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Showing 1–24 of 96 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Primary Motor Cortex Clear all
Completed Early Phase 1 Interventional Accepts healthy volunteers

Imaging Laterality in Chronic Stroke Patients

NCT03584425
View directory record Official record
Conditions
Stroke, Motor Cortex; Lesion
Interventions
Rasch modified version of the Fugl-Meyer Motor assessment, Anatomical image acquisition, Functional MRI task and acquisition
Diagnostic Test
Lead sponsor
Medical University of South Carolina
Other
Eligibility
21 Years to 80 Years
Enrollment
44 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2019
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Jul 22, 2019 · Synced Jun 25, 2026, 10:05 PM EDT
Not yet recruiting Not applicable Interventional

Investigating the Effects of Repetitive Transcranial Magnetic Stimulation (rTMS) on the Brain in People With Fibromyalgia

NCT07260864
View directory record Official record
Conditions
Fibromyalgia (FM)
Interventions
rTMS
Other
Lead sponsor
University of Rochester
Other
Eligibility
18 Years to 65 Years · Female only
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Dec 2, 2025 · Synced Jun 25, 2026, 10:05 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Brain Plus Spinal Stimulation for Cervical SCI

NCT04727866
View directory record Official record
Conditions
Spinal Cord Injuries, Spinal Cord Injury at C5-C7 Level, Tetraplegia/Tetraparesis
Interventions
transcutaneous spinal direct current stimulation (tsDCS) - coronal, transcutaneous spinal direct current stimulation (tsDCS) - caudal, transcutaneous spinal direct current stimulation (tsDCS) - rostral, intermittent theta burst stimulation (iTBS)
Device
Lead sponsor
Bronx VA Medical Center
Federal
Eligibility
18 Years to 75 Years
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2024
U.S. locations
1
States / cities
The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Jan 16, 2024 · Synced Jun 25, 2026, 10:05 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Modulation of Motor Cortex Excitability by TMS and tDCS (MAGS1)

NCT03481309
View directory record Official record
Conditions
Motor Activity, Motor Neuroplasticity
Interventions
anodal tDCS, cathodal tDCS, sham tDCS
Device
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years to 35 Years · Male only
Enrollment
19 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Mar 3, 2021 · Synced Jun 25, 2026, 10:05 PM EDT
Recruiting Early Phase 1 Interventional Accepts healthy volunteers

Spinal Cord Associative Plasticity Study

NCT05163639
View directory record Official record
Conditions
Cervical Spinal Cord Injury, Tetraplegia/Tetraparesis, Cervical Myelopathy
Interventions
Non-invasive pairing of cortical and spinal stimulation, Intraoperative pairing of cortical and spinal stimulation, Non-invasive repeated pairing of cortical and spinal stimulation (SCAP), Intraoperative repeated pairing of cortical and spinal stimulation (SCAP), Intraoperative repeated pairing of cortical and spinal stimulation (SCAP) at or below myelopathic region
Procedure
Lead sponsor
Columbia University
Other
Eligibility
18 Years to 80 Years
Enrollment
92 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2027
U.S. locations
3
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jun 17, 2026 · Synced Jun 25, 2026, 10:05 PM EDT
Completed No phase listed Observational

Transcranial Magnetic Stimulation and Electrical Stimulation of Nerves to Study Focal Dystonia

NCT00050024
View directory record Official record
Conditions
Dystonic Disorders
Interventions
Not listed
Lead sponsor
National Institute of Neurological Disorders and Stroke (NINDS)
NIH
Eligibility
18 Years and older
Enrollment
38 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2002 – 2008
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Jul 1, 2017 · Synced Jun 25, 2026, 10:05 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Brain Excitability During Self-Paced Voluntary Movements

NCT00017966
View directory record Official record
Conditions
Movement Disorder, Healthy
Interventions
Not listed
Lead sponsor
National Institute of Neurological Disorders and Stroke (NINDS)
NIH
Eligibility
Not listed
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2001 – 2002
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Mar 3, 2008 · Synced Jun 25, 2026, 10:05 PM EDT
Completed Not applicable Interventional

