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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Completed Phase 4 Interventional Accepts healthy volunteers

The Role of Massage in Increasing Total Motile Sperm Count of IUI

NCT01969825
View directory record Official record
Conditions
Infertility
Interventions
Massage
Behavioral
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years to 70 Years · Male only
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2005 – 2006
U.S. locations
1
States / cities
Charlotte, North Carolina
Source: ClinicalTrials.gov public record
Updated Apr 27, 2022 · Synced Sep 5, 2026, 4:10 AM EDT
Terminated No phase listed Observational

Split Cohort Trial Comparing IVF Outcomes After the Use of Testicular vs. Ejaculated Sperm for ICSI

NCT03483298
View directory record Official record
Conditions
Infertility
Interventions
ICSI
Other
Lead sponsor
Reproductive Medicine Associates of New Jersey
Other
Eligibility
18 Years to 65 Years · Male only
Enrollment
7 participants
Timeline
2018 – 2021
U.S. locations
1
States / cities
Basking Ridge, New Jersey
Source: ClinicalTrials.gov public record
Updated Jan 27, 2022 · Synced Sep 5, 2026, 4:10 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Study of the Consumer Use of a New Home Test to Measure Sperm Concentration

NCT02475395
View directory record Official record
Conditions
Fertility, Male, Sub-Fertility, Male
Interventions
TRAK device
Device
Lead sponsor
Sandstone Diagnostics
Industry
Eligibility
20 Years to 50 Years
Enrollment
272 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015
U.S. locations
3
States / cities
Encino, California • Tarzana, California • Great Neck, New York
Source: ClinicalTrials.gov public record
Updated Oct 17, 2017 · Synced Sep 5, 2026, 4:10 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

A Study to Examine the Effects of Minocycline Extended-Release Tablets on Sperm Production in Human Males.

NCT00765336
View directory record Official record
Conditions
Human Volunteer
Interventions
minocycline extended release, Placebo
Drug
Lead sponsor
Medicis Pharmaceutical Corporation
Industry
Eligibility
18 Years and older · Male only
Enrollment
180 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2009
U.S. locations
10
States / cities
Tarzana, California • Minneapolis, Minnesota • Lawrenceville, New Jersey + 7 more
Source: ClinicalTrials.gov public record
Updated Dec 6, 2011 · Synced Sep 5, 2026, 4:10 AM EDT
Completed No phase listed Observational

Correlating In Vitro Fertilization Outcomes After Euploid Blastocyst Transfer With Sperm DNA Fragmentation

NCT02268123
View directory record Official record
Conditions
Male Infertility
Interventions
Not listed
Lead sponsor
Reproductive Medicine Associates of New Jersey
Other
Eligibility
35 Years to 40 Years
Enrollment
323 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2018
U.S. locations
2
States / cities
Basking Ridge, New Jersey • Allentown, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Sep 10, 2018 · Synced Sep 5, 2026, 4:10 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Effect of Environmental Exposures on the Egg Fertilizing Ability of Human Sperm

NCT00012480
View directory record Official record
Conditions
Male Infertility, Testicular Diseases, Urologic and Male Genital Diseases, Lead Poisoning
Interventions
Not listed
Lead sponsor
National Institute of Environmental Health Sciences (NIEHS)
NIH
Eligibility
21 Years to 55 Years · Male only
Enrollment
400 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2002 – 2007
U.S. locations
3
States / cities
Los Angeles, California • Manhasset, New York • Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Apr 14, 2015 · Synced Sep 5, 2026, 4:10 AM EDT
Completed Phase 3 Interventional Results available

Phase III Study to Evaluated Morning Testosterone Normalization in Men With Secondary Hypogonadism

NCT01532414
View directory record Official record
Conditions
Secondary Hypogonadism
Interventions
Androxal, Placebo
Drug
Lead sponsor
Repros Therapeutics Inc.
Industry
Eligibility
18 Years to 60 Years · Male only
Enrollment
151 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2013
U.S. locations
23
States / cities
Mobile, Alabama • Little Rock, Arkansas • Garden Grove, California + 19 more
Source: ClinicalTrials.gov public record
Updated May 26, 2015 · Synced Sep 5, 2026, 4:10 AM EDT
Recruiting Not applicable Interventional

