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ClinicalTrials.gov public records Last synced Oct 10, 2026, 12:58 PM EDT

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Showing 121–144 of 755 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Postoperative Analgesia Clear all
Completed Phase 3 Interventional Results available

Intraoperative Lidocaine Infusion for Postoperative Pain Management in Obese Patients

NCT01944098
View directory record Official record
Conditions
Bariatric Surgical Pain
Interventions
Lidocaine, Placebo
Drug
Lead sponsor
University of South Florida
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2014
U.S. locations
1
States / cities
Tampa, Florida
Source: ClinicalTrials.gov public record
Updated Oct 26, 2017 · Synced Oct 10, 2026, 12:58 PM EDT
Terminated Phase 4 Interventional Accepts healthy volunteers Results available

A Prospective Study to Compare Bupivacaine and Exparel Versus Bupivacaine or Exparel Alone for Postoperative Pain Relief

NCT03514277
View directory record Official record
Conditions
Low Back Pain, Lumbosacral Radiculopathy, Lumbar Disc Degeneration, Lumbar Disc Herniation, Stenosis, Spondylolisthesis, Spondylolysis, Deformity of Spine
Interventions
Exparel, Bupivacaine
Drug
Lead sponsor
Virtua Health, Inc.
Other
Eligibility
18 Years and older
Enrollment
19 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2019
U.S. locations
1
States / cities
Mount Holly, New Jersey
Source: ClinicalTrials.gov public record
Updated Jan 6, 2021 · Synced Oct 10, 2026, 12:58 PM EDT
Completed Phase 2Phase 3 Interventional Results available

Femoral Nerve Block With Liposome Bupivacaine for Postsurgical Analgesia Following Total Knee Arthroplasty

NCT01683071
View directory record Official record
Conditions
Postoperative Pain
Interventions
Placebo, EXPAREL 67 mg, EXPAREL 133 mg, EXPAREL 266 mg
Drug
Lead sponsor
Pacira Pharmaceuticals, Inc
Industry
Eligibility
18 Years and older
Enrollment
297 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2013
U.S. locations
30
States / cities
Birmingham, Alabama • Mobile, Alabama • Sheffield, Alabama + 23 more
Source: ClinicalTrials.gov public record
Updated Dec 9, 2020 · Synced Oct 10, 2026, 12:58 PM EDT
Withdrawn Phase 4 Interventional

Improving Pain Management After Total Shoulder Replacement Using Bupivacaine Liposome

NCT04134442
View directory record Official record
Conditions
Osteoarthritis of the Shoulder, Shoulder Pain, Pain, Postoperative
Interventions
Bupivacaine Liposome Injection, Standard Therapy
Drug · Other
Lead sponsor
University of Massachusetts, Worcester
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
1
States / cities
Worcester, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 6, 2022 · Synced Oct 10, 2026, 12:58 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

NSS-2-BRIDGE Study for Total Knee and Hip Arthroplasties, Bariatric, and Kidney Transplant Surgeries

NCT03834142
View directory record Official record
Conditions
Acute Pain, Arthropathy of Knee, Arthropathy of Hip, Pain, Postoperative, Kidney Transplant Donor, Bariatric Surgery Candidate
Interventions
NSS-2 Bridge
Device
Lead sponsor
Jacques E. Chelly
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2021
U.S. locations
3
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Aug 3, 2022 · Synced Oct 10, 2026, 12:58 PM EDT
Terminated Phase 4 Interventional Accepts healthy volunteers Results available

Opioid-Free Anesthetic for Tonsillectomy

NCT04528173
View directory record Official record
Conditions
Anesthesia, Opioid Use, Tonsillitis, Sleep Disorder, Surgery
Interventions
Ketorolac, Dexmedetomidine, Morphine, Fentanyl
Drug
Lead sponsor
Children's Hospital of Philadelphia
Other
Eligibility
2 Years to 18 Years
Enrollment
35 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2023
U.S. locations
2
States / cities
Philadelphia, Pennsylvania • Memphis, Tennessee
Source: ClinicalTrials.gov public record
Updated Dec 20, 2024 · Synced Oct 10, 2026, 12:58 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers Results available

Methadone vs. Fentanyl Administration on Postoperative Pain Control in Pediatric Patients Undergoing Cardiac Surgery

NCT02747875
View directory record Official record
Conditions
Opioid Use, Unspecified
Interventions
Methadone, Fentanyl
Drug
Lead sponsor
Andrew Waberski
Other
Eligibility
2 Years to 7 Years
Enrollment
26 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2019
U.S. locations
1
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated Jun 1, 2021 · Synced Oct 10, 2026, 12:58 PM EDT
Completed Not applicable Interventional

