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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Sepsis, Severe Sepsis and Septic Shock Clear all
Completed No phase listed Observational

IMproved PREdiction of Severe Sepsis in the Emergency Department

NCT01392508
View directory record Official record
Conditions
Systemic Inflammatory Response Syndrome (SIRS), Sepsis, Severe Sepsis, Septic Shock
Interventions
Not listed
Lead sponsor
Axis Shield Diagnostics Ltd
Industry
Eligibility
18 Years and older
Enrollment
759 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2015
U.S. locations
1
States / cities
Camden, New Jersey
Source: ClinicalTrials.gov public record
Updated Apr 13, 2017 · Synced Jun 26, 2026, 7:22 AM EDT
Terminated Phase 2 Interventional Results available

Early Metabolic Resuscitation for Septic Shock

NCT03895853
View directory record Official record
Conditions
Multiple Organ Failure, Septic Shock, Severe Sepsis
Interventions
Best Practice, early metabolic resuscitation
Other · Dietary Supplement
Lead sponsor
M.D. Anderson Cancer Center
Other
Eligibility
18 Years and older
Enrollment
2 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Oct 28, 2024 · Synced Jun 26, 2026, 7:22 AM EDT
Completed Not applicable Interventional

Implementation and Evaluations of Sepsis Watch

NCT03655626
View directory record Official record
Conditions
Sepsis, Severe Sepsis, Septic Shock
Interventions
Sepsis Watch
Other
Lead sponsor
Duke University
Other
Eligibility
18 Years and older
Enrollment
32,003 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Jul 31, 2019 · Synced Jun 26, 2026, 7:22 AM EDT
Completed No phase listed Observational

Outcomes of Septic Shock Patients Treated With a Metabolic Resuscitation Bundle Consisting of Intravenous Hydrocortisone, Ascorbic Acid and Thiamine.

NCT03913468
View directory record Official record
Conditions
Septic Shock, Ascorbic Acid Deficiency
Interventions
Intravenous Ascorbic Acid
Drug
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
18 Years to 90 Years
Enrollment
206 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019
U.S. locations
1
States / cities
Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated Sep 13, 2021 · Synced Jun 26, 2026, 7:22 AM EDT
Terminated Not applicable Interventional

EMS Prehospital Blood Culture Collection and Antibiotic Administration: A Two-Phase Pilot Project to Reduce Mortality in Patients With Severe Sepsis and Septic Shock

NCT04134624
View directory record Official record
Conditions
Sepsis, Sepsis, Severe, Septic Shock
Interventions
Sepsis care bundle
Other
Lead sponsor
HealthPartners Institute
Other
Eligibility
18 Years to 100 Years
Enrollment
215 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
1
States / cities
Stillwater, Minnesota
Source: ClinicalTrials.gov public record
Updated Sep 21, 2021 · Synced Jun 26, 2026, 7:22 AM EDT
Not listed No phase listed Observational

Electronic Application of a Severe Sepsis Screening Tool and Management Bundle

NCT01724463
View directory record Official record
Conditions
Systemic Inflammatory Response Syndrome (SIRS), Sepsis, Severe Sepsis, Septic Shock
Interventions
Severe Sepsis Management Bundle
Other
Lead sponsor
University of Tennessee
Other
Eligibility
1 Month to 18 Years
Enrollment
30,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2018
U.S. locations
1
States / cities
Memphis, Tennessee
Source: ClinicalTrials.gov public record
Updated Mar 30, 2015 · Synced Jun 26, 2026, 7:22 AM EDT
Completed Not applicable Interventional

Sepsis, Severe Sepsis and Septic Shock Detection by Breath Analysis

NCT03497182
View directory record Official record
Conditions
Sepsis
Interventions
Breath sample collection
Device
Lead sponsor
Landon Pediatric Foundation
Other
Eligibility
18 Years and older
Enrollment
45 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
1
States / cities
Ventura, California
Source: ClinicalTrials.gov public record
Updated May 6, 2019 · Synced Jun 26, 2026, 7:22 AM EDT
Not listed Phase 2 Interventional Accepts healthy volunteers

Machine Learning Sepsis Alert Notification Using Clinical Data

NCT04005001
View directory record Official record
Conditions
Sepsis, Severe Sepsis, Septic Shock
Interventions
HindSight, InSight
Other
Lead sponsor
Dascena
Industry
Eligibility
18 Years and older
Enrollment
37,986 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
3
States / cities
Springfield, Massachusetts • Camden, New Jersey • Cape May, New Jersey
Source: ClinicalTrials.gov public record
Updated May 2, 2022 · Synced Jun 26, 2026, 7:22 AM EDT
Completed Phase 1Phase 2 Interventional Results available

