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Showing 1–24 of 217 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Postpartum Depressive Mood Clear all
Completed Phase 3 Interventional

A Study to Assess the Safety and Efficacy of Oral LPCN 1154A in Women With Severe PPD

NCT06979544
View directory record Official record
Conditions
Depression, Postpartum, Depression, Post-Partum, Postpartum Depression (PPD), Post-Natal Depression, Peripartum Depression, Postnatal Depression
Interventions
LPCN 1154A, Placebo
Drug
Lead sponsor
Lipocine Inc.
Industry
Eligibility
15 Years to 45 Years · Female only
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
18
States / cities
Anahiem, California • Canoga Park, California • Miami, Florida + 14 more
Source: ClinicalTrials.gov public record
Updated Feb 23, 2026 · Synced Sep 9, 2026, 11:06 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

The Effect of Exercise on Preventing PostPartum Depression

NCT00961402
View directory record Official record
Conditions
PostPartum Depression
Interventions
Wellness Control, Exercise Intervention
Behavioral
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years and older · Female only
Enrollment
130 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2011
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Nov 17, 2019 · Synced Sep 9, 2026, 11:06 PM EDT
Suspended Phase 1 Interventional Accepts healthy volunteers

Ketamine Pharmacokinetics and Pharmacodynamics for Postpartum Depression and Pain After Cesarean Delivery

NCT06767566
View directory record Official record
Conditions
Pain, Postpartum Depression
Interventions
Ketamine (Ketalar)
Drug
Lead sponsor
University of Utah
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2028
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jun 28, 2026 · Synced Sep 9, 2026, 11:06 PM EDT
Recruiting Not applicable Interventional

Maternal Stress on Human Milk and Infant Outcomes

NCT04821544
View directory record Official record
Conditions
Postpartum Depression, Preterm Labor
Interventions
Mindfulness-based intervention (with a focus on self-compassion; MBSC), Vitamin D
Behavioral · Dietary Supplement
Lead sponsor
University of Idaho
Other
Eligibility
18 Years to 50 Years · Female only
Enrollment
500 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2027
U.S. locations
1
States / cities
Coeur d'Alene, Idaho
Source: ClinicalTrials.gov public record
Updated May 17, 2025 · Synced Sep 9, 2026, 11:06 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Fresh RX: NHS 2020

NCT04845230
View directory record Official record
Conditions
Premature Birth, Birth Weight, Post Partum Depression, Health Care Utilization, Nutrition Deficiency Due to Insufficient Food, Housing Problems, Fetal Complications, Food Deprivation
Interventions
FreshRx Nourishing Healthy Starts
Behavioral
Lead sponsor
Washington University School of Medicine
Other
Eligibility
14 Years to 55 Years · Female only
Enrollment
750 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2026
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Nov 28, 2022 · Synced Sep 9, 2026, 11:06 PM EDT
Not listed Not applicable Interventional

Translating Research Into Practice for Postpartum Depression

NCT00548743
View directory record Official record
Conditions
Postpartum Depression
Interventions
Screening and follow up, Usual care
Behavioral
Lead sponsor
Olmsted Medical Center
Other
Eligibility
18 Years to 45 Years · Female only
Enrollment
3,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2010
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Dec 3, 2007 · Synced Sep 9, 2026, 11:06 PM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

Clinical Validation of a Predictive Test for Postpartum Depression

NCT06831968
View directory record Official record
Conditions
Postpartum Depression (PPD), Pregnancy
Interventions
Enlighten
Diagnostic Test
Lead sponsor
University of Virginia
Other
Eligibility
18 Years and older · Female only
Enrollment
500 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2028
U.S. locations
2
States / cities
Charlottesville, Virginia • Falls Church, Virginia
Source: ClinicalTrials.gov public record
Updated Dec 2, 2025 · Synced Sep 9, 2026, 11:06 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Pilot Trial of CenteringPregnancy With Mindfulness Skills

NCT01646463
View directory record Official record
Conditions
Premature Birth, Low Birth Weight, Postpartum Depression
Interventions
CenteringPregnancy, CenteringPregnancy with Mindfulness Skills
Behavioral
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years and older · Female only
Enrollment
49 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2017
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Feb 16, 2020 · Synced Sep 9, 2026, 11:06 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Implementation of a Clinical Decision Support Tool for Postpartum Depression

