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ClinicalTrials.gov public records Last synced Oct 20, 2026, 5:00 PM EDT

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Showing 25–48 of 1,844 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Post-Operative Pain Clear all
Not yet recruiting Phase 1 Interventional Accepts healthy volunteers

Effectiveness of Bupivacaine, Ketorolac, Ketamine, vs Bupivacaine Alone in Reducing Postoperative Pocket Pain

NCT05575999
View directory record Official record
Conditions
Pain Management
Interventions
Bupivacaine alone OR Bupivacaine-Ketorolac-Ketamine (BKK) Combination
Drug
Lead sponsor
Kansas City Heart Rhythm Research Foundation
Other
Eligibility
18 Years and older
Enrollment
200 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026
U.S. locations
3
States / cities
Loma Linda, California • Overland Park, Kansas
Source: ClinicalTrials.gov public record
Updated Aug 28, 2025 · Synced Oct 20, 2026, 5:00 PM EDT
Completed Phase 3 Interventional Results available

Evaluation of Preoperative N1539 in Total Knee Arthroplasty

NCT03434275
View directory record Official record
Conditions
Pain, Postoperative
Interventions
N1539, Placebo
Drug
Lead sponsor
Baudax Bio
Industry
Eligibility
35 Years to 80 Years
Enrollment
194 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
6
States / cities
Florence, Alabama • Mobile, Alabama • Sheffield, Alabama + 3 more
Source: ClinicalTrials.gov public record
Updated May 25, 2023 · Synced Oct 20, 2026, 5:00 PM EDT
Completed Not applicable Interventional

Lumbar Plexus Block Versus Quadratus Lumborum Block for Primary Anterior Total Hip Arthroplasty

NCT03409900
View directory record Official record
Conditions
Osteoarthritis, Total Hip Arthroplasty
Interventions
LPB, QLB
Other
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years to 95 Years
Enrollment
44 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated May 12, 2020 · Synced Oct 20, 2026, 5:00 PM EDT
Not listed Phase 4 Interventional Accepts healthy volunteers

Pain Control After Lumbar Spine Fusion

NCT06484192
View directory record Official record
Conditions
Spine Fusion, NSAID (Non-Steroidal Anti-Inflammatory Drug), Postoperative Pain
Interventions
Naproxen 500 Mg, Ketorolac, OxyCODONE 5 mg Oral Tablet, Metaxalone 800 MG
Drug
Lead sponsor
Rothman Institute Orthopaedics
Other
Eligibility
18 Years and older
Enrollment
428 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jul 3, 2024 · Synced Oct 20, 2026, 5:00 PM EDT
Not listed Phase 2 Interventional

Evaluating Efficacy of the Dexmedetomidine Transdermal System for Postoperative Analgesia Following Abdominoplasty

NCT04242407
View directory record Official record
Conditions
Pain, Postoperative
Interventions
DMTS, Placebo
Drug
Lead sponsor
Teikoku Pharma USA, Inc.
Industry
Eligibility
18 Years and older
Enrollment
164 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
4
States / cities
Phoenix, Arizona • Bellaire, Texas • San Antonio, Texas + 1 more
Source: ClinicalTrials.gov public record
Updated Jul 23, 2020 · Synced Oct 20, 2026, 5:00 PM EDT
Terminated Not applicable Interventional

Acupressure for Pain and Opioid Use Among Breast Cancer Patients

NCT03655600
View directory record Official record
Conditions
Breast Cancer, Fatigue, Chronic Pain
Interventions
Self-administered acupressure
Other
Lead sponsor
University of Michigan
Other
Eligibility
18 Years and older · Female only
Enrollment
8 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Oct 25, 2019 · Synced Oct 20, 2026, 5:00 PM EDT
Withdrawn Not applicable Interventional

Erector Spinae Plane Blocks (ESP) for Postoperative Pain in Lumbo-sacral Spine Surgery

NCT04233736
View directory record Official record
Conditions
Erector Spinae Plane Block, Lumbar Spine Surgery
Interventions
Bilateral lumbar erector spinae plane block
Procedure
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Sep 1, 2026 · Synced Oct 20, 2026, 5:00 PM EDT
Recruiting No phase listed Observational

Characterization of Acute Pain

NCT07336264
View directory record Official record
Conditions
Acute Pain, Postoperative, Postoperative Pain, Acute Pain
Interventions
AlgometRx Nociometer
Device
Lead sponsor
Children's National Research Institute
Other
Eligibility
6 Years to 21 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
1
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated Jan 14, 2026 · Synced Oct 20, 2026, 5:00 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Psychological Distress and Outcomes in Hip Preservation Patients

