Search | Clinical Trials Finder

These results were retrieved from the live ClinicalTrials.gov registry. Filters and sort order apply to this result list.

ClinicalTrials.gov public records Last synced Nov 15, 2026, 6:46 AM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 169–192 of 1,847 matching trials from the live ClinicalTrials.gov search.

Filters: Condition: Post-Surgical Pain Clear all

Conditions: Post Operative Pain, Acute
Interventions: Bupivacaine 0.25% Injectable Solution, Bupivacaine 0.25% Injectable Solution, Magnesium Sulfate 150 mg, Bupivacaine 0.25% Injectable Solution, Magnesium Sulfate 150 mg, Buprenorphine 300 mcg; Drug
Lead sponsor: Wayne State University; Other
Eligibility: 18 Years to 100 Years
Enrollment: 120 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2022
U.S. locations: 1
States / cities: Pontiac, Michigan

Conditions: Pain
Interventions: Skin conductance monitor for measuring skin conductance; Device
Lead sponsor: Milton S. Hershey Medical Center; Other
Eligibility: Up to 5 Years
Enrollment: 162 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2020
U.S. locations: 1
States / cities: Hershey, Pennsylvania

Conditions: Inguinal Hernia, Ventral Hernia
Interventions: Liposomal Bupivacaine, Bupivacaine; Drug
Lead sponsor: Leslie Son; Other
Eligibility: 18 Years and older
Enrollment: 200 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2025
U.S. locations: 1
States / cities: Baton Rouge, Louisiana

Conditions: Post Operative Pain
Interventions: SABER-Bupivacaine (Part 1), SABER-Bupivacaine (Part 2), Saline Placebo, Bupivacaine HCl; Drug
Lead sponsor: Durect; Industry
Eligibility: 18 Years and older
Enrollment: 399 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2017
U.S. locations: 21
States / cities: Florence, Alabama • Sheffield, Alabama • Arcadia, California + 13 more

Conditions: Arthroplasty, Replacement, Knee, Pain, Postoperative
Interventions: Adductor Canal Block, Adductor Canal Block; Procedure · Drug
Lead sponsor: University of Wisconsin, Madison; Other
Eligibility: 18 Years to 80 Years
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2017
U.S. locations: 1
States / cities: Madison, Wisconsin

Conditions: Phantom Limb Pain, Neuroma Amputation
Interventions: Cooled Radiofrequency Ablation; Device
Lead sponsor: University of Utah; Other
Eligibility: 18 Years and older
Enrollment: 8 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2023
U.S. locations: 1
States / cities: Salt Lake City, Utah

Conditions: Post Operative Pain, Opioid Use, Unspecified
Interventions: Not listed
Lead sponsor: Boston Medical Center; Other
Eligibility: 18 Years and older
Enrollment: 40 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2026
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Pain, Postoperative Depression
Interventions: Ketamine, Placebo Comparator; Drug · Other
Lead sponsor: NYU Langone Health; Other
Eligibility: 18 Years to 65 Years
Enrollment: 90 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2017
U.S. locations: 1
States / cities: New York, New York

Conditions: Primary Osteoarthritis Patients Scheduled for Total Knee Replacement Surgery
Interventions: Cold and Compression, SOC (Standard of care); Device · Other
Lead sponsor: Ochsner Health System; Other
Eligibility: 50 Years and older
Enrollment: 90 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2028
U.S. locations: 1
States / cities: New Orleans, Louisiana

Conditions: Postoperative Pain
Interventions: MDT-10013, Standard of care for pain; Drug
Lead sponsor: Medtronic Spinal and Biologics; Industry
Eligibility: 18 Years to 80 Years
Enrollment: 192 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2016
U.S. locations: 2
States / cities: Phoenix, Arizona • Austin, Texas

Conditions: Postoperative Pain, Total Knee Replacement, Total Knee Arthroplasty, Partial Knee Replacement
Interventions: SPRINT Peripheral Nerve Stimulation (PNS) System; Device
Lead sponsor: SPR Therapeutics, Inc.; Industry
Eligibility: 21 Years and older
Enrollment: 56 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2024
U.S. locations: 10
States / cities: Little Rock, Arkansas • San Diego, California • Gainesville, Florida + 7 more

Conditions: Post Operative Pain
Interventions: AtriCure Cryo Nerve Block (cryoNB) Device Family; Device
Lead sponsor: AtriCure, Inc.; Industry
Eligibility: 12 Years and older
Enrollment: 5,000 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2040
U.S. locations: 7
States / cities: Jacksonville, Florida • Orlando, Florida • Annapolis, Maryland + 4 more

Conditions: Pain, Postoperative
Interventions: .5% bupivacaine with epinephrine; Drug
Lead sponsor: University of South Florida; Other
Eligibility: Female only
Enrollment: 100 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2006 – 2007
U.S. locations: 1
States / cities: Tampa, Florida

Conditions: Postoperative Pain
Interventions: Low Dose SKY0402, High Dose SKY0402, Placebo, Fentanyl via PCA, Bupivacaine via epidural; Drug
Lead sponsor: Pacira Pharmaceuticals, Inc; Industry
Eligibility: 18 Years and older
Enrollment: 3 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2009
U.S. locations: 5
States / cities: Pasadena, California • Orlando, Florida • Houston, Texas + 1 more

Conditions: Pain Management, Spinal Fusion, Scoliosis
Interventions: Intrathecal morphine, Extended Release Epidural Morphine; Drug
Lead sponsor: University of Colorado, Denver; Other
Eligibility: 8 Years to 17 Years
Enrollment: 84 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2012
U.S. locations: 1
States / cities: Aurora, Colorado

Conditions: Failed Back Surgery Syndrome, Post-Laminectomy Syndrome, Low Back Pain
Interventions: SCS and PNfS, SCS Alone; Device
Lead sponsor: Abbott Medical Devices; Industry
Eligibility: 22 Years and older
Enrollment: 38 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2016
U.S. locations: 28
States / cities: Phoenix, Arizona • Scottsdale, Arizona • Little Rock, Arkansas + 24 more

Conditions: Pain, Postoperative
Interventions: diclofenac potassium (XP21L), Placebo; Drug
Lead sponsor: Xanodyne Pharmaceuticals; Industry
Eligibility: 18 Years to 65 Years
Enrollment: 200 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: Started 2006
U.S. locations: 4
States / cities: Austin, Texas • Houston, Texas • San Marcos, Texas + 1 more

Conditions: Pain, Postoperative, Postoperative Hemorrhage
Interventions: Bupivacaine, Fibrin Sealant; Drug · Biological
Lead sponsor: Indiana University; Other
Eligibility: 1 Year to 12 Years
Enrollment: 18 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2015 – 2017
U.S. locations: 1
States / cities: Indianapolis, Indiana

Conditions: Hemorrhoids, Fissure in Ano, Rectal Fistula, Anal Condyloma
Interventions: Gabapentin, Ketamine, Acetaminophen, Dexamethasone, Placebo; Drug
Lead sponsor: University of Vermont; Other
Eligibility: 18 Years and older
Enrollment: 90 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2017
U.S. locations: 2
States / cities: Burlington, Vermont • Colchester, Vermont

Conditions: Anesthesia, Intravenous, Pain, Postoperative, Delayed Recovery From Anesthesia, Satisfaction, Relaxation Therapy
Interventions: Virtual Reality Immersive Relaxation; Other
Lead sponsor: Beth Israel Deaconess Medical Center; Other
Eligibility: 18 Years and older
Enrollment: 40 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2021
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Pain, Postoperative, Ankle Fracture Surgery, Opioid Use Disorder, Opioid Dependence, Opioid Analgesia
Interventions: Buprenorphine Transdermal System, Placebo Patch; Drug
Lead sponsor: Jenna-Leigh Wilson; Other
Eligibility: 18 Years and older
Enrollment: 100 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2027
U.S. locations: 1
States / cities: St Louis, Missouri

Conditions: Pain, Phantom, Pain, Neuropathic
Interventions: Valproic Acid, Cherry Syrup; Drug · Other
Lead sponsor: Duke University; Other
Eligibility: 18 Years and older
Enrollment: 128 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2017
U.S. locations: 2
States / cities: Bethesda, Maryland • Durham, North Carolina

Conditions: Pain, Postoperative, Morbid Obesity
Interventions: Injected bupivacaine post-operatively, Streamed bupivacaine versus streamed normal saline, Aerosolized bupivacaine versus aerosolized saline, Injected lidocaine pre-incision vs saline pre-incision; Drug
Lead sponsor: Pinnacle Health System; Other
Eligibility: 18 Years to 65 Years
Enrollment: 100 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2007 – 2008
U.S. locations: 1
States / cities: Harrisburg, Pennsylvania

Conditions: Pain, Postoperative
Interventions: Naproxen Sodium 440 mg / DPH 25 mg (BAY98-7111), Naproxen Sodium 440 mg (BAYH6689), DPH 50 mg; Drug
Lead sponsor: Bayer; Industry
Eligibility: 12 Years and older
Enrollment: 267 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2011 – 2012
U.S. locations: 2
States / cities: Austin, Texas • Salt Lake City, Utah

Search by objective public record fields.

Serratus Anterior Plane Block With and Without Adjuvants in Video-assisted Thoracoscopy

Post-surgical Pain Assessment in Children: Roles of Skin Conductance and Genomics

Post-operative Pain Control-TAP Block Using Exparel vs. Marcaine for Hernia Repairs

Trial of Extended Release Bupivacaine for Pain Relief After Surgery

Adductor Canal Block for Total Knee Arthroplasty

C-RFA of Residual Limb Neuroma

Sensory Outcomes in Active Substance Users

Study on the Use of Low Dose Ketamine After Gastric Bypass and Gastrectomy

Cold and Compression Post TKA

A Study of MDT-10013 in the Treatment of Acute Postoperative Pain Following Bunionectomy

Treatment of Post-Operative Pain Following Orthopedic Surgery With SPRINT® Peripheral Nerve Stimulation (PNS) System

A Multicenter Patient Registry on Outcomes From Cryoanalgesia of the Intercostal Nerves

Cesarean Delivery and Post-operative Pain Management With Local Anesthesia

Dose Finding Posterolateral Thoracotomy Study

Intrathecal Morphine Versus Epidural Extended Release Morphine for Pediatric Patients Undergoing Spinal Fusion

SENSE (Subcutaneous and Epidural Neuromodulation System Evaluation) Study

Multicenter Study to Evaluate the Analgesic Efficacy of XP21L in Subjects With Pain Following Bunionectomy Surgery

Effect of Bupivacaine-infused Fibrin Sealant Application on Post-tonsillectomy Pain & Hemorrhage

Pre-Emptive Analgesia in Ano-Rectal Surgery

Virtual Reality in the Operating Room

Buprenorphine as a Post-operative Analgesic in Opioid-Naive Patients After Ankle Fracture Surgery

Valproic Acid for the Prevention of Post-Amputation Pain

Clinical Proposal for the Comparison of Intraperitoneal Anesthetic to Injected Local Anesthetic

Evaluate Analgesic / Sedative Efficacy of Naproxen Sodium and Diphenhydramine in Patients With Postsurgical Dental Pain