NCT06818734
View directory record Official record
Conditions
Postpartum Depression
Interventions
Clinical Decision Support Tool
Other
Lead sponsor
Weill Medical College of Cornell University
Other
Eligibility
18 Years and older · Female only
Enrollment
160 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026
U.S. locations
4
States / cities
Brooklyn, New York • New York, New York
Source: ClinicalTrials.gov public record
Updated Jul 29, 2026 · Synced Sep 9, 2026, 11:06 PM EDT
Withdrawn Not applicable Interventional Accepts healthy volunteers

Carrying for the Culture

NCT06148831
View directory record Official record
Conditions
Postpartum Depression, Breast Feeding
Interventions
Infant Carrier
Device
Lead sponsor
Nurturely
Other
Eligibility
18 Years and older · Female only
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2026
U.S. locations
1
States / cities
Eugene, Oregon
Source: ClinicalTrials.gov public record
Updated Jan 28, 2026 · Synced Sep 9, 2026, 11:06 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Yoga in the NICU for Parents Study

NCT05322161
View directory record Official record
Conditions
Postpartum Depression, Anxiety, Depression, Stress Disorder, Prematurity
Interventions
yoga classes
Behavioral
Lead sponsor
Seattle Children's Hospital
Other
Eligibility
Not listed
Enrollment
51 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2024
U.S. locations
2
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated May 16, 2024 · Synced Sep 9, 2026, 11:06 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Engaging Mothers & Babies; Reimagining Antenatal Care for Everyone (EMBRACE) Study

NCT04154423
View directory record Official record
Conditions
Premature Birth, Pregnancy Preterm, Prenatal Stress, Depression, Anxiety, Depression, Postpartum, Satisfaction, Patient, Health Problems in Pregnancy
Interventions
Glow! Group Prenatal Care, Individual Prenatal Care with CPSP
Other
Lead sponsor
University of California, San Francisco
Other
Eligibility
Female only
Enrollment
678 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2024
U.S. locations
2
States / cities
Fresno, California • San Francisco, California
Source: ClinicalTrials.gov public record
Updated Aug 16, 2026 · Synced Sep 9, 2026, 11:06 PM EDT
Completed Not applicable Interventional

Nurtured in Nature

NCT04146025
View directory record Official record
Conditions
Postpartum Depression, Pregnancy Related, Environmental Exposure
Interventions
Nature Coach Intervention
Behavioral
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years and older · Female only
Enrollment
36 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Nov 23, 2020 · Synced Sep 9, 2026, 11:06 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Case Management Study for Postpartum Depression and Intimate Partner Violence

NCT00560027
View directory record Official record
Conditions
Postpartum Depression, Intimate Partner Violence
Interventions
Case Management by Family Support Counselor (not RCT)
Other
Lead sponsor
Johns Hopkins University
Other
Eligibility
Female only
Enrollment
173 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2013
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated May 27, 2015 · Synced Sep 9, 2026, 11:06 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Behavioral Change in the Mother-Infant Dyad: Preventing Postpartum Depression

NCT01379781
View directory record Official record
Conditions
Postpartum Depression
Interventions
Behavioral Intervention for PPD
Behavioral
Lead sponsor
New York State Psychiatric Institute
Other
Eligibility
18 Years to 35 Years · Female only
Enrollment
54 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2018
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jul 2, 2024 · Synced Sep 9, 2026, 11:06 PM EDT
Completed Not applicable Interventional

Study of Probiotic Use After Childbirth in Relation to Emotional Well-Being

NCT04472065
View directory record Official record
Conditions
Mental Health Wellness
Interventions
Lactobacillus reuteri, Placebo
Dietary Supplement · Other
Lead sponsor
Elizabeth Austen Lawson
Other
Eligibility
18 Years and older · Female only
Enrollment
46 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Oct 24, 2023 · Synced Sep 9, 2026, 11:06 PM EDT
Completed Phase 2 Interventional

A Study of BRII-296 in Adults With Severe Postpartum Depression (PPD)

