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Showing 1–24 of 272 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Positive Pressure Ventilation Clear all
Withdrawn Not applicable Interventional

Effects of Different PEEP Levels on Work of Breathing in Morbidly Obese Patients Prior to and After Extubation

NCT02492113
View directory record Official record
Conditions
Obesity
Interventions
Positive end-expiratory pressure (PEEP), ZEEP
Procedure
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2025
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Feb 19, 2026 · Synced Jul 22, 2026, 4:50 PM EDT
Terminated Phase 4 Interventional Results available

Palatal Implants in Combination With Continuous Positive Airway Pressure to Treat Obstructive Sleep Apnea

NCT00730041
View directory record Official record
Conditions
Obstructive Sleep Apnea (OSA)
Interventions
Pillar Palatal Implant System, Sham system
Device
Lead sponsor
Medtronic Xomed, Inc.
Industry
Eligibility
18 Years and older
Enrollment
51 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2009
U.S. locations
7
States / cities
Little Rock, Arkansas • Berkeley, California • Denver, Colorado + 4 more
Source: ClinicalTrials.gov public record
Updated Jan 11, 2010 · Synced Jul 22, 2026, 4:50 PM EDT
Completed Phase 2 Interventional

Endotype-Targeted Therapy to Rescue OSA Patients Struggling With CPAP Adherence (TOP-CPAP)

NCT05951023
View directory record Official record
Conditions
Obstructive Sleep Apnea
Interventions
Eszopiclone 2 mg, Placebo
Drug
Lead sponsor
University of California, San Diego
Other
Eligibility
21 Years to 65 Years
Enrollment
42 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
La Jolla, California
Source: ClinicalTrials.gov public record
Updated Nov 24, 2025 · Synced Jul 22, 2026, 4:50 PM EDT
Completed Phase 1Phase 2 Interventional Results available

Using Telemedicine to Improve Veteran Sleep Apnea Care

NCT01259440
View directory record Official record
Conditions
Sleep Apnea Syndromes
Interventions
Video Teleconferencing Care, Usual Care
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
23 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2012
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Nov 3, 2015 · Synced Jul 22, 2026, 4:50 PM EDT
Completed Not applicable Interventional

Impact of Automated Education and Follow-up Mechanisms on Patient Engagement

NCT02279901
View directory record Official record
Conditions
Obstructive Sleep Apnea
Interventions
Telemedicine Education, IVR
Behavioral
Lead sponsor
Kaiser Permanente
Other
Eligibility
18 Years and older
Enrollment
1,873 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
1
States / cities
Fontana, California
Source: ClinicalTrials.gov public record
Updated Mar 5, 2017 · Synced Jul 22, 2026, 4:50 PM EDT
Terminated Not applicable Interventional Results available

The Efficacy of a New Mathematical Formula to Predict Continuous Positive Air Pressure With an Oronasal Mask Interface.

NCT02816255
View directory record Official record
Conditions
Obstructive Sleep Apnea (OSA)
Interventions
Full Face Mask with same CPAP Pressure, Full Face Mask with new Pressure
Device
Lead sponsor
Weill Medical College of Cornell University
Other
Eligibility
18 Years and older
Enrollment
11 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Sep 27, 2022 · Synced Jul 22, 2026, 4:50 PM EDT
Completed No phase listed Observational Results available

Third International Study on Mechanical Ventilation

NCT01093482
View directory record Official record
Conditions
Acute Respiratory Failure
Interventions
Not listed
Lead sponsor
Hospital Universitario Getafe
Other
Eligibility
18 Years and older
Enrollment
8,151 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010
U.S. locations
18
States / cities
Iowa City, Iowa • Louisville, Kentucky • Boston, Massachusetts + 12 more
Source: ClinicalTrials.gov public record
Updated Feb 28, 2018 · Synced Jul 22, 2026, 4:50 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Mechanisms of Endothelial Cell Dysfunction in Sleep Apnea

NCT00859950
View directory record Official record
Conditions
Obstructive Sleep Apnea, Hypoxemia
Interventions
Continuous Positive Airway Pressure (CPAP)
Device
Lead sponsor
Weill Medical College of Cornell University
Other
Eligibility
21 Years and older
Enrollment
70 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2015
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Feb 3, 2019 · Synced Jul 22, 2026, 4:50 PM EDT
Completed Not applicable Interventional Results available

Auto Bilevel Adherence Following a Poor Initial Encounter With Continuous Positive Airway Pressure (CPAP)

