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Showing 1–24 of 44 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Sciatica Pain Clear all
Terminated Not applicable Interventional

Chiropractic Prone Distraction for Lower Back Pain

NCT00269503
View directory record Official record
Conditions
Herniated Disc, Lower Back Pain, Sciatica
Interventions
Prone Distraction, Side-Posture Manipulation, Side-Posture Manipulation & Prone Distraction, Usual Care (Control Group)
Procedure
Lead sponsor
Samueli Institute for Information Biology
Other
Eligibility
18 Years to 45 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated May 7, 2008 · Synced Jul 22, 2026, 10:41 AM EDT
Completed Phase 3 Interventional Results available

Corticosteroid Lumbar Epidural Analgesia for Radiculopathy

NCT03372161
View directory record Official record
Conditions
Lumbosacral Radicular Pain
Interventions
SP-102, Placebo
Drug
Lead sponsor
Scilex Pharmaceuticals, Inc.
Industry
Eligibility
18 Years to 70 Years
Enrollment
401 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2022
U.S. locations
37
States / cities
Mobile, Alabama • Phoenix, Arizona • Tempe, Arizona + 30 more
Source: ClinicalTrials.gov public record
Updated Sep 18, 2022 · Synced Jul 22, 2026, 10:41 AM EDT
Completed Not applicable Interventional

Does Magnetic Resonance Imaging (MRI) Improve Interventional Outcomes for Lumbosacral Radiculopathy?

NCT00826124
View directory record Official record
Conditions
Lumbosacral Radiculopathy
Interventions
Epidural steroid injection, Magnetic Resonance Imaging (MRI)
Procedure
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years and older
Enrollment
131 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2011
U.S. locations
2
States / cities
Washington D.C., District of Columbia • Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Jun 22, 2011 · Synced Jul 22, 2026, 10:41 AM EDT
Completed Not applicable Interventional

Ultrasound-guided Transgluteal Sciatic Nerve Hydrodissection for the Treatment of Sciatica in the Emergency Department

NCT07588126
View directory record Official record
Conditions
Sciatica Acute, Sciatica Pain
Interventions
Ultrasound guided transgluteal sciatic nerve hydrodissection
Procedure
Lead sponsor
Kaiser Permanente
Other
Eligibility
18 Years and older
Enrollment
69 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated May 13, 2026 · Synced Jul 22, 2026, 10:41 AM EDT
Completed Phase 1Phase 2 Interventional

Study to Evaluate the Safety and Efficacy of Placulumab (CEP-37247) Administered by the Transforaminal Epidural Route for the Treatment of Patients With Lumbosacral Radicular Pain Associated With Disk Herniation

NCT01240876
View directory record Official record
Conditions
Sciatica
Interventions
CEP-37247, Placebo
Drug
Lead sponsor
Cephalon
Industry
Eligibility
18 Years to 70 Years
Enrollment
98 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2013
U.S. locations
20
States / cities
La Mesa, California • Laguna Hills, California • Pasadena, California + 15 more
Source: ClinicalTrials.gov public record
Updated Jul 20, 2016 · Synced Jul 22, 2026, 10:41 AM EDT
Completed Phase 2Phase 3 Interventional Results available

A 3-arm Multi-center, Randomized Controlled Study Comparing Transforaminal Corticosteroid, Transforaminal Etanercept and Transforaminal Saline for Lumbosacral Radiculopathy

NCT00733096
View directory record Official record
Conditions
Lumbosacral Radiculopathy
Interventions
etanercept, methylprednisolone, normal saline
Drug
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years to 70 Years
Enrollment
84 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2011
U.S. locations
2
States / cities
Washington D.C., District of Columbia • Fort Bragg, North Carolina
Source: ClinicalTrials.gov public record
Updated Oct 7, 2012 · Synced Jul 22, 2026, 10:41 AM EDT
Completed Phase 2 Interventional Results available

A Research Study to Characterize the Pharmacodynamics and Safety of Repeat Dose SP-102

NCT03613662
View directory record Official record
Conditions
Lumbosacral Radicular Pain
Interventions
SP-102
Drug
Lead sponsor
Semnur Pharmaceuticals, Inc.
Industry
Eligibility
18 Years to 70 Years
Enrollment
19 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
Boise, Idaho
Source: ClinicalTrials.gov public record
Updated Jan 12, 2022 · Synced Jul 22, 2026, 10:41 AM EDT
Completed Phase 2 Interventional

Topiramate in the Treatment of Sciatica

NCT00011804
View directory record Official record
Conditions
Sciatica
Interventions
Topiramate
Drug
Lead sponsor
National Institute of Dental and Craniofacial Research (NIDCR)
NIH
Eligibility
Not listed
Enrollment
65 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2001 – 2005
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Mar 3, 2008 · Synced Jul 22, 2026, 10:41 AM EDT
Completed No phase listed Observational

