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Showing 1–24 of 713 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Pre Diabetes Clear all
Completed Not applicable Interventional Accepts healthy volunteers

Fuel Utilization, Diet Composition, and Exercise in African American Women

NCT04293367
View directory record Official record
Conditions
Obesity, Diabetes, Insulin Resistance
Interventions
High Intensity Interval Training (HIIT)
Other
Lead sponsor
Icahn School of Medicine at Mount Sinai
Other
Eligibility
20 Years to 40 Years · Female only
Enrollment
28 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2013
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Mar 2, 2020 · Synced Jul 23, 2026, 6:08 PM EDT
Active, not recruiting Not applicable Interventional

Mastering Diabetes Study

NCT04454957
View directory record Official record
Conditions
Diabetes Mellitus, Type 2, PreDiabetes
Interventions
Mastering Diabetes
Behavioral
Lead sponsor
Ohio University
Other
Eligibility
18 Years to 65 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2025
U.S. locations
1
States / cities
Athens, Ohio
Source: ClinicalTrials.gov public record
Updated Nov 21, 2024 · Synced Jul 23, 2026, 6:08 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Pre-diabetes in Subject With Impaired Fasting Glucose (IFG) and Impaired Glucose Tolerance (IGT)

NCT02969798
View directory record Official record
Conditions
Diabetes Mellitus, Type 2, Impaired Glucose Tolerance (IGT), Impaired Fasting Glucose (IFG)
Interventions
Dapagliflozin, Saxagliptin, Pioglitazone, Metformin
Drug
Lead sponsor
The University of Texas Health Science Center at San Antonio
Other
Eligibility
18 Years to 65 Years
Enrollment
700 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2027
U.S. locations
1
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Aug 26, 2025 · Synced Jul 23, 2026, 6:08 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Metformin in Longevity Study (MILES).

NCT02432287
View directory record Official record
Conditions
Aging
Interventions
Metformin, Placebo
Drug
Lead sponsor
Albert Einstein College of Medicine
Other
Eligibility
60 Years and older
Enrollment
16 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2017
U.S. locations
1
States / cities
The Bronx, New York
Source: ClinicalTrials.gov public record
Updated May 20, 2021 · Synced Jul 23, 2026, 6:08 PM EDT
Withdrawn Not applicable Interventional Accepts healthy volunteers

Home-based Prediabetes Care in Acoma Pueblo - Study 1

NCT04029298
View directory record Official record
Conditions
PreDiabetes
Interventions
Lifestyle Interventions
Behavioral
Lead sponsor
University of New Mexico
Other
Eligibility
21 Years to 60 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
Acoma Pueblo, New Mexico
Source: ClinicalTrials.gov public record
Updated Jul 2, 2024 · Synced Jul 23, 2026, 6:08 PM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

Blood Markers of Early Pancreas Cancer

NCT03568630
View directory record Official record
Conditions
Diabetes Mellitus, Type 2, PreDiabetes, Pancreas Cyst, Chronic Pancreatitis, Genetic Predisposition to Disease, Inherited Disease
Interventions
Not listed
Lead sponsor
University of Nebraska
Other
Eligibility
19 Years and older
Enrollment
1,250 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2028
U.S. locations
1
States / cities
Omaha, Nebraska
Source: ClinicalTrials.gov public record
Updated Feb 1, 2026 · Synced Jul 23, 2026, 6:08 PM EDT
Recruiting Not applicable Interventional

Stand up for Your Health With a Sit-stand Desk

NCT05585190
View directory record Official record
Conditions
Pre Diabetes, Obesity, Metabolic Syndrome, Sedentary Behavior
Interventions
Control, Sit-Stand Desk at Work
Other
Lead sponsor
Medical College of Wisconsin
Other
Eligibility
18 Years to 79 Years
Enrollment
198 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
1
States / cities
Milwaukee, Wisconsin
Source: ClinicalTrials.gov public record
Updated May 3, 2026 · Synced Jul 23, 2026, 6:08 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Vitamin K and Glucose Metabolism in Children at Risk for Diabetes (Vita-K 'n' Kids Study)