NCT02522442
View directory record Official record
Conditions
Obstructive Sleep Apnea
Interventions
CPAP, Auto BiLevel
Device
Lead sponsor
Philips Respironics
Industry
Eligibility
21 Years to 75 Years
Enrollment
51 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2009
U.S. locations
3
States / cities
Boston, Massachusetts • Rochester, Minnesota • St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Apr 25, 2019 · Synced Jul 22, 2026, 4:50 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Noninvasive Ventilation Masks Carbon Dioxide Clearance in Normal Volunteers

NCT03882723
View directory record Official record
Conditions
CO2 Clearance, Mask Comfort, Rebreathing Exhaled Gas
Interventions
Evaluated 4 masks used for NIV with mechanical ventilators
Device
Lead sponsor
Rush University Medical Center
Other
Eligibility
18 Years and older
Enrollment
8 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Jun 27, 2023 · Synced Jul 22, 2026, 4:50 PM EDT
Completed Phase 2 Interventional

Weekly Phone Calls Versus Brief Patient Education to Improve Continuous Positive Airway Pressure (CPAP) Compliance

NCT00945776
View directory record Official record
Conditions
Obstructive Sleep Apnea (OSA)
Interventions
Weekly phone calls, Frequently asked questions, Usual care
Behavioral
Lead sponsor
CAMC Health System
Other
Eligibility
18 Years and older
Enrollment
128 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2009
U.S. locations
1
States / cities
Charleston, West Virginia
Source: ClinicalTrials.gov public record
Updated Jul 23, 2009 · Synced Jul 22, 2026, 4:50 PM EDT
Terminated Phase 2 Interventional Results available

Feasibility Study of Aerosolized Surfaxin in the Prevention of Respiratory Distress Syndrome (RDS) in Premature Infants

NCT00807235
View directory record Official record
Conditions
Respiratory Distress Syndrome
Interventions
Aerosolized lucinactant
Drug
Lead sponsor
Windtree Therapeutics
Industry
Eligibility
15 Minutes to 30 Minutes
Enrollment
17 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Jun 12, 2012 · Synced Jul 22, 2026, 4:50 PM EDT
Terminated Phase 1Phase 2 Interventional

PEEP and V/Q Mismatch in Premature Infants

NCT03109613
View directory record Official record
Conditions
Respiratory Insufficiency Syndrome of Newborn, Infant, Premature, Diseases
Interventions
Positive end-expiratory pressure (PEEP)
Device
Lead sponsor
Children's Hospital of Philadelphia
Other
Eligibility
0 Days to 28 Days
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2018
U.S. locations
3
States / cities
Newark, Delaware • Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Nov 16, 2020 · Synced Jul 22, 2026, 4:50 PM EDT
Completed Not applicable Interventional Results available

PEEP Mask for Tracheobronchomalacia-Induced Cough

NCT04169282
View directory record Official record
Conditions
Tracheobronchomalacia
Interventions
nPEP (non-invasive positive expiratory pressure) mask
Device
Lead sponsor
Duke University
Other
Eligibility
18 Years and older
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Sep 27, 2023 · Synced Jul 22, 2026, 4:50 PM EDT
Completed No phase listed Observational

Effect of Nasal CPAP on Cardiopulmonary Exercise Testing in Patients With Overlap Syndrome

NCT01033266
View directory record Official record
Conditions
Obstructive Sleep Apnea, Chronic Obstructive Pulmonary Disease
Interventions
CPET
Diagnostic Test
Lead sponsor
University of Oklahoma
Other
Eligibility
18 Years and older
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2014
U.S. locations
2
States / cities
Oklahoma City, Oklahoma
Source: ClinicalTrials.gov public record
Updated Apr 13, 2020 · Synced Jul 22, 2026, 4:50 PM EDT
Completed Not applicable Interventional

Effect of CPAP (Continuous Positive Airway Pressure) on Lung Function in Asthmatics With Sleep Apnea

NCT00238069
View directory record Official record
Conditions
Asthma, Sleep Apnea
Interventions
CPAP machine as a result of sleep study
Device
Lead sponsor
National Jewish Health
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2005
U.S. locations
1
States / cities
Denver, Colorado
Source: ClinicalTrials.gov public record
Updated Mar 28, 2017 · Synced Jul 22, 2026, 4:50 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Revised Algorithm for Next Generation DeVilbiss Healthcare AutoAdjust Continuous Positive Airway Pressure (CPAP)