NCT01550263
View directory record Official record
Conditions
Psychological Distress
Interventions
Not listed
Lead sponsor
University of Utah
Other
Eligibility
18 Years and older
Enrollment
217 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2022
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Feb 8, 2023 · Synced Oct 20, 2026, 5:00 PM EDT
Completed Phase 2 Interventional Results available

Dose-ranging Study for Postoperative Analgesia in Subjects Undergoing Primary Unilateral Inguinal Hernia Repair

NCT00485433
View directory record Official record
Conditions
Postoperative Pain
Interventions
Bupivacaine HCl, SKY0402
Drug
Lead sponsor
Pacira Pharmaceuticals, Inc
Industry
Eligibility
18 Years and older · Male only
Enrollment
98 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2008
U.S. locations
7
States / cities
Arcadia, California • Laguna Hills, California • Pasadena, California + 3 more
Source: ClinicalTrials.gov public record
Updated Mar 2, 2021 · Synced Oct 20, 2026, 5:00 PM EDT
Withdrawn Not applicable Interventional

Longitudinal Virtual Reality Use in Pediatric Surgical Procedures

NCT03832478
View directory record Official record
Conditions
Anxiety, Pain, Pain, Postoperative
Interventions
Virtual Reality Headset Given
Device
Lead sponsor
Stanford University
Other
Eligibility
5 Years to 25 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
2
States / cities
Palo Alto, California
Source: ClinicalTrials.gov public record
Updated Mar 22, 2021 · Synced Oct 20, 2026, 5:00 PM EDT
Terminated Not applicable Interventional

Stellate Ganglion Block in Head and Neck Cancer Surgery

NCT03714906
View directory record Official record
Conditions
Head and Neck Cancer, Pain, Postoperative
Interventions
Stellate ganglion block
Procedure
Lead sponsor
Augusta University
Other
Eligibility
18 Years and older
Enrollment
22 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
1
States / cities
Augusta, Georgia
Source: ClinicalTrials.gov public record
Updated Aug 29, 2023 · Synced Oct 20, 2026, 5:00 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Early Patient Removal of Urinary Catheters After Urogynecologic Surgery

NCT06344884
View directory record Official record
Conditions
Urinary Retention Postoperative, Postoperative Urinary Tract Infection, Catheter Site Pain
Interventions
Early catheter removal
Procedure
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years to 99 Years · Female only
Enrollment
128 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
1
States / cities
Raleigh, North Carolina
Source: ClinicalTrials.gov public record
Updated Jan 28, 2026 · Synced Oct 20, 2026, 5:00 PM EDT
Not listed Phase 4 Interventional Accepts healthy volunteers

Surgical Site Infiltration of Exparel vs TAP Block With Exparel in Patients Undergoing Laparotomy Via Midline Incision

NCT03870685
View directory record Official record
Conditions
Postoperative Pain, Postoperative Nausea and Vomiting, Opioid Use
Interventions
TAP Block, Surgical Site Infiltration, Exparel
Procedure · Drug
Lead sponsor
Danbury Hospital
Other
Eligibility
18 Years and older · Female only
Enrollment
43 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2021
U.S. locations
1
States / cities
Danbury, Connecticut
Source: ClinicalTrials.gov public record
Updated Jul 14, 2021 · Synced Oct 20, 2026, 5:00 PM EDT
Completed Not applicable Interventional

Mindfulness Surgical Pain Outcomes

NCT05838443
View directory record Official record
Conditions
Post Surgical Pain, Surgery
Interventions
Self-directed mindfulness utilizing a multi-sensor EEG-supported device with neurofeedback-assisted and technology-supported meditation, Provider-directed mindfulness, Conventional Care
Other
Lead sponsor
Children's Hospital Medical Center, Cincinnati
Other
Eligibility
10 Years to 18 Years
Enrollment
92 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Nov 12, 2024 · Synced Oct 20, 2026, 5:00 PM EDT
Completed Phase 1 Interventional Results available

Dose Dependent Effects of tDCS on Post-Operative Pain

NCT02241967
View directory record Official record
Conditions
Total Knee Arthroplasty (Postoperative Pain), Total Hip Arthroplasty(Postoperative Pain)
Interventions
4 Real sessions of Transcranial Direct Current Stimulation, 2 Real Sessions of Transcranial Direct Current Stimulation, 1 Real Session of Transcranial Direct Current Stimulation, Sham Transcranial Direct Current Stimulation
Device
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
19 Years to 90 Years
Enrollment
119 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2020
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Jul 13, 2022 · Synced Oct 20, 2026, 5:00 PM EDT
Terminated Phase 4 Interventional