Pain Management Following TRAM Flap for Breast Reconstruction

NCT00500565
View directory record Official record
Conditions
Breast Cancer
Interventions
Saline, Bupivicaine
Drug
Lead sponsor
M.D. Anderson Cancer Center
Other
Eligibility
Not listed
Enrollment
61 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2008
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Oct 11, 2013 · Synced Oct 10, 2026, 12:58 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

IV Acetaminophen for Post-Operative Pain Management in Enhanced Recovery After Surgery (ERAS) Population

NCT03198871
View directory record Official record
Conditions
Abdominal Wall Hernia, Pancreatic Diseases, Bowel Disease, Gastric Disease
Interventions
Acetaminophen Injectable Product, Sodium Chloride 0.9%, Intravenous
Drug
Lead sponsor
Kathirvel Subramaniam
Other
Eligibility
18 Years and older
Enrollment
180 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2020
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jan 28, 2021 · Synced Oct 10, 2026, 12:58 PM EDT
Terminated Not applicable Interventional Results available

Ultrasound Guided Local Infiltration Analgesia for Hip Arthroscopy

NCT01907191
View directory record Official record
Conditions
Hip Injuries
Interventions
liposomal bupivacaine, Bupivacaine
Drug
Lead sponsor
Trinity Health Of New England
Other
Eligibility
18 Years to 80 Years
Enrollment
23 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2019
U.S. locations
1
States / cities
Hartford, Connecticut
Source: ClinicalTrials.gov public record
Updated Aug 16, 2022 · Synced Oct 10, 2026, 12:58 PM EDT
Completed Phase 4 Interventional

Sub-Paraspinal Block in Nuss Patients. A Pilot Project

NCT02169297
View directory record Official record
Conditions
Pectus Excavatum, Pain, Postoperative
Interventions
Ultrasound-guided Sub-Paraspinal Block, PCA only
Procedure
Lead sponsor
Nemours Children's Clinic
Other
Eligibility
12 Years to 17 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2014
U.S. locations
1
States / cities
Jacksonville, Florida
Source: ClinicalTrials.gov public record
Updated Jun 23, 2014 · Synced Oct 10, 2026, 12:58 PM EDT
Recruiting Phase 4 Interventional

Suprainguinal Fascia Iliaca Block With vs Without Dexmedetomidine

NCT07316166
View directory record Official record
Conditions
Postoperative Pain Management
Interventions
Dexmedetomidine, Ropivacaine
Drug
Lead sponsor
Rhode Island Hospital
Other
Eligibility
18 Years to 80 Years
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Mar 25, 2026 · Synced Oct 10, 2026, 12:58 PM EDT
Recruiting Phase 3 Interventional

Intrathecal Morphine Versus Intravenous Methadone for Postoperative Analgesia Following Retroperitoneal Lymph Node Dissection.

NCT06593665
View directory record Official record
Conditions
Testicular Cancer
Interventions
Inrathecal Morphine, Intravenous Methadone
Drug
Lead sponsor
Indiana University
Other
Eligibility
18 Years to 80 Years · Male only
Enrollment
142 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
2
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Feb 13, 2026 · Synced Oct 10, 2026, 12:58 PM EDT
Active, not recruiting Phase 3 Interventional

A Study of TLC590 for Postsurgical Pain Following Bunionectomy

NCT07222748
View directory record Official record
Conditions
Postoperative Pain
Interventions
TLC590, Liposomal Bupivacaine, Saline Placebo
Drug
Lead sponsor
TLC Biopharmaceuticals, Inc.
Industry
Eligibility
18 Years and older
Enrollment
304 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
4
States / cities
Miami, Florida • Bellaire, Texas • Houston, Texas + 1 more
Source: ClinicalTrials.gov public record
Updated Jul 2, 2026 · Synced Oct 10, 2026, 12:58 PM EDT
Completed Not applicable Interventional

Abdominal Wall Block Study

NCT03074240
View directory record Official record
Conditions
Umbilical Hernia, Obesity
Interventions
TAPB Group, RSB Group, conversion to general anesthesia
Procedure
Lead sponsor
University of Florida
Other
Eligibility
18 Years to 99 Years
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2021
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated May 30, 2024 · Synced Oct 10, 2026, 12:58 PM EDT
Recruiting Phase 4 Interventional

COMFORT Trial: Complex Obstetric Management With Focused Regional Transversus Abdominis Plane Block

