- Conditions
- Postoperative Delirium, Postoperative Cognitive Dysfunction
- Interventions
- CN-105, Placebo
- Drug
- Lead sponsor
- Miles Berger, MD PhD
- Other
- Eligibility
- 60 Years and older
- Enrollment
- 203 participants
- Healthy volunteers
- Accepts healthy volunteers
- Timeline
- 2018 – 2022
- U.S. locations
- 1
- States / cities
- Durham, North Carolina
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Showing 1–14
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- Conditions
- Post-Operative Cognitive Decline in Older Adults
- Interventions
- Magnetic Resonance Imaging, Cognitive assessment testing
- Other · Behavioral
- Lead sponsor
- University of Florida
- Other
- Eligibility
- 60 Years and older
- Enrollment
- 147 participants
- Healthy volunteers
- Accepts healthy volunteers
- Timeline
- 2013 – 2018
- U.S. locations
- 1
- States / cities
- Gainesville, Florida
- Conditions
- Lumbar Spondylosis, Cervical Spondylosis, Hip Osteoarthritis, Knee Osteoarthritis
- Interventions
- inhalation anesthesia with isoflurane vs. TIVA with propofol
- Drug
- Lead sponsor
- Duke University
- Other
- Eligibility
- 65 Years and older
- Enrollment
- 200 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2008 – 2013
- U.S. locations
- 2
- States / cities
- Durham, North Carolina
- Conditions
- Postoperative Cognitive Dysfunction
- Interventions
- Midazolam (0.02mg/kg)
- Drug
- Lead sponsor
- University of Alabama at Birmingham
- Other
- Eligibility
- 55 Years and older
- Enrollment
- 20 participants
- Healthy volunteers
- Accepts healthy volunteers
- Timeline
- 2015 – 2020
- U.S. locations
- 1
- States / cities
- Birmingham, Alabama
- Conditions
- Delayed Emergence From Anesthesia, Postoperative Delirium, Postoperative Cognitive Dysfunction
- Interventions
- Functional magnetic resonance imaging
- Procedure
- Lead sponsor
- Icahn School of Medicine at Mount Sinai
- Other
- Eligibility
- 40 Years to 80 Years
- Enrollment
- 104 participants
- Healthy volunteers
- Accepts healthy volunteers
- Timeline
- 2015 – 2020
- U.S. locations
- 1
- States / cities
- New York, New York
- Conditions
- Neurocognitive Disorders, Postoperative Cognitive Dysfunction
- Interventions
- Brain Imaging, Cognitive Testing, Blood Biomarkers
- Diagnostic Test
- Lead sponsor
- University of California, Los Angeles
- Other
- Eligibility
- 65 Years to 75 Years
- Enrollment
- 32 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2020 – 2024
- U.S. locations
- 1
- States / cities
- Los Angeles, California
- Conditions
- Post-operative Cognitive Decline, Post-operative Delirium
- Interventions
- Aspart insulin, Normal saline, Intranasal mucosal atomizer device
- Drug · Device
- Lead sponsor
- Albert Einstein College of Medicine
- Other
- Eligibility
- 65 Years and older
- Enrollment
- 22 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2012 – 2014
- U.S. locations
- 1
- States / cities
- The Bronx, New York
- Conditions
- Postoperative Delirium, Postoperative Cognitive Dysfunction
- Interventions
- fMRI, Montreal Cognitive Assessment (MoCA), Digital Clock Drawing Test Command and Copy, Wide Range Achievement Test reading subtest, Hopkins Verbal Learning Test (HVLT), General Depression Scale (GDS)
- Behavioral
- Lead sponsor
- University of Florida
- Other
- Eligibility
- 65 Years to 99 Years
- Enrollment
- 2 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2017 – 2019
- U.S. locations
- 1
- States / cities
- Gainesville, Florida
- Conditions
- Post-Operative Delirium, Postoperative Cognitive Dysfunction
- Interventions
- SctO2 < 60 %.
- Procedure
- Lead sponsor
- Icahn School of Medicine at Mount Sinai
- Other
- Eligibility
- 65 Years and older
- Enrollment
- 15 participants
- Healthy volunteers
- Accepts healthy volunteers
- Timeline
- 2009 – 2010
- U.S. locations
- 1
- States / cities
- New York, New York
- Conditions
- Delirium, Postoperative Delirium, Cognitive Impairment
- Interventions
- Not listed
- Lead sponsor
- Stanford University
- Other
- Eligibility
- 65 Years and older
- Enrollment
- 250 participants
- Healthy volunteers
- Accepts healthy volunteers
- Timeline
- 2024
- U.S. locations
- 1
- States / cities
- Palo Alto, California
- Conditions
- Postoperative Complications, Delirium
- Interventions
- Donepezil
- Drug
- Lead sponsor
- Indiana University Health
- Other
- Eligibility
- 65 Years and older
- Enrollment
- 30 participants
- Healthy volunteers
- Accepts healthy volunteers
- Timeline
- 2004 – 2007
- U.S. locations
- 1
- States / cities
- Indianapolis, Indiana
- Conditions
- 1. Postoperative Cognitive Dysfunction
- Interventions
- The intervention will be Mini-Mental Status Examination (MMSE)
- Other
- Lead sponsor
- Loma Linda University
- Other
- Eligibility
- 65 Years and older
- Enrollment
- 110 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2010 – 2014
- U.S. locations
- 1
- States / cities
- Loma Linda, California
- Conditions
- Neurocognitive Disorders, Anesthesia, Post-operative Delirium, Post-operative Cognitive Dysfunction
- Interventions
- Sevoflurane, Propofol
- Drug
- Lead sponsor
- Oregon Health and Science University
- Other
- Eligibility
- 70 Years to 110 Years
- Enrollment
- 260 participants
- Healthy volunteers
- Accepts healthy volunteers
- Timeline
- 2023 – 2027
- U.S. locations
- 1
- States / cities
- Portland, Oregon
- Conditions
- Cognitive Impairment, Frail Elderly Syndrome
- Interventions
- Mini Cog
- Other
- Lead sponsor
- Brigham and Women's Hospital
- Other
- Eligibility
- 70 Years and older
- Enrollment
- 229 participants
- Healthy volunteers
- Accepts healthy volunteers
- Timeline
- 2017 – 2019
- U.S. locations
- 1
- States / cities
- Boston, Massachusetts