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ClinicalTrials.gov public records Last synced Sep 13, 2026, 11:38 PM EDT

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Showing 1–24 of 50 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Post-operative Tooth Pain Clear all
Recruiting Not applicable Interventional Accepts healthy volunteers

Impact of Nd:YAG Laser Photobiostimulation on Healing of Gingiva

NCT07095556
View directory record Official record
Conditions
Wound Healing and Prevention, Oral Inflammation, Photobiomodulation, Post-operative Pain Management, Tooth Extraction Site Healing
Interventions
Low-level laser therapy
Other
Lead sponsor
Medical University of South Carolina
Other
Eligibility
18 Years and older
Enrollment
39 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2027
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Nov 11, 2025 · Synced Sep 13, 2026, 11:38 PM EDT
Completed Phase 2 Interventional

To Evaluate the Safety, Tolerability and Analgesic Efficacy of SAF312 in Postoperative Dental Pain Patients

NCT00986882
View directory record Official record
Conditions
Postoperative Pain
Interventions
SAF312A, Placebo, Ibuprofen
Drug
Lead sponsor
Novartis
Industry
Eligibility
18 Years to 45 Years
Enrollment
183 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2011
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Dec 18, 2020 · Synced Sep 13, 2026, 11:38 PM EDT
Withdrawn Not applicable Interventional

A Mobile Application for Post-op Analgesic Consumption

NCT03197311
View directory record Official record
Conditions
Tooth Extraction Status Nos, Post Operative Pain, Patient Satisfaction, Narcotic Use, Mobile App
Interventions
Mobile app
Other
Lead sponsor
Boston University
Other
Eligibility
18 Years to 40 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Oct 7, 2019 · Synced Sep 13, 2026, 11:38 PM EDT
Completed Phase 4 Interventional Results available

Post-operative Dental Pain Study Comparing Two Different Dosage of Analgesic Efficacy

NCT01075243
View directory record Official record
Conditions
Post-surgical Dental Pain
Interventions
Paracetamol 1000 mg, Paracetamol 650 mg, Placebo
Drug
Lead sponsor
GlaxoSmithKline
Industry
Eligibility
18 Years to 45 Years
Enrollment
401 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2010
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Apr 28, 2015 · Synced Sep 13, 2026, 11:38 PM EDT
Completed Phase 2 Interventional

Study of Acetaminophen (ACE) in Post-operative Dental Pain

NCT02320708
View directory record Official record
Conditions
Dental Pain
Interventions
Acetaminophen (ACE) (1000 mg), Commercial ACE (1000 mg), Commercial Ibuprofen (IBU) (400 mg), Placebo
Drug
Lead sponsor
Johnson & Johnson Healthcare Products Division of McNEIL-PPC, Inc.
Industry
Eligibility
17 Years to 50 Years
Enrollment
240 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Dec 2, 2021 · Synced Sep 13, 2026, 11:38 PM EDT
Recruiting Early Phase 1 Interventional

A Phase 1 Study of ARC-001 in Participants Undergoing Third Molar Extraction

NCT06864884
View directory record Official record
Conditions
Acute Post Operative Pain, Third Molar Extraction Surgery
Interventions
ARC-001, Placebo gel
Drug
Lead sponsor
Arcato Laboratories, Inc.
Industry
Eligibility
18 Years to 55 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Mar 10, 2025 · Synced Sep 13, 2026, 11:38 PM EDT
Recruiting Phase 4 Interventional Accepts healthy volunteers

Efficacy of Preoperative Administration of Gabapentin in 3rd Molar Dental Extraction.

NCT04860141
View directory record Official record
Conditions
Dental Pain and Sensation Disorder, Pain, Postoperative
Interventions
Gabapentin 600mg, Placebo
Drug
Lead sponsor
Loma Linda University
Other
Eligibility
18 Years to 59 Years
Enrollment
98 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2026
U.S. locations
1
States / cities
Loma Linda, California
Source: ClinicalTrials.gov public record
Updated Feb 3, 2026 · Synced Sep 13, 2026, 11:38 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

DPBRN Peri-operative Pain and Root Canal Therapy

NCT01201681
View directory record Official record
Conditions
Post-operative Tooth Pain, Root Canal Therapy
Interventions
Not listed
Lead sponsor
Dental Practice-Based Research Network
Network
Eligibility
19 Years to 70 Years
Enrollment
500 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2011
U.S. locations
7
States / cities
Birmingham, Alabama • Gainesville, Florida • Minneapolis, Minnesota + 1 more
Source: ClinicalTrials.gov public record
Updated Sep 19, 2011 · Synced Sep 13, 2026, 11:38 PM EDT
Completed Phase 2 Interventional Results available

A Dental Pain Study to Test the Effectiveness of a New Pain Reliever Medicine

NCT02209181
View directory record Official record
Conditions
Pain
Interventions
JNJ-10450232 / Not yet marketed, acetaminophen / Tylenol
Drug
Lead sponsor
McNeil Consumer Healthcare Division of McNEIL-PPC, Inc.
Industry
Eligibility
18 Years to 45 Years · Male only
Enrollment
269 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Feb 2, 2017 · Synced Sep 13, 2026, 11:38 PM EDT
Completed Phase 3 Interventional

Study of Acetaminophen (ACM) in Post-operative Dental Pain

NCT02735122
View directory record Official record
Conditions
Post Operative Dental Pain
Interventions
acetaminophen Tablet, acetaminophen Caplet, ibuprofen Liquid-filled capsule, Placebo Tablet, Placebo Caplet, Placebo Liquid-filled capsule
Drug
Lead sponsor
Johnson & Johnson Consumer Inc., McNeil Consumer Healthcare Division
Industry
Eligibility
17 Years to 50 Years
Enrollment
420 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Sep 27, 2022 · Synced Sep 13, 2026, 11:38 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Effectiveness of GentleWave System in Endodontic Treatment

NCT06518304
View directory record Official record
Conditions
Pain, Postoperative, Root Canal Infection, Endodontically Treated Teeth
Interventions
GentleWave, Conventional Protocol
Other
Lead sponsor
University of Salamanca
Other
Eligibility
18 Years to 80 Years
Enrollment
70 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024
U.S. locations
1
States / cities
Manhattan, New York
Source: ClinicalTrials.gov public record
Updated Aug 20, 2024 · Synced Sep 13, 2026, 11:38 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Postoperative Pain and Healing in Teeth Treated With GentleWave or EndoActivator

NCT04552132
View directory record Official record
Conditions
Symptomatic Irreversible Pulpitis, Apical Periodontitis
Interventions
Multisonic vs Sonic activation of irrigants
Device
Lead sponsor
St. Louis University
Other
Eligibility
18 Years and older
Enrollment
63 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2022
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Jun 14, 2023 · Synced Sep 13, 2026, 11:38 PM EDT
Completed Phase 3 Interventional Accepts healthy volunteers Results available

Evaluate Efficacy and Safety of Extended Release (ER) Naproxen Sodium

NCT01389284
View directory record Official record
Conditions
Pain, Postoperative
Interventions
Naproxen Sodium ER (BAYH6689), Naproxen Sodium IR (Aleve, BAYH6689), Naproxen Sodium ER Placebo, Naproxen Sodium IR Placebo
Drug
Lead sponsor
Bayer
Industry
Eligibility
15 Years and older
Enrollment
300 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011
U.S. locations
1
States / cities
Austin, Texas
Source: ClinicalTrials.gov public record
Updated Aug 24, 2015 · Synced Sep 13, 2026, 11:38 PM EDT
Completed Phase 3 Interventional Accepts healthy volunteers Results available

Evaluate Analgesic / Sedative Efficacy of Naproxen Sodium and Diphenhydramine in Patients With Postsurgical Dental Pain

NCT01495858
View directory record Official record
Conditions
Pain, Postoperative
Interventions
Naproxen Sodium 440 mg / DPH 25 mg (BAY98-7111), Naproxen Sodium 440 mg (BAYH6689), DPH 50 mg
Drug
Lead sponsor
Bayer
Industry
Eligibility
12 Years and older
Enrollment
267 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2012
U.S. locations
2
States / cities
Austin, Texas • Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Jun 7, 2015 · Synced Sep 13, 2026, 11:38 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Postoperative Pain After Activation of Irrigant

NCT06528574
View directory record Official record
Conditions
Pain
Interventions
Conventional root canal treatment, Ultrasonic, Apical negative pressure, Combined Ultrasonic and negative pressure
Device
Lead sponsor
Cleveland Dental Institute
Other
Eligibility
18 Years to 50 Years
Enrollment
84 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2025
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Jul 29, 2024 · Synced Sep 13, 2026, 11:38 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers

Methodological Validation of Ibuprofen Verses Placebo for Post Operative Pain After Third Molar Extraction Surgery

NCT02096926
View directory record Official record
Conditions
Dental Pain
Interventions
Placebo, Ibuprofen
Drug
Lead sponsor
Lotus Clinical Research, LLC
Other
Eligibility
18 Years to 40 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014
U.S. locations
1
States / cities
Pasadena, California
Source: ClinicalTrials.gov public record
Updated Apr 7, 2015 · Synced Sep 13, 2026, 11:38 PM EDT
Completed Phase 3 Interventional Results available

Evaluate Analgesic/Sedative Efficacy of Naproxen Sodium and Diphenhydramine in Patients With Postsurgical Dental Pain

NCT01280591
View directory record Official record
Conditions
Pain, Postoperative
Interventions
Naproxen sodium 440 mg / DPH 50 mg (BAY98-7111), Naproxen sodium 220 mg / DPH 50 mg (BAY98-7111), Naproxen sodium 440 mg (BAYH6689), DPH 50 mg
Drug
Lead sponsor
Bayer
Industry
Eligibility
12 Years to 45 Years
Enrollment
712 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2011
U.S. locations
2
States / cities
Austin, Texas • Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Jun 7, 2015 · Synced Sep 13, 2026, 11:38 PM EDT
Completed Phase 2 Interventional

This is a Study Evaluating the Efficacy and Safety of LTG-001 for Acute Pain After Surgical Removal of Impacted Third Molars

NCT06774625
View directory record Official record
Conditions
Acute Pain, Postoperative
Interventions
LTG-001 High Dose, LTG-001 Mid Dose, LTG-001 Low Dose, Placebo, Suzetrigine
Drug · Other
Lead sponsor
Latigo Biotherapeutics
Industry
Eligibility
18 Years to 50 Years
Enrollment
250 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated May 21, 2026 · Synced Sep 13, 2026, 11:38 PM EDT
Completed Phase 3 Interventional Results available

Ibuprofen/Acetaminophen Versus Nurofen Plus® and Panadeine® Extra Dental Pain Study

NCT01229449
View directory record Official record
Conditions
Post-operative Pain
Interventions
Ibuprofen/acetaminophen, Ibuprofen/acetaminophen (higher dose), Nurofen Plus®, Panadeine® Extra, Placebo
Drug
Lead sponsor
Reckitt Benckiser LLC
Industry
Eligibility
16 Years and older
Enrollment
678 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009
U.S. locations
1
States / cities
Austin, Texas
Source: ClinicalTrials.gov public record
Updated Sep 16, 2018 · Synced Sep 13, 2026, 11:38 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Optimizing Acute Post-Operative Dental Pain Management Using New Health Information Technology

NCT03881891
View directory record Official record
Conditions
Pain, Postoperative, Complication, Postoperative
Interventions
Follow-app intervention arm
Behavioral
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years and older
Enrollment
1,525 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2022
U.S. locations
2
States / cities
San Francisco, California • Hillsboro, Oregon
Source: ClinicalTrials.gov public record
Updated Aug 3, 2022 · Synced Sep 13, 2026, 11:38 PM EDT
Completed Phase 2 Interventional Results available

Acetaminophen/Naproxen Sodium Dose Ranging Study

NCT04447040
View directory record Official record
Conditions
Pain
Interventions
Acetaminophen/naproxen sodium Dose A, Acetaminophen/naproxen sodium Dose B, Acetaminophen/naproxen sodium Dose C, Acetaminophen/naproxen sodium Dose D, Acetaminophen/naproxen sodium Dose E, Placebo
Drug
Lead sponsor
Johnson & Johnson Consumer Inc., McNeil Consumer Healthcare Division
Industry
Eligibility
17 Years to 50 Years
Enrollment
304 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Mar 23, 2025 · Synced Sep 13, 2026, 11:38 PM EDT
Completed Phase 2 Interventional Results available

Dose-Response Study of MR-107A-01 in The Treatment of Post-Surgical Dental Pain

NCT04571515
View directory record Official record
Conditions
Pain, Postoperative Pain, Pain, Acute
Interventions
MR-107A-01, Placebo
Drug
Lead sponsor
Mylan Inc.
Industry
Eligibility
18 Years and older
Enrollment
114 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Aug 7, 2022 · Synced Sep 13, 2026, 11:38 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Occurrence of Post-op Pain Following Gentlewave

NCT03635515
View directory record Official record
Conditions
Root Canal Infection, Endodontic Disease, Endodontic Inflammation, Post-Operative Pain
Interventions
Gentlewave, Standard Endodontic Protocol
Device · Procedure
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years and older
Enrollment
87 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2021
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Feb 14, 2023 · Synced Sep 13, 2026, 11:38 PM EDT
Completed Phase 2 Interventional Results available

Naproxen Sodium/Acetaminophen Proof of Concept Dosing Study

NCT03879408
View directory record Official record
Conditions
Pain
Interventions
440 mg naproxen sodium with 1000 mg acetaminophen, 220 mg naproxen sodium with 650 mg acetaminophen, 10 mg hydrocodone + 650 mg acetaminophen, 440 mg naproxen sodium, Placebo tablet
Drug
Lead sponsor
Johnson & Johnson Consumer Inc., McNeil Consumer Healthcare Division
Industry
Eligibility
17 Years to 50 Years
Enrollment
290 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Dec 4, 2022 · Synced Sep 13, 2026, 11:38 PM EDT