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ClinicalTrials.gov public records Last synced Nov 5, 2026, 8:46 AM EST

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Showing 1–24 of 198 matching trials from the live ClinicalTrials.gov search.

Filters: Condition: Rhinosinusitis Chronic Clear all

Conditions: Sinusitis
Interventions: Balloon sinus dilation, Medical Management; Device · Drug
Lead sponsor: Integra LifeSciences Corporation; Industry
Eligibility: 19 Years and older
Enrollment: 198 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2015
U.S. locations: 20
States / cities: Denver, Colorado • Miami, Florida • Tampa, Florida + 17 more

Conditions: Chronic Sinusitis
Interventions: PROPEL Mini Sinus Implant., Sinus Surgery alone, Propel Nova Sinus Implant; Device · Procedure
Lead sponsor: Intersect ENT; Industry
Eligibility: 18 Years and older
Enrollment: 160 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2016
U.S. locations: 10
States / cities: Sacramento, California • Torrance, California • Norwalk, Connecticut + 7 more

Conditions: Nasal Polyps
Interventions: Depemokimab (GSK3511294), Placebo; Biological · Drug
Lead sponsor: GlaxoSmithKline; Industry
Eligibility: 18 Years and older
Enrollment: 276 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2024
U.S. locations: 26
States / cities: Tucson, Arizona • Buena Park, California • Los Angeles, California + 22 more

Conditions: CRS
Interventions: EDSPD; Other
Lead sponsor: University of Alabama at Birmingham; Other
Eligibility: 18 Years and older
Enrollment: 30 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2027
U.S. locations: 1
States / cities: Birmingham, Alabama

Conditions: Sinonasal Disorder, Chronic Rhinosinusitis (Diagnosis)
Interventions: Control Group, Chronic rhinosinusitis (CRS) with and without Nasal Polyposis; Other · Procedure
Lead sponsor: University of Chicago; Other
Eligibility: 18 Years and older
Enrollment: 285 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025 – 2029
U.S. locations: 1
States / cities: Hyde Park, Illinois

Conditions: Severe Eosinophilic Chronic Sinusitis Without Nasal Polyposis
Interventions: Dupilumab 300 MG/2 ML Subcutaneous Solution [DUPIXENT], Placebo; Drug · Other
Lead sponsor: University of South Florida; Other
Eligibility: 18 Years and older
Enrollment: 30 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2025
U.S. locations: 1
States / cities: Tampa, Florida

Conditions: Healthy, Chronic Rhinosinusitis With Nasal Polyps, Atopic Dermatitis
Interventions: PF-06817024, Placebo for PF-06817024; Biological · Other
Lead sponsor: Pfizer; Industry
Eligibility: 18 Years to 75 Years
Enrollment: 97 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2016 – 2021
U.S. locations: 20
States / cities: Sacramento, California • New Haven, Connecticut • Shelton, Connecticut + 12 more

Conditions: Sinusitis
Interventions: Zithromax (azithromycin) 500mg tablets, Endoscopic Sinus Surgery, Blood sampling for hematology, Blood sampling for plasma chemistry profile, Serum pregnancy test (for women of child-bearing potential); Drug · Procedure
Lead sponsor: Pfizer; Industry
Eligibility: 18 Years and older
Enrollment: 72 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2005 – 2006
U.S. locations: 18
States / cities: Alabaster, Alabama • Birmingham, Alabama • Hoover, Alabama + 11 more

Conditions: Chronic Rhinosinusitis Without Nasal Polyps (CRSsNP)
Interventions: Prednisone, Placebo; Drug
Lead sponsor: Loma Linda University; Other
Eligibility: 18 Years to 80 Years
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2018
U.S. locations: 1
States / cities: Redlands, California

Conditions: Chronic Sinusitis
Interventions: Xylitol, Saline; Drug
Lead sponsor: University of Iowa; Other
Eligibility: 18 Years and older
Enrollment: 53 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2014
U.S. locations: 1
States / cities: Iowa City, Iowa