The EPIC Study: Exploring Paternal Age and the Influence on Blastocyst Culture

NCT06629766
View directory record Official record
Conditions
Infertility (IVF Patients), Oocyte Competence, Sperm DNA Fragmentation, Paternal Age, Sperm Selection
Interventions
Microfluidic sperm separation device, Density grade centrifugation
Device · Other
Lead sponsor
Reproductive Medicine Associates of New Jersey
Other
Eligibility
18 Years to 41 Years · Female only
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
1
States / cities
Basking Ridge, New Jersey
Source: ClinicalTrials.gov public record
Updated Jun 2, 2026 · Synced Sep 5, 2026, 4:10 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Polscope Sperm: A Non-invasive Method to Assess DNA Damage in Individual Sperm

NCT01461395
View directory record Official record
Conditions
DNA Damage, Other Complications Associated With Artificial Fertilization
Interventions
Not listed
Lead sponsor
University of South Florida
Other
Eligibility
18 Years to 60 Years · Male only
Enrollment
84 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2012
U.S. locations
1
States / cities
Tampa, Florida
Source: ClinicalTrials.gov public record
Updated Aug 23, 2012 · Synced Sep 5, 2026, 4:10 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Evaluation of Discarded Laboratory Pathological Specimens and Media

NCT01219439
View directory record Official record
Conditions
Non-viable Oocytes, Extra Spermatozoa, Seminal Fluid, Granulosa Cells, Serum, Follicular Fluid, Conditioned IVF Media
Interventions
Not listed
Lead sponsor
Reproductive Medicine Associates of New Jersey
Other
Eligibility
18 Years to 65 Years
Enrollment
10,000 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2022
U.S. locations
1
States / cities
Basking Ridge, New Jersey
Source: ClinicalTrials.gov public record
Updated May 2, 2023 · Synced Sep 5, 2026, 4:10 AM EDT
Completed Not applicable Interventional

Laser-Assisted Versus Conventional Intracytoplasmic Sperm Injection

NCT00114725
View directory record Official record
Conditions
Infertility, Infertility, Male
Interventions
Laser-assisted intracytoplasmic sperm injection
Procedure
Lead sponsor
Shady Grove Fertility Reproductive Science Center
Other
Eligibility
18 Years to 45 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004
U.S. locations
1
States / cities
Rockville, Maryland
Source: ClinicalTrials.gov public record
Updated Jun 23, 2005 · Synced Sep 5, 2026, 4:10 AM EDT
Not listed Not applicable Interventional

Use of Semen TEX101 to Improve Sperm Retrieval Rates for Men With Non-obstructive Azoospermia

NCT02851966
View directory record Official record
Conditions
Non-obstructive Azoospermia
Interventions
mTESE
Procedure
Lead sponsor
Mount Sinai Hospital, Canada
Other
Eligibility
18 Years and older · Male only
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2020
U.S. locations
2
States / cities
San Francisco, California • New York, New York
Source: ClinicalTrials.gov public record
Updated Mar 11, 2019 · Synced Sep 5, 2026, 4:10 AM EDT
Withdrawn Phase 3 Interventional

To Assess Effects of Arbaclofen ER Tablets Compared With Placebo on Sperm Parameters in Male Subjects With MS

NCT02869425
View directory record Official record
Conditions
Multiple Sclerosis, Sperm
Interventions
arbaclofen ER Tablets, Placebo for arbaclofen ER tablets
Drug
Lead sponsor
RVL Pharmaceuticals, Inc.
Industry
Eligibility
18 Years to 55 Years · Male only
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2019
U.S. locations
2
States / cities
Miami, Florida • Tampa, Florida
Source: ClinicalTrials.gov public record
Updated Apr 26, 2022 · Synced Sep 5, 2026, 4:10 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Automated Intracytoplasmic Sperm Injection (ICSIA)

NCT05633316
View directory record Official record
Conditions
Infertility, Female
Interventions
Investigational device named ICSIA, Manual ICSI
Device
Lead sponsor
Overture Life
Industry
Eligibility
18 Years to 50 Years · Female only
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2024
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jul 5, 2023 · Synced Sep 5, 2026, 4:10 AM EDT
Terminated No phase listed Observational

The Effect of Methotrexate on Sperm Quality in Men With Inflammatory Bowel Disease

NCT02461784
View directory record Official record
Conditions
Inflammatory Bowel Disease (IBD)
Interventions
Semen & Data Collection
Procedure
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
18 Years to 40 Years · Male only
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2020
U.S. locations
1
States / cities
Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated Mar 8, 2023 · Synced Sep 5, 2026, 4:10 AM EDT
Completed No phase listed Observational Results available