NCT01797705
View directory record Official record
Conditions
Obstructive Sleep Apnea
Interventions
DeVilbiss AutoAdjust CPAP with revised algorithm
Device
Lead sponsor
DeVilbiss Healthcare LLC
Industry
Eligibility
21 Years to 75 Years
Enrollment
33 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2014
U.S. locations
1
States / cities
Newton, Massachusetts
Source: ClinicalTrials.gov public record
Updated May 28, 2015 · Synced Jul 22, 2026, 4:50 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Targeted CPAP Therapy for Obstructive Sleep Apnea in Pregnancy

NCT02755831
View directory record Official record
Conditions
Obstructive Sleep Apnea
Interventions
CPAP, Pre-natal care
Device · Other
Lead sponsor
United States Naval Medical Center, San Diego
Federal
Eligibility
18 Years and older · Female only
Enrollment
193 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2019
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Nov 26, 2019 · Synced Jul 22, 2026, 4:50 PM EDT
Completed Phase 1 Interventional

Study of TAK-925 in Participants With Obstructive Sleep Apnea (OSA) Who Are Experiencing Excessive Daytime Sleepiness (EDS) Despite Adequate Use of Continuous Positive Airway Pressure (CPAP)

NCT04091425
View directory record Official record
Conditions
Obstructive Sleep Apnea
Interventions
TAK-925, Placebo
Drug
Lead sponsor
Millennium Pharmaceuticals, Inc.
Industry
Eligibility
18 Years to 67 Years
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
18
States / cities
Alabaster, Alabama • Glendale, Arizona • Little Rock, Arkansas + 15 more
Source: ClinicalTrials.gov public record
Updated Apr 19, 2020 · Synced Jul 22, 2026, 4:50 PM EDT
Recruiting Phase 2 Interventional

A Clinical Trial of Early Ventilation in Amyotrophic Lateral Sclerosis (EVENT ALS)

NCT07071935
View directory record Official record
Conditions
Amyotrophic Lateral Sclerosis (ALS), Chronic Respiratory Failure, Neuromuscular Disease Patients, Neuromuscular Disease, Respiratory Insufficiency, Respiratory Insufficiency Requiring Mechanical Ventilation, Positive Pressure Ventilation, Non-invasive Ventilation, Non-invasive Ventilation Support, Non-invasive Ventilatory Support
Interventions
Non-invasive ventilation
Device
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years and older
Enrollment
48 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
3
States / cities
Hershey, Pennsylvania • Philadelphia, Pennsylvania • Philadelphi, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jun 25, 2026 · Synced Jul 22, 2026, 4:50 PM EDT
Completed Not applicable Interventional

PROVHILO:Protective Ventilation During General Anesthesia for Open Abdominal Surgery

NCT01441791
View directory record Official record
Conditions
Postoperative Respiratory Complications
Interventions
Lung protective strategy ventilation
Procedure
Lead sponsor
Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Other
Eligibility
18 Years and older
Enrollment
900 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2013
U.S. locations
2
States / cities
Boston, Massachusetts • Rochester, New York
Source: ClinicalTrials.gov public record
Updated Dec 8, 2014 · Synced Jul 22, 2026, 4:50 PM EDT
Completed Phase 2 Interventional Results available

High Flow Oxygen and Bilevel Airway Pressure for Persistent Dyspnea in Patients With Advanced Cancer

NCT00934128
View directory record Official record
Conditions
Advanced Cancers
Interventions
Vapotherm, BIPAP
Device
Lead sponsor
M.D. Anderson Cancer Center
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2012
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Mar 1, 2016 · Synced Jul 22, 2026, 4:50 PM EDT
Withdrawn Not applicable Interventional

Effects of PAP on Afib Recurrence Risk After Catheter Ablation in OSA Patients

NCT03242720
View directory record Official record
Conditions
Obstructive Sleep Apnea, Atrial Fibrillation
Interventions
Cardiac Ablation for Atrial Fibrillation
Procedure
Lead sponsor
Stanford University
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
1
States / cities
Redwood City, California
Source: ClinicalTrials.gov public record
Updated May 23, 2022 · Synced Jul 22, 2026, 4:50 PM EDT
Completed Not applicable Interventional

Postoperative Nasal High Flow Versus Oxygen for Positive Airway Pressure Non-Compliance Sleep Apnea Patients

NCT02485236
View directory record Official record
Conditions
Obstructive Sleep Apnea
Interventions
Low flow oxygen via nasal cannula, Humidified Nasal High Flow Therapy
Device
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2017
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Oct 8, 2019 · Synced Jul 22, 2026, 4:50 PM EDT