Handheld Dynamometer During Awake Craniotomy Pilot

NCT04742231
View directory record Official record
Conditions
Brain Lesion, Brain Tumor Adult, Brain Tumor
Interventions
Hand-held dynamometer
Device
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2024
U.S. locations
1
States / cities
Jacksonville, Florida
Source: ClinicalTrials.gov public record
Updated Mar 3, 2025 · Synced Jun 25, 2026, 10:05 PM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers Results available

Effects of L-theanine on Motor Cortex Excitability in Healthy Subjects: A Paired-Pulse TMS Study

NCT04749745
View directory record Official record
Conditions
Cortical Excitability, Psychiatric Disorder
Interventions
L-theanine, Placebo
Drug
Lead sponsor
Butler Hospital
Other
Eligibility
18 Years to 65 Years
Enrollment
11 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2021
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Sep 22, 2021 · Synced Jun 25, 2026, 10:05 PM EDT
Completed No phase listed Observational

Brain Function in Primary Lateral Sclerosis and Amyotrophic Lateral Sclerosis

NCT00334516
View directory record Official record
Conditions
Cerebral Cortex Dysfunction
Interventions
Not listed
Lead sponsor
National Institute of Neurological Disorders and Stroke (NINDS)
NIH
Eligibility
18 Years and older
Enrollment
77 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2015
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated May 30, 2019 · Synced Jun 25, 2026, 10:05 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Metaplasticity Experimental Design and Comparison of Motor Outcome Measure Sensitivity to Change

NCT03304262
View directory record Official record
Conditions
Healthy
Interventions
rTMS
Device
Lead sponsor
University of New Mexico
Other
Eligibility
18 Years to 99 Years · Female only
Enrollment
13 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
1
States / cities
Albuquerque, New Mexico
Source: ClinicalTrials.gov public record
Updated Aug 24, 2023 · Synced Jun 25, 2026, 10:05 PM EDT
Completed No phase listed Observational

Effect of Levetiracetam on Brain Excitability

NCT00006191
View directory record Official record
Conditions
Healthy, Myoclonic Epilepsy
Interventions
Not listed
Lead sponsor
National Institute of Neurological Disorders and Stroke (NINDS)
NIH
Eligibility
Not listed
Enrollment
14 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2000 – 2001
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Mar 3, 2008 · Synced Jun 25, 2026, 10:05 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Comparing the Location of the Motor Cortex in Children Using Two Methods

NCT02015338
View directory record Official record
Conditions
Congenital Hemiparesis
Interventions
Not listed
Lead sponsor
University of Minnesota
Other
Eligibility
8 Years to 17 Years
Enrollment
47 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2015
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Jul 17, 2019 · Synced Jun 25, 2026, 10:05 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Recognition of Second Language Spoken Words, Signs, and Characters Via Perception and Production in Adults

NCT05587218
View directory record Official record
Conditions
Second Language Acquisition in Healthy Young Adults
Interventions
Self-production
Behavioral
Lead sponsor
University of Alabama, Tuscaloosa
Other
Eligibility
18 Years to 35 Years
Enrollment
120 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2026
U.S. locations
1
States / cities
Tuscaloosa, Alabama
Source: ClinicalTrials.gov public record
Updated Oct 19, 2022 · Synced Jun 25, 2026, 10:05 PM EDT
Completed No phase listed Observational

Cortical Excitability and Inhibition in MDD

NCT01718730
View directory record Official record
Conditions
Major Depressive Disorder, Recurrent, Mild, Depressive Disorder, Major
Interventions
Transcranial Magnetic Stimulation (TMS), Magnetic Resonance Spectroscopy and Imaging
Device
Lead sponsor
Mayo Clinic
Other
Eligibility
13 Years to 21 Years
Enrollment
23 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2019
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Oct 21, 2019 · Synced Jun 25, 2026, 10:05 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Action Regulation Behavioral