NCT01972113
View directory record Official record
Conditions
Obesity, Insulin Resistance, Insulin Sensitivity, Prediabetes, Dyslipidemia, Diabetes
Interventions
Placebo-Control, Low-Dose Vitamin K2 (menaquinone-7; 45 mcg/d), High-Dose Vitamin K2 (menaquinone-7; 90 mcg/d)
Dietary Supplement
Lead sponsor
Augusta University
Other
Eligibility
8 Years to 17 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2020
U.S. locations
1
States / cities
Augusta, Georgia
Source: ClinicalTrials.gov public record
Updated Nov 18, 2019 · Synced Jul 23, 2026, 6:08 PM EDT
Recruiting Phase 2 Interventional Accepts healthy volunteers

Social Determinants and a Diabetes Prevention Program Tailored for African Americans

NCT05301413
View directory record Official record
Conditions
PreDiabetes, Overweight and Obesity
Interventions
Culturally Tailored Diabetes Prevention Program, Culturally Tailored DPP Enhanced with Socioeconomic Supports, Diabetes Prevention Program
Behavioral
Lead sponsor
University of Missouri, Kansas City
Other
Eligibility
18 Years and older
Enrollment
360 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2026
U.S. locations
2
States / cities
Kansas City, Missouri
Source: ClinicalTrials.gov public record
Updated May 24, 2025 · Synced Jul 23, 2026, 6:08 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Vitamin D and Pregnancy: Camden Study

NCT02032459
View directory record Official record
Conditions
Reproductive Effects, Pregnancy
Interventions
Not listed
Lead sponsor
Rowan University
Other
Eligibility
18 Years and older · Female only
Enrollment
1,141 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
Started 2007
U.S. locations
1
States / cities
Stratford, New Jersey
Source: ClinicalTrials.gov public record
Updated Jan 9, 2014 · Synced Jul 23, 2026, 6:08 PM EDT
Recruiting Not applicable Interventional

A Randomized Controlled Trial of Diabetes Screening Immediately Postpartum (DIP) and Follow Up PP CARE

NCT05909046
View directory record Official record
Conditions
Pre-Gestational Diabetes, Type2diabetes, Pregnancy in Diabetic, Pregnancy, High Risk, Gestational Diabetes, Gestational Diabetes Mellitus in the Puerperium
Interventions
Immediate inpatient postpartum OGTT, Standard of care 4-12 week postpartum OGTT
Diagnostic Test
Lead sponsor
Ohio State University
Other
Eligibility
18 Years and older · Female only
Enrollment
104 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Nov 23, 2025 · Synced Jul 23, 2026, 6:08 PM EDT
Recruiting Not applicable Interventional

Fresh Takes!: An Evaluation of the Impact of Receiving Fresh Food Boxes

NCT06019624
View directory record Official record
Conditions
Diabetes, PreDiabetes, Food Insecurity
Interventions
Fresh Takes!
Behavioral
Lead sponsor
Montefiore Medical Center
Other
Eligibility
18 Years to 75 Years
Enrollment
400 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
1
States / cities
The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Sep 25, 2025 · Synced Jul 23, 2026, 6:08 PM EDT
Withdrawn Not applicable Interventional Accepts healthy volunteers

Weight Loss Using a Feedback Device in Obese People With the Metabolic Syndrome

NCT03491930
View directory record Official record
Conditions
Weight Loss, Obesity, Pre-Diabetes, Metabolic Syndrome
Interventions
VA MOVE! Coach app, Telephone Coaching, Standard of Care for weight loss.
Device · Behavioral
Lead sponsor
Rockefeller University
Other
Eligibility
40 Years to 70 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2018
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Oct 23, 2018 · Synced Jul 23, 2026, 6:08 PM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Fructose: Substrate, Stimulus, or Both?

NCT04168372
View directory record Official record
Conditions
Insulin Resistance, Insulin Sensitivity, Pre Diabetes
Interventions
High fructose, fructose labeled meal, High fructose, pyruvate labeled meal, Low fructose, fructose labeled meal, Low fructose, pyruvate labeled meal
Other
Lead sponsor
Touro University, California
Other
Eligibility
20 Years to 55 Years
Enrollment
35 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2027
U.S. locations
1
States / cities
Vallejo, California
Source: ClinicalTrials.gov public record
Updated Jul 9, 2026 · Synced Jul 23, 2026, 6:08 PM EDT
Completed Not applicable Interventional Results available

Implementation and Evaluation of a Diabetes Prevention Clinical Pathway in Primary Care

