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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Post Operative Pain Clear all
Not listed Not applicable Interventional Accepts healthy volunteers

Microcurrent Stimulation Reduces Post-Operative Swelling and Healing Time Following Knee Replacement Surgery

NCT02623660
View directory record Official record
Conditions
Osteoarthritis of Knee, Edema, Wounds and Injuries
Interventions
ODIN1, Standard Care, Diagnostic Device Testing
Device · Other
Lead sponsor
Bioelectric Research Corporation
Industry
Eligibility
18 Years to 80 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016
U.S. locations
2
States / cities
Las Vegas, Nevada
Source: ClinicalTrials.gov public record
Updated Jan 11, 2016 · Synced Jul 21, 2026, 12:06 PM EDT
Completed Not applicable Interventional Results available

A Comparison of Postoperative Analgesic Nerve Block Ropivacaine Concentrations

NCT01556724
View directory record Official record
Conditions
Total Hip Arthroplasty, Postoperative Pain
Interventions
0.1% or 0.2% ropivacaine nerve blocks
Drug
Lead sponsor
Sylvia Wilson
Other
Eligibility
18 Years to 75 Years
Enrollment
41 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2014
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jan 16, 2018 · Synced Jul 21, 2026, 12:06 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

Intrathecal Hydromorphone for Pain Control After Cesarean Section

NCT02096003
View directory record Official record
Conditions
Pain, Cesarean Section
Interventions
Intrathecal morphine, Intrathecal hydromorphone
Drug
Lead sponsor
Icahn School of Medicine at Mount Sinai
Other
Eligibility
18 Years to 40 Years · Female only
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2017
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Aug 19, 2019 · Synced Jul 21, 2026, 12:06 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

Ambulatory Gynecologic Surgery: Finding the Optimal Opioid Prescription

NCT03588910
View directory record Official record
Conditions
Surgery
Interventions
Acetaminophen, Ibuprofen 600 mg, Oxycodone
Drug
Lead sponsor
Montefiore Medical Center
Other
Eligibility
18 Years and older · Female only
Enrollment
120 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
1
States / cities
The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Aug 12, 2021 · Synced Jul 21, 2026, 12:06 PM EDT
Not yet recruiting Phase 4 Interventional

RCT: Suzetrigine vs Norco for Post-op Pain

NCT07195669
View directory record Official record
Conditions
Pain Control
Interventions
Suzetrigine (SUZ), Norco
Drug
Lead sponsor
Jacob Lensing
Other
Eligibility
18 Years to 45 Years
Enrollment
76 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
New Orleans, Louisiana
Source: ClinicalTrials.gov public record
Updated Sep 28, 2025 · Synced Jul 21, 2026, 12:06 PM EDT
Completed No phase listed Observational

Ultrasound Image Quality of the Brachial Plexus at the Interscalene Space Before and After Shoulder Arthroscopy

NCT03657173
View directory record Official record
Conditions
Pain, Postoperative
Interventions
Not listed
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Jan 29, 2019 · Synced Jul 21, 2026, 12:06 PM EDT
Completed Phase 2Phase 3 Interventional Results available

The Use of Cannabidiol (CBD) in Pain Reduction and Opioid Use After Shoulder Arthroscopy

NCT04672252
View directory record Official record
Conditions
Pain, Postoperative
Interventions
CBD Oral Disintegrating Tablet (ODT), Placebo ODT
Drug · Other
Lead sponsor
NYU Langone Health
Other
Eligibility
18 Years to 75 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Mar 6, 2023 · Synced Jul 21, 2026, 12:06 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Virtual Reality Treatment for Phantom Limb Pain

NCT03338842
View directory record Official record
Conditions
Lower Limb Amputation Above Knee (Injury), Lower Limb Amputation Below Knee (Injury), Phantom Limb Pain
Interventions
Distractor and Lower limb VR
Device
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years and older
Enrollment
14 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jun 15, 2020 · Synced Jul 21, 2026, 12:06 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Latinx Children and Surgery

NCT06020677
View directory record Official record
Conditions
Pain, Postoperative, Pain, Acute
Interventions
L-WebTIPS
Other
Lead sponsor
University of California, Irvine
Other
Eligibility
2 Years to 7 Years
Enrollment
120 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2027
U.S. locations
1
States / cities
Orange, California
Source: ClinicalTrials.gov public record
Updated Apr 13, 2026 · Synced Jul 21, 2026, 12:06 PM EDT
Completed Phase 4 Interventional Results available

