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ClinicalTrials.gov public records Last synced Nov 6, 2026, 11:37 AM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 1–24 of 692 matching trials from the live ClinicalTrials.gov search.

Filters: Condition: Primary Headache Disorders Clear all

Conditions: Migraine
Interventions: Fremanezumab; Drug
Lead sponsor: Teva Branded Pharmaceutical Products R&D LLC; Industry
Eligibility: 6 Years to 17 Years
Enrollment: 499 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2025
U.S. locations: 32
States / cities: Aurora, Colorado • Colorado Springs, Colorado • Jacksonville, Florida + 27 more

Conditions: Migraine With Aura, Migraine Without Aura, Chronic Migraine
Interventions: milnacipran; Drug
Lead sponsor: California Medical Clinic for Headache; Other
Eligibility: 18 Years to 70 Years
Enrollment: 45 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2012
U.S. locations: 1
States / cities: Santa Monica, California

Conditions: Migraine
Interventions: Dexamethasone 4mg, Dexamethasone 16mg; Drug
Lead sponsor: Montefiore Medical Center; Other
Eligibility: 18 Years and older
Enrollment: 209 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2022
U.S. locations: 1
States / cities: The Bronx, New York

Conditions: Migraine, Chronic Headache
Interventions: Topiramate; Drug
Lead sponsor: Emerald City Headache Organization; Other
Eligibility: 18 Years to 55 Years
Enrollment: 10 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2006
U.S. locations: 1
States / cities: Seattle, Washington

Conditions: Migraine Disorders
Interventions: onabotulinumtoxinA, Topiramate; Biological · Drug
Lead sponsor: Allergan; Industry
Eligibility: 18 Years to 65 Years
Enrollment: 282 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2017
U.S. locations: 32
States / cities: Phoenix, Arizona • Encinitas, California • Fresno, California + 28 more

Conditions: Migraine, Obesity
Interventions: Behavioral Weight Loss Intervention, Migraine Education; Behavioral · Other
Lead sponsor: The Miriam Hospital; Other
Eligibility: 18 Years to 50 Years · Female only
Enrollment: 112 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2012 – 2017
U.S. locations: 1
States / cities: Providence, Rhode Island

Conditions: Migraine
Interventions: Erenumab, Placebo; Drug
Lead sponsor: Amgen; Industry
Eligibility: 18 Years and older
Enrollment: 512 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2023
U.S. locations: 31
States / cities: Long Beach, California • Los Angeles, California • Basalt, Colorado + 28 more

Conditions: Migraine
Interventions: RELAXaHEAD Smartphone App, In-Person Training, Virtual Training; Behavioral
Lead sponsor: NYU Langone Health; Other
Eligibility: 18 Years to 65 Years
Enrollment: 50 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2024
U.S. locations: 1
States / cities: New York, New York

Conditions: Migraine
Interventions: topiramate, frovatriptan; Drug
Lead sponsor: Clinvest; Individual
Eligibility: 18 Years and older
Enrollment: 55 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2009 – 2011
U.S. locations: 2
States / cities: Oviedo, Florida • Springfield, Missouri

Conditions: Cluster Headache
Interventions: Vitamin D, multivitamin, Placebo; Dietary Supplement
Lead sponsor: The University of Texas Health Science Center, Houston; Other
Eligibility: 18 Years to 70 Years
Enrollment: 27 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2024
U.S. locations: 1
States / cities: Houston, Texas

Conditions: Chronic Migraine
Interventions: IONIS-PKKRx (ISIS 546254), Placebo; Drug · Other
Lead sponsor: Smith, Timothy R., M.D.; Individual
Eligibility: 18 Years to 65 Years
Enrollment: 30 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2019
U.S. locations: 2
States / cities: City of Saint Peters, Missouri • Springfield, Missouri

Conditions: Low Back Pain, Migraine, Diabetic Neuropathies, Osteoarthritis
Interventions: OraVescent Fentanyl; Drug
Lead sponsor: Cephalon; Industry
Eligibility: 18 Years to 80 Years
Enrollment: 500 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2005 – 2007
U.S. locations: 38
States / cities: Calera, Alabama • Hoover, Alabama • Phoenix, Arizona + 29 more

Conditions: Cyclic Vomiting Syndrome
Interventions: 3mg AZ-010, 1mg AZ010, Staccato Placebo; Combination Product
Lead sponsor: Alexza Pharmaceuticals, Inc.; Other
Eligibility: 18 Years to 60 Years
Enrollment: 150 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2022
U.S. locations: 18
States / cities: Lancaster, California • Los Angeles, California • San Diego, California + 14 more

Conditions: Migraine With or Without Aura
Interventions: Naltrexone and Acetaminophen, Naltrexone and Acetaminophen-High Dose, Naltrexone Alone (regular dose), Acetaminophen Alone, Matching Placebo; Drug
Lead sponsor: Allodynic Therapeutics, Inc; Industry
Eligibility: 18 Years and older
Enrollment: 92 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2018
U.S. locations: 1
States / cities: North Miami, Florida

Conditions: Migraine
Interventions: Mindfulness Based Stress Reduction, Migraine/stress Education; Other
Lead sponsor: Wake Forest University Health Sciences; Other
Eligibility: 18 Years and older
Enrollment: 89 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2019
U.S. locations: 1
States / cities: Winston-Salem, North Carolina