NAPS: Non-awake Versus Awake Placement of Spinal Cord Stimulators

NCT02284542
View directory record Official record
Conditions
Chronic Pain, Sciatica, Failed Back Surgery Syndrome
Interventions
Awake, Non-Awake
Procedure
Lead sponsor
St. Luke's Hospital, Pennsylvania
Other
Eligibility
18 Years and older
Enrollment
34 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2017
U.S. locations
4
States / cities
Bethlehem, Pennsylvania • Danville, Pennsylvania • Hershey, Pennsylvania + 1 more
Source: ClinicalTrials.gov public record
Updated Oct 21, 2021 · Synced Jul 22, 2026, 10:41 AM EDT
Suspended Not applicable Interventional Accepts healthy volunteers

Aromatherapy Randomization of Pain Management in Adults

NCT03377088
View directory record Official record
Conditions
Back Pain, Back Pain, Low, Sciatica
Interventions
Rose oil, Almond Oil
Other
Lead sponsor
Stony Brook University
Other
Eligibility
18 Years to 110 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2024
U.S. locations
1
States / cities
Stony Brook, New York
Source: ClinicalTrials.gov public record
Updated Feb 13, 2024 · Synced Jul 22, 2026, 10:41 AM EDT
Completed Phase 2 Interventional

A Study of the Pharmacokinetics, Safety, and Preliminary Efficacy of MDT-15 in Subjects With Lumbosacral Radiculopathy

NCT01917825
View directory record Official record
Conditions
Sciatica, Lumbosacral Radiculopathy
Interventions
MDT-15
Drug
Lead sponsor
Medtronic Spinal and Biologics
Industry
Eligibility
18 Years and older
Enrollment
54 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2016
U.S. locations
6
States / cities
Fort Lauderdale, Florida • Bloomington, Illinois • Carmel, Indiana + 3 more
Source: ClinicalTrials.gov public record
Updated Apr 19, 2017 · Synced Jul 22, 2026, 10:41 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Study to Evaluate the Effectiveness of Orthopedic Spinal Supports in the Treatment of Low Back Pain

NCT00553540
View directory record Official record
Conditions
Low Back Pain
Interventions
Back supports
Device
Lead sponsor
Cleveland Clinic Florida
Other
Eligibility
18 Years to 65 Years
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2008
U.S. locations
1
States / cities
Weston, Florida
Source: ClinicalTrials.gov public record
Updated Nov 24, 2019 · Synced Jul 22, 2026, 10:41 AM EDT
Completed No phase listed Observational

Cost Effectiveness of OMT for Chronic Low Back Pain

NCT03532230
View directory record Official record
Conditions
Lumbar Radiculopathy, Lesion of Sciatic Nerve, Left Lower Limb, Lesion of Sciatic Nerve, Right Lower Limb, Lumbar Spinal Stenosis, Lumbar Spondylosis, Lumbago With Sciatica, Left Side, Lumbago With Sciatica, Right Side
Interventions
Osteopathic Manipulative Treatment (OMT)
Procedure
Lead sponsor
Rowan University
Other
Eligibility
18 Years to 84 Years
Enrollment
146 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
3
States / cities
East Lansing, Michigan • Stratford, New Jersey • Voorhees Township, New Jersey
Source: ClinicalTrials.gov public record
Updated May 3, 2020 · Synced Jul 22, 2026, 10:41 AM EDT
Not listed Phase 2Phase 3 Interventional Accepts healthy volunteers

Fibrin for Chronic Multi-level Discogenic Low Back Pain

NCT04621799
View directory record Official record
Conditions
Low Back Pain, Disc Disease, Disc Degeneration, Radiculopathy, Annular Disc Tear
Interventions
Fibrin sealant
Drug
Lead sponsor
Pauza, Kevin, MD
Other
Eligibility
18 Years to 80 Years
Enrollment
400 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2021
U.S. locations
1
States / cities
Tyler, Texas
Source: ClinicalTrials.gov public record
Updated Nov 8, 2020 · Synced Jul 22, 2026, 10:41 AM EDT
Completed Phase 3 Interventional Results available

SI-6603 (Condoliase) Study for Lumbar Disc Herniation (Discovery 6603 Study)

NCT03607838
View directory record Official record
Conditions
Lumbar Disc Herniation
Interventions
SI-6603, Sham injection
Drug
Lead sponsor
Seikagaku Corporation
Industry
Eligibility
30 Years to 70 Years
Enrollment
352 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2023
U.S. locations
67
States / cities
Mobile, Alabama • Fountain Valley, California • La Jolla, California + 60 more
Source: ClinicalTrials.gov public record
Updated Jul 23, 2025 · Synced Jul 22, 2026, 10:41 AM EDT
Completed Phase 1Phase 2 Interventional