Impact of Sperm DNA Integrity on In Vitro Cycles

NCT01232465
View directory record Official record
Conditions
Male Infertility, Unexplained Infertility, Abortion, Habitual
Interventions
Not listed
Lead sponsor
Northwell Health
Other
Eligibility
Male only
Enrollment
420 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2013
U.S. locations
1
States / cities
Manhasset, New York
Source: ClinicalTrials.gov public record
Updated Apr 10, 2014 · Synced Sep 5, 2026, 4:10 AM EDT
Terminated Phase 3 Interventional Results available

Aromatase Inhibitors in the Treatment of Male Infertility

NCT00440180
View directory record Official record
Conditions
Obesity, Oligospermia
Interventions
Anastrozole, Placebo
Drug
Lead sponsor
University of Utah
Other
Eligibility
16 Years to 80 Years · Male only
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2014
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Apr 5, 2016 · Synced Sep 5, 2026, 4:10 AM EDT
Active, not recruiting Not applicable Interventional

A Randomized Clinical Trial Comparing Embryo Euploidy Rates Following Ultrashort Versus Standard Abstinence

NCT07062237
View directory record Official record
Conditions
Infertility, Male Factor Infertility
Interventions
Ultrashort abstinence, Standard abstinence
Other
Lead sponsor
UConn Health
Other
Eligibility
18 Years to 42 Years
Enrollment
187 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Farmington, Connecticut
Source: ClinicalTrials.gov public record
Updated Jul 8, 2026 · Synced Sep 5, 2026, 4:10 AM EDT
Completed Phase 3 Interventional Results available

Phase III Study to Evaluate Morning Testosterone Normalization in Overweight Men With Secondary Hypogonadism

NCT01739595
View directory record Official record
Conditions
Secondary Hypogonadism
Interventions
enclomiphene citrate, Placebo
Drug
Lead sponsor
Repros Therapeutics Inc.
Industry
Eligibility
18 Years to 60 Years · Male only
Enrollment
181 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2013
U.S. locations
13
States / cities
Mobile, Alabama • Little Rock, Arkansas • Rancho Cucamonga, California + 10 more
Source: ClinicalTrials.gov public record
Updated May 26, 2015 · Synced Sep 5, 2026, 4:10 AM EDT
Terminated No phase listed Observational Accepts healthy volunteers

Impact of Sperm DNA Integrity on Artificial Reproductive Treatment (ART)

NCT00875095
View directory record Official record
Conditions
Sperm DNA Impact on ART Outcomes
Interventions
Not listed
Lead sponsor
Northwell Health
Other
Eligibility
18 Years and older · Male only
Enrollment
8 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2008
U.S. locations
1
States / cities
Manhasset, New York
Source: ClinicalTrials.gov public record
Updated Sep 7, 2016 · Synced Sep 5, 2026, 4:10 AM EDT
Completed No phase listed Observational

Human Sperm Binding to Transgenic Mouse Eggs

NCT00340587
View directory record Official record
Conditions
Fertilization
Interventions
Not listed
Lead sponsor
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
NIH
Eligibility
18 Years and older
Enrollment
13 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
1997 – 2016
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Apr 4, 2018 · Synced Sep 5, 2026, 4:10 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

A Sibling Oocyte Study- Comparison of ZyMotTM Microfluidics Device to Density Gradient for Sperm Selection During ICSI

NCT04818593
View directory record Official record
Conditions
ART
Interventions
ZyMot Multi Sperm Separation Device (850 ul), Density Gradient Centrifugation
Device · Other
Lead sponsor
NYU Langone Health
Other
Eligibility
18 Years and older
Enrollment
108 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jun 4, 2023 · Synced Sep 5, 2026, 4:10 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Sperm Selection by Microfluidic Separation Improves Embryo Quality

NCT03085433
View directory record Official record
Conditions
Sperm DNA Fragmentation, Embryo Quality, Fertility Disorders, Infertility, Infertility, Male, Infertility Unexplained
Interventions
Microfluidic Sperm Sorting, in vitro fertilization
Device · Procedure
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years to 65 Years
Enrollment
393 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2022
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Dec 30, 2025 · Synced Sep 5, 2026, 4:10 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Cannabis Use and Epigenetic Alterations in Human Male Sperm Cells

NCT03614637
View directory record Official record
Conditions
Cannabis Use
Interventions
Cannabis use abstinence for 11 weeks
Other
Lead sponsor
Duke University
Other
Eligibility
18 Years to 40 Years · Male only
Enrollment
42 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2020
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Jul 6, 2020 · Synced Sep 5, 2026, 4:10 AM EDT