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Showing 1–24 of 137 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Rheumatoid and Osteoarthritis Clear all
Completed Phase 3 Interventional Accepts healthy volunteers

Study of the Scandinavian Total Ankle Replacement (STAR) for the Treatment of Bilateral Degenerative Ankle Disease

NCT00586781
View directory record Official record
Conditions
Osteoarthritis, Post-Traumatic Arthritis, Rheumatoid Arthritis
Interventions
Scandinavian Total Ankle Replacement (STAR)
Device
Lead sponsor
Link America, Inc.
Industry
Eligibility
18 Years and older
Enrollment
21 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
Started 2001
U.S. locations
5
States / cities
Jacksonville, Florida • Iowa City, Iowa • Kansas City, Kansas + 2 more
Source: ClinicalTrials.gov public record
Updated Jan 3, 2008 · Synced Sep 28, 2026, 5:43 PM EDT
Recruiting No phase listed Observational

Exactech Shoulder Post Market Clinical Follow-up Study

NCT05603728
View directory record Official record
Conditions
Osteo Arthritis Shoulders, Osteonecrosis, Rotator Cuff Tears, Rotator Cuff Tear Arthropathy, Ankylosing Spondylitis, Post-traumatic Osteoarthritis, Rheumatoid Arthritis, Fracture, Infections
Interventions
Not listed
Lead sponsor
Exactech
Industry
Eligibility
21 Years and older
Enrollment
20,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2031
U.S. locations
24
States / cities
Laguna Woods, California • Redwood City, California • Stockton, California + 20 more
Source: ClinicalTrials.gov public record
Updated Sep 16, 2026 · Synced Sep 28, 2026, 5:43 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Self-Directed Exercise Program for Adults With Arthritis

NCT01172327
View directory record Official record
Conditions
Arthritis, Osteoarthritis, Rheumatoid Arthritis, Fibromyalgia
Interventions
Multicomponent exercise, Nutrition
Behavioral
Lead sponsor
University of South Carolina
Other
Eligibility
18 Years and older
Enrollment
401 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2012
U.S. locations
1
States / cities
Columbia, South Carolina
Source: ClinicalTrials.gov public record
Updated Apr 27, 2021 · Synced Sep 28, 2026, 5:43 PM EDT
Terminated No phase listed Observational

INBONE Total Ankle Arthroplasty(TAA)Using Calcaneal Stem Fixation

NCT01366989
View directory record Official record
Conditions
Arthrodesis, Degenerative Arthritis, Rheumatoid Arthritis, Complications; Arthroplasty, Mechanical
Interventions
Radiographic evaluation of previously implanted patients
Device
Lead sponsor
Stryker Trauma and Extremities
Industry
Eligibility
18 Years and older
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2013
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Feb 16, 2017 · Synced Sep 28, 2026, 5:43 PM EDT
Terminated No phase listed Observational

Efficacy of the CLP® Hip - Retrospective

NCT00764842
View directory record Official record
Conditions
Osteoarthritis, Avascular Necrosis, Rheumatoid Arthritis
Interventions
Encore CLP® Hip stem
Device
Lead sponsor
Encore Medical, L.P.
Industry
Eligibility
18 Years and older
Enrollment
61 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2011
U.S. locations
1
States / cities
Fresno, California
Source: ClinicalTrials.gov public record
Updated Feb 8, 2011 · Synced Sep 28, 2026, 5:43 PM EDT
Completed Not applicable Interventional Results available

Randomized Fixed Bearing vs Mobile Bearing Cruciate Substituting TKA

NCT00289107
View directory record Official record
Conditions
Osteoarthritis, Rheumatoid Arthritis, Other Inflammatory Arthritis, Post-Traumatic Arthritis, Juvenile Rheumatoid Arthritis, Avascular Necrosis
Interventions
Total Knee Arthroplasty, Total knee replacement
Device
Lead sponsor
DePuy Orthopaedics
Industry
Eligibility
18 Years to 75 Years
Enrollment
149 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2001 – 2007
U.S. locations
3
States / cities
Greensboro, North Carolina • Austin, Texas • Lakewood, Washington
Source: ClinicalTrials.gov public record
Updated May 2, 2023 · Synced Sep 28, 2026, 5:43 PM EDT
Active, not recruiting Not applicable Interventional