Efficacy of Epidural Etanercept in the Treatment of Sciatica

NCT00364572
View directory record Official record
Conditions
Sciatica
Interventions
epidural injection of etanercept, placebo (control procedure)
Drug
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years to 70 Years
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2007
U.S. locations
1
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated Jan 21, 2009 · Synced Jul 22, 2026, 10:41 AM EDT
Completed Phase 2 Interventional

Navigator vs Standard Needle Injection for Hip

NCT02066844
View directory record Official record
Conditions
Hip Pain Etiology Unknown
Interventions
Celestone, Lidocaine
Drug
Lead sponsor
Cartiva, Inc.
Industry
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Jan 27, 2016 · Synced Jul 22, 2026, 10:41 AM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers

[18F]FTC-146 PET/MRI in Healthy Volunteers and in CRPS and Sciatica

NCT02753101
View directory record Official record
Conditions
Complex Regional Pain Syndrome, Sciatica
Interventions
[18F]-FTC-146
Drug
Lead sponsor
Stanford University
Other
Eligibility
18 Years and older
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2017
U.S. locations
1
States / cities
Stanford, California
Source: ClinicalTrials.gov public record
Updated Mar 4, 2018 · Synced Jul 22, 2026, 10:41 AM EDT
Completed Phase 2 Interventional

A Study to Evaluate the Safety and Efficacy of Subcutaneously Administered REGN475(SAR164877) in Patients With Sciatic Pain

NCT00991172
View directory record Official record
Conditions
Sciatica
Interventions
REGN475, Placebo Injection
Drug
Lead sponsor
Regeneron Pharmaceuticals
Industry
Eligibility
18 Years to 65 Years
Enrollment
159 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2010
U.S. locations
30
States / cities
Birmingham, Alabama • Mobile, Alabama • Peoria, Arizona + 27 more
Source: ClinicalTrials.gov public record
Updated Dec 7, 2011 · Synced Jul 22, 2026, 10:41 AM EDT
Not listed No phase listed Observational

Injection of Autologous Bone Marrow Aspirate in Patients With Degenerative Disc Disease.

NCT05146583
View directory record Official record
Conditions
Lumbar Disc Disease
Interventions
Autologous bone marrow aspirate injected intradiscal after microdiscectomy, Discectomy only
Procedure
Lead sponsor
New York Presbyterian Hospital
Other
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Dec 20, 2021 · Synced Jul 22, 2026, 10:41 AM EDT
Completed Phase 3 Interventional

The Efficacy of Oral Steroids in the Treatment of Acute Sciatica

NCT00317447
View directory record Official record
Conditions
Sciatica
Interventions
Oral Prednisone
Drug
Lead sponsor
Kaiser Permanente
Other
Eligibility
20 Years to 60 Years
Enrollment
160 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2002 – 2004
U.S. locations
1
States / cities
Santa Rosa, California
Source: ClinicalTrials.gov public record
Updated Apr 23, 2006 · Synced Jul 22, 2026, 10:41 AM EDT
Completed Not applicable Interventional Results available

Steroids Versus Gabapentin

NCT01495923
View directory record Official record
Conditions
Sciatica, Radiculopathy
Interventions
epidural steroid injection, Sham epidural steroid injection, Gabapentin, Placebo gabapentin
Procedure · Drug
Lead sponsor
Johns Hopkins University
Other
Eligibility
17 Years to 100 Years
Enrollment
145 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2014
U.S. locations
3
States / cities
San Diego, California • Baltimore, Maryland • Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Apr 10, 2017 · Synced Jul 22, 2026, 10:41 AM EDT
Recruiting Not applicable Interventional

Comparing Ultrasound-Guided Transgluteal Nerve Block to Standard Care

NCT07397117
View directory record Official record
Conditions
Sciatica Acute
Interventions
nerve block with ropivacaine, Standard medical treatment
Procedure · Other
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Jun 1, 2026 · Synced Jul 22, 2026, 10:41 AM EDT
Terminated Phase 2 Interventional Results available

Ultrasound Guided Posterior Sacroiliac Ligament Corticosteroid Injection in Pregnancy-Related Pelvic Girdle Pain

NCT02044991
View directory record Official record
Conditions
Pelvic Girdle Pain
Interventions
Corticosteroid, Placebo Injection
Drug
Lead sponsor
Loyola University
Other
Eligibility
21 Years to 50 Years · Female only
Enrollment
2 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2017
U.S. locations
1
States / cities
Maywood, Illinois
Source: ClinicalTrials.gov public record
Updated Aug 7, 2018 · Synced Jul 22, 2026, 10:41 AM EDT