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ClinicalTrials.gov public records Last synced May 22, 2026, 5:38 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Showing 1–20 of 20 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Persistent Post Concussion Syndrome Clear all
Not listed Phase 3 Interventional
View directory record Official record
Conditions
Post-Concussion Syndrome, Traumatic Brain Injury
Interventions
Hyperbaric Oxygen, No Hyperbaric Oxygen
Drug
Lead sponsor
Louisiana State University Health Sciences Center in New Orleans
Other
Eligibility
18 Years to 65 Years
Enrollment
59 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2019
U.S. locations
1
States / cities
New Orleans, Louisiana
Source: ClinicalTrials.gov public record
Updated Apr 17, 2017 · Synced May 22, 2026, 5:38 AM EDT
Completed Phase 2 Interventional
View directory record Official record
Conditions
Brain Injury, Chronic
Interventions
Hyperbaric Oxygen, Minimal pressure air
Combination Product
Lead sponsor
Lindell Weaver
Other
Eligibility
18 Years to 70 Years
Enrollment
49 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2022
U.S. locations
2
States / cities
Murray, Utah • Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Aug 3, 2022 · Synced May 22, 2026, 5:38 AM EDT
Not yet recruiting Not applicable Interventional
View directory record Official record
Conditions
Persistent Post-concussive Symptoms, Post Traumatic Headache
Interventions
SPINEPASS Physical Therapy, Standard Physical Therapy
Other
Lead sponsor
The University of Queensland
Other
Eligibility
18 Years to 65 Years
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
1
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Mar 17, 2025 · Synced May 22, 2026, 5:38 AM EDT
Active, not recruiting Not applicable Interventional
View directory record Official record
Conditions
Concussion, Brain, Concussion, Mild, Brain Injuries, Traumatic, Persistent Post Traumatic Headache, Post-Concussion Syndrome, Post-Concussive Syndrome, Chronic
Interventions
MSTEP, Stretching
Behavioral
Lead sponsor
Seattle Children's Hospital
Other
Eligibility
11 Years to 18 Years
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2025
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated May 15, 2025 · Synced May 22, 2026, 5:38 AM EDT
Completed Phase 2 Interventional
View directory record Official record
Conditions
Persistent Post-concussive Syndrome, Concussion Post Syndrome
Interventions
Hyperbaric oxygen at 1.5 ATA, Sham treatment
Drug
Lead sponsor
Essentia Health
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
1
States / cities
Fargo, North Dakota
Source: ClinicalTrials.gov public record
Updated Dec 23, 2025 · Synced May 22, 2026, 5:38 AM EDT
Completed Phase 2 Interventional Results available
View directory record Official record
Conditions
Post-concussive Symptoms, Traumatic Brain Injury
Interventions
hyperbaric oxygen, sham hyperbaric air
Drug · Other
Lead sponsor
U.S. Army Medical Research and Development Command
Federal
Eligibility
18 Years to 65 Years
Enrollment
79 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2012
U.S. locations
5
States / cities
Camp Pendleton, California • Fort Carson, Colorado • Fort Gordon, Georgia + 2 more
Source: ClinicalTrials.gov public record
Updated Sep 4, 2014 · Synced May 22, 2026, 5:38 AM EDT
Completed Not applicable Interventional
View directory record Official record
Conditions
Concussion, Brain, TBI, Depression, Anxiety
Interventions
Collaborative Care
Behavioral
Lead sponsor
Seattle Children's Hospital
Other
Eligibility
11 Years to 18 Years
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2020
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Apr 7, 2021 · Synced May 22, 2026, 5:38 AM EDT
Completed Not applicable Interventional
View directory record Official record
Conditions
Persistent Concussion Symptoms
Interventions
Subthreshold exercise (STEP) with mobile health coaching, Light stretching (LS)
Behavioral
Lead sponsor
Seattle Children's Hospital
Other
Eligibility
11 Years to 18 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2018
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Oct 25, 2018 · Synced May 22, 2026, 5:38 AM EDT
Completed Not applicable Interventional
View directory record Official record
Conditions
Persistent Post-concussive Symptoms, Convergence Insufficiency, Mild Traumatic Brain Injury, Concussion, Mild, Concussion; Eye
Interventions
Office-based Vergence and Accommodative Therapy
Behavioral
Lead sponsor
New Jersey Institute of Technology
Other
Eligibility
11 Years to 35 Years
Enrollment
112 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2026
U.S. locations
2
States / cities
Newark, New Jersey • Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jan 21, 2026 · Synced May 22, 2026, 5:38 AM EDT
Not listed No phase listed Observational
View directory record Official record
Conditions
Headache, Migraine, Persistent Post Traumatic Headache, Cervicogenic Headache
Interventions
COMPASS 31 questionnaire
Other
Lead sponsor
Brooke Army Medical Center
Federal
Eligibility
18 Years to 64 Years
Enrollment
35 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jul 20, 2022 · Synced May 22, 2026, 5:38 AM EDT
