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Showing 1–24 of 268 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Positive-Pressure Respiration Clear all
Completed Not applicable Interventional Results available

Comparison of Breathing Event Detection by a Continuous Positive Airway Pressure Device to Clinical Polysomnography

NCT00836758
View directory record Official record
Conditions
Sleep Apnea
Interventions
Analysis with AED and manual PSG scoring
Device
Lead sponsor
Philips Respironics
Industry
Eligibility
21 Years to 75 Years
Enrollment
115 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Jan 15, 2019 · Synced Jun 11, 2026, 9:35 AM EDT
Completed Not applicable Interventional

Early Caffeine and LISA Compared to Caffeine and CPAP in Preterm Infants

NCT04209946
View directory record Official record
Conditions
Premature Lungs, Respiratory Distress Syndrome, Surfactant Deficiency Syndrome Neonatal
Interventions
Less Invasive Surfactant Administration LISA, Continuous Positive Airway Pressure CPAP
Procedure
Lead sponsor
Sharp HealthCare
Other
Eligibility
24 Weeks to 29 Weeks
Enrollment
180 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2025
U.S. locations
3
States / cities
Irvine, California • Loma Linda, California • San Diego, California
Source: ClinicalTrials.gov public record
Updated Dec 17, 2025 · Synced Jun 11, 2026, 9:35 AM EDT
Completed Not applicable Interventional

Comparison of Humidified High Flow Nasal Cannula to Nasal CPAP in Neonates

NCT00609882
View directory record Official record
Conditions
Respiratory Insufficiency
Interventions
Nasal CPAP, Humidified High Flow Nasal Cannula (HHFNC)
Other
Lead sponsor
University of Utah
Other
Eligibility
Up to 8 Weeks
Enrollment
420 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2012
U.S. locations
8
States / cities
Philadelphia, Pennsylvania • Lackland Air Force Base, Texas • Ogden, Utah + 3 more
Source: ClinicalTrials.gov public record
Updated Feb 5, 2013 · Synced Jun 11, 2026, 9:35 AM EDT
Completed Not applicable Interventional Results available

Non-Inferiority Study of the FRESCA Airbox Positive Airway Pressure System

NCT03999944
View directory record Official record
Conditions
Sleep Apnea
Interventions
positive airway pressure system
Device
Lead sponsor
FRESCA Medical
Industry
Eligibility
22 Years to 75 Years
Enrollment
52 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
6
States / cities
St. Petersburg, Florida • Atlanta, Georgia • Gainesville, Georgia + 3 more
Source: ClinicalTrials.gov public record
Updated Jun 22, 2021 · Synced Jun 11, 2026, 9:35 AM EDT
Completed Not applicable Interventional Results available

Pilot Study of High-flow Humidified Nasal Oxygen During Breaks From Noninvasive Ventilation

NCT01925534
View directory record Official record
Conditions
Acute Respiratory Failure, Treatment With Noninvasive Positive Pressure Ventilation
Interventions
High-flow humidified nasal oxygen delivery system, Standard oxygen therapy
Device
Lead sponsor
Tufts Medical Center
Other
Eligibility
18 Years and older
Enrollment
47 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2016
U.S. locations
2
States / cities
Boston, Massachusetts • Winchester, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 2, 2024 · Synced Jun 11, 2026, 9:35 AM EDT
Completed Not applicable Interventional Results available

Feasibility of Improving Sleep Apnea Treatment Adherence After Brain Injury

NCT04221009
View directory record Official record
Conditions
Sleep Apnea, Obstructive, Brain Injuries, Traumatic
Interventions
MI and CBT 4-session manualized intervention
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
17 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
1
States / cities
Tampa, Florida
Source: ClinicalTrials.gov public record
Updated Jul 7, 2024 · Synced Jun 11, 2026, 9:35 AM EDT
Completed Phase 1Phase 2 Interventional Results available

Stroke and CPAP Outcome Study: A Sham-controlled Trial of CPAP Among Stroke Rehabilitation Patients

NCT02551757
View directory record Official record
Conditions
Stroke, Sleep Apnea, Obstructive
Interventions
Auto-titrating CPAP, Sham-CPAP
Device
Lead sponsor
University of Washington
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2015
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Jan 12, 2021 · Synced Jun 11, 2026, 9:35 AM EDT
Not yet recruiting Not applicable Interventional

The Improving Sleep in African American Couples Study (ISAAC)

