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ClinicalTrials.gov public records Last synced Oct 25, 2026, 12:35 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Showing 1–24 of 56 matching trials from the live ClinicalTrials.gov search.

Filters: Condition: Physical Dependence Clear all

Conditions: Schizophrenia
Interventions: LY2140023, Placebo; Drug
Lead sponsor: Denovo Biopharma LLC; Industry
Eligibility: 18 Years to 65 Years
Enrollment: 123 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2012
U.S. locations: 8
States / cities: Oakland, California • San Diego, California • Torrance, California + 5 more

Conditions: Tobacco Dependence
Interventions: CEASE, CEASE + BIO; Behavioral
Lead sponsor: Massachusetts General Hospital; Other
Eligibility: 18 Years and older
Enrollment: 865 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023 – 2026
U.S. locations: 1
States / cities: Cleveland, Ohio

Conditions: Nicotine Dependence
Interventions: Placebo, Varenicline; Drug
Lead sponsor: University of Minnesota; Other
Eligibility: 18 Years to 60 Years
Enrollment: 7 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2008 – 2009
U.S. locations: 1
States / cities: Minneapolis, Minnesota

Conditions: Alcohol Use Disorder, Alcohol Drinking, Alcohol Abuse, Alcohol Dependence
Interventions: Contingency Management, Computer Based Training for Cognitive Behavioral Therapy for AUD (CBT4CBT); Behavioral
Lead sponsor: Washington State University; Other
Eligibility: 18 Years and older
Enrollment: 200 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2028
U.S. locations: 1
States / cities: Spokane, Washington

Conditions: Alcohol Dependence
Interventions: LPA+Fitbit, HEC; Behavioral
Lead sponsor: Butler Hospital; Other
Eligibility: 18 Years to 65 Years · Female only
Enrollment: 70 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2019
U.S. locations: 1
States / cities: Providence, Rhode Island

Conditions: Alcohol Dependence
Interventions: Fit&Sober App, Brief Advice; Behavioral
Lead sponsor: Butler Hospital; Other
Eligibility: 18 Years to 65 Years
Enrollment: 70 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2022
U.S. locations: 1
States / cities: Providence, Rhode Island

Conditions: Smoking Dependence, Smoking
Interventions: oral nicotine, Placebo; Drug
Lead sponsor: GlaxoSmithKline; Industry
Eligibility: 18 Years and older
Enrollment: 323 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2011
U.S. locations: 1
States / cities: Burbank, California

Conditions: Respiratory Infections in Old Age
Interventions: Not listed
Lead sponsor: University Hospital, Grenoble; Other
Eligibility: 60 Years and older
Enrollment: 1,600 participants
Timeline: 2026 – 2028
U.S. locations: 1
States / cities: Rochester, New York

Conditions: Tobacco Dependence
Interventions: Tobacco/Physical Activity Intervention, Diet plus BP/CHOL Intervention; Behavioral
Lead sponsor: Stanford University; Other
Eligibility: 19 Years and older
Enrollment: 299 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2015 – 2020
U.S. locations: 2
States / cities: Nome, Alaska • Stanford, California

Conditions: Nicotine Dependence
Interventions: Varenicline; Drug
Lead sponsor: University of Pennsylvania; Other
Eligibility: 21 Years to 65 Years
Enrollment: 48 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2009 – 2010
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Alcoholism, Alcohol Dependence, Alcohol Drinking Related Problems
Interventions: Not listed
Lead sponsor: National Institute on Alcohol Abuse and Alcoholism (NIAAA); NIH
Eligibility: 18 Years and older
Enrollment: 1,192 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2005 – 2015
U.S. locations: 1
States / cities: Bethesda, Maryland

Conditions: Stigma, Activity Space, Social Networks, HIV Status, Drug Abuse/Dependence
Interventions: Not listed
Lead sponsor: National Institute on Drug Abuse (NIDA); NIH
Eligibility: 18 Years to 100 Years
Enrollment: 1,651 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: Started 2012
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Cannabis Dependence
Interventions: Exercise; Behavioral
Lead sponsor: Vanderbilt University; Other
Eligibility: 18 Years to 35 Years
Enrollment: 30 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2009 – 2013
U.S. locations: 1
States / cities: Nashville, Tennessee

Conditions: Cocaine Dependence
Interventions: Behavioral Incentives, Education Control; Behavioral
Lead sponsor: Virginia Commonwealth University; Other
Eligibility: 18 Years and older · Female only
Enrollment: 26 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2013
U.S. locations: 1
States / cities: Richmond, Virginia

Conditions: Nicotine Dependence
Interventions: MarkTen and e-Go e-cigarettes; Device
Lead sponsor: Truth Initiative; Other
Eligibility: 18 Years to 65 Years
Enrollment: 80 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2016 – 2018
U.S. locations: 2
States / cities: Washington D.C., District of Columbia • Richmond, Virginia