Persona Ti-Nidium Post-Market Clinical Follow-up

NCT04817969
View directory record Official record
Conditions
Knee Pain Chronic, Osteoarthritis, Rheumatoid Arthritis, Traumatic Arthritis, Polyarthritis, Varus Deformity, Valgus Deformity, Flexion Deformity of the Knee, Avascular Necrosis, Patellofemoral Osteoarthritis
Interventions
Zimmer Biomet Persona Ti-Nidium Total Knee System
Device
Lead sponsor
Zimmer Biomet
Industry
Eligibility
18 Years and older
Enrollment
240 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2034
U.S. locations
7
States / cities
Parker, Colorado • Hyattsville, Maryland • Jackson, Mississippi + 4 more
Source: ClinicalTrials.gov public record
Updated Sep 21, 2026 · Synced Sep 28, 2026, 5:43 PM EDT
Completed No phase listed Observational

Cup Position in THA With Standard Instruments

NCT03189303
View directory record Official record
Conditions
Osteoarthritis; Rheumatoid Arthritis; Post Traumatic Arthritis
Interventions
Primary Uncemented Total Hip Arthroplasty
Device
Lead sponsor
DePuy Orthopaedics
Industry
Eligibility
21 Years and older
Enrollment
183 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2021
U.S. locations
5
States / cities
Grand Rapids, Michigan • New York, New York • Gastonia, North Carolina + 2 more
Source: ClinicalTrials.gov public record
Updated Feb 14, 2022 · Synced Sep 28, 2026, 5:43 PM EDT
Completed Not applicable Interventional Results available

Randomized Fixed Bearing vs Mobile Bearing Cruciate Retaining TKA

NCT00289094
View directory record Official record
Conditions
Osteoarthritis, Rheumatoid Arthritis, Post-traumatic Arthritis, Juvenile Rheumatoid Arthritis, Avascular Necrosis of Bone
Interventions
Total knee replacement
Device
Lead sponsor
DePuy Orthopaedics
Industry
Eligibility
18 Years to 75 Years
Enrollment
99 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2001 – 2007
U.S. locations
2
States / cities
Billings, Montana • Vancouver, Washington
Source: ClinicalTrials.gov public record
Updated Sep 12, 2022 · Synced Sep 28, 2026, 5:43 PM EDT
Withdrawn Phase 2 Interventional

Low Dose Naltrexone for Chronic Pain in Osteoarthritis and Inflammatory Arthritis

NCT04115020
View directory record Official record
Conditions
Osteoarthritis, Arthritis, Rheumatoid, Arthritis, Psoriatic
Interventions
Naltrexone, Placebo
Drug
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jan 8, 2020 · Synced Sep 28, 2026, 5:43 PM EDT
Completed No phase listed Observational

Prospective Study Measuring Clinical Outcomes of Knee Arthroplasty Using the VERASENSE™ Knee System

NCT01469299
View directory record Official record
Conditions
Osteoarthritis, Avascular Necrosis, Rheumatoid Arthritis, Post-traumatic Arthritis
Interventions
Not listed
Lead sponsor
Orthosensor, Inc.
Industry
Eligibility
50 Years and older
Enrollment
285 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2016
U.S. locations
8
States / cities
St. Helena, California • Fort Lauderdale, Florida • Naples, Florida + 5 more
Source: ClinicalTrials.gov public record
Updated Jan 10, 2017 · Synced Sep 28, 2026, 5:43 PM EDT
Completed Not applicable Interventional Results available

Breaking Implicit Bias Habits: An Individuation Pilot Study In Rheumatology

NCT05116163
View directory record Official record
Conditions
Systemic Lupus Erythematosus, Rheumatoid Arthritis, Inflammatory Arthritis, Osteoarthritis
Interventions
Individuation Intervention plus implicit bias educational modules, Implicit bias educational modules
Behavioral · Other
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
18 Years and older
Enrollment
201 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
2
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Nov 11, 2025 · Synced Sep 28, 2026, 5:43 PM EDT
Completed Phase 3 Interventional