Liposomal Bupivacaine for Post Operative Pain After Knee Replacement Surgery

NCT02274870
View directory record Official record
Conditions
Post-operative Pain
Interventions
Liposome Bupivacaine, Bupivacaine HCl
Drug
Lead sponsor
Northwell Health
Other
Eligibility
18 Years to 74 Years
Enrollment
65 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2017
U.S. locations
1
States / cities
Valley Stream, New York
Source: ClinicalTrials.gov public record
Updated Jun 13, 2018 · Synced Jul 21, 2026, 12:06 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Drug Interactions Between Morphine and Orally or IV Administered Acetaminophen

NCT02848729
View directory record Official record
Conditions
Pain
Interventions
Oral Acetaminophen, IV Acetaminophen, IV Morphine, Placebo Tablets, Saline
Drug
Lead sponsor
Mallinckrodt
Industry
Eligibility
18 Years to 55 Years
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016
U.S. locations
3
States / cities
Tucson, Arizona • Naples, Florida • Kingston, Rhode Island
Source: ClinicalTrials.gov public record
Updated Feb 4, 2020 · Synced Jul 21, 2026, 12:06 PM EDT
Not listed Phase 2 Interventional

Study to Determine if Pre- and Post- Operative TAP Catheters With Ropivacaine Versus Placebo Affects Anesthetic, Narcotic Dosing, and Pain Scores

NCT03149783
View directory record Official record
Conditions
Pain, Postoperative, Delirium, Anesthesia, Local
Interventions
Ropivacaine HCL, sodium chloride
Drug
Lead sponsor
University of Colorado, Denver
Other
Eligibility
50 Years and older
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2021
U.S. locations
1
States / cities
Denver, Colorado
Source: ClinicalTrials.gov public record
Updated May 26, 2021 · Synced Jul 21, 2026, 12:06 PM EDT
Completed Phase 4 Interventional Results available

ICE-T Pain Regimen for Total Laparoscopic Hysterectomy

NCT03987022
View directory record Official record
Conditions
Opioid Substitution Treatment
Interventions
Ketorolac, Opioids, Ice Packs, Tylenol, Motrin, Dilaudid Injectable Product, Percocet 5Mg-325Mg Tablet
Drug · Other
Lead sponsor
MetroHealth Medical Center
Other
Eligibility
18 Years to 80 Years · Female only
Enrollment
66 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Jan 23, 2025 · Synced Jul 21, 2026, 12:06 PM EDT
Enrolling by invitation Phase 3 Interventional Accepts healthy volunteers

RCT to Test Regional Anesthesia Effect on Decreased Opiate Use

NCT06989866
View directory record Official record
Conditions
Postoperative Pain
Interventions
Bupivacaine, Saline (NaCl 0,9 %) (placebo)
Drug
Lead sponsor
United States Naval Medical Center, Portsmouth
Federal
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2026
U.S. locations
1
States / cities
Portsmouth, Virginia
Source: ClinicalTrials.gov public record
Updated Oct 8, 2025 · Synced Jul 21, 2026, 12:06 PM EDT
Completed Not applicable Interventional

Effects of Spinal Cord Stimulation on Sensory Perceptions of Chronic Pain Patients

NCT02837822
View directory record Official record
Conditions
Chronic Pain, Complex Regional Pain Syndrome, Failed Back Surgery Syndrome
Interventions
Spinal cord stimulator, Implantation of a spinal cord stimulator
Device · Procedure
Lead sponsor
CHU de Quebec-Universite Laval
Other
Eligibility
18 Years and older
Enrollment
38 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2018
U.S. locations
1
States / cities
Toledo, Ohio
Source: ClinicalTrials.gov public record
Updated Jul 16, 2018 · Synced Jul 21, 2026, 12:06 PM EDT
Recruiting Phase 2 Interventional

Supplemental Postoperative Bupivacaine Following Non-Surgical Endodontic Treatment

NCT06655454
View directory record Official record
Conditions
Pain Assessment, Quality of Life (QOL), Analgesic Use
Interventions
Supplemental Postoperative Bupivacaine, Placebo Injection
Drug
Lead sponsor
New York University
Other
Eligibility
18 Years and older
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Apr 12, 2026 · Synced Jul 21, 2026, 12:06 PM EDT
Withdrawn Not applicable Interventional

