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Conditions: Reperfusion Injury, Liver Injury
Interventions: inhaled nitric oxide, nitrogen gas; Drug
Lead sponsor: University of Alabama at Birmingham; Other
Eligibility: 19 Years to 80 Years
Enrollment: 80 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2012
U.S. locations: 2
States / cities: Birmingham, Alabama • Seattle, Washington

Conditions: Atrial Fibrillation, Postoperative, Postoperative Complications, Inflammation
Interventions: Transcutaneous Low-Level Vagal Nerve Stimulation (LLVNS), Sham LLVNS; Device
Lead sponsor: Duke University; Other
Eligibility: 40 Years to 90 Years
Enrollment: 2 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2020
U.S. locations: 1
States / cities: Durham, North Carolina

Conditions: Sepsis, Respiratory Failure, Renal Failure, Surgical Site Infection
Interventions: Novolin R (human recombinant Insulin); Drug
Lead sponsor: Genesys; Other
Eligibility: 18 Years and older
Enrollment: 317 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2003 – 2005
U.S. locations: 1
States / cities: Grand Blanc, Michigan

Conditions: Postoperative Complications
Interventions: Risk estimation; Other
Lead sponsor: University of Florida; Other
Eligibility: 18 Years to 100 Years
Enrollment: 200 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2028
U.S. locations: 2
States / cities: Gainesville, Florida • Jacksonville, Florida

Conditions: Inflammatory Bowel Diseases, Short Bowel Syndrome, Ileostomy - Stoma
Interventions: amino acid mixture beverage, glucose-based sports drink; Other
Lead sponsor: Entrinsic Bioscience Inc.; Industry
Eligibility: 18 Years and older
Enrollment: 7 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2021
U.S. locations: 3
States / cities: Boston, Massachusetts • Nashua, New Hampshire • Chapel Hill, North Carolina

Conditions: Surgery
Interventions: atenolol, placebo; Drug
Lead sponsor: Saini Foundation; Other
Eligibility: 18 Years and older
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2002 – 2008
U.S. locations: 1
States / cities: Hyannis, Massachusetts

Conditions: Inflammation Eye Pain, Postoperative Cataract
Interventions: OCS-01, Vehicle; Drug
Lead sponsor: Oculis; Industry
Eligibility: 18 Years and older
Enrollment: 117 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2024
U.S. locations: 24
States / cities: Glendale, California • Inglewood, California • Newport Beach, California + 21 more

Conditions: Colchicine, Inflammation in Cardiac Surgery, Post Operative Atrial Fibrillation, Inflammatory Markers, Colchicine Adverse Reaction
Interventions: Colchicine (Colcrys®), Placebo; Drug
Lead sponsor: Ayesha Ather; Other
Eligibility: 18 Years to 99 Years
Enrollment: 24 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026
U.S. locations: 1
States / cities: Lexington, Kentucky

Conditions: Edematous, Synovitis, Foreign Body Reaction, Osteolysis
Interventions: Placebo, Apatone®B; Drug
Lead sponsor: IC-MedTech Corporation; Industry
Eligibility: 50 Years to 85 Years
Enrollment: 57 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2010 – 2015
U.S. locations: 1
States / cities: Akron, Ohio

Conditions: Complications; Arthroplasty, Infection or Inflammation, Wound Complication
Interventions: PREVENA; Device
Lead sponsor: University of North Carolina, Chapel Hill; Other
Eligibility: 18 Years and older
Enrollment: 16 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2017
U.S. locations: 1
States / cities: Chapel Hill, North Carolina

Conditions: Spinal Fusion, Hyperglycemia, Postoperative Pain Management, Postoperative Care, Spine Disease, Neurologic Deficits, Neurological Disorder, Inflammation, Spine Condition, Spinal (Fusion) Surgery, Cytokine Levels, Spine Fusion
Interventions: Auricular vagus nerve stimulation, Sham Auricular Vagus nerve Stimulation; Device
Lead sponsor: Alexander T. Yahanda; Other
Eligibility: 18 Years and older
Enrollment: 50 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2027
U.S. locations: 1
States / cities: St Louis, Missouri

Conditions: Seroma
Interventions: Microporous Polysaccharide Hemospheres (MPH); Device
Lead sponsor: Memorial Health University Medical Center; Other
Eligibility: 18 Years and older · Female only
Enrollment: 50 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2015
U.S. locations: 1
States / cities: Savannah, Georgia

Conditions: Cataract
Interventions: Dexycu intracameral dexamethasone, Prednisolone Acetate; Drug
Lead sponsor: Research Insight LLC; Industry
Eligibility: 18 Years and older
Enrollment: 31 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2020
U.S. locations: 2
States / cities: Laguna Hills, California • Garden City, New York

Conditions: Postoperative Delirium, Postoperative Cognitive Dysfunction
Interventions: CN-105, Placebo; Drug
Lead sponsor: Miles Berger, MD PhD; Other
Eligibility: 60 Years and older
Enrollment: 203 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018 – 2022
U.S. locations: 1
States / cities: Durham, North Carolina

Conditions: Wounds and Injuries
Interventions: Leukoreduced blood transfusion; Procedure
Lead sponsor: University of Washington; Other
Eligibility: 18 Years and older
Enrollment: 300 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2003 – 2004
U.S. locations: 1
States / cities: Seattle, Washington

Conditions: Surgical Wound Infection, Cystitis, Bacteremia, Pneumonia, Enterocolitis, Pseudomembranous
Interventions: Synbiotic 2000; Drug
Lead sponsor: Beth Israel Medical Center; Other
Eligibility: Not listed
Enrollment: 40 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2005 – 2007
U.S. locations: 1
States / cities: New York, New York

