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Showing 1–23 of 23 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Periorbital Clear all
Enrolling by invitation Not applicable Interventional Accepts healthy volunteers

Non-invasive Rejuvenation of the Periorbital Area and Lower Eyelid

NCT07028203
View directory record Official record
Conditions
Periorbital Wrinkles, Periorbital Area, Under-eyes Dark Circles, Crows Feet
Interventions
Treatment with BTL-785 with the applicator BTL-785-7-11
Device
Lead sponsor
BTL Industries Ltd.
Industry
Eligibility
21 Years and older
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
3
States / cities
Sacramento, California • Solana Beach, California • Youngstown, Ohio
Source: ClinicalTrials.gov public record
Updated Jun 18, 2025 · Synced Jul 23, 2026, 8:19 PM EDT
Completed Phase 2 Interventional Results available

Phase 2 Study of XAF5 (XOPH5) Ointment for Reduction of Excess Eyelid Fat (Steatoblepharon)

NCT02230761
View directory record Official record
Conditions
Lower Eyelid Steatoblepharon (Excess Eyelid Fat)
Interventions
XOPH5 Ointment, Placebo
Drug
Lead sponsor
Topokine Therapeutics, Inc.
Industry
Eligibility
40 Years to 70 Years
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Feb 7, 2016 · Synced Jul 23, 2026, 8:19 PM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers

Fractional Laser vs. Ultrasound for Periorbital Wrinkles

NCT01529983
View directory record Official record
Conditions
Wrinkles
Interventions
Laser treatment, High-intensity focused ultrasound
Procedure · Device
Lead sponsor
Northwestern University
Other
Eligibility
35 Years to 60 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2024
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Jun 30, 2026 · Synced Jul 23, 2026, 8:19 PM EDT
Suspended Phase 1Phase 2 Interventional

Safety and Efficacy Study of JV-GL1 in Patients With Open-Angle Glaucoma or Ocular Hypertension

NCT04761705
View directory record Official record
Conditions
Ocular Hypertension, Open Angle Glaucoma
Interventions
JV-GL1, Latanoprost 0.005% Ophthalmic Solution
Drug
Lead sponsor
JeniVision, Inc.
Industry
Eligibility
18 Years and older
Enrollment
70 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2025
U.S. locations
1
States / cities
Newport Beach, California
Source: ClinicalTrials.gov public record
Updated May 9, 2024 · Synced Jul 23, 2026, 8:19 PM EDT
Not listed No phase listed Observational Accepts healthy volunteers

Evaluation of Ocular Surface Changes Following RF Electrocoagulation Treatment of the Periorbital Region

NCT03280069
View directory record Official record
Conditions
Skin Laxity, Meibomian Gland Dysfunction
Interventions
THERMIeyes® 20 RF System
Device
Lead sponsor
Ophthalmic Consultants of Long Island
Other
Eligibility
40 Years to 70 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2019
U.S. locations
1
States / cities
Lynbrook, New York
Source: ClinicalTrials.gov public record
Updated Sep 11, 2017 · Synced Jul 23, 2026, 8:19 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

A Clinical Trial to Evaluate the Effects of a Skin Balm on the Appearance of the Eye Area

NCT06452810
View directory record Official record
Conditions
Skin Health
Interventions
Experimental: Sahajan Golden Glow Balm
Dietary Supplement
Lead sponsor
Sahajan
Industry
Eligibility
35 Years and older · Female only
Enrollment
35 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024
U.S. locations
1
States / cities
Santa Monica, California
Source: ClinicalTrials.gov public record
Updated Jun 10, 2024 · Synced Jul 23, 2026, 8:19 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Evaluation of the Effectiveness and Safety of the Ulthera™ System for the Treatment of Wrinkles Around the Eyes

NCT00747422
View directory record Official record
Conditions
Periorbital Wrinkles
Interventions
Ulthera™ System
Device
Lead sponsor
Ulthera, Inc
Industry
Eligibility
40 Years to 70 Years
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2009
U.S. locations
4
States / cities
San Diego, California • Chicago, Illinois • Chestnut Hill, Massachusetts + 1 more
Source: ClinicalTrials.gov public record
Updated Nov 23, 2017 · Synced Jul 23, 2026, 8:19 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Energy-Based Lower Eyelid Rejuvenation - Proof of Concept for InMode AccuTite With or Without Morpheus8