Continuous Transversus Abdominis Plane Nerve Block for Postoperative Analgesia

NCT00944151
View directory record Official record
Conditions
Incisional Pain
Interventions
TAP Catheter and Infusion of Study Solution
Procedure
Lead sponsor
University of California, San Diego
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2010
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated May 20, 2014 · Synced Oct 20, 2026, 5:00 PM EDT
Not listed Not applicable Interventional

TAP Catheters Versus Intrathecal Morphine for Cesarean Section

NCT01593280
View directory record Official record
Conditions
Abdominal Muscles/Ultrasonography, Adult, Anesthetics, Local/Administration & Dosage, Ropivacaine/Administration & Dosage, Ropivacaine/Analogs & Derivatives, Cesarean Section, Humans, Nerve Block/Methods, Pain Measurement/Methods, Pain, Postoperative/Prevention & Control, Ultrasonography, Interventional
Interventions
TAP catheter, intrathecal morphine
Device · Drug
Lead sponsor
Stamford Anesthesiology Services, PC
Other
Eligibility
18 Years to 45 Years · Female only
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2012
U.S. locations
1
States / cities
Stamford, Connecticut
Source: ClinicalTrials.gov public record
Updated May 8, 2012 · Synced Oct 20, 2026, 5:00 PM EDT
Completed Not applicable Interventional Results available

Effect of Root Canal Treatment (Versus no Treatment) for Patients With Tooth Infections and Toothaches

NCT01870973
View directory record Official record
Conditions
Postoperative Pain
Interventions
root canal treatment, anesthesia, pain medications, and antibiotic, no root canal treatment, anesthesia, pain medications, and antibiotic
Procedure
Lead sponsor
Ohio State University
Other
Eligibility
18 Years and older
Enrollment
108 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2014
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Jun 18, 2015 · Synced Oct 20, 2026, 5:00 PM EDT
Completed Phase 3 Interventional Results available

A Trial to Evaluate CG5503 Efficacy and Safety in Acute Pain After Bunionectomy

NCT00609466
View directory record Official record
Conditions
Bunionectomy, Pain, Postoperative Pain, Acute Pain
Interventions
CG5503 IR, Morphine, Placebo
Drug
Lead sponsor
Grünenthal GmbH
Industry
Eligibility
18 Years to 80 Years
Enrollment
291 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2008
U.S. locations
6
States / cities
Pasadena, Maryland • Austin, Texas • Houston, Texas + 3 more
Source: ClinicalTrials.gov public record
Updated Nov 16, 2011 · Synced Oct 20, 2026, 5:00 PM EDT
Recruiting No phase listed Observational

Personalized Postoperative Pain Management Following Thoracic Surgery in Adults

NCT05525923
View directory record Official record
Conditions
Thoracic Surgery, Pneumonectomy, Lobectomy, Segmentectomy
Interventions
Not listed
Lead sponsor
OpalGenix, Inc
Industry
Eligibility
18 Years to 99 Years
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2028
U.S. locations
4
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 1, 2025 · Synced Oct 20, 2026, 5:00 PM EDT
Not listed Phase 3 Interventional

Phase 3 Efficacy and Safety Study of VVZ-149 Injections for Postoperative Pain Following Bunionectomy

NCT04430088
View directory record Official record
Conditions
Pain, Postoperative
Interventions
VVZ-149 Injections, Placebo
Drug
Lead sponsor
Vivozon, Inc.
Industry
Eligibility
18 Years and older
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
3
States / cities
Phoenix, Arizona • Anaheim, California • San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Jul 23, 2020 · Synced Oct 20, 2026, 5:00 PM EDT
Recruiting Phase 4 Interventional

Epidural Analgesia Versus Opioid-sparing Analgesia for Open Ventral Hernia Repair With Transversus Abdominis Release

NCT07840183
View directory record Official record
Conditions
Ventral Hernia, Ventral Hernia Repair, Postoperative Pain
Interventions
Bupivicaine, Fentanyl, Thoracic epidural analgesia, Hydromorphone, Acetaminophen, Ketorolac, magnesium sulfate, Tramadol, Gabapentin, Cyclobenzaprine, transversus abdominis plane block
Drug · Device · Procedure
Lead sponsor
Northwestern University
Other
Eligibility
18 Years to 80 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Oct 7, 2026 · Synced Oct 20, 2026, 5:00 PM EDT
Terminated Phase 3 Interventional Results available

Pre-op Paravertebral Blocks to Decrease Post-op Pain Following Mastectomy With Immediate Tissue Expander (TE) Reconstruction

NCT02161705
View directory record Official record
Conditions
Postoperative Pain, Postoperative Nausea and Vomiting, Quality of Life
Interventions
Ropivacaine, Saline
Drug
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years and older · Female only
Enrollment
18 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2019
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Apr 16, 2020 · Synced Oct 20, 2026, 5:00 PM EDT