Conditions: Headache, Migraine
Interventions: Metoclopramide, Haloperidol, Normal Saline, Diphenhydramine; Drug · Other
Lead sponsor: OhioHealth; Other
Eligibility: 18 Years and older
Enrollment: 66 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2017
U.S. locations: 1
States / cities: Columbus, Ohio

Conditions: Migraine, Traumatic Brain Injury, Anomalous Health Incidents
Interventions: Xeomin (incobotulinumtoxinA); Drug
Lead sponsor: Uniformed Services University of the Health Sciences; Federal
Eligibility: 18 Years and older
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2028
U.S. locations: 1
States / cities: Bethesda, Maryland

Conditions: Migraine
Interventions: Not listed
Lead sponsor: Duke University; Other
Eligibility: 4 Years to 17 Years
Enrollment: 201 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2021
U.S. locations: 19
States / cities: San Francisco, California • Colorado Springs, Colorado • Wilmington, Delaware + 16 more

Conditions: Cluster Headache
Interventions: Topiramate; Drug
Lead sponsor: Thomas Jefferson University; Other
Eligibility: 18 Years to 65 Years
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2004 – 2006
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Migraine, With or Without Aura
Interventions: Rimegepant, Placebo; Drug
Lead sponsor: Pfizer; Industry
Eligibility: 18 Years and older
Enrollment: 1,485 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2018
U.S. locations: 50
States / cities: Birmingham, Alabama • Gilbert, Arizona • Tempe, Arizona + 45 more

Conditions: Migraine Headache, Episodic
Interventions: neuromodulation for episodic migraine headache; Device
Lead sponsor: Scion NeuroStim; Industry
Eligibility: 18 Years to 65 Years
Enrollment: 100 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2016
U.S. locations: 5
States / cities: San Diego, California • Ann Arbor, Michigan • Chapel Hill, North Carolina + 2 more

Conditions: Migraine
Interventions: lidocaine, bupivicaine and saline, lidocaine plus bupivicaine plus triamcinolone (steroid); Drug
Lead sponsor: Thomas Jefferson University; Other
Eligibility: 18 Years to 65 Years
Enrollment: 45 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2005 – 2006
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Headache, Migraine
Interventions: subjects personal triptan; Other
Lead sponsor: Clinvest; Other
Eligibility: 18 Years to 65 Years
Enrollment: 34 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2009
U.S. locations: 1
States / cities: Springfield, Missouri

Conditions: Headache Disorders, Dizziness, Vestibular Diseases, Sinus Disease, Vestibular Disorder, Migraine Disorders, Headache, Migraine, Facial Pain
Interventions: Not listed
Lead sponsor: Association of Migraine Disorders; Other
Eligibility: 18 Years and older
Enrollment: 10,000 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023 – 2033
U.S. locations: 1
States / cities: North Kingstown, Rhode Island

Search by objective public record fields.

A Trial to Test if Fremanezumab is Effective in Preventing Migraine in Children and Adolescents

Preventive Treatment of Episodic and Chronic Migraine

Dexamethasone for Migraine - Dose Comparison

Does Topiramate Adjust the Excitability of the Brain in Migraine Sufferers?

Efficacy and Safety Study of BOTOX® Compared to Topiramate for the Prevention of Chronic Migraine in Adults

Behavioral Weight Loss as a Treatment for Migraine in Obese Women

Erenumab - Comprehensive Assessment of Efficacy in (High-Frequency) Episodic Migraine

NYU Langone Health Headache Center Learning Migraine Self-Management Techniques Study

Pilot Study to Compare Frovatriptan vs. Topiramate for Prevention of Migraine

High Dose Vitamin D Plus Multivitamin in the Prevention of Cluster Headache

Efficacy and Safety of IONIS-PKKRx for Preventive Treatment of Chronic Migraine

Evaluating the Safety and Tolerability of OraVescent Fentanyl for Opioid Tolerant Patients With Noncancer Related Breakthrough Pain

Staccato Granisetron® (AZ 010) for the Treatment of Cyclic Vomiting Syndrome

An Acute Migraine Factorial Study

Mindfulness and Mechanisms of Pain Processing in Adults With Migraines

Efficacy of Haloperidol vs. Metoclopramide for Treatment of Acute Headaches and Migraines in the Emergency Department

Efficacy of Xeomin for Migraines in Patients With Traumatic Brain Injuries vs. Anomalous Health Incidents

Study of Pediatric Migraine: The Pediatric Migraine Registry

A Double-Blind, Placebo-Controlled Study Examining the Use of Topiramate in the Treatment of Cluster Headache

Safety and Efficacy Study in Adult Subjects With Acute Migraines

A Non-Invasive Neuromodulation Device for Treatment of Migraine Headache

A Research Study to Examine the Difference Between Local Anesthetics Alone and Local Anesthetics Plus Steroids in the Treatment of Chronic Headache

Correlation of Calcitonin Gene-Related Peptide (CGRP) Levels in Saliva With the Evolution of an Attack of Migraine

Headache Ear Auditory Dizziness Sinus (HEADS) Registry