Conditions: Chronic Rhinosinusitis (Diagnosis)
Interventions: Bupivacaine or Ropivacaine with epinephrine plus dexamethasone - Group 1, Bupivacaine or Ropivacaine with epinephrine plus dexamethasone - Group 2; Drug
Lead sponsor: University of Florida; Other
Eligibility: 18 Years to 90 Years
Enrollment: 80 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2026
U.S. locations: 1
States / cities: Gainesville, Florida

Conditions: Chronic Sinusitis
Interventions: Propel Nova Sinus Implant; Device
Lead sponsor: Intersect ENT; Industry
Eligibility: 18 Years and older
Enrollment: 15 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2015
U.S. locations: 2
States / cities: Miami, Florida • Dublin, Ohio

Conditions: Sinusitis, Nasal Polyps
Interventions: Verapamil Hydrochloride Intranasal; Drug
Lead sponsor: Benjamin Bleier; Other
Eligibility: 18 Years to 80 Years
Enrollment: 6 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2018
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Chronic Sinusitis
Interventions: Seprapack Sinus Dressing; Device
Lead sponsor: Genzyme, a Sanofi Company; Industry
Eligibility: 18 Years and older
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2003 – 2005
U.S. locations: 3
States / cities: Charleston, North Carolina • Cincinnati, Ohio • Memphis, Tennessee

Conditions: Chronic Rhinosinusitis (CRS)
Interventions: Patient Centered CRS Treatment Decision Support; Other
Lead sponsor: University of Southern California; Other
Eligibility: 18 Years and older
Enrollment: 50 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2026
U.S. locations: 1
States / cities: Arcadia, California

Conditions: Sinusitis, Chronic, Cystic Fibrosis With Other Manifestations
Interventions: Synrinse; Drug
Lead sponsor: University of Washington; Other
Eligibility: 18 Years and older
Enrollment: 30 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2018
U.S. locations: 1
States / cities: Seattle, Washington

Conditions: Chronic Sinusitis, Nasal Obstruction, Turbinate; Hypertrophy Mucous Membrane, Deviated Nasal Septum - Congenital, Deviated Nasal Septum Acquired
Interventions: Tranexamic Acid 1,000 Mg/10 mL (100 Mg/mL) INTRAVEN VIAL (ML); Drug
Lead sponsor: Stanford University; Other
Eligibility: 18 Years and older
Enrollment: 40 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2022
U.S. locations: 1
States / cities: Stanford, California

Conditions: Chronic Rhinosinusitis With Nasal Polyps
Interventions: AMG 282, Placebo; Drug
Lead sponsor: Amgen; Industry
Eligibility: 18 Years to 65 Years
Enrollment: 41 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2014 – 2016
U.S. locations: 4
States / cities: Santa Monica, California • Aurora, Colorado • South Miami, Florida + 1 more

Conditions: Chronic Rhinosinusitis, Recurrent Acute Rhinosinusitis
Interventions: Not listed
Lead sponsor: Integra LifeSciences Corporation; Industry
Eligibility: 18 Years and older
Enrollment: 252 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015
U.S. locations: 25
States / cities: Phoenix, Arizona • Los Angeles, California • Sacramento, California + 22 more

Conditions: Chronic Rhinosinusitis With Nasal Polyps
Interventions: Experimental: Tezepelumab, Placebo, Mometasone furoate or equivalent intranasal corticosteroid; Biological · Other · Drug
Lead sponsor: AstraZeneca; Industry
Eligibility: 18 Years and older
Enrollment: 416 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2024
U.S. locations: 21
States / cities: Birmingham, Alabama • Bakersfield, California • Newport Beach, California + 18 more

Conditions: Cystic Fibrosis (CF), Chronic Rhinosinusitis (CRS)
Interventions: STOP NASAL SALINE IRRIGATION WITH OR WITHOUT STEROID, CONTINUE NASAL SALINE IRRIGATION WITH OR WITHOUT STEROID; Other · Drug
Lead sponsor: Indiana University; Other
Eligibility: 18 Years and older
Enrollment: 64 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2026
U.S. locations: 1
States / cities: Indianapolis, Indiana