NCT07447284
View directory record Official record
Conditions
Obstructive Sleep Apnea (OSA)
Interventions
CPAP Training and Education, Virtual Disease Support Group Sessions, Couple CPAP Training and Education, Couples Virtual OSA Support Group Sessions, CPAP Tele-monitoring and Feedback, Couples' Cognitive Behavioral Therapy
Behavioral
Lead sponsor
MetroHealth Medical Center
Other
Eligibility
30 Years and older
Enrollment
440 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
2
States / cities
Cleveland, Ohio • Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 2, 2026 · Synced Jun 11, 2026, 9:35 AM EDT
Completed Not applicable Interventional Results available

Obstructive Sleep Apnea and Neurocognitive and Cardiovascular Function in Children With Down Syndrome

NCT01808508
View directory record Official record
Conditions
Down Syndrome, Obstructive Sleep Apnea Syndrome
Interventions
Continuous positive airway pressure, Sham or placebo continuous positive airway pressure
Device
Lead sponsor
Children's Hospital of Philadelphia
Other
Eligibility
8 Years to 20 Years
Enrollment
27 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2014
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Feb 7, 2016 · Synced Jun 11, 2026, 9:35 AM EDT
Completed Not applicable Interventional

Portable Monitoring for Diagnosis and Management of Sleep Apnea

NCT00642486
View directory record Official record
Conditions
Sleep Apnea, Obstructive
Interventions
Portable (Embla Embletta X30 system and Respironic REMStar Auto M series with CFlex), Standard polysomnography (PSG)
Other
Lead sponsor
Case Western Reserve University
Other
Eligibility
18 Years and older
Enrollment
373 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2010
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Aug 4, 2025 · Synced Jun 11, 2026, 9:35 AM EDT
Completed No phase listed Observational Results available

Total Shoulder Arthroplasty Near-infrared Spectroscopy

NCT02198183
View directory record Official record
Conditions
Cerebral Ischemia
Interventions
Casmed Fore-Sight Elite, Non-invasive Cardiac Output Monitor (NICOM)
Device
Lead sponsor
Hospital for Special Surgery, New York
Other
Eligibility
18 Years and older
Enrollment
34 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jan 16, 2023 · Synced Jun 11, 2026, 9:35 AM EDT
Recruiting Not applicable Interventional

Supraglottic Airway for Resuscitation Trial

NCT07150923
View directory record Official record
Conditions
Neonatal Resuscitation, Delivery Room Resuscitation, Positive Pressure Ventilation, Infant, Newborn, Supraglottic Airway, Laryngeal Mask Airways, Implementation Research
Interventions
Enhanced Standard of Care ("Enhanced"), Enhanced Standard of Care ("Enhanced-Plus")
Other
Lead sponsor
Children's Hospital of Philadelphia
Other
Eligibility
0 Days and older
Enrollment
36,503 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
30
States / cities
Birmingham, Alabama • Little Rock, Arkansas • Chula Vista, California + 25 more
Source: ClinicalTrials.gov public record
Updated Feb 26, 2026 · Synced Jun 11, 2026, 9:35 AM EDT
Completed Phase 2Phase 3 Interventional Results available

Effect of Self-Management on Improving Sleep Apnea Outcomes

NCT00310310
View directory record Official record
Conditions
Sleep Apnea Syndromes
Interventions
Sleep Apnea Self-Management Program, Usual care
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
240 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2009
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Apr 19, 2017 · Synced Jun 11, 2026, 9:35 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Effects of Continuous Positive Airway Pressure on Peripheral Oxygen Saturation, Work of Breathing, and Exercise Tolerance at Altitude

NCT05971290
View directory record Official record
Conditions
Hypoxemia, Altitude Hypoxia
Interventions
Continuous positive airway pressure, Ambient air
Device
Lead sponsor
University of Colorado, Denver
Other
Eligibility
18 Years to 70 Years
Enrollment
25 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023
U.S. locations
1
States / cities
Denver, Colorado
Source: ClinicalTrials.gov public record
Updated Aug 1, 2023 · Synced Jun 11, 2026, 9:35 AM EDT
Completed Phase 1 Interventional

Trial of Early Noninvasive Ventilation for Amyotrophic Lateral Sclerosis (ALS)

NCT00580593
View directory record Official record
Conditions
Amyotrophic Lateral Sclerosis
Interventions
BiPAP® S/T System, sham-NIPPV
Device · Other
Lead sponsor
University of Michigan
Other
Eligibility
18 Years to 79 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2012
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Jul 9, 2013 · Synced Jun 11, 2026, 9:35 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Health Coaching for Positive Airway Pressure Adherence

NCT04067128
View directory record Official record
Conditions
Sleep Apnea
Interventions
Health coaching
Behavioral
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years and older
Enrollment
131 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Aug 27, 2019 · Synced Jun 11, 2026, 9:35 AM EDT
Completed Not applicable Interventional

Effect of CPAP (Continuous Positive Airway Pressure) on Lung Function in Asthmatics With Sleep Apnea

NCT00238069
View directory record Official record
Conditions
Asthma, Sleep Apnea
Interventions
CPAP machine as a result of sleep study
Device
Lead sponsor
National Jewish Health
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2005
U.S. locations
1
States / cities
Denver, Colorado
Source: ClinicalTrials.gov public record
Updated Mar 28, 2017 · Synced Jun 11, 2026, 9:35 AM EDT
Not listed Not applicable Interventional

The Impact of Daily Sinus Irrigation on Nasal Symptoms in Continuous Positive Airway Pressure (CPAP) Users - A Pilot Study

NCT01121445
View directory record Official record
Conditions
Obstructive Sleep Apnea
Interventions
NeilMed nose and sinus irrigation
Device
Lead sponsor
Bridgeport Hospital
Other
Eligibility
18 Years to 90 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2011
U.S. locations
1
States / cities
Bridgeport, Connecticut
Source: ClinicalTrials.gov public record
Updated May 11, 2010 · Synced Jun 11, 2026, 9:35 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Cognitive Behavioral Therapy to Increase CPAP Adherence in Veterans With PTSD

NCT02641496
View directory record Official record
Conditions
Obstructive Sleep Apnea, PTSD, Posttraumatic Stress Disorder
Interventions
CBT-OSA, Sleep Education
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years to 99 Years
Enrollment
76 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2023
U.S. locations
1
States / cities
Palo Alto, California
Source: ClinicalTrials.gov public record
Updated Jul 28, 2024 · Synced Jun 11, 2026, 9:35 AM EDT
Completed Not applicable Interventional

Nasal Mask Ventilation During the Induction of General Anesthesia

NCT01651286
View directory record Official record
Conditions
Mechanical Ventilation Complication, Upper Airway Obstruction
Interventions
nasal mask, full face mask
Procedure
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 65 Years
Enrollment
52 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2013
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jan 17, 2017 · Synced Jun 11, 2026, 9:35 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Use of Non-Invasive Positive Pressure Ventilation in Patients With Severe Obesity Undergoing Upper Endoscopy Procedures

NCT03529461
View directory record Official record
Conditions
Severe Obesity, Hypoxia
Interventions
Non-invasive positive pressure ventilation through nasal mask, Rescue non-invasive positive pressure ventilation through nasal mask, Secondary rescue maneuvers
Device · Other
Lead sponsor
Bristol Hospital
Other
Eligibility
18 Years to 65 Years
Enrollment
56 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
1
States / cities
Bristol, Connecticut
Source: ClinicalTrials.gov public record
Updated May 30, 2019 · Synced Jun 11, 2026, 9:35 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effect of PEEP on TRJV in Mechanically Intubated Pediatric Patients

NCT06229886
View directory record Official record
Conditions
Tricuspid Regurgitation, Mechanical Ventilation Pressure High, Pediatric Respiratory Diseases
Interventions
Application of positive-end-expiratory pressure
Other
Lead sponsor
Northwell Health
Other
Eligibility
3 Months to 18 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
New Hyde Park, New York
Source: ClinicalTrials.gov public record
Updated Sep 25, 2024 · Synced Jun 11, 2026, 9:35 AM EDT
Completed Not applicable Interventional

Promoting the Use of CPAP Therapy Among OSA Patients

NCT04372329
View directory record Official record
Conditions
Obstructive Sleep Apnea
Interventions
CPAP4HealthySleep system
Behavioral
Lead sponsor
Sarah Alismail
Other
Eligibility
18 Years and older
Enrollment
59 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
1
States / cities
Claremont, California
Source: ClinicalTrials.gov public record
Updated Aug 17, 2022 · Synced Jun 11, 2026, 9:35 AM EDT
Completed Not applicable Interventional Results available

High Intensity Non-Invasive Positive Pressure Ventilation (HINPPV)

NCT01214200
View directory record Official record
Conditions
Chronic Obstructive Pulmonary Disease (COPD)
Interventions
Bilevel positive airway pressure (BiPAP)
Device
Lead sponsor
Philips Respironics
Industry
Eligibility
Up to 80 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2012
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jan 1, 2019 · Synced Jun 11, 2026, 9:35 AM EDT