NCT04103619
View directory record Official record
Conditions
Periorbital Edema
Interventions
AccuTite, AccuTite + Morpheus 8
Device
Lead sponsor
InMode MD Ltd.
Industry
Eligibility
29 Years to 75 Years
Enrollment
12 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2021
U.S. locations
2
States / cities
Sarasota, Florida • Youngstown, Ohio
Source: ClinicalTrials.gov public record
Updated Jan 9, 2022 · Synced Jul 23, 2026, 8:19 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

A Clinical Trial to Evaluate the Effects of an Eye Serum on Improving the Appearance of the Periorbital Area

NCT06143033
View directory record Official record
Conditions
Periorbital Area
Interventions
DIME Beauty Luminosity Eye Serum
Other
Lead sponsor
Dime Beauty Co.
Industry
Eligibility
18 Years to 65 Years · Female only
Enrollment
35 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
Santa Monica, California
Source: ClinicalTrials.gov public record
Updated Feb 21, 2024 · Synced Jul 23, 2026, 8:19 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

A Prospective, Single Center, Single-Arm Clinical Study of 20 Participants to Reduce the Appearance of the Peri-orbital Wrinkles. Participants Will Receive up to Four Treatments With Tixel Every 4 Weeks. Follow-up Will Occur 1 Month and 3 Months Following Last Treatment.

NCT05282979
View directory record Official record
Conditions
Wrinkle
Interventions
Tixel 2
Device
Lead sponsor
Physicians Laser and Dermatology Institute
Other
Eligibility
35 Years to 75 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Mar 15, 2022 · Synced Jul 23, 2026, 8:19 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Clinical Study Evaluating the Safety and Effectiveness of The Tixel Fractional System in The Treatment of Periorbital Wrinkles

NCT04639713
View directory record Official record
Conditions
Wrinkle, Periorbital, Tixel 2, Fractional, Resurfacing
Interventions
Tixel 2
Device
Lead sponsor
Novoxel Ltd.
Industry
Eligibility
35 Years to 70 Years
Enrollment
51 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
2
States / cities
Chicago, Illinois • New York, New York
Source: ClinicalTrials.gov public record
Updated Mar 18, 2024 · Synced Jul 23, 2026, 8:19 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers

Brow Lifting With Dysport

NCT01401803
View directory record Official record
Conditions
Brow Ptosis, Lid Ptosis
Interventions
Dysport
Drug
Lead sponsor
Kenneth Beer
Individual
Eligibility
25 Years to 75 Years
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2012
U.S. locations
1
States / cities
West Palm Beach, Florida
Source: ClinicalTrials.gov public record
Updated Sep 25, 2013 · Synced Jul 23, 2026, 8:19 PM EDT
Withdrawn Not applicable Interventional

Validation of Non-Invasive Intracranial Pressure Estimation Using CPMX3 in the Periorbital Vein: A Feasibility Study in Pediatric Patients

NCT07550361
View directory record Official record
Conditions
Intracranial Pressure
Interventions
CPMX3 measurement
Device
Lead sponsor
Compremium AG
Industry
Eligibility
8 Years to 21 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated Apr 23, 2026 · Synced Jul 23, 2026, 8:19 PM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

A Phase 4 Clinical Study to Investigate the Effectiveness and Safety of Skin Resurfacing

NCT07214272
View directory record Official record
Conditions
Skin Resurfacing
Interventions
Fraxel® FTX Laser System
Device
Lead sponsor
Bausch Health Americas, Inc.
Industry
Eligibility
21 Years to 60 Years
Enrollment
49 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
5
States / cities
La Jolla, California • Miami, Florida • Naperville, Illinois + 2 more
Source: ClinicalTrials.gov public record
Updated Jun 10, 2026 · Synced Jul 23, 2026, 8:19 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers Results available

A Safety and Effectiveness Study of the Tixel Device, (Fractional Peri-orbital Wrinkles Treatment ) Compared With Laser

NCT03454672
View directory record Official record
Conditions
Wrinkle
Interventions
Tixel, Laser
Device
Lead sponsor
Novoxel Ltd.
Industry
Eligibility
40 Years to 70 Years
Enrollment
68 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2020
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Aug 22, 2024 · Synced Jul 23, 2026, 8:19 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

A 12 Week Study to Evaluate the Efficacy of an Eye Cream

NCT05807620
View directory record Official record
Conditions
Periorbital Hyperpigmentation, Periorbital Edema, Fine Lines, Wrinkle
Interventions
Gentle Cleansing Lotion, Facial Moisturizer, Sunscreen SPF 30
Other
Lead sponsor
Revision Skincare
Industry
Eligibility
35 Years to 60 Years · Female only
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022
U.S. locations
1
States / cities
Teaneck, New Jersey
Source: ClinicalTrials.gov public record
Updated Nov 29, 2023 · Synced Jul 23, 2026, 8:19 PM EDT
Completed Not applicable Interventional

Treatment of Periorbital and Perioral Wrinkles With the Applications of the Iluminage Diode Laser

NCT01813760
View directory record Official record
Conditions
Peri-orbital Wrinkles, Peri-oral Wrinkles
Interventions
Illuiminage ® Diode Laser
Device
Lead sponsor
Cynosure, Inc.
Industry
Eligibility
35 Years to 60 Years · Female only
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2013
U.S. locations
1
States / cities
Westford, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 25, 2014 · Synced Jul 23, 2026, 8:19 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Physiopathologic Aspects and Quality of Life in Participants With Eye Dark Circles

NCT03400202
View directory record Official record
Conditions
Periorbital Hyperpigmentation
Interventions
Skin imaging, Facial cleanser
Device · Other
Lead sponsor
Allergan
Industry
Eligibility
25 Years to 50 Years
Enrollment
44 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018
U.S. locations
1
States / cities
Irvine, California
Source: ClinicalTrials.gov public record
Updated Jan 22, 2019 · Synced Jul 23, 2026, 8:19 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers

Upper Facial Remodeling With Perlane-L and Dysport

NCT01354743
View directory record Official record
Conditions
Mild to Moderate Temporal Atrophy, Moderate to Severe Glabellar Rhytids, Moderate to Severe Periorbital Rhytids
Interventions
Dysport, Perlane L
Drug · Device
Lead sponsor
Beer, Kenneth R., M.D., PA
Individual
Eligibility
40 Years to 75 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2012
U.S. locations
1
States / cities
West Palm Beach, Florida
Source: ClinicalTrials.gov public record
Updated Sep 25, 2013 · Synced Jul 23, 2026, 8:19 PM EDT
Not listed Phase 3 Interventional Accepts healthy volunteers

Improvement in the Appearance of Periorbital Wrinkles

NCT05082766
View directory record Official record
Conditions
Periorbital Wrinkles
Interventions
enhanced DefenAge 8-in-1 BioSerum
Drug
Lead sponsor
Goldman, Butterwick, Fitzpatrick and Groff
Other
Eligibility
31 Years and older
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Oct 27, 2021 · Synced Jul 23, 2026, 8:19 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Reducing Wrinkles Around the Eyes Using the Ulthera® System

NCT01368900
View directory record Official record
Conditions
Periorbital Wrinkles
Interventions
Ulthera® System treatment
Device
Lead sponsor
Ulthera, Inc
Industry
Eligibility
30 Years to 65 Years
Enrollment
68 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2012
U.S. locations
2
States / cities
Hunt Valley, Maryland • Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Dec 12, 2017 · Synced Jul 23, 2026, 8:19 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Investigation of the Efficacy and Tolerability of a Cosmetic Product With Onabotulinumtoxin A in the Treatment of Facial Lines

NCT05089851
View directory record Official record
Conditions
Wrinkles, Photoaging, Fine Lines
Interventions
Onabotulinumtoxin A, Facial Cleanser, Facial Moisturizer, Sunscreen
Procedure · Combination Product
Lead sponsor
Revision Skincare
Industry
Eligibility
35 Years to 60 Years · Female only
Enrollment
29 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2021
U.S. locations
3
States / cities
Fort Lauderdale, Florida • Coralville, Iowa • Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Oct 27, 2021 · Synced Jul 23, 2026, 8:19 PM EDT
Recruiting Not applicable Interventional

Non-invasive Intracranial Pressure Estimation by Measurement of the Occlusion Pressure of the Isolated Periorbital Vein

NCT07222826
View directory record Official record
Conditions
Intracranial Pressure, Intracranial Pressure Changes
Interventions
CPMX3
Device
Lead sponsor
Compremium AG
Industry
Eligibility
18 Years and older
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Oct 29, 2025 · Synced Jul 23, 2026, 8:19 PM EDT