NCT06057012
View directory record Official record
Conditions
Severe Postpartum Depression
Interventions
BRII-296, Depo Medrol
Drug
Lead sponsor
Brii Biosciences Limited
Industry
Eligibility
18 Years to 45 Years
Enrollment
11 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
11
States / cities
Sherman Oaks, California • Torrance, California • Boynton Beach, Florida + 7 more
Source: ClinicalTrials.gov public record
Updated Jan 26, 2025 · Synced Sep 9, 2026, 11:06 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

The Maternal Well-Being Study

NCT05484999
View directory record Official record
Conditions
Postpartum Depression, Postpartum Anxiety, Weight Retention, Postpartum, Nutritional and Metabolic Diseases
Interventions
Meals, Meals + Social Support, Control
Other
Lead sponsor
Texas Tech University Health Sciences Center
Other
Eligibility
18 Years and older · Female only
Enrollment
84 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2025
U.S. locations
1
States / cities
Amarillo, Texas
Source: ClinicalTrials.gov public record
Updated Aug 28, 2024 · Synced Sep 9, 2026, 11:06 PM EDT
Not listed Phase 4 Interventional Accepts healthy volunteers

Oral Contraceptive Ethinyl Estradiol Dose Effect on Postpartum Depression and Sexual Functioning Scales

NCT02210702
View directory record Official record
Conditions
Postpartum Depressive Mood, Postpartum Sexual Function
Interventions
Ethinyl Estradiol 35mcg/Norethindrone 1mg, Ethinyl Estradiol 20mcg/Norethindrone 1mg
Drug
Lead sponsor
The Jones Institute
Other
Eligibility
18 Years to 45 Years · Female only
Enrollment
33 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
Started 2014
U.S. locations
1
States / cities
Norfolk, Virginia
Source: ClinicalTrials.gov public record
Updated Aug 6, 2014 · Synced Sep 9, 2026, 11:06 PM EDT
Completed Phase 2 Interventional Results available

Evaluate SAGE-547 in Female Participants With Severe Postpartum Depression

NCT02285504
View directory record Official record
Conditions
Postpartum Depression
Interventions
SAGE-547
Drug
Lead sponsor
Supernus Pharmaceuticals, Inc.
Industry
Eligibility
18 Years to 45 Years · Female only
Enrollment
4 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Sep 14, 2025 · Synced Sep 9, 2026, 11:06 PM EDT
Recruiting Not applicable Interventional

Physiological and Psychological Effects of Music Therapy in the Pregnant Woman and Fetus

NCT05893485
View directory record Official record
Conditions
Music Therapy, Preterm Premature Rupture of Membrane (PPROM)
Interventions
Music Therapy Intervention
Behavioral
Lead sponsor
Christina Chianis Reed
Other
Eligibility
18 Years to 64 Years · Female only
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Sep 18, 2024 · Synced Sep 9, 2026, 11:06 PM EDT
Recruiting Not applicable Interventional

HeartGPS: A Study Exploring the Effects of a Psychological Intervention for Parents and Their Babies After Prenatal Cardiac Diagnosis

NCT06175104
View directory record Official record
Conditions
Heart Defects, Congenital, Anxiety in Pregnancy, Depression, Postpartum, Trauma, Psychological, Neurodevelopmental Disorders
Interventions
HeartGPS
Behavioral
Lead sponsor
Children's Hospital Medical Center, Cincinnati
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
2
States / cities
Los Angeles, California • Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Jul 19, 2025 · Synced Sep 9, 2026, 11:06 PM EDT
Completed Not applicable Interventional

Group Therapy for Postpartum Depression

NCT00051246
View directory record Official record
Conditions
Depression, Postpartum
Interventions
Mother-Infant Group Psychotherapy, Interpersonal Psychotherapy
Behavioral
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
18 Years and older · Female only
Enrollment
147 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2002 – 2008
U.S. locations
1
States / cities
Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated Jan 23, 2014 · Synced Sep 9, 2026, 11:06 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Parenting Skills Group for Mothers With Postpartum Depression

NCT05772897
View directory record Official record
Conditions
Postpartum Depression
Interventions
Circle of Security Parenting program
Behavioral
Lead sponsor
University of Colorado, Denver
Other
Eligibility
18 Years to 50 Years · Female only
Enrollment
750 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2035
U.S. locations
1
States / cities
Denver, Colorado
Source: ClinicalTrials.gov public record
Updated Nov 29, 2023 · Synced Sep 9, 2026, 11:06 PM EDT