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Conditions: Atypical Alzheimers Disease, Logopenic Variant of Primary Progressive Aphasia (LPA), Posterior Cortical Atrophy (PCA)
Interventions: C-11 PiB; Drug
Lead sponsor: Mayo Clinic; Other
Eligibility: 18 Years and older
Enrollment: 27 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2015
U.S. locations: 1
States / cities: Rochester, Minnesota

Conditions: Primary Progressive Aphasia, Caregiver Burnout
Interventions: PPA Tele-Savvy Pilot Intervention; Behavioral
Lead sponsor: Northwestern University; Other
Eligibility: 18 Years and older
Enrollment: 29 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2023
U.S. locations: 1
States / cities: Chicago, Illinois

Conditions: Primary Progressive Aphasia, Frontotemporal Dementia
Interventions: Monthly Check-in Session; Behavioral
Lead sponsor: University of Chicago; Other
Eligibility: Not listed
Enrollment: 57 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2020
U.S. locations: 1
States / cities: Chicago, Illinois

Conditions: Logopenic Variant Primary Progressive Aphasia, Non-Fluent Primary Progressive Aphasia
Interventions: Active rTMS, SHAM rTMS; Device
Lead sponsor: Massachusetts General Hospital; Other
Eligibility: 18 Years to 90 Years
Enrollment: 12 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2022
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Alzheimer Disease, Dementia, Primary Progressive Aphasia, Aphasia, Progressive Aphasia, Progressive Aphasia in Alzheimer's Disease
Interventions: Psychosocial educational, support group and implementation of strategies; Behavioral
Lead sponsor: University of Texas at Austin; Other
Eligibility: 18 Years and older
Enrollment: 120 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024 – 2030
U.S. locations: 1
States / cities: Austin, Texas

Conditions: PPA, Primary Progressive Aphasia, Aphasia, Non-fluent Aphasia, Semantic Dementia, Apraxia of Speech, Primary Progressive Nonfluent Aphasia, Progressive Aphasia
Interventions: C-11 PiB, F-18 FDG; Drug
Lead sponsor: Mayo Clinic; Other
Eligibility: 18 Years and older
Enrollment: 168 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2015
U.S. locations: 1
States / cities: Rochester, Minnesota

Conditions: Aphasia, Primary Progressive, Anomia, Alzheimer Disease
Interventions: Phonological, Orthographic, Semantic, Lexical, Untrained; Behavioral
Lead sponsor: Georgetown University; Other
Eligibility: 40 Years and older
Enrollment: 84 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2024
U.S. locations: 2
States / cities: Washington D.C., District of Columbia • Baltimore, Maryland

Conditions: Aphasia, Acquired, Language Disorders, Primary Progressive Aphasia, Stroke, Cerebrovascular
Interventions: individualized speech-language training, standard language intervention; Behavioral
Lead sponsor: University of Arizona; Other
Eligibility: 21 Years to 80 Years
Enrollment: 30 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2028
U.S. locations: 1
States / cities: Tucson, Arizona

Conditions: Frontotemporal Degeneration(FTD), Primary Progressive Aphasia(PPA), Familial Frontotemporal Lobar Degeneration (fFTLD), Amyotrophic Lateral Sclerosis(ALS), Lewy Body Disease(LBD), Progressive Supranuclear Palsy(PSP), Corticobasal Syndrome(CBS), Posterior Cortical Atrophy(PCA), Alzheimer's Disease(AD)
Interventions: No intervention; Other
Lead sponsor: University of Pennsylvania; Other
Eligibility: 18 Years and older
Enrollment: 1,000 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2020 – 2070
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Primary Progressive Aphasia
Interventions: Transcranial Direct Current Stimulation (tDCS), Sham tDCS, Modified Contraint-Induced Language Therapy (mCILT); Device · Behavioral
Lead sponsor: University of Pennsylvania; Other
Eligibility: 45 Years to 80 Years
Enrollment: 23 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2024
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Predicted Tauopathies, Including, Progressive Supranuclear Palsy, Frontotemporal Dementia With Parkinsonism Linked to Chromosome 17, Corticobasal Degeneration Syndrome, Progressive Nonfluent Aphasia
Interventions: davunetide (AL-108, NAP), Placebo nasal spray; Drug
Lead sponsor: University of California, San Francisco; Other
Eligibility: 40 Years to 85 Years
Enrollment: 12 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2012
U.S. locations: 1
States / cities: San Francisco, California