NCT06489483
View directory record Official record
Conditions
Parkinson Disease
Interventions
Action Regulation Movement Task
Behavioral
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
18 Years to 80 Years
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2027
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Dec 11, 2025 · Synced Jun 25, 2026, 10:05 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Motor Skill Learning in People With Parkinson's Disease

NCT00396942
View directory record Official record
Conditions
Parkinson's Disease
Interventions
Not listed
Lead sponsor
National Institute of Neurological Disorders and Stroke (NINDS)
NIH
Eligibility
21 Years to 80 Years
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2008
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Jul 1, 2017 · Synced Jun 25, 2026, 10:05 PM EDT
Recruiting Not applicable Interventional

Feasibility of the BrainGate2 Neural Interface System in Persons With Tetraplegia

NCT05724173
View directory record Official record
Conditions
Anarthria, Dysarthria, Tetraplegia, Spinal Cord Injuries, Amyotrophic Lateral Sclerosis, Brain Stem Infarctions, Locked in Syndrome, Muscular Dystrophies
Interventions
BrainGate Neural Interface System
Device
Lead sponsor
Leigh R. Hochberg, MD, PhD.
Other
Eligibility
18 Years to 80 Years
Enrollment
3 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
2
States / cities
Stanford, California • Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jun 1, 2026 · Synced Jun 25, 2026, 10:05 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Transcranial Magnetic Stimulation to Study Imagination of Movement

NCT00046215
View directory record Official record
Conditions
Healthy
Interventions
Not listed
Lead sponsor
National Institute of Neurological Disorders and Stroke (NINDS)
NIH
Eligibility
Not listed
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2002 – 2003
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Mar 3, 2008 · Synced Jun 25, 2026, 10:05 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Effects of Flumazenil on Brain Excitability

NCT00015678
View directory record Official record
Conditions
Stroke, Healthy
Interventions
Not listed
Lead sponsor
National Institute of Neurological Disorders and Stroke (NINDS)
NIH
Eligibility
Not listed
Enrollment
7 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2001 – 2002
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Mar 3, 2008 · Synced Jun 25, 2026, 10:05 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Detecting a Reward Signal in the Motor Cortex

NCT00422071
View directory record Official record
Conditions
Healthy
Interventions
Not listed
Lead sponsor
National Institute of Neurological Disorders and Stroke (NINDS)
NIH
Eligibility
18 Years to 60 Years
Enrollment
168 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2014
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Dec 16, 2019 · Synced Jun 25, 2026, 10:05 PM EDT
Recruiting Not applicable Interventional

tDCS + CCFES-mediated Functional Task Practice for Post-stroke Upper Extremity Hemiplegia

NCT05866003
View directory record Official record
Conditions
Stroke, Upper Extremity Paresis, Hemiplegia
Interventions
Active conventional tDCS montage plus CCFES, Active unconventional tDCS montage plus CCFES, Sham tDCS plus CCFES, CCFES with Occupational Therapy
Device · Behavioral
Lead sponsor
MetroHealth Medical Center
Other
Eligibility
21 Years to 90 Years
Enrollment
63 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2028
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Sep 28, 2025 · Synced Jun 25, 2026, 10:05 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Noninvasive VNS to Facilitate Excitability in Motor Cortex

NCT04130646
View directory record Official record
Conditions
Stroke, Stroke Sequelae, Motor Activity
Interventions
Transcranial Magnetic Stimulation, transcutaneous auricular vagus nerve stimulation (taVNS)
Device
Lead sponsor
Medical University of South Carolina
Other
Eligibility
18 Years to 65 Years
Enrollment
12 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2024
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Apr 19, 2025 · Synced Jun 25, 2026, 10:05 PM EDT
Completed No phase listed Observational

Enhancing Brain Activity With Magnetic Stimulation

NCT00396890
View directory record Official record
Conditions
Healthy
Interventions
Not listed
Lead sponsor
National Institute of Neurological Disorders and Stroke (NINDS)
NIH
Eligibility
18 Years to 55 Years
Enrollment
72 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2008
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Jul 1, 2017 · Synced Jun 25, 2026, 10:05 PM EDT