LIPIDS-P Trial Phase I/II Trial

NCT03405870
View directory record Official record
Conditions
Sepsis, Severe, Septic Shock
Interventions
Smoflipid
Drug
Lead sponsor
University of Florida
Other
Eligibility
18 Years and older
Enrollment
59 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2023
U.S. locations
3
States / cities
Gainesville, Florida • Jacksonville, Florida
Source: ClinicalTrials.gov public record
Updated Aug 10, 2025 · Synced Jun 26, 2026, 7:22 AM EDT
Completed No phase listed Observational

The Role of Dysfunctional HDL in Severe Sepsis

NCT02370186
View directory record Official record
Conditions
Severe Sepsis, Septic Shock, Sepsis
Interventions
Not listed
Lead sponsor
University of Florida
Other
Eligibility
18 Years and older
Enrollment
110 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2017
U.S. locations
1
States / cities
Jacksonville, Florida
Source: ClinicalTrials.gov public record
Updated Jan 26, 2021 · Synced Jun 26, 2026, 7:22 AM EDT
Completed Not applicable Interventional

Clinical Trial of the Optimal Endpoint of Early Sepsis Resuscitation

NCT00372502
View directory record Official record
Conditions
Severe Sepsis, Septic Shock
Interventions
Modified EGDT, Standard EGDT
Procedure
Lead sponsor
National Institute of General Medical Sciences (NIGMS)
NIH
Eligibility
18 Years and older
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2008
U.S. locations
3
States / cities
Boston, Massachusetts • Camden, New Jersey • Charlotte, North Carolina
Source: ClinicalTrials.gov public record
Updated Jan 13, 2009 · Synced Jun 26, 2026, 7:22 AM EDT
Completed Phase 3 Interventional

ACCESS: A Controlled Comparison of Eritoran Tetrasodium and Placebo in Patients With Severe Sepsis

NCT00334828
View directory record Official record
Conditions
Severe Sepsis
Interventions
eritoran tetrasodium, Placebo
Drug
Lead sponsor
Eisai Inc.
Industry
Eligibility
18 Years and older
Enrollment
2,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2006
U.S. locations
69
States / cities
Birmingham, Alabama • Mobile, Alabama • Mesa, Arizona + 66 more
Source: ClinicalTrials.gov public record
Updated Jul 24, 2017 · Synced Jun 26, 2026, 7:22 AM EDT
Completed Phase 2 Interventional Results available

AZD9773 Dose Escalation Study

NCT00615017
View directory record Official record
Conditions
Severe Sepsis
Interventions
AZD9773 (CytoFab), Placebo
Drug · Other
Lead sponsor
AstraZeneca
Industry
Eligibility
18 Years and older
Enrollment
70 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2009
U.S. locations
26
States / cities
Birmingham, Alabama • Newark, Delaware • Bay Pines, Florida + 23 more
Source: ClinicalTrials.gov public record
Updated Aug 21, 2013 · Synced Jun 26, 2026, 7:22 AM EDT
Not listed Not applicable Interventional

Protocol-driven Hemodynamic Support for Patients With Septic Shock

NCT00335907
View directory record Official record
Conditions
Shock, Septic, Severe Sepsis, Sepsis
Interventions
Fluid and Vasopressor Protocol
Procedure
Lead sponsor
National Institute of General Medical Sciences (NIGMS)
NIH
Eligibility
18 Years and older
Enrollment
70 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2011
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Aug 24, 2010 · Synced Jun 26, 2026, 7:22 AM EDT
Completed No phase listed Observational

Procalcitonin Monitoring Sepsis Study

NCT01523717
View directory record Official record
Conditions
Severe Sepsis, Septic Shock
Interventions
Not listed
Lead sponsor
Brahms AG
Industry
Eligibility
18 Years and older
Enrollment
858 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2014
U.S. locations
13
States / cities
Sacramento, California • Chicago, Illinois • Boston, Massachusetts + 7 more
Source: ClinicalTrials.gov public record
Updated Mar 16, 2015 · Synced Jun 26, 2026, 7:22 AM EDT
No Longer Available No phase listed Expanded access

Evaluating the Use of Polymyxin B Cartridge Hemoperfusion for Patients With Septic Shock and COVID 19

NCT04352985
View directory record Official record
Conditions
Septic Shock, Endotoxemia, COVID, Corona Virus Infection, Sepsis, Severe
Interventions
Toraymyxin PMX-20R (PMX Cartridge)
Device
Lead sponsor
Spectral Diagnostics (US) Inc.
Industry
Eligibility
18 Years and older
U.S. locations
3
States / cities
Farmington, Connecticut • Washington D.C., District of Columbia • Stony Brook, New York
Source: ClinicalTrials.gov public record
Updated Sep 19, 2021 · Synced Jun 26, 2026, 7:22 AM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Utility of High-Fidelity Simulation In the Education and Assessment of Residents in the Recognition and Management of the Sepsis Syndrome