NCT05265312
View directory record Official record
Conditions
PreDiabetes, Prediabetic State
Interventions
START diabetes prevention clinical pathway
Other
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years and older
Enrollment
1,910 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
Lutherville, Maryland
Source: ClinicalTrials.gov public record
Updated Feb 4, 2025 · Synced Jul 23, 2026, 6:08 PM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

PASO A PASO: Tailored Diabetes Prevention Program for Spanish-Speaking Communities Feasibility Study

NCT07392008
View directory record Official record
Conditions
Pre Diabetic
Interventions
Paso a Paso
Behavioral
Lead sponsor
University of Utah
Other
Eligibility
18 Years and older
Enrollment
45 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Feb 5, 2026 · Synced Jul 23, 2026, 6:08 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers

Pistachios Blood Sugar Control, Heart and Gut Health

NCT04056208
View directory record Official record
Conditions
Type 2 Diabetes, Cardiovascular Diseases
Interventions
Pistachio, Usual care
Drug · Other
Lead sponsor
Penn State University
Other
Eligibility
30 Years to 65 Years
Enrollment
66 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2022
U.S. locations
1
States / cities
University Park, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Aug 17, 2023 · Synced Jul 23, 2026, 6:08 PM EDT
Completed Phase 1Phase 2 Interventional Results available

Metformin and Muscle in Insulin-resistant Older Veterans

NCT01804049
View directory record Official record
Conditions
Prediabetes
Interventions
metformin, placebo
Drug
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
65 Years and older
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2018
U.S. locations
1
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Feb 10, 2020 · Synced Jul 23, 2026, 6:08 PM EDT
Completed Not applicable Interventional Results available

Translating the DPP Into the Community

NCT00302042
View directory record Official record
Conditions
Prediabetic State, Overweight, Obesity
Interventions
Brief counseling plus group diabetes prevention in community, Brief Counseling for pre-diabetes alone
Behavioral
Lead sponsor
Northwestern University
Other
Eligibility
18 Years and older
Enrollment
92 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2007
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Jul 17, 2017 · Synced Jul 23, 2026, 6:08 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Microlearning Application for Diabetes Prevention

NCT05071820
View directory record Official record
Conditions
PreDiabetes, Elevated Blood Sugar
Interventions
Health U mobile application, National Diabetes Prevention Program
Other
Lead sponsor
Stanford University
Other
Eligibility
18 Years to 85 Years
Enrollment
12 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023
U.S. locations
1
States / cities
Palo Alto, California
Source: ClinicalTrials.gov public record
Updated Dec 9, 2024 · Synced Jul 23, 2026, 6:08 PM EDT
Completed Phase 1 Interventional

Glycemic Effect of Diazoxide in NAFLD

NCT05729282
View directory record Official record
Conditions
Hyperinsulinemia, Insulin Resistance, Non-Alcoholic Fatty Liver Disease, Prediabetic State
Interventions
Diazoxide oral suspension, 1 mg per kg per dose, Diazoxide oral suspension, 2 mg per kg per dose, Placebo, FreeStyle Libre Pro, Deuterated water (2H2O/D2O)
Drug · Device
Lead sponsor
Columbia University
Other
Eligibility
18 Years to 70 Years
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jan 6, 2026 · Synced Jul 23, 2026, 6:08 PM EDT
Recruiting Not applicable Interventional

Food as Medicine for HIV and Diabetes

NCT05026723
View directory record Official record
Conditions
Diabetes Mellitus, Type 2, HIV Infections, PreDiabetes
Interventions
MTM + ILI, Standard MTM
Behavioral
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years and older
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2027
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Dec 10, 2025 · Synced Jul 23, 2026, 6:08 PM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Recreational Basketball to Increase Participation in Diabetes Prevention

NCT05066542
View directory record Official record
Conditions
Type 2 Diabetes, PreDiabetes
Interventions
NDPP + Basketball (BB), NDPP Standard of Care SOC
Behavioral
Lead sponsor
Kaiser Permanente
Other
Eligibility
18 Years to 44 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2026
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Mar 17, 2025 · Synced Jul 23, 2026, 6:08 PM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

Inflammation, Diabetes, Ethnicity and Obesity Cohort

NCT03022682
View directory record Official record
Conditions
Obesity, Diabetes Mellitus, Pre Diabetes
Interventions
Not listed
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years to 75 Years
Enrollment
350 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2026
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Jul 3, 2025 · Synced Jul 23, 2026, 6:08 PM EDT