Completed Phase 2 Interventional Results available
View directory record Official record
Conditions
Traumatic Brain Injury With Brief Loss of Consciousness, Post-Concussion Syndrome
Interventions
Hyperbaric oxygen (HBO2) at 1.5 atms, Sham control 1.2 atms
Drug
Lead sponsor
U.S. Army Medical Research and Development Command
Federal
Eligibility
18 Years to 65 Years
Enrollment
71 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2016
U.S. locations
5
States / cities
Colorado Springs, Colorado • Fort Carson, Colorado • Jacksonville, North Carolina + 2 more
Source: ClinicalTrials.gov public record
Updated Nov 20, 2018 · Synced May 22, 2026, 5:38 AM EDT
Not listed Not applicable Interventional
View directory record Official record
Conditions
Concussion, Brain
Interventions
Apollo Neuro
Device
Lead sponsor
University of South Carolina
Other
Eligibility
10 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
1
States / cities
Columbia, South Carolina
Source: ClinicalTrials.gov public record
Updated Jan 12, 2023 · Synced May 22, 2026, 5:38 AM EDT
Recruiting Phase 2 Interventional
View directory record Official record
Conditions
Post-Concussion Syndrome, Concussion, Brain, Mild Traumatic Brain Injury, Head Injury, Headache, Dizziness, Cognitive Symptom, Dysautonomia, Anxiety, Irritability; Syndrome, Depression, Post-traumatic Stress Disorder
Interventions
Active cTBS, Inactive/Sham cTBS, Imaginal exposure
Device · Behavioral
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years to 65 Years
Enrollment
75 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Westwood, Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Feb 23, 2026 · Synced May 22, 2026, 5:38 AM EDT
Completed Not applicable Interventional
View directory record Official record
Conditions
Concussion; Syndrome
Interventions
Compass Course
Behavioral
Lead sponsor
Mary Radomski
Other
Eligibility
18 Years and older
Enrollment
22 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Jul 16, 2024 · Synced May 22, 2026, 5:38 AM EDT
Recruiting Not applicable Interventional
View directory record Official record
Conditions
Persistent Post Concussion Syndrome, Mild Traumatic Brain Injury
Interventions
Active tDCS, Sham tDCS
Device
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years to 65 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Mar 16, 2026 · Synced May 22, 2026, 5:38 AM EDT
Completed Not applicable Interventional
View directory record Official record
Conditions
Traumatic Brain Injury
Interventions
Global Z-Score Neurofeedback Training
Behavioral
Lead sponsor
The Defense and Veterans Brain Injury Center
Federal
Eligibility
18 Years to 50 Years
Enrollment
172 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2022
U.S. locations
1
States / cities
Fort Carson, Colorado
Source: ClinicalTrials.gov public record
Updated Apr 3, 2022 · Synced May 22, 2026, 5:38 AM EDT
Recruiting Not applicable Interventional
View directory record Official record
Conditions
Mild Traumatic Brain Injury, Concussion, Mild, Concussion, Severe, Concussion, Intermediate
Interventions
RPM-assisted specialist access
Other
Lead sponsor
Children's Hospital of Philadelphia
Other
Eligibility
13 Years to 18 Years
Enrollment
210 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jun 19, 2025 · Synced May 22, 2026, 5:38 AM EDT
Completed No phase listed Observational Accepts healthy volunteers
View directory record Official record
Conditions
Mild Traumatic Brain Injury, Post-Concussive Symptoms
Interventions
Not listed
Lead sponsor
VA Eastern Colorado Health Care System
Federal
Eligibility
18 Years to 45 Years
Enrollment
3 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2016
U.S. locations
1
States / cities
Denver, Colorado
Source: ClinicalTrials.gov public record
Updated Jan 14, 2016 · Synced May 22, 2026, 5:38 AM EDT
Recruiting Not applicable Interventional
View directory record Official record
Conditions
Concussion, Brain, Brain Injury Traumatic Mild
Interventions
Concussion-focused cognitive behavioral therapy, Parent skills training, Care management
Behavioral
Lead sponsor
Seattle Children's Hospital
Other
Eligibility
11 Years to 18 Years
Enrollment
304 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2028
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Mar 12, 2025 · Synced May 22, 2026, 5:38 AM EDT
Recruiting Phase 2Phase 3 Interventional
View directory record Official record
Conditions
Autonomic Nervous System Disease, Concussive Injury, Mild Traumatic Brain Injury, Post Traumatic Stress Disorder, Persistent Post Concussion Syndrome
Interventions
HRV Coherence Ratio, NSI, Pittsburgh Sleep Quality Index (PSQI), Quantitative Sleep Measures, Patient Global Impression of Change (PGIC), Cognitive Performance/NIH Toolbox Cognitive Battery, Pain Interference/TBI-QoL Pain Interference Short-Form, Patient Health Questionnaire-9 (PHQ-9), PTSD Checklist for DSM-5 (PCL-5), HRV Biofeedback (HRV-B), Psychoeducational (Edu) Comparator Intervention
Other · Behavioral
Lead sponsor
Virginia Commonwealth University
Other
Eligibility
18 Years and older
Enrollment
148 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
1
States / cities
Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Sep 16, 2025 · Synced May 22, 2026, 5:38 AM EDT