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Conditions: Motion Sickness
Interventions: Transcutaneous Auricular Neurostimulation device; Device
Lead sponsor: 59th Medical Wing; Federal
Eligibility: 18 Years to 50 Years
Enrollment: 36 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025
U.S. locations: 1
States / cities: San Antonio, Texas

Conditions: Traumatic Brain Injury (Tbi), Traumatic Meningeal Enhancement (Tme)
Interventions: Not listed
Lead sponsor: National Institutes of Health Clinical Center (CC); NIH
Eligibility: 21 Years to 65 Years
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024
U.S. locations: 1
States / cities: Bethesda, Maryland

Conditions: Trigeminal Neuralgia
Interventions: lamotrigine, Placebo; Drug
Lead sponsor: Thomas Jefferson University; Other
Eligibility: 15 Years to 75 Years
Enrollment: 20 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2003 – 2006
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: B-cell Mediated Autoimmune Disorders
Interventions: Azercabtagene zapreleucel (azer-cel); Drug
Lead sponsor: TG Therapeutics, Inc.; Industry
Eligibility: 18 Years and older
Enrollment: 100 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2029
U.S. locations: 8
States / cities: La Jolla, California • Ann Arbor, Michigan • Omaha, Nebraska + 5 more

Conditions: Corticobasal Degeneration (CBD), Corticobasal Syndrome (CBS), Cortical-basal Ganglionic Degeneration (CBGD), Progressive Supranuclear Palsy (PSP), Nonfluent Variant Primary Progressive Aphasia (nfvPPA), Oligosymptomatic/Variant Progressive Supranuclear Palsy (o/vPSP)
Interventions: Observational Study; Other
Lead sponsor: University of California, San Francisco; Other
Eligibility: 40 Years to 80 Years
Enrollment: 293 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2016 – 2024
U.S. locations: 7
States / cities: San Diego, California • San Francisco, California • Baltimore, Maryland + 4 more

Conditions: Brain Tumor, Central Nervous System Tumors, Cachexia, Leukemia, Lymphoma, Myelodysplastic Syndromes, Myelodysplastic/Myeloproliferative Diseases, Unspecified Childhood Solid Tumor, Protocol Specific
Interventions: cyproheptadine hydrochloride, megestrol acetate; Drug
Lead sponsor: University of South Florida; Other
Eligibility: 2 Years to 20 Years
Enrollment: 70 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2003 – 2007
U.S. locations: 40
States / cities: Oakland, California • Washington D.C., District of Columbia • Gainesville, Florida + 33 more

Conditions: Head and Neck Cancer, Squamous Cell Carcinoma, Oral Cavity Cancer, Oropharyngeal Cancer, Laryngeal Cancer, Sinonasal Squamous Cell Carcinoma, HPV (Human Papillomavirus)-Associated Carcinoma, Skull Base Tumors, HPV 16 Positive Oropharyngeal Tumors (OPC)
Interventions: Toripalimab + Chemotherapy, Toripalimab, Chemoradiotherapy or radiation; Drug · Radiation
Lead sponsor: Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; Other
Eligibility: 18 Years and older
Enrollment: 75 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2030
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Progressive Supranuclear Palsy, Parkinson's Disease
Interventions: Not listed
Lead sponsor: Oregon Health and Science University; Other
Eligibility: 40 Years to 85 Years
Enrollment: 36 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2011 – 2013
U.S. locations: 1
States / cities: Portland, Oregon

Conditions: Glaucoma, Age Related Macular Degeneration, Optic Neuropathy, Retinal Degeneration
Interventions: nGoggle; Device
Lead sponsor: NGoggle; Industry
Eligibility: 18 Years to 90 Years
Enrollment: 200 participants
Timeline: 2019 – 2024
U.S. locations: 1
States / cities: Durham, North Carolina

Conditions: Bell's Palsy, Ramsay Hunt Syndrome, Lyme Disease, Facial Palsy
Interventions: BlinkER device.; Device
Lead sponsor: Neurotrigger Ltd; Industry
Eligibility: 22 Years to 120 Years
Enrollment: 80 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2026
U.S. locations: 1
States / cities: Deerfield Beach, Florida

Conditions: Strabismus, Esotropia, Exotropia, Graves Disease, Ptosis, Eyelid
Interventions: Bupivacaine; Drug
Lead sponsor: Smith-Kettlewell Eye Research Institute; Other
Eligibility: 8 Years to 95 Years
Enrollment: 120 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2020
U.S. locations: 1
States / cities: San Francisco, California

Conditions: Breast Cancer, Colorectal Cancer, Head and Neck Cancer, Lung Cancer, Prostate Cancer
Interventions: venipuncture, radiation therapy; Procedure · Radiation
Lead sponsor: Vanderbilt-Ingram Cancer Center; Other
Eligibility: 18 Years and older
Enrollment: 25 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2006 – 2010
U.S. locations: 3
States / cities: Nashville, Tennessee

Conditions: Cancer
Interventions: cyclophosphamide, Cryoablation; Drug · Device
Lead sponsor: Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; Other
Eligibility: 18 Years to 120 Years
Enrollment: 19 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2007 – 2013
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: ALS, Amyotrophic Lateral Sclerosis, Alzheimer Disease, Alzheimer Disease, Early Onset, Alzheimer Disease, Late Onset, Batten Disease, Corticobasal Degeneration, Dementia, Frontotemporal Dementia, Huntington Disease, Lewy Body Disease, Multiple Sclerosis, Multiple System Atrophy, Parkinson Disease, Parkinson's Disease and Parkinsonism, Progressive Supranuclear Palsy, INAD, Diabetes, Diabetes Mellitus, Diabetes Mellitus, Type 2, Diabetes Mellitus, Type 1, Macular Degeneration, Ovarian Cancer, Cervical Cancer, Uterine Cancer, Vaginal Cancer, Vulvar Cancer, PTSD, Post Traumatic Stress Disorder
Interventions: Biological Sample Collection; Other
Lead sponsor: New York Stem Cell Foundation Research Institute; Other
Eligibility: 30 Days and older
Enrollment: 10,000 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2045
U.S. locations: 1
States / cities: New York, New York

