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ClinicalTrials.gov public records Last synced Oct 20, 2026, 7:03 PM EDT

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Showing 97–120 of 1,844 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Post-Operative Pain Clear all
Enrolling by invitation Phase 4 Interventional

Comparison of Suzetrigine and Oxycodone for Postoperative Pain After Primary Total Knee Arthroplasty

NCT07219888
View directory record Official record
Conditions
Osteoarthritis (OA) of the Knee
Interventions
oral suzetrigine, oral Oxycodone
Drug
Lead sponsor
University of Louisville
Other
Eligibility
21 Years to 89 Years
Enrollment
140 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Louisville, Kentucky
Source: ClinicalTrials.gov public record
Updated May 4, 2026 · Synced Oct 20, 2026, 7:03 PM EDT
Completed Not applicable Interventional Results available

Reducing Post-Op Pain After Sacrospinous Ligament Colpopexy

NCT02037061
View directory record Official record
Conditions
Pain
Interventions
Bupivacaine, Normal Saline
Drug · Other
Lead sponsor
The Cleveland Clinic
Other
Eligibility
18 Years and older · Female only
Enrollment
46 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Aug 14, 2019 · Synced Oct 20, 2026, 7:03 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Examining Brain Changes Using Functional Magnetic Resonance Imaging (fMRI) in Amputees With Phantom Limb Pain Following Mirror Therapy

NCT00662415
View directory record Official record
Conditions
Phantom Limb Pain
Interventions
mirror-box treatment, observation
Device · Behavioral
Lead sponsor
United States Department of Defense
Federal
Eligibility
18 Years to 75 Years
Enrollment
42 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2010
U.S. locations
2
States / cities
Washington D.C., District of Columbia • Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Apr 21, 2008 · Synced Oct 20, 2026, 7:03 PM EDT
Completed Phase 3 Interventional Results available

Study of Post-Herniorrhaphy Non-opioid MMA Regimens

NCT03907176
View directory record Official record
Conditions
Analgesia
Interventions
HTX-011, Luer lock applicator, Ibuprofen, Acetaminophen
Drug · Device
Lead sponsor
Heron Therapeutics
Industry
Eligibility
18 Years and older
Enrollment
209 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
30
States / cities
Anaheim, California • La Mesa, California • Orange, California + 22 more
Source: ClinicalTrials.gov public record
Updated Jun 4, 2026 · Synced Oct 20, 2026, 7:03 PM EDT
Terminated Phase 1Phase 2 Interventional Accepts healthy volunteers Results available

Study of TAP and Laparoscopic and Robotic Gynecologic Procedures and Obese Women

NCT01866917
View directory record Official record
Conditions
Pain
Interventions
Ropivacaine 0.5% 20cc injectate bilaterally, Placebo
Drug
Lead sponsor
Montefiore Medical Center
Other
Eligibility
18 Years and older · Female only
Enrollment
35 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2016
U.S. locations
1
States / cities
The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Aug 20, 2020 · Synced Oct 20, 2026, 7:03 PM EDT
Withdrawn Not applicable Interventional

Single Shot Infraclavicular Brachial Plexus Block vs Local Infiltration After Wrist Arthroscopy Surgery

NCT02970097
View directory record Official record
Conditions
Wrist Injuries, Postoperative Pain Control
Interventions
20ml bolus of 0.5% ropivicaine, 10 ml of 0.5% ropivicaine, Midazolam, Fentanyl
Drug
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2018
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Feb 21, 2020 · Synced Oct 20, 2026, 7:03 PM EDT
Completed Phase 4 Interventional Results available

Study of EXPAREL in Patients Undergoing Breast Augmentation

NCT01582490
View directory record Official record
Conditions
Mammoplasty, Postoperative Pain
Interventions
Instillation - EXPAREL, Infiltration - EXPAREL
Drug
Lead sponsor
Pacira Pharmaceuticals, Inc
Industry
Eligibility
18 Years to 75 Years · Female only
Enrollment
19 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012
U.S. locations
1
States / cities
Brighton, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 2, 2014 · Synced Oct 20, 2026, 7:03 PM EDT
Completed Phase 2Phase 3 Interventional Accepts healthy volunteers

Pectoral Nerve Blocks (PECs) for Cardiovascular Implantable Electronic Device Placement

NCT05283980
View directory record Official record
Conditions
Pain, Postoperative, Pain, Acute, Pain, Chest, Pain, Satisfaction, Patient, Opioid Use, Unspecified, Opioids; Harmful Use
Interventions
0.25% Bupivacaine
Drug
Lead sponsor
Beth Israel Deaconess Medical Center
Other
Eligibility
18 Years and older
Enrollment
62 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2024
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 30, 2026 · Synced Oct 20, 2026, 7:03 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Multimodal Analgesic Protocol to Moderate Acute Pain

NCT03456141
View directory record Official record
Conditions
Pain, Post-operative
Interventions
third molar surgery
Procedure
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years to 35 Years
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2022
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Feb 23, 2023 · Synced Oct 20, 2026, 7:03 PM EDT
Terminated Phase 3 Interventional Results available

Ibuprofen to Decrease Opioid Use and Post-operative Pain Following Unilateral Inguinal Herniorrhaphy

NCT02929589
View directory record Official record
Conditions
Pain, Hernia
Interventions
Ibuprofen, Opioid Medication, Placebo, Ibuprofen + Opioid medication
Drug
Lead sponsor
Mike O'Callaghan Military Hospital
Federal
Eligibility
18 Years and older
Enrollment
18 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2021
U.S. locations
1
States / cities
Nellis Air Force Base, Nevada
Source: ClinicalTrials.gov public record
Updated Mar 26, 2024 · Synced Oct 20, 2026, 7:03 PM EDT
Enrolling by invitation Not applicable Interventional Accepts healthy volunteers

Meditation Effects on Discomfort, Pain InTerference, and AnxieTy After urEteroscopy

NCT06783946
View directory record Official record
Conditions
Kidney Stone, Pain, Postoperative, Anxiety Postoperative
Interventions
Meditation
Behavioral
Lead sponsor
Children's Hospital of Philadelphia
Other
Eligibility
12 Years and older
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2026
U.S. locations
2
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Dec 4, 2025 · Synced Oct 20, 2026, 7:03 PM EDT
Completed Phase 1 Interventional

Patient Controlled Administration of Liquid Acetaminophen

NCT06498713
View directory record Official record
Conditions
Pain, Pain, Postoperative
Interventions
Acetaminophen 650 mg Oral Tablet, Acetaminophen 650mg Liquid, CADD pump
Drug · Device
Lead sponsor
Yale University
Other
Eligibility
18 Years and older
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Aug 6, 2026 · Synced Oct 20, 2026, 7:03 PM EDT
Completed Not applicable Interventional

Study of a Multimodality Pain Management Protocol on Postoperative Neurosurgical Pain

NCT01693588
View directory record Official record
Conditions
Pain, Postoperative Pain, Surgical Pain, Neurosurgical Pain
Interventions
Pain Management Bundle
Other
Lead sponsor
University of Florida
Other
Eligibility
18 Years and older
Enrollment
94 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2013
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Jan 14, 2014 · Synced Oct 20, 2026, 7:03 PM EDT
Terminated Phase 4 Interventional Results available

US Guided GNB vs Saline Injection for TKA

NCT03316118
View directory record Official record
Conditions
Postoperative Pain, Total Knee Arthroplasty, Nerve Block
Interventions
bupivacaine, saline
Drug
Lead sponsor
Northwestern University
Other
Eligibility
40 Years to 85 Years
Enrollment
2 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2021
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Sep 28, 2022 · Synced Oct 20, 2026, 7:03 PM EDT
Recruiting Phase 4 Interventional

The Pericapsular Nerve Block in Total Hip Arthroplasty

NCT04729686
View directory record Official record
Conditions
Hip Osteoarthritis, Hip Arthropathy
Interventions
Pericapsular Nerve Block, Fascia Iliaca Nerve Block
Drug
Lead sponsor
LifeBridge Health
Other
Eligibility
18 Years to 80 Years
Enrollment
78 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2025
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Jan 22, 2025 · Synced Oct 20, 2026, 7:03 PM EDT
Recruiting Phase 4 Interventional

Post Operative Infusion Pump Pain Study

NCT07349810
View directory record Official record
Conditions
Post Operative Pain
Interventions
Bupivacaine 0.5% Injectable Solution, Ropivacaine 0.2% Injectable Solution, 1.3% liposomal bupivacaine (Exparel), ambIT Infusion Pump
Drug · Device
Lead sponsor
Rutgers, The State University of New Jersey
Other
Eligibility
18 Years and older
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026
U.S. locations
1
States / cities
Somerset, New Jersey
Source: ClinicalTrials.gov public record
Updated Jan 21, 2026 · Synced Oct 20, 2026, 7:03 PM EDT
Withdrawn Not applicable Interventional Accepts healthy volunteers

Acupuncture for Pain Management After Hip or Knee Arthroplasty

NCT00455182
View directory record Official record
Conditions
Pain, Postoperative Complications
Interventions
Acupuncture, Sham Acupuncture, Standard medical care
Procedure
Lead sponsor
HealthEast Care System
Other
Eligibility
18 Years to 80 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2011
U.S. locations
1
States / cities
Woodbury, Minnesota
Source: ClinicalTrials.gov public record
Updated Mar 19, 2015 · Synced Oct 20, 2026, 7:03 PM EDT
Enrolling by invitation No phase listed Observational

Cannulated Bone Bolt® Screw System Versus Standard Cannulated Screw System Fixation for Pelvic Fractures

NCT07209280
View directory record Official record
Conditions
Pain
Interventions
Cannulated Bone Bolt® Screw System, Standard Cannulated Screw System
Other
Lead sponsor
University of Utah
Other
Eligibility
18 Years to 80 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Apr 23, 2026 · Synced Oct 20, 2026, 7:03 PM EDT
Completed Phase 4 Interventional Results available

Efficacy of Liposomal Bupivacaine Versus 0.25% Bupivacaine for Laparoscopic Urologic Surgery

NCT02222129
View directory record Official record
Conditions
Pain, Postoperative
Interventions
Bupivacaine, liposomal bupivacaine
Drug
Lead sponsor
Knight, Richard, M.D.
Individual
Eligibility
18 Years and older
Enrollment
206 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2013
U.S. locations
2
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Apr 16, 2015 · Synced Oct 20, 2026, 7:03 PM EDT
Completed Phase 1Phase 2 Interventional Results available

Dose-Escalation Study of HTX-034 Following Bunionectomy

NCT04398329
View directory record Official record
Conditions
Bunions, Postoperative Pain
Interventions
HTX-034 low dose, HTX-034 high dose, Luer lock applicator, Bupivacaine HCl
Drug · Device
Lead sponsor
Heron Therapeutics
Industry
Eligibility
18 Years and older
Enrollment
78 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
4
States / cities
Phoenix, Arizona • Bellaire, Texas • San Antonio, Texas + 1 more
Source: ClinicalTrials.gov public record
Updated Jun 9, 2026 · Synced Oct 20, 2026, 7:03 PM EDT
Completed Phase 1Phase 2 Interventional Results available

Phase I/II Dose-escalation Study to Evaluate Safety, PK and Efficacy of TLC590 for Postsurgical Pain Management

NCT03591146
View directory record Official record
Conditions
Inguinal Hernia
Interventions
TLC590, Naropin
Drug
Lead sponsor
Taiwan Liposome Company
Industry
Eligibility
18 Years to 65 Years
Enrollment
65 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
Draper, Utah
Source: ClinicalTrials.gov public record
Updated Jul 14, 2021 · Synced Oct 20, 2026, 7:03 PM EDT
Completed Not applicable Interventional Results available

Punch vs. Drill Tunnel Use for Anchor Tunnel Creation and Correlation With Post-operative Pain

NCT04288570
View directory record Official record
Conditions
Rotator Cuff Tears
Interventions
suture anchor socket creation with punch, suture anchor socket creation with drill
Procedure
Lead sponsor
Matt Smith
Other
Eligibility
18 Years to 80 Years
Enrollment
43 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2023
U.S. locations
1
States / cities
Columbia, Missouri
Source: ClinicalTrials.gov public record
Updated Apr 8, 2025 · Synced Oct 20, 2026, 7:03 PM EDT
Completed Phase 3 Interventional Results available

Thoracic Epidural Analgesia Versus Rectus Sheath Block Versus Surgeon Infiltration With Liposomal Bupivacaine or Standard Bupivacaine for Post-Operative Pain Control After Cystectomy

NCT04300231
View directory record Official record
Conditions
Cystectomy
Interventions
epidural bupivacaine 0.05%, Liposomal bupivacaine, bupivacaine 0.125%, bupivacaine 0.5%, /hydromorphone 0.05mg/ml, injectable saline
Drug
Lead sponsor
Indiana University
Other
Eligibility
18 Years and older
Enrollment
160 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Feb 10, 2025 · Synced Oct 20, 2026, 7:03 PM EDT
Completed Phase 2 Interventional Results available

Efficacy Of PF-05089771 In Treating Postoperative Dental Pain

NCT01529346
View directory record Official record
Conditions
Postoperative Dental Pain
Interventions
PF-05089771, Placebo, Ibuprofen
Drug · Other
Lead sponsor
Pfizer
Industry
Eligibility
18 Years to 55 Years
Enrollment
235 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2012
U.S. locations
3
States / cities
Austin, Texas
Source: ClinicalTrials.gov public record
Updated Jun 1, 2018 · Synced Oct 20, 2026, 7:03 PM EDT