Conditions: Chronic Rhinosinusitis With Nasal Polyps
Interventions: CBP-201, Placebo; Drug
Lead sponsor: Connect Biopharm LLC; Industry
Eligibility: 18 Years to 75 Years
Enrollment: 40 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2022
U.S. locations: 32
States / cities: Birmingham, Alabama • Bakersfield, California • La Mesa, California + 26 more

Conditions: Chronic Sinusitis
Interventions: non-coated Intranasal Splint, Sinexus Intranasal Splint; Device
Lead sponsor: Intersect ENT; Industry
Eligibility: 18 Years and older
Enrollment: 50 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2009
U.S. locations: 1
States / cities: Fresno, California

Conditions: Chronic Sinusitis With or Without Nasal Polyps
Interventions: Fluticasone Propionate; Drug
Lead sponsor: Optinose US Inc.; Industry
Eligibility: 18 Years and older
Enrollment: 705 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2015
U.S. locations: 18
States / cities: Phoenix, Arizona • Colorado Springs, Colorado • Largo, Florida + 15 more

Search by objective public record fields.

Medical Therapy Versus Balloon Sinus Dilation for Patients With Chronic Rhinosinusitis

Safety and Efficacy of the Propel Mini and Propel Nova Steroid-Eluting Sinus Implant in Frontal Sinus

Efficacy and Safety of Depemokimab (GSK3511294) in Participants With Chronic Rhinosinusitis With Nasal Polyps

Ivacaftor for Acquired CFTR Dysfunction in Chronic Rhinosinusitis (EDSPD Protocol)

The Sinonasal Microbiome

Dupilumab Severe Eosinophilic Chronic Sinusitis Without Nasal Polyposis

Study Of PF-06817024 In Healthy Subjects, In Patients With Chronic Rhinosinusitis With Nasal Polyps And in Patients With Atopic Dermatitis

A Study To Measure The Level Of Drug In Nasal Tissue And Blood After Taking A Single 2g Dose Or 500mg Tablets For Up To

Systemic Corticosteroids in the Perioperative Management of Chronic Rhinosinusitis Without Nasal Polyps (CRSsNP)

Xylitol Versus Saline in Chronic Sinusitis

Functional Endoscopic Sinus Surgery Study

Clinical Evaluation of Propel Nova Sinus Implant in Peripheral Sinus Ostia

Trial of Topical Verapamil in Chronic Rhinosinusitis With Nasal Polyps

Efficacy of Seprapack Sinus Dressing Versus No Dressing in the Prevention of Intranasal Adhesions Following Sinus Surgery

Treatment Decision-Making Among Patients With Chronic Rhinosinusitis

SynRinse Irrigation Pilot (SIP) Trial

Effect of Tranexamic Acid on Postoperative Bleeding Following Sinus and Nasal Surgery

A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of AMG 282 in Healthy Subjects and Subjects With Chronic Rhinosinusitis With Nasal Polyps

Global Sinus Surgery Registry

Efficacy and Safety of Tezepelumab in Participants With Severe Chronic Rhinosinusitis With Nasal Polyposis

Sinonasal Therapies and Histologic Correlations of Patients With Cystic Fibrosis in the Era of Highly Effective Modulator Therapy

A Study to Evaluate CBP-201, Rademikibart, in Adult Patients With Chronic Rhinosinusitis With Nasal Polyps

A Clinical Evaluation of the Sinexus Intranasal Splint Following Functional Endoscopic Sinus Surgery in Patients With Chronic Rhinosinusitis

Study Evaluating the Safety of Intranasal Administration of 400 μg of Fluticasone Propionate Twice a Day (BID) Using a Novel Bi-Directional Device in Subjects With Chronic Sinusitis With or Without Nasal Polyps