Conditions: Logopenic Progressive Aphasia, Primary Progressive Aphasia
Interventions: High-definition active tDCS (HD-tDCS) + "Repeat After Me" (RAM) Treatment, Sham + "Repeat After Me" (RAM) Treatment; Device
Lead sponsor: Johns Hopkins University; Other
Eligibility: 50 Years to 80 Years
Enrollment: 60 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2027
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Logopenic Variant Primary Progressive Aphasia, Non-fluent Variant Primary Progressive Aphasia, Semantic Variant Primary Progressive Aphasia
Interventions: Active rTMS, SHAM rTMS; Device
Lead sponsor: Massachusetts General Hospital; Other
Eligibility: 18 Years to 90 Years
Enrollment: 10 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2024
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Primary Progressive Aphasia, Dementia, Dementia, Frontotemporal, Alzheimer Disease, Neurodegenerative Diseases, Frontotemporal Lobar Degeneration, Apraxia, Motor, Dysarthria, Communication Disorders, Language Disorders, Speech Disorders, Neurocognitive Disorders, Aphasia, Bilingual Aphasia
Interventions: Video-Implemented Script Training for Aphasia (VISTA), Lexical Retrieval Training (LRT); Behavioral
Lead sponsor: University of Texas at Austin; Other
Eligibility: 40 Years and older
Enrollment: 60 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023 – 2027
U.S. locations: 1
States / cities: Austin, Texas

Conditions: Mild Cognitive Impairment, Primary Progressive Aphasia, Dementia
Interventions: Computerized Cognitive Training, Active tDCS (tDCS) on DLPFC; Other · Device
Lead sponsor: Johns Hopkins University; Other
Eligibility: 50 Years to 90 Years
Enrollment: 36 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2025
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Alzheimer Disease, Early Onset, Alzheimer Disease, Alzheimer Disease, Late Onset, Dementia, Alzheimer Type, Logopenic Progressive Aphasia, Primary Progressive Aphasia, Visuospatial/Perceptual Abilities, Posterior Cortical Atrophy, Executive Dysfunction, Corticobasal Degeneration, Ideomotor Apraxia
Interventions: Not listed
Lead sponsor: University of California, Los Angeles; Other
Eligibility: 50 Years to 85 Years
Enrollment: 180 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2016 – 2021
U.S. locations: 1
States / cities: Los Angeles, California

Conditions: Primary Progressive Aphasia
Interventions: Remotely supervised Transcranial Direct Current Stimulation (RS-tDCS), Remotely supervised sham tDCS (RS-sham-tDCS), Lexical Retrieval Training (LRT), Video Implemented Script Training in Aphasia (VISTA); Device · Behavioral
Lead sponsor: University of Texas at Austin; Other
Eligibility: Not listed
Enrollment: 10 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023 – 2026
U.S. locations: 2
States / cities: San Francisco, California • Austin, Texas

Conditions: Primary Progressive Aphasia
Interventions: Not listed
Lead sponsor: Northwestern University; Other
Eligibility: Not listed
Enrollment: 500 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2007 – 2027
U.S. locations: 1
States / cities: Chicago, Illinois

Conditions: Atypical Alzheimer's Disease, Logopenic Progressive Aphasia (LPA), Posterior Cortical Atrophy (PCA), Alzheimer Disease, Alzheimer Disease, Early Onset, Amnestic Disorder, Amnestic Symptoms, Amnestic Mild Cognitive Disorder
Interventions: F-18 AV 1451, C-11 PiB; Drug
Lead sponsor: Mayo Clinic; Other
Eligibility: 21 Years to 80 Years
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2027
U.S. locations: 1
States / cities: Rochester, Minnesota