Conditions: Major Depressive Disorder
Interventions: Active CES, Sham CES; Device
Lead sponsor: Massachusetts General Hospital; Other
Eligibility: 18 Years to 65 Years
Enrollment: 30 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2015
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Skull Base, Pituitary, Robotics, Endonasal Surgery, Sinus Surgery
Interventions: Use of force sensing surgical curette, Removal of pituitary tumor using modified curette; Device · Procedure
Lead sponsor: Vanderbilt University; Other
Eligibility: 18 Years to 75 Years
Enrollment: 3 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2013
U.S. locations: 1
States / cities: Nashville, Tennessee

Conditions: Trigeminal Neuralgia
Interventions: Carbon Dioxide Drug Delivery System (CDDS); Drug
Lead sponsor: Capnia, Inc.; Industry
Eligibility: 18 Years and older
Enrollment: 30 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2017
U.S. locations: 6
States / cities: Los Angeles, California • Tampa, Florida • New York, New York + 3 more

Conditions: Unilateral Vocal Cord Paralysis
Interventions: vocal fold medialization, vocal fold reinnervation; Procedure
Lead sponsor: National Institute on Deafness and Other Communication Disorders (NIDCD); NIH
Eligibility: 18 Years and older
Enrollment: 300 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2002 – 2005
U.S. locations: 12
States / cities: Birmingham, Alabama • Irvine, California • Washington D.C., District of Columbia + 9 more

Conditions: Antibody-mediated Rejection, NMO Spectrum Disorder, TTP, CIDP
Interventions: Not listed
Lead sponsor: Charles M Knudson; Other
Eligibility: 12 Years to 99 Years
Enrollment: 200 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2040
U.S. locations: 1
States / cities: Iowa City, Iowa

Conditions: Neuromyelitis Optica Spectrum Disorder
Interventions: MR-C-014; Device
Lead sponsor: MedRhythms, Inc.; Industry
Eligibility: 18 Years to 70 Years
Enrollment: 30 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2026
U.S. locations: 2
States / cities: Atlanta, Georgia • Boston, Massachusetts

Conditions: Anosmia, Skull Base Neoplasms
Interventions: Olfactory training, Placebo training; Other
Lead sponsor: Johns Hopkins University; Other
Eligibility: 18 Years and older
Enrollment: 41 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023 – 2026
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Mandibular Fractures
Interventions: Surgery, Non-Surgical fracture treatment; Procedure · Other
Lead sponsor: AO Clinical Investigation and Publishing Documentation; Other
Eligibility: 60 Years and older
Enrollment: 25 participants
Timeline: 2019 – 2023
U.S. locations: 3
States / cities: Sacramento, California • Baltimore, Maryland • Seattle, Washington

Conditions: Unilateral Vocal Cord Paralysis, Vocal Cord Atrophy
Interventions: Laryngeal Framework Surgery; Procedure
Lead sponsor: University of California, San Francisco; Other
Eligibility: 18 Years and older
Enrollment: 500 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2028
U.S. locations: 10
States / cities: La Jolla, California • Los Angeles, California • San Francisco, California + 7 more

Conditions: Vitrectomy, Macular Pucker, Retinal Edema
Interventions: Dexamethasone Intracanalicular Insert, 0.4 mg, Prednisone acetate 1%; Drug
Lead sponsor: Kovach Eye Institute; Industry
Eligibility: 18 Years and older
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2024
U.S. locations: 1
States / cities: Elmhurst, Illinois

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Evaluation of a Device to Reduce Motion Sickness and Spatial Disorientation

Imaging Characterization of the Biomechanical Coupling of Brain and Skull

Research Study to Test Safety and Effectiveness of Investigational Drug in Patients With Trigeminal Neuralgia

A Study to Assess the Safety and Clinical Activity of Azer-cel in Participants With B-cell Mediated Autoimmune Disorders

4-Repeat Tauopathy Neuroimaging Initiative - Cycle 2

Cyproheptadine and Megestrol in Preventing Weight Loss in Children With Cachexia Caused By Cancer or Cancer Treatment

Neoadjuvant Chemotherapy and Programmed Cell Death Protein 1(PD-1) Inhibition for Head and Neck Cancer Treatment De-escalation (NeoScorch HN)

Postural Instability in Progressive Supranuclear Palsy

Assessment of Visual Function With a Portable Brain-computer Interface

Safety and Effectiveness of the BlinkER System in Participants With Facial Nerve Palsy

Bupivacaine Injection of Eye Muscles to Treat Strabismus

Growth Factor Levels in the Blood of Patients Undergoing Radiation Therapy for Epithelial Cancer

Cyclophosphamide and Cryoablation in Treating Patients With Advanced or Metastatic Epithelial Cancer

NYSCF Scientific Discovery Biobank

Efficacy and Safety of Cranial Electrical Stimulation (CES) for Major Depressive Disorder (MDD)

Forces During Skull Base Surgery

Nasal Carbon Dioxide for the Symptomatic Treatment of Classical Trigeminal Neuralgia

Surgery for Vocal Cord Paralysis

Biorepository and Registry for Plasma Exchange Patients

Acceptability and Safety of MR-C-014 in Persons With Neuromyelitis Optica Spectrum Disorder

Chemosensory Dysfunction and Recovery in Endoscopic Endonasal Skull Base Surgery

Patients 60 Years and