Conditions: Opioid Induced Bowel Dysfunction
Interventions: Naldemedine, Placebo; Drug
Lead sponsor: Shionogi; Industry
Eligibility: 18 Years to 65 Years
Enrollment: 72 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2011
U.S. locations: 1
States / cities: Salt Lake City, Utah

Conditions: Methamphetamine Dependence
Interventions: Lobeline; Drug
Lead sponsor: National Institute on Drug Abuse (NIDA); NIH
Eligibility: 18 Years to 45 Years · Female only
Enrollment: 10 participants
Healthy volunteers: Accepts healthy volunteers
U.S. locations: 1
States / cities: San Francisco, California

Conditions: Methamphetamine Dependence, Methamphetamine Abuse
Interventions: OROS-MPH; Drug
Lead sponsor: University of Cincinnati; Other
Eligibility: 18 Years to 45 Years
Enrollment: 16 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2008 – 2009
U.S. locations: 1
States / cities: Cincinnati, Ohio

Conditions: Cocaine Dependence
Interventions: SYN117 Placebo, SYN117 80 mg, SYN117 160 mg, Cocaine 10mg, Cocaine 20mg, Cocaine 40mg, Saline; Drug
Lead sponsor: Biotie Therapies Inc.; Industry
Eligibility: 18 Years to 50 Years
Enrollment: 20 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2009
U.S. locations: 1
States / cities: Galveston, Texas

Conditions: Substance Withdrawal Syndrome
Interventions: Not listed
Lead sponsor: Banner Health; Other
Eligibility: 2 Weeks to 18 Years
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2010
U.S. locations: 1
States / cities: Mesa, Arizona

Conditions: Schizophrenia
Interventions: SEP-363856, Placebo; Drug
Lead sponsor: Otsuka Pharmaceutical Development & Commercialization, Inc.; Industry
Eligibility: 18 Years to 65 Years
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2024
U.S. locations: 7
States / cities: Little Rock, Arkansas • Rogers, Arkansas • Miami Lakes, Florida + 4 more

Conditions: Nicotine Dependence
Interventions: Not listed
Lead sponsor: National Institute on Drug Abuse (NIDA); NIH
Eligibility: 18 Years to 55 Years
Enrollment: 17 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2009 – 2012
U.S. locations: 1
States / cities: Catonsville, Maryland

Conditions: Cocaine Addiction, Opiate Addiction
Interventions: Not listed
Lead sponsor: National Institute on Drug Abuse (NIDA); NIH
Eligibility: 18 Years to 65 Years
Enrollment: 230 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2003 – 2013
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Opioid-Related Disorders
Interventions: Morphine; Drug
Lead sponsor: National Institute on Drug Abuse (NIDA); NIH
Eligibility: 21 Years to 55 Years · Male only
Healthy volunteers: Healthy volunteers not accepted
Timeline: 1995 – 1996
U.S. locations: 1
States / cities: Washington D.C., District of Columbia

Search by objective public record fields.

A Physical Dependence Study in Schizophrenia

Assessment of Biomarkers in Children to Help Parents Quit Tobacco

Human Laboratory Study Of Varenicline in Smokers

Virtual Incentive Treatment for Alcohol

Lifestyle Physical Activity Intervention for Depressed Alcohol Dependent Women

A Tailored Physical Activity Smartphone App for Patients With Alcohol Dependence

Provoked Craving Assessment

Functional Impact of Acute Respiratory Viral Infections in Older Adults

Healing and Empowering Alaskan Lives Towards Healthy-Hearts Study

Measuring Smoking Behaviors While Using Varenicline

Alcoholism Assessment and Treatment

Health Outcomes by Neighborhood - Baltimore

Interactions Between Physical Activity and Cannabis Use in Adults

Behavioral Incentives to Increase Exercise in Cocaine Dependent Women

Lab to Real World Assessment of E-cigarette Abuse Liability and Appeal

Study to Evaluate the Safety and Efficacy of Naldemedine (S-297995) for the Treatment of Opioid-Induced Bowel Dysfunction in Subjects With Chronic Pain

Ph1 Lobeline Interaction Study - 1

Safety Assessment of Potential Interactions Between IV Methamphetamine and Osmotic-Release Methylphenidate (OROS-MPH)

Study of Safety and Potential Efficacy of SYN117 in Cocaine Dependent Volunteers

Validation of a Pediatric-Specific Abstinence Syndrome Assessment Tool

A Clinical Study to Learn if SEP-363856 Has Physical Dependence in Adults With Schizophrenia

Assessment of Craving in Nicotine-Dependent Patients With Schizophrenia Using Virtual Reality

Real Time Assessment of Drug Craving, Use, and Abstinence During Outpatient: A Development and Feasibility Study

Activity Monitoring Assessment of Opiate Withdrawal - 4