Conditions: Primary Progressive Aphasia, Semantic Dementia, Semantic Memory Disorder, Logopenic Progressive Aphasia, Nonfluent Aphasia, Progressive, Aphasia, Aphasia, Progressive
Interventions: Lexical Retrieval Training (LRT), Video-Implemented Script Training for Aphasia (VISTA); Behavioral
Lead sponsor: University of Texas at Austin; Other
Eligibility: Not listed
Enrollment: 60 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017 – 2025
U.S. locations: 2
States / cities: San Francisco, California • Austin, Texas

Conditions: PPA, Non-fluent Aphasia, Apraxia of Speech, Primary Progressive Non-fluent Aphasia, Primary Progressive Aphasia
Interventions: AV-1451; Drug
Lead sponsor: Mayo Clinic; Other
Eligibility: 18 Years and older
Enrollment: 50 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2028
U.S. locations: 1
States / cities: Rochester, Minnesota

Conditions: Primary Progressive Aphasia, Alzheimer Disease, Dementia
Interventions: Florbetapir F 18, Positron Emission Tomography; Drug · Device
Lead sponsor: University of Chicago; Other
Eligibility: 18 Years and older
Enrollment: 48 participants
Timeline: 2012 – 2017
U.S. locations: 1
States / cities: Chicago, Illinois

Conditions: Primary Progressive Aphasia
Interventions: Transcranial Direct Current Stimulation (tDCS), Word-Naming Activity; Device · Behavioral
Lead sponsor: NYU Langone Health; Other
Eligibility: 45 Years to 80 Years
Enrollment: 11 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2023
U.S. locations: 1
States / cities: New York, New York

Conditions: Frontotemporal Dementia, FTD, FTD-GRN, Dementia, Frontotemporal
Interventions: Intrathalamic AAV.PGRN administration, Intrathalamic AVB-101; Procedure · Genetic
Lead sponsor: AviadoBio Ltd; Industry
Eligibility: 30 Years to 75 Years
Enrollment: 18 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2030
U.S. locations: 3
States / cities: Columbus, Ohio • Nashville, Tennessee • Houston, Texas

Search by objective public record fields.

Amyloid-related Imaging Abnormalities (Microbleeds) in Atypical AD

PPA Tele-Savvy: A Pilot Study of an Online Intervention for Caregivers of Persons Living With PPA

Communication Bridge Speech Therapy Research Study

rTMS as a Treatment for PPA

Educational Support Group Program for Bilingual and Spanish-speaking Carepartners and People With Progressive Aphasia

PiB PET Scanning in Speech and Language Based Dementias

Rehabilitation and Prophylaxis of Anomia in Primary Progressive Aphasia

Enhancing Language Function in Aphasia

UPenn Observational Research Repository on Neurodegenerative Disease

Treating Primary Progressive Aphasia (PPA) Using tDCS

Davunetide (AL-108) in Predicted Tauopathies - Pilot Study

Targeting Language-specific and Executive-control Networks With Transcranial Direct Current Stimulation in Logopenic Variant PPA

TMS for the Treatment of Primary Progressive Aphasia

Cognitive Reserve and Response to Speech-Language Intervention in Bilingual Speakers With Primary Progressive Aphasia

Home-based tDCS in Frontotemporal Dementia or Alzheimer's Disease

Early-onset Alzheimer's Disease Phenotypes: Neuropsychology and Neural Networks

Speech-Language Treatment With Remotely Supervised Transcranial Direct Current Stimulation in Primary Progressive Aphasia

Language in Primary Progressive Aphasia

Molecular and Structural Imaging in Alzheimer's Disease: A Longitudinal Study

Treatment for Speech and Language in Primary Progressive Aphasia

Longitudinal Multi-Modality Imaging in Progressive Apraxia of Speech

Clinical Evaluation of Florbetapir in Primary Progressive Aphasia

Remotely Supervised Transcranial Direct Current Stimulation (tDCS) for Primary Progressive Aphasia (PPA)

A Study to Evaluate the Safety and Effect of AVB-101, a Gene Therapy Product, in Subjects With a Genetic Sub-type of Frontotemporal Dementia (FTD-GRN)