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Showing 1–24 of 194 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Rhinosinusitis Chronic Clear all
Recruiting Not applicable Interventional

3D Printing to Improve Nasal Irrigation Outcome

NCT06118554
View directory record Official record
Conditions
Chronic Rhinosinusitis With Nasal Polyps, Chronic Rhinosinusitis Without Nasal Polyps
Interventions
Irrigation head position
Other
Lead sponsor
Ohio State University
Other
Eligibility
18 Years to 75 Years
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2027
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated May 25, 2026 · Synced Sep 10, 2026, 4:40 PM EDT
Completed Phase 2 Interventional Results available

Nasally Delivered Pulmozyme for Sinusitis in Cystic Fibrosis

NCT00416182
View directory record Official record
Conditions
Sinusitis, Cystic Fibrosis
Interventions
Pulmozyme (dornase alfa), Placebo
Drug
Lead sponsor
University of Vermont
Other
Eligibility
5 Years and older
Enrollment
16 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2012
U.S. locations
1
States / cities
Burlington, Vermont
Source: ClinicalTrials.gov public record
Updated Nov 13, 2014 · Synced Sep 10, 2026, 4:40 PM EDT
Recruiting Early Phase 1 Interventional

Ivacaftor for Acquired CFTR Dysfunction in Chronic Rhinosinusitis

NCT03439865
View directory record Official record
Conditions
Chronic Rhinosinusitis (Diagnosis)
Interventions
Ivacaftor, standard of care treatment
Drug
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2027
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Apr 21, 2026 · Synced Sep 10, 2026, 4:40 PM EDT
Completed No phase listed Observational

Response Shift in Sinus Surgery Outcomes

NCT01391910
View directory record Official record
Conditions
Chronic Rhinosinusitis
Interventions
Not listed
Lead sponsor
Greg Davis
Other
Eligibility
18 Years and older
Enrollment
32 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2013
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Dec 11, 2013 · Synced Sep 10, 2026, 4:40 PM EDT
Terminated Phase 1 Interventional Results available

Trial of Topical Verapamil in Chronic Rhinosinusitis With Nasal Polyps

NCT03102190
View directory record Official record
Conditions
Sinusitis, Nasal Polyps
Interventions
Verapamil Hydrochloride Intranasal
Drug
Lead sponsor
Benjamin Bleier
Other
Eligibility
18 Years to 80 Years
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 22, 2019 · Synced Sep 10, 2026, 4:40 PM EDT
Terminated Not applicable Interventional Results available

Total Intravenous Anesthesia (TIVA) vs. Inhaled Anesthesia for Endoscopic Sinus Surgery.

NCT01214057
View directory record Official record
Conditions
Chronic Rhinosinusitis
Interventions
Propofol and Remifentanyl, Sevoflurane and Remifentanyl
Drug
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
18 Years and older
Enrollment
23 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2012
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Oct 31, 2021 · Synced Sep 10, 2026, 4:40 PM EDT
Recruiting Phase 3 Interventional

Sinonasal Therapies and Histologic Correlations of Patients With Cystic Fibrosis in the Era of Highly Effective Modulator Therapy

NCT06996951
View directory record Official record
Conditions
Cystic Fibrosis (CF), Chronic Rhinosinusitis (CRS)
Interventions
STOP NASAL SALINE IRRIGATION WITH OR WITHOUT STEROID, CONTINUE NASAL SALINE IRRIGATION WITH OR WITHOUT STEROID
Other · Drug
Lead sponsor
Indiana University
Other
Eligibility
18 Years and older
Enrollment
64 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Dec 15, 2025 · Synced Sep 10, 2026, 4:40 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers Results available

Study Of PF-06817024 In Healthy Subjects, In Patients With Chronic Rhinosinusitis With Nasal Polyps And in Patients With Atopic Dermatitis

NCT02743871
View directory record Official record
Conditions
Healthy, Chronic Rhinosinusitis With Nasal Polyps, Atopic Dermatitis
Interventions
PF-06817024, Placebo for PF-06817024
Biological · Other
Lead sponsor
Pfizer
Industry
Eligibility
18 Years to 75 Years
Enrollment
97 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2021
U.S. locations
20
States / cities
Sacramento, California • New Haven, Connecticut • Shelton, Connecticut + 12 more
Source: ClinicalTrials.gov public record
Updated May 18, 2022 · Synced Sep 10, 2026, 4:40 PM EDT
Active, not recruiting No phase listed Observational Accepts healthy volunteers

Genetic Factors in Chronic Sinusitis

NCT00880516
View directory record Official record
Conditions
Chronic Sinusitis
Interventions
Not listed
Lead sponsor
University of Chicago
Other
Eligibility
18 Years and older
Enrollment
1,200 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2027
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Feb 1, 2026 · Synced Sep 10, 2026, 4:40 PM EDT
Completed Not applicable Interventional Results available

Clinical Evaluation of Propel Nova Sinus Implant in Peripheral Sinus Ostia

NCT02228720
View directory record Official record
Conditions
Chronic Sinusitis
Interventions
Propel Nova Sinus Implant
Device
Lead sponsor
Intersect ENT
Industry
Eligibility
18 Years and older
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
2
States / cities
Miami, Florida • Dublin, Ohio
Source: ClinicalTrials.gov public record
Updated Aug 3, 2017 · Synced Sep 10, 2026, 4:40 PM EDT
Terminated Phase 3 Interventional Results available

Efficacy and Safety Study of Benralizumab in Patient With Eosinophilic Chronic Rhinosinusitis With Nasal Polyps (ORCHID)

NCT04157335
View directory record Official record
Conditions
Nasal Polyposis, Eosinophilic Chronic Rhinosinusitis
Interventions
Benralizumab 30 mg, Matched placebo
Biological
Lead sponsor
AstraZeneca
Industry
Eligibility
18 Years to 75 Years
Enrollment
295 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2025
U.S. locations
15
States / cities
Huntington Beach, California • Grand Junction, Colorado • Gainesville, Florida + 12 more
Source: ClinicalTrials.gov public record
Updated Feb 18, 2026 · Synced Sep 10, 2026, 4:40 PM EDT
Recruiting Not applicable Interventional

Paclitaxel-Coated Balloon Treatment of Chronic Rhinosinusitis

NCT07290140
View directory record Official record
Conditions
Chronic Rhinosinusitis (CRS) With and Without Nasal Polyps
Interventions
Airiver ESSpand DCB, ESS
Combination Product · Procedure
Lead sponsor
Airiver Medical, Inc.
Industry
Eligibility
18 Years and older
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2031
U.S. locations
10
States / cities
Birmingham, Alabama • San Diego, California • Colorado Springs, Colorado + 6 more
Source: ClinicalTrials.gov public record
Updated Jul 29, 2026 · Synced Sep 10, 2026, 4:40 PM EDT
Completed No phase listed Observational

Analysis of Inflammation and Microbiome in Patients With Sinusitis and Asthma

NCT02548598
View directory record Official record
Conditions
Asthma, Chronic Rhinosinusitis
Interventions
Endoscopic sinus surgery
Procedure
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years and older
Enrollment
9 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2021
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated May 2, 2021 · Synced Sep 10, 2026, 4:40 PM EDT
Withdrawn Not applicable Interventional

Vitamin D Supplementation in Chronic Rhinosinusitis With Nasal Polyps

NCT01185808
View directory record Official record
Conditions
Chronic Sinusitis
Interventions
Vitamin D
Biological
Lead sponsor
Medical University of South Carolina
Other
Eligibility
14 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Apr 30, 2018 · Synced Sep 10, 2026, 4:40 PM EDT
Completed Phase 3 Interventional Results available

Oral Versus Topical Antibiotics for Chronic Rhinosinusitis Exacerbations

NCT01988779
View directory record Official record
Conditions
Chronic Rhinosinusitis
Interventions
oral levofloxacin, nebulized levofloxacin
Drug
Lead sponsor
University of Rochester
Other
Eligibility
18 Years and older
Enrollment
33 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2020
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Mar 23, 2021 · Synced Sep 10, 2026, 4:40 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Total Intravenous Anesthesia in Sinus Surgery

NCT02578862
View directory record Official record
Conditions
Advanced Chronic Rhinosinusitis
Interventions
Propofol, Sevoflurane
Drug
Lead sponsor
Ochsner Health System
Other
Eligibility
18 Years and older
Enrollment
72 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2018
U.S. locations
1
States / cities
New Orleans, Louisiana
Source: ClinicalTrials.gov public record
Updated Dec 20, 2018 · Synced Sep 10, 2026, 4:40 PM EDT
Completed No phase listed Interventional Accepts healthy volunteers Results available

A Clinical Evaluation of the Intersect ENT Sinus Device (ASCEND)

NCT03599271
View directory record Official record
Conditions
Chronic Rhinosinusitis (Diagnosis)
Interventions
Drug-Coated Device, Control Device
Device
Lead sponsor
Intersect ENT
Industry
Eligibility
18 Years and older
Enrollment
75 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2020
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated May 25, 2021 · Synced Sep 10, 2026, 4:40 PM EDT
Completed Phase 4 Interventional Results available

EValuating trEatment RESponses of Dupilumab Versus Omalizumab in Type 2 Patients

NCT04998604
View directory record Official record
Conditions
Chronic Rhinosinusitis With Nasal Polyps, Asthma
Interventions
Dupilumab, Omalizumab, Placebo
Drug
Lead sponsor
Sanofi
Industry
Eligibility
18 Years and older
Enrollment
360 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
16
States / cities
Los Angeles, California • Tampa, Florida • Chicago, Illinois + 12 more
Source: ClinicalTrials.gov public record
Updated Oct 22, 2025 · Synced Sep 10, 2026, 4:40 PM EDT
Withdrawn Phase 4 Interventional

Nasospore Stent For Use in Enodscopic Sinus Surgery

NCT00671541
View directory record Official record
Conditions
Chronic Sinusitis
Interventions
Merogel Nasal Stent and Nasopore Stent, Nasopore Stent and either Gentamycin or Bacitracin
Drug
Lead sponsor
Lahey Clinic
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2012
U.S. locations
1
States / cities
Burlington, Massachusetts
Source: ClinicalTrials.gov public record
Updated Feb 16, 2012 · Synced Sep 10, 2026, 4:40 PM EDT
Completed Phase 2 Interventional

Evaluating SPRC-AB01 in Post-Surgical Subjects With Chronic Sinusitis

NCT00447837
View directory record Official record
Conditions
Chronic Sinusitis
Interventions
SPRC-AB01
Drug
Lead sponsor
Naryx Pharma
Industry
Eligibility
16 Years and older
Enrollment
180 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2008
U.S. locations
43
States / cities
Hoover, Alabama • Jonesboro, Arkansas • Fresno, California + 40 more
Source: ClinicalTrials.gov public record
Updated Mar 16, 2008 · Synced Sep 10, 2026, 4:40 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Laser Assisted Treatment of Chronic Sinusitis With and Without Light Activated Agents

NCT00948519
View directory record Official record
Conditions
Rhinosinusitis
Interventions
Laser + ICG, Laser only
Device
Lead sponsor
New York Head & Neck Institute
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2011
U.S. locations
3
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jul 21, 2011 · Synced Sep 10, 2026, 4:40 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

QOL Outcomes in CRS With Polyps

NCT03144375
View directory record Official record
Conditions
Chronic Rhinosinusitis, Polyps
Interventions
Medical optimization and education, Standard of Care sinus surgery
Other · Procedure
Lead sponsor
University of Miami
Other
Eligibility
18 Years to 100 Years
Enrollment
28 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2016
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated May 7, 2017 · Synced Sep 10, 2026, 4:40 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

TIVA vs TXA in Sinus Surgery to Evaluate Operative Blood Loss and Surgical Field Quality

NCT05639686
View directory record Official record
Conditions
Rhinosinusitis Chronic, Sinus Cancer, Sinus Polyp, Encephalocele
Interventions
Tranexamic acid injection, Total Intravenous Anesthesia, Inhalational isoflurane
Drug
Lead sponsor
Our Lady of the Lake Hospital
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2025
U.S. locations
1
States / cities
Baton Rouge, Louisiana
Source: ClinicalTrials.gov public record
Updated Mar 22, 2023 · Synced Sep 10, 2026, 4:40 PM EDT
Not yet recruiting Phase 1Phase 2 Interventional

Nebulized Nasal Steroids

NCT07270302
View directory record Official record
Conditions
Chronic Rhinosinusitis
Interventions
nebulized budesonide via NasoNeb, budesonide lavage via NeilMed
Combination Product
Lead sponsor
Washington University School of Medicine
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Dec 7, 2025 · Synced Sep 10, 2026, 4:40 PM EDT