Conditions: Respiratory Failure, Respiratory Arrest, Respiratory Distress Syndrome, Acute Respiratory Failure, Acute Respiratory Failure With Hypoxia, Acute Respiratory Failure With Hypercapnia, Acute Respiratory Failure Post Surgical, Acute Respiratory Failure Postprocedural, Acute Respiratory Failure Following Trauma and Surgery, Acute Respiratory Failure Requiring Reintubation, Acute Respiratory Failure Post Traumatic, Acute Respiratory Decompensation, Shock, Shock, Septic, Shock, Cardiogenic, Acute Cardiac Failure, Multi Organ Failure, Acute Kidney Failure
Interventions: Observational retrospective cohort to describe data validity; and Data reliability; and Completeness of the data; Other
Lead sponsor: Efficacy Care R&D Ltd; Industry
Eligibility: 18 Years to 90 Years
Enrollment: 50,000 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2020
U.S. locations: 1
States / cities: Houston, Texas

Conditions: Cataract
Interventions: Dexamethasone Drug Delivery System, Placebo Drug Delivery System; Drug
Lead sponsor: Allergan; Industry
Eligibility: 18 Years and older
Enrollment: 8 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012
U.S. locations: 1
States / cities: Newport Beach, California

Conditions: Postoperative Complications, Inflammation, Glaucoma, Open-Angle
Interventions: Not listed
Lead sponsor: University of Pittsburgh; Other
Eligibility: 18 Years to 95 Years
Enrollment: 1 participant
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2006 – 2007
U.S. locations: 1
States / cities: Pittsburgh, Pennsylvania

Conditions: Keratoconus, Unstable, Collagen Crosslinking, Postoperative Pain
Interventions: Dextenza, Prednisolone Acetate; Drug
Lead sponsor: Sight Medical Doctors PLLC; Other
Eligibility: 18 Years and older
Enrollment: 20 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2023
U.S. locations: 1
States / cities: Babylon, New York

Conditions: Amputation, Amputation; Postoperative, Sequelae, Wound Dehiscence, Seroma, Wound Infection, Surgical, Lymph Leakage
Interventions: PREVENA™ PEEL & PLACE™ Dressing Kit; Device
Lead sponsor: Thomas Jefferson University; Other
Eligibility: 18 Years and older
Enrollment: 272 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2024
U.S. locations: 2
States / cities: Valhalla, New York • Philadelphia, Pennsylvania

Conditions: Abdomen Hernia
Interventions: Prevena, Prineo, Traditional; Device · Drug
Lead sponsor: Ohio State University; Other
Eligibility: 18 Years and older
Enrollment: 300 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2028
U.S. locations: 1
States / cities: Columbus, Ohio

Conditions: Cataracts
Interventions: heparin-surface modified intraocular lens; Device
Lead sponsor: National Eye Institute (NEI); NIH
Eligibility: Not listed
Enrollment: 80 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 1992 – 2001
U.S. locations: 1
States / cities: Bethesda, Maryland

Conditions: Atrial Fibrillation
Interventions: Placebo, Ramipril, Spironolactone; Drug
Lead sponsor: Vanderbilt University; Other
Eligibility: 18 Years to 80 Years
Enrollment: 455 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2005 – 2010
U.S. locations: 1
States / cities: Nashville, Tennessee

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Study to Evaluate if Inhaled Nitric Oxide Improves Liver Function After Transplantation

Transcutaneous Autonomic Modulation in Thoracic Surgery

The Effect of Intensive Insulin Therapy in the Surgical Critical Care Unit

Integrating Data, Algorithms and Clinical Reasoning for Surgical Risk Assessment

Effects of an Amino Acid Mixture on Gastrointestinal Function, Inflammation and Fluid Balance: A Pilot Study in Patients With Inflammatory Bowel Disease

Perioperative Effect of Atenolol on Cytokine Profiles

A Phase 3 Study Evaluating the Efficacy and Safety of OCS-01 Opthalmic Suspension Compared to Vehicle for the Treatment of Ocular Inflammation and Pain Following Cataract Surgery

Colchicine's Effect on Inflammatory Markers

Double-Blinded Clinical Trial Using Apatone®B for Symptomatic Postoperative Total Joint Replacements

Improvement in Wound Healing With Negative Pressure Wound Therapy for Postoperative Total Hip Arthroplasty

Trans-Auricular Stimulation for Postoperative Inflammation in Spine Surgery

The Effect of Arista on Post-Operative Bleeding and Wound Drainage Following Mastectomy

A Prospective Clinical Study Evaluating Dexycu vs Prednisolone Acetate 1%

Modulating ApoE Signalling to Reduce Brain Inflammation, deLirium and postopErative Cognitive Dysfunction

Effect of Leukoreduced Blood Transfusions on Infection Following Trauma

The Role of Synbiotics in Reducing Post-Operative Infections in Patients Undergoing Cardiac Surgery: A Pilot Study

Postoperative Respiratory Abnormalities

A Safety and Efficacy Study of a Dexamethasone Drug Delivery System for Postoperative Inflammation and Pain After Cataract Surgery

Trial Comparing Ketorolac Tromethamine 0.4% & Prednisolone Acetate 1% in Reducing Post-SLT Anterior Chamber Flare & Cells

Intracanalicular Dexamethasone Insert for Post-Corneal Cross-Linking Inflammation and Pain- The LINK Study

Evaluation of Closed Incision Negative Pressure Dressing (PREVENA) to Prevent Lower Extremity Amputation Wound Complications

The Effects of Post-Operative Interventions on Surgical Site Occurrences in AWR

Modified Intraocular Lens to Reduce Eye Inflammation After Cataract Surgery in Uveitis Patients

Renin-angiotensin-aldosterone System (RAAS), Inflammation, and Post-Operative Atrial Fibrillation (AF)