Phase 4 Clinical Study to Investigate the Effectiveness and Safety of Skin Resurfacing

A Clinical Trial to Evaluate the Effects of an Eye Serum on Improving the Appearance of the Periorbital Area