NCT01992120
View directory record Official record
Conditions
Medical Knowledge, Clinical Performance
Interventions
Debriefing of high-fidelity sepsis simulation scenarios, Placebo: Debriefing of high-fidelity non-sepsis simulation scenarios
Other
Lead sponsor
NYU Langone Health
Other
Eligibility
20 Years to 60 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2014
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Dec 7, 2015 · Synced Jun 26, 2026, 7:22 AM EDT
Terminated Phase 1 Interventional

Safety, Pharmacokinetics and Pharmacodynamics of BMS-936559 in Severe Sepsis

NCT02576457
View directory record Official record
Conditions
Severe Sepsis, Septic Shock
Interventions
BMS-936559, Placebo
Biological · Other
Lead sponsor
Bristol-Myers Squibb
Industry
Eligibility
18 Years and older
Enrollment
35 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2017
U.S. locations
13
States / cities
Sacramento, California • Denver, Colorado • Gainesville, Florida + 10 more
Source: ClinicalTrials.gov public record
Updated Sep 14, 2017 · Synced Jun 26, 2026, 7:22 AM EDT
Terminated Phase 4 Interventional Results available

Minimally-Invasive Cardiovascular Hemodynamic Optimization (MiCHO) Versus Early Goal-Directed Therapy (EGDT) in the Management of Septic Shock

NCT00535821
View directory record Official record
Conditions
Severe Sepsis, Septic Shock
Interventions
Esophageal Doppler monitoring - CardioQ, Deltex Inc, Central line with CVP and continuous ScvO2 monitoring
Device
Lead sponsor
Loma Linda University
Other
Eligibility
18 Years and older
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2010
U.S. locations
4
States / cities
Loma Linda, California • Worcester, Massachusetts • Detroit, Michigan
Source: ClinicalTrials.gov public record
Updated Jun 24, 2014 · Synced Jun 26, 2026, 7:22 AM EDT
Completed No phase listed Observational Results available

Effect of Emergency Department Care Reorganization on Door-to-antibiotic Times for Sepsis (LDS SWARM)

NCT03226366
View directory record Official record
Conditions
Septic Shock, Sepsis
Interventions
Immediate evaluation by multidisciplinary team
Other
Lead sponsor
Intermountain Health Care, Inc.
Other
Eligibility
18 Years and older
Enrollment
3,230 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2020
U.S. locations
4
States / cities
Murray, Utah • Riverton, Utah • Salt Lake City, Utah + 1 more
Source: ClinicalTrials.gov public record
Updated Jun 17, 2020 · Synced Jun 26, 2026, 7:22 AM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

Role of Transposable Elements in Septic Immune Aging

NCT06809868
View directory record Official record
Conditions
Sepsis, Sepsis and Septic Shock, Sepsis With Multiple Organ Dysfunction (MOD), Sepsis With Acute Organ Dysfunction, Sepsis, Severe, Sepsis at Intensive Care Unit, Sepsis, Severe Sepsis and Septic Shock, Sepsis, Septic Shock
Interventions
RNA and DNA Sequencing
Genetic
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years and older
Enrollment
116 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2028
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Jan 29, 2026 · Synced Jun 26, 2026, 7:22 AM EDT
Not listed No phase listed Observational

Function of Circulating Exosomes in Sepsis-induced Immunosuppression

NCT04979767
View directory record Official record
Conditions
Sepsis, Septic Shock, Sepsis Syndrome, Sepsis Bacterial, Sepsis, Severe, Sepsis Bacteremia
Interventions
Not listed
Lead sponsor
University of Kansas Medical Center
Other
Eligibility
50 Years and older
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Kansas City, Kansas
Source: ClinicalTrials.gov public record
Updated Jul 27, 2021 · Synced Jun 26, 2026, 7:22 AM EDT
Not listed No phase listed Observational

Pharmacogenomic Biomarker Study for Recombinant Human Activated Protein C Treatment in Severe Sepsis

NCT01486524
View directory record Official record
Conditions
Severe Sepsis, Septic Shock
Interventions
Not listed
Lead sponsor
Sirius Genomics Inc.
Industry
Eligibility
18 Years and older
Enrollment
3,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2012
U.S. locations
4
States / cities
Atlanta, Georgia • Baltimore, Maryland • Boston, Massachusetts + 1 more
Source: ClinicalTrials.gov public record
Updated Dec 5, 2011 · Synced Jun 26, 2026, 7:22 AM EDT
Completed Phase 2 Interventional

A Safety and Efficacy Study of Intravenous E5564 in Patients With Severe Sepsis

NCT00046072
View directory record Official record
Conditions
Sepsis, Shock, Septic, Sepsis Syndrome, Septicemia, Infection
Interventions
E5564
Drug
Lead sponsor
Eisai Inc.
Industry
Eligibility
18 Years to 85 Years
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2001 – 2005
U.S. locations
17
States / cities
Mobile, Alabama • San Diego, California • Santa Barbara, California + 14 more
Source: ClinicalTrials.gov public record
Updated Dec 11, 2005 · Synced Jun 26, 2026, 7:22 AM EDT