NCT06925152
View directory record Official record
Conditions
Complex Obstetric Surgery, Perioperative Pain Management, Cesarean Delivery, Postoperative Pain Control
Interventions
Bupivicaine intervention arm, Placebo arm
Drug
Lead sponsor
University of Tennessee
Other
Eligibility
18 Years to 50 Years · Female only
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
1
States / cities
Memphis, Tennessee
Source: ClinicalTrials.gov public record
Updated Mar 11, 2026 · Synced Oct 10, 2026, 12:58 PM EDT
Terminated Not applicable Interventional

Patient Satisfaction and Postoperative Analgesia Between Subarachnoid Block With 2-chloroprocaine Versus General Anesthesia for Knee Arthroscopy

NCT03173326
View directory record Official record
Conditions
Knee Arthroscopy, General Anesthesia, Subarachnoid Block
Interventions
General anesthesia, Subarachnoid block
Procedure
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
30 Years to 65 Years
Enrollment
1 participant
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Aug 8, 2018 · Synced Oct 10, 2026, 12:58 PM EDT
Completed Phase 4 Interventional Results available

Methadone Versus Morphine for Orthopedic Surgery Patients

NCT00892606
View directory record Official record
Conditions
Fracture, Pain, Postoperative
Interventions
Methadone, Morphine
Drug
Lead sponsor
University of Louisville
Other
Eligibility
18 Years to 65 Years
Enrollment
75 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2013
U.S. locations
1
States / cities
Louisville, Kentucky
Source: ClinicalTrials.gov public record
Updated Jun 14, 2017 · Synced Oct 10, 2026, 12:58 PM EDT
Terminated Not applicable Interventional

Mindfulness Meditation for Spine Surgery Pain

NCT02104349
View directory record Official record
Conditions
Meditation, Spine Surgery, Pain, Postoperative
Interventions
Mindfulness meditation
Behavioral
Lead sponsor
Icahn School of Medicine at Mount Sinai
Other
Eligibility
18 Years to 80 Years
Enrollment
38 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2020
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Apr 4, 2025 · Synced Oct 10, 2026, 12:58 PM EDT
Completed Phase 3 Interventional Results available

Evaluation of Preoperative N1539 in Colorectal Surgery

NCT03323385
View directory record Official record
Conditions
Pain, Postoperative
Interventions
N1539, Placebo
Drug
Lead sponsor
Baudax Bio
Industry
Eligibility
18 Years to 80 Years
Enrollment
57 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
10
States / cities
Florence, Alabama • Mobile, Alabama • Miami, Florida + 6 more
Source: ClinicalTrials.gov public record
Updated Jun 18, 2023 · Synced Oct 10, 2026, 12:58 PM EDT
Terminated Phase 4 Interventional Results available

Post-operative Pain Management in Children With Supracondylar Humerus Fractures

NCT05640674
View directory record Official record
Conditions
Supracondylar Humerus Fracture
Interventions
Ibuprofen, Hydrocodone/acetaminophen, Acetaminophen
Drug
Lead sponsor
Baylor College of Medicine
Other
Eligibility
3 Years to 12 Years
Enrollment
29 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
3
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Feb 10, 2026 · Synced Oct 10, 2026, 12:58 PM EDT
Completed Phase 4 Interventional Results available

Dexamethasone for Post Cesarean Delivery Analgesia

NCT01868633
View directory record Official record
Conditions
Postoperative Pain
Interventions
Dexamethasone, Placebo
Drug
Lead sponsor
University of Iowa
Other
Eligibility
18 Years to 50 Years · Female only
Enrollment
52 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2015
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Sep 19, 2017 · Synced Oct 10, 2026, 12:58 PM EDT
Completed Phase 4 Interventional

Liposomal Bupivacaine Versus Bupivacaine for for Postoperative Pain Control in Shoulder Surgery

NCT04180943
View directory record Official record
Conditions
Anesthesia, Local
Interventions
interscalene nerve block
Drug
Lead sponsor
Bassett Healthcare
Other
Eligibility
18 Years and older
Enrollment
85 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
1
States / cities
Cooperstown, New York
Source: ClinicalTrials.gov public record
Updated Mar 2, 2022 · Synced Oct 10, 2026, 12:58 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Pudendal Nerve Block in Vaginal Surgery

NCT04198714
View directory record Official record
Conditions
Nerve Block, Pain, Postoperative, Pelvic Floor Disorders, Pelvic Organ Prolapse, Pudendal Neuralgia, Surgery
Interventions
Pudendal block
Procedure
Lead sponsor
MetroHealth Medical Center
Other
Eligibility
18 Years to 80 Years · Female only
Enrollment
72 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2021
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Aug 12, 2024 · Synced Oct 10, 2026, 12:58 PM EDT