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ClinicalTrials.gov public records Last synced Oct 21, 2026, 1:36 PM EDT

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Showing 241–264 of 342 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Prosthesis Clear all
Completed Not applicable Interventional

Study to Determine if Different Prosthetic Sockets Effect How Much Oxygen is in the Tissue of Lower Limb Amputees While They Are Walking

NCT00985842
View directory record Official record
Conditions
Amputation, Diabetes Complications, Leg Injuries, Traumatic Amputation
Interventions
Pe-Lite and sleeve suspension socket, Total Surface bearing a socket with a sleeve suspension but without suction, Total surface bearing suction socket with a pin lock suspension, Total surface bearing suction socket with a sleeve suspension, Vacuum-assisted socket system (Harmony System, Otto Bock)
Device
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years to 70 Years
Enrollment
7 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2012
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Jun 29, 2018 · Synced Oct 21, 2026, 1:36 PM EDT
Not listed No phase listed Observational Accepts healthy volunteers

Musculoskeletal Measurements in Transfemoral Amputees

NCT00909922
View directory record Official record
Conditions
Lower Limb Loss
Interventions
Not listed
Lead sponsor
Miami VA Healthcare System
Federal
Eligibility
18 Years to 80 Years
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2010
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated May 29, 2009 · Synced Oct 21, 2026, 1:36 PM EDT
Terminated Phase 2 Interventional

CTI-01 (Ethyl Pyruvate) Safety and Complication Prevention in Cardiac Surgery Patients on Cardiopulmonary Bypass (CPB)

NCT00107666
View directory record Official record
Conditions
Coronary Disease, Heart Valve Diseases
Interventions
CTI-01 (ethyl pyruvate)
Drug
Lead sponsor
Critical Therapeutics
Industry
Eligibility
18 Years and older
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2006
U.S. locations
17
States / cities
Laguna Hills, California • Los Angeles, California • San Francisco, California + 14 more
Source: ClinicalTrials.gov public record
Updated Mar 17, 2006 · Synced Oct 21, 2026, 1:36 PM EDT
Recruiting Not applicable Interventional

Powered Prosthesis for Use With TF Osseointegration Recipients

NCT06160882
View directory record Official record
Conditions
Amputation
Interventions
Powered Prosthesis Training and EMG data collection, Perform Osseointegration (OI) surgery and Targeted Muscle Reinnervation (TMR)
Other · Procedure
Lead sponsor
Shirley Ryan AbilityLab
Other
Eligibility
18 Years to 70 Years
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2028
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Mar 18, 2025 · Synced Oct 21, 2026, 1:36 PM EDT
Completed No phase listed Observational

Study of Surgical Technique With Use of Single-radius Prosthesis in Total Knee Replacement

NCT01505452
View directory record Official record
Conditions
Arthritis of Knee
Interventions
Not listed
Lead sponsor
Athens Orthopedic Clinic, P.A.
Other
Eligibility
18 Years and older
Enrollment
43 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2014
U.S. locations
2
States / cities
Athens, Georgia
Source: ClinicalTrials.gov public record
Updated Jan 9, 2019 · Synced Oct 21, 2026, 1:36 PM EDT
Completed No phase listed Observational Accepts healthy volunteers Results available

Falls in Older Persons With Limb Loss

NCT03670004
View directory record Official record
Conditions
Amputation, Elderly
Interventions
Not listed
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
65 Years to 85 Years
Enrollment
23 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2020
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Nov 7, 2022 · Synced Oct 21, 2026, 1:36 PM EDT
Active, not recruiting Not applicable Interventional

Neural Enabled Prosthesis for Upper Limb Amputees

NCT03432325
View directory record Official record
Conditions
Amputation Arm and Hand, Unilateral Right, Amputation Arm and Hand, Unilateral Left, Prosthesis User
Interventions
Neural Enabled Prosthesis
Device
Lead sponsor
University of Arkansas, Fayetteville
Other
Eligibility
18 Years and older
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2028
U.S. locations
2
States / cities
Fayetteville, Arkansas • Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Apr 30, 2026 · Synced Oct 21, 2026, 1:36 PM EDT
Completed Not applicable Interventional Results available

Randomized On-X Anticoagulation Trial

NCT00291525
View directory record Official record
Conditions
Heart Valve Disease
Interventions
On-X valve using reduced anticoagulation, On-X Valve with Standard warfarin Therapy
Device
Lead sponsor
On-X Life Technologies, Inc.
Industry
Eligibility
18 Years to 70 Years
Enrollment
977 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2023
U.S. locations
44
States / cities
Tucson, Arizona • Loma Linda, California • Hartford, Connecticut + 34 more
Source: ClinicalTrials.gov public record
Updated Dec 24, 2024 · Synced Oct 21, 2026, 1:36 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Postoperative Function Following Partial and Total Knee Replacement

NCT00492219
View directory record Official record
Conditions
Osteoarthritis, Post-traumatic Arthritis
Interventions
Vanguard M fixed-bearing or Oxford mobile-bearing prostheses, Total Knee Replacement
Device
Lead sponsor
New Lexington Clinic
Other
Eligibility
18 Years and older
Enrollment
324 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2007
U.S. locations
1
States / cities
Lexington, Kentucky
Source: ClinicalTrials.gov public record
Updated Oct 19, 2012 · Synced Oct 21, 2026, 1:36 PM EDT
Not yet recruiting Not applicable Interventional Accepts healthy volunteers

Investigation of Motorized Lower-limb Prostheses

NCT07584707
View directory record Official record
Conditions
Ambulation With the "Take Home" or Passive Prosthesis, Ambulation With the Motorized Prosthesis in the "Off" Configuration, Ambulation With the Motorized Prosthesis in the "Transparent" Condition, Ambulation With the Motorized Prosthesis in the "Powered" Condition
Interventions
Passive prosthesis, Motorized prosthesis
Device
Lead sponsor
Northern Arizona University
Other
Eligibility
18 Years to 85 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2029
U.S. locations
1
States / cities
Flagstaff, Arizona
Source: ClinicalTrials.gov public record
Updated May 13, 2026 · Synced Oct 21, 2026, 1:36 PM EDT
Completed No phase listed Observational

Improved Training Program for Fall Prevention of War Fighters

NCT03446131
View directory record Official record
Conditions
Limb Injury
Interventions
Not listed
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years to 55 Years
Enrollment
45 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
4
States / cities
San Diego, California • Bethesda, Maryland • Rochester, Minnesota + 1 more
Source: ClinicalTrials.gov public record
Updated Jan 7, 2021 · Synced Oct 21, 2026, 1:36 PM EDT
Terminated Not applicable Interventional

Treatment With Fixture Microthread™ in Patients With Poor Bone Quality and no Teeth in the Upper Jaw, When Using Two-Stage Surgery

NCT00748670
View directory record Official record
Conditions
Jaw, Edentulous, Poor Bone Quality
Interventions
Fixture MicroThread (Micro-Macro)
Device
Lead sponsor
Dentsply Sirona Implants and Consumables
Industry
Eligibility
18 Years to 75 Years
Enrollment
23 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 1999
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Sep 8, 2008 · Synced Oct 21, 2026, 1:36 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Functional Performance of Voluntary Opening and Closing Body Powered Prostheses

NCT02136238
View directory record Official record
Conditions
Upper Limb Amputation
Interventions
Hosmer 5XA voluntary opening hook, TRS Grip 3 voluntary closing hook
Device
Lead sponsor
University of South Florida
Other
Eligibility
18 Years to 85 Years
Enrollment
18 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2014
U.S. locations
1
States / cities
Tampa, Florida
Source: ClinicalTrials.gov public record
Updated Dec 28, 2023 · Synced Oct 21, 2026, 1:36 PM EDT
Recruiting Not applicable Interventional

Prosthesis Guided Speech Rehabilitation of T1/T2 Cancers of the Tongue

NCT02584270
View directory record Official record
Conditions
Tongue Neoplasms, Tongue Cancer, Oral Cancer
Interventions
Palatal Augmentation Prosthesis (PAP), Articulation Therapy
Device · Other
Lead sponsor
University of Michigan
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2028
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated May 8, 2026 · Synced Oct 21, 2026, 1:36 PM EDT
Recruiting Not applicable Interventional

Comparing the Attentional Demands and Functional Outcomes in People With Transradial Amputation

NCT07075042
View directory record Official record
Conditions
Amputation, Prosthesis Use
Interventions
Training with PRC, Training with DC, PRC Device use in community and home, DC Device use in community and home
Device
Lead sponsor
Virginia Commonwealth University
Other
Eligibility
18 Years and older
Enrollment
32 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
2
States / cities
Austin, Texas • Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Sep 8, 2026 · Synced Oct 21, 2026, 1:36 PM EDT
Completed Not applicable Interventional

PRIMA US-Feasibility Study in Atrophic Dry AMD

NCT03392324
View directory record Official record
Conditions
Dry Age-related Macular Degeneration
Interventions
PRIMA
Device
Lead sponsor
Science Corporation
Industry
Eligibility
60 Years and older
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2026
U.S. locations
3
States / cities
Palo Alto, California • Miami, Florida • Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Aug 17, 2026 · Synced Oct 21, 2026, 1:36 PM EDT
Recruiting No phase listed Observational

Pro APP Prosthetic Outcome Registry

NCT06210620
View directory record Official record
Conditions
Amputation
Interventions
Not listed
Lead sponsor
Össur Iceland ehf
Industry
Eligibility
18 Years and older
Enrollment
2,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2033
U.S. locations
1
States / cities
Irvine, California
Source: ClinicalTrials.gov public record
Updated Sep 15, 2025 · Synced Oct 21, 2026, 1:36 PM EDT
Recruiting Not applicable Interventional

Effects of Myoelectric Channel Count and Targeting for Upper Limb Prosthetic Control

NCT07011420
View directory record Official record
Conditions
Amputation, Amputation, Traumatic, Amputation, Congenital, Prosthesis User, Upper Limb Amputation Below Elbow (Injury), Amputation; Traumatic, Arm: Forearm, Between Elbow and Wrist
Interventions
Experimental socket with 4 untargeted channels active, Experimental socket with 8 untargeted channels active, Experimental socket with up to 16 untargeted channels active, Experimental socket with 8 targeted channels active, Coapt EMG Cuff
Device
Lead sponsor
Liberating Technologies, Inc.
Industry
Eligibility
18 Years and older
Enrollment
32 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
2
States / cities
Chicago, Illinois • Holliston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Sep 3, 2025 · Synced Oct 21, 2026, 1:36 PM EDT
Completed Not applicable Interventional Results available

Determining the Potential Benefit of Powered Prostheses

NCT02828982
View directory record Official record
Conditions
Unilateral Traumatic Amputation, Amputation, Traumatic
Interventions
Powered ankle prosthesis, Dynamic Response Foot
Device
Lead sponsor
Deanna H Gates
Other
Eligibility
21 Years and older
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2019
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Jan 18, 2022 · Synced Oct 21, 2026, 1:36 PM EDT
Completed Not applicable Interventional

Comparison of Various Prosthetic Foot-Ankle Mechanisms

NCT05964855
View directory record Official record
Conditions
Transtibial Amputation - Unilateral
Interventions
MIT Variable Stiffness Prosthesis v1, MIT Variable Equilibrium Angle Prosthesis v1, MIT Sliding Beam Passive Prosthesis, Ossur Pro-Flex XC, Blatchford Elan Variable-Dampening Prosthesis, Ossur Proprio Variable Angle Prosthesis, MIT Variable Stiffness Prosthesis v2, MIT Variable Equilibrium Angle Prosthesis v2
Device
Lead sponsor
Massachusetts Institute of Technology
Other
Eligibility
18 Years to 65 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
2
States / cities
Burlington, Massachusetts • Cambridge, Massachusetts
Source: ClinicalTrials.gov public record
Updated Aug 20, 2026 · Synced Oct 21, 2026, 1:36 PM EDT
Completed Not applicable Interventional Results available

Efficacy of a Vented Liner and Socket System for Individuals With Trans-femoral Amputation

NCT05279885
View directory record Official record
Conditions
Prosthesis User
Interventions
Vented suspension system, Non-vented suspension system
Device
Lead sponsor
Jóna Valgerður Kristjánsdóttir
Industry
Eligibility
18 Years and older
Enrollment
13 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Oct 21, 2026 · Synced Oct 21, 2026, 1:36 PM EDT
Completed Phase 3 Interventional Results available

Core Gel Study of the Safety and Effectiveness of Mentor Round Low Bleed Silicone Gel-filled Mammary Prostheses

NCT00753922
View directory record Official record
Conditions
Breast Reconstruction, Breast Augmentation, Breast Revision
Interventions
Mentor Round Low Bleed Gel-filled Mammary Protheses, both Siltex and Smooth Surface
Device
Lead sponsor
Mentor Worldwide, LLC
Industry
Eligibility
18 Years and older · Female only
Enrollment
1,008 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2000 – 2012
U.S. locations
1
States / cities
Santa Barbara, California
Source: ClinicalTrials.gov public record
Updated Apr 16, 2014 · Synced Oct 21, 2026, 1:36 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

A Comparative Analysis Between College Park Sidekick Feet and Conventional Stubby Prosthesis

NCT02921295
View directory record Official record
Conditions
Amputation Stumps
Interventions
Sidekick Stubbies
Device
Lead sponsor
Angela DeCandia
Other
Eligibility
18 Years to 65 Years
Enrollment
1 participant
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2017
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jun 21, 2018 · Synced Oct 21, 2026, 1:36 PM EDT
Recruiting Not applicable Interventional

Evaluation of a Neural-Controlled Powered Prosthesis Across Diverse Real-World Tasks

NCT07204912
View directory record Official record
Conditions
Transfemoral Amputation
Interventions
MIT Powered Leg
Device
Lead sponsor
Massachusetts Institute of Technology
Other
Eligibility
18 Years to 70 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
1
States / cities
Cambridge, Massachusetts
Source: ClinicalTrials.gov public record
Updated Oct 2, 2025 · Synced Oct 21, 2026, 1:36 PM EDT