Help Arthritis With Exercise in West Virginia

NCT00526201
View directory record Official record
Conditions
Arthritis
Interventions
12-weeks EnhanceFitness, Control
Behavioral
Lead sponsor
Jennifer Hootman
Federal
Eligibility
18 Years to 85 Years
Enrollment
323 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2011
U.S. locations
1
States / cities
Morgantown, West Virginia
Source: ClinicalTrials.gov public record
Updated Dec 23, 2015 · Synced Sep 28, 2026, 5:43 PM EDT
Completed Not applicable Interventional Results available

Robotic Arm Assisted Total Knee Arthroplasty

NCT02058069
View directory record Official record
Conditions
Osteoarthritis, Rheumatoid Arthritis, Post-traumatic Arthritis
Interventions
Robotic Arm Assisted Total Knee Arthroplasty
Device
Lead sponsor
MAKO Surgical Corp.
Industry
Eligibility
21 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
3
States / cities
St. Helena, California • Tampa, Florida • Houston, Texas
Source: ClinicalTrials.gov public record
Updated Apr 17, 2017 · Synced Sep 28, 2026, 5:43 PM EDT
Enrolling by invitation No phase listed Observational

LinkSymphoKnee (LSK) Total Knee Replacement System Study - Ultra-congruent (UC)

NCT06670651
View directory record Official record
Conditions
Osteoarthritis (OA) of the Knee, Fracture, Rheumatoid Arthritis
Interventions
total knee arthroplasty device
Device
Lead sponsor
LinkBio Corp.
Industry
Eligibility
18 Years to 79 Years
Enrollment
600 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2031
U.S. locations
2
States / cities
Birmingham, Alabama • Libertyville, Illinois
Source: ClinicalTrials.gov public record
Updated Sep 2, 2026 · Synced Sep 28, 2026, 5:43 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Journey II Bi-Cruciate Stabilized (BCS) Total Knee System Retrospective Study

NCT03292003
View directory record Official record
Conditions
Total Knee Arthroplasty
Interventions
Journey II BCS Total Knee System
Device
Lead sponsor
Smith & Nephew, Inc.
Industry
Eligibility
Not listed
Enrollment
1,694 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2018
U.S. locations
9
States / cities
Aurora, Colorado • Gulf Breeze, Florida • Indianapolis, Indiana + 6 more
Source: ClinicalTrials.gov public record
Updated Mar 27, 2019 · Synced Sep 28, 2026, 5:43 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Catalyst CSR Shoulder System for Semi or Total Shoulder Arthroplasty

NCT04968405
View directory record Official record
Conditions
Osteoarthritis Shoulder, Avascular Necrosis of the Head of Humerus, Rheumatoid Arthritis Shoulder
Interventions
Catalyst CSR Total Shoulder System
Device
Lead sponsor
Catalyst OrthoScience
Industry
Eligibility
18 Years and older
Enrollment
87 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2026
U.S. locations
3
States / cities
Royal Oak, Michigan • Portland, Oregon • Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Mar 30, 2026 · Synced Sep 28, 2026, 5:43 PM EDT
Completed Phase 3 Interventional

Study to Evaluate the Incidence of Gastric Ulcers Following Administration of Either PN 200 or Naproxen in Subjects Who Are at Risk for Developing NSAID-Associated Ulcers.

NCT00367211
View directory record Official record
Conditions
Osteoarthritis, Rheumatoid Arthritis, Ankylosing Spondylitis
Interventions
PN 200 tablets (500 mg naproxen and 20 mg omeprazole), Naproxen 500 mg tablets (PN 200 minus omeprazole)
Drug
Lead sponsor
POZEN
Industry
Eligibility
18 Years and older
Enrollment
400 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2007
U.S. locations
1
States / cities
Pompano Beach, Florida
Source: ClinicalTrials.gov public record
Updated Apr 21, 2008 · Synced Sep 28, 2026, 5:43 PM EDT
Active, not recruiting Not applicable Interventional

Post Market Clinical Follow-up (PMCF) Study of the A.L.P.S. Proximal Humerus Plating System

NCT03626038
View directory record Official record
Conditions
Osteoarthritis, Rheumatoid Arthritis, Post-Traumatic Arthritis, Psoriatic Arthritis, Proximal Humeral Fracture
Interventions
A.L.P.S. Proximal Humerus Plating System
Device
Lead sponsor
Zimmer Biomet
Industry
Eligibility
18 Years and older
Enrollment
135 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2026
U.S. locations
1
States / cities
Tampa, Florida
Source: ClinicalTrials.gov public record
Updated Feb 12, 2026 · Synced Sep 28, 2026, 5:43 PM EDT
Not listed Not applicable Interventional

Cellular & Biocellular Regenerative Therapy in Musculoskeletal Pain, Dysfunction,Degenerative or Inflammatory Disease

NCT03090672
View directory record Official record
Conditions
Osteoarthritis, Rheumatoid Nodule, Degenerative Joint Disease, Tendinopathy, Tendinosis, Back Pain
Interventions
Normal Saline, Tissue Stromal Vascular Fraction, Platelet Rich Plasma, Cellular Stromal Vascular Fraction
Drug · Procedure · Biological
Lead sponsor
Robert W Alexander, MD
Other
Eligibility
18 Years to 90 Years
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2022
U.S. locations
1
States / cities
North Attleboro, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jan 17, 2020 · Synced Sep 28, 2026, 5:43 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers

Web-based Support to Manage Arthritis Pain

NCT01463189
View directory record Official record
Conditions
Osteoarthritis, Rheumatoid Arthritis, Ankylosing Spondylitis, Other Arthritic Conditions (e.g., Psoriatic Arthritis)
Interventions
painACTION: Arthritis
Behavioral
Lead sponsor
Inflexxion, Inc.
Industry
Eligibility
18 Years and older
Enrollment
228 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2012
U.S. locations
1
States / cities
Newton, Massachusetts
Source: ClinicalTrials.gov public record
Updated Dec 9, 2012 · Synced Sep 28, 2026, 5:43 PM EDT
Completed Phase 2 Interventional Results available

Low Dose Naltrexone for Chronic Pain From Arthritis

NCT03008590
View directory record Official record
Conditions
Osteoarthritis, Arthritis, Rheumatoid, Arthritis, Psoriatic
Interventions
Naltrexone, Placebo
Drug
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
Not listed
Enrollment
29 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 2, 2021 · Synced Sep 28, 2026, 5:43 PM EDT
Active, not recruiting No phase listed Observational

Zimmer Continuum Metal on Polyethylene (MoP) PostMarket Clinical Followup (PMCF) Study

NCT01307384
View directory record Official record
Conditions
Avascular Necrosis, Osteoarthritis, Inflammatory Arthritis, Post-traumatic Arthritis, Rheumatoid Arthritis
Interventions
Continuum Metal on Polyethylene Acetabular System
Device
Lead sponsor
Zimmer Biomet
Industry
Eligibility
18 Years to 75 Years
Enrollment
165 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2027
U.S. locations
2
States / cities
Fremont, California • Denver, Colorado
Source: ClinicalTrials.gov public record
Updated Jun 17, 2025 · Synced Sep 28, 2026, 5:43 PM EDT
Active, not recruiting No phase listed Observational

Shoulder iD™ Primary Reversed Glenoid Outcomes Clinical Study

NCT05868148
View directory record Official record
Conditions
Rotator Cuff Tears, Rheumatoid Arthritis Shoulder, Osteoarthritis Shoulder, Avascular Necrosis of the Head of Humerus, Fracture, Humeral, Traumatic Arthritis of Right Shoulder Region (Diagnosis), Shoulder Deformity
Interventions
Shoulder iD™ Primary Reversed Glenoid
Device
Lead sponsor
Stryker Trauma and Extremities
Industry
Eligibility
18 Years and older
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2035
U.S. locations
5
States / cities
San Francisco, California • Columbus, Ohio • Frisco, Texas + 2 more
Source: ClinicalTrials.gov public record
Updated Aug 27, 2026 · Synced Sep 28, 2026, 5:43 PM EDT