Pectoral Nerves Block to Relieve Post-sternotomy Pain After Cardiac Surgery

NCT04282239
View directory record Official record
Conditions
Pain, Postoperative, Cardiac Surgery
Interventions
PECS2 block, Ropivacaine 0.5% Injectable Solution, Lidocaine Epinephrine, Dexmedetomidine 0.004 MG/ML
Procedure · Drug
Lead sponsor
NYU Langone Health
Other
Eligibility
19 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Mineola, New York
Source: ClinicalTrials.gov public record
Updated Dec 28, 2021 · Synced Jul 21, 2026, 12:06 PM EDT
Not listed No phase listed Observational

Pilot Study Evaluating Neuro-Imaging Correlates of Epigenetic Finding in Prediction of Chronic Postsurgical Pain

NCT04681183
View directory record Official record
Conditions
Chronic Post-surgical Pain
Interventions
Not listed
Lead sponsor
Children's Hospital Medical Center, Cincinnati
Other
Eligibility
8 Years and older
Enrollment
13 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2024
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Mar 12, 2024 · Synced Jul 21, 2026, 12:06 PM EDT
Terminated Not applicable Interventional Results available

Liposomal Bupivacaine in Implant Based Breast Reconstruction

NCT02659501
View directory record Official record
Conditions
Breast Cancer, Postoperative Pain
Interventions
Liposomal bupivacaine, Bupivacaine with epinephrine, Morphine sulfate, Hydrocodone/acetaminophen, Diazepam
Drug
Lead sponsor
Loma Linda University
Other
Eligibility
18 Years to 99 Years · Female only
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2017
U.S. locations
1
States / cities
Loma Linda, California
Source: ClinicalTrials.gov public record
Updated Jan 11, 2021 · Synced Jul 21, 2026, 12:06 PM EDT
Withdrawn Phase 3 Interventional Accepts healthy volunteers

Efficacy of Transversus Abdominis Plane Block for Laparoscopic Cholecystectomy

NCT02712151
View directory record Official record
Conditions
Pain, Postoperative
Interventions
Abdominal Wall Block, Surgical infiltration, Sterile saline, Ropivacaine 0.2%, Ultrasound, Ropivacaine 0.5%
Procedure · Drug · Device
Lead sponsor
Boston Children's Hospital
Other
Eligibility
5 Years to 17 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2026
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 7, 2024 · Synced Jul 21, 2026, 12:06 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

A Phase 2 Study to Evaluate Pregabalin and Acetaminophen Compared to Acetaminophen and Placebo in Subjects Undergoing Bunionectomy

NCT04495283
View directory record Official record
Conditions
Postoperative Pain
Interventions
Pregabalin, Acetaminophen, Placebo 1, Placebo 2
Drug · Other
Lead sponsor
Nevakar, Inc.
Industry
Eligibility
18 Years to 65 Years
Enrollment
87 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020
U.S. locations
2
States / cities
Pasadena, California • Bellaire, Texas
Source: ClinicalTrials.gov public record
Updated Nov 22, 2021 · Synced Jul 21, 2026, 12:06 PM EDT
Completed Phase 3 Interventional Accepts healthy volunteers Results available

Opioid Analgesic Reduction Study (OARS) - Pilot

NCT05283499
View directory record Official record
Conditions
Post Operative Pain
Interventions
OPIOID, NON-OPIOID
Drug
Lead sponsor
Rutgers, The State University of New Jersey
Other
Eligibility
18 Years to 99 Years
Enrollment
53 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2021
U.S. locations
5
States / cities
Chicago, Illinois • Baltimore, Maryland • Ann Arbor, Michigan + 2 more
Source: ClinicalTrials.gov public record
Updated Jun 5, 2023 · Synced Jul 21, 2026, 12:06 PM EDT
Recruiting Not applicable Interventional

Home-based Rehabilitation Intervention for Phantom Limb Pain in Veterans With Lower Limb Amputations

NCT06106984
View directory record Official record
Conditions
Phantom Limb Pain
Interventions
Graded motor imagery mobile app
Device
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years to 89 Years
Enrollment
36 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2029
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Oct 28, 2025 · Synced Jul 21, 2026, 12:06 PM EDT
Completed Not applicable Interventional Results available

Efficacy of Fascia Iliaca Block Versus Intraoperative Nerve Infiltration During Anterior Hip Replacement Surgery

NCT01693900
View directory record Official record
Conditions
Pain, Postoperative
Interventions
Pre-operative Ultrasound FICB Group, Intra-operative FICB Group
Procedure
Lead sponsor
Randy Fayne, DO
Other
Eligibility
18 Years to 65 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2015
U.S. locations
1
States / cities
Royal Oak, Michigan
Source: ClinicalTrials.gov public record
Updated Feb 14, 2018 · Synced Jul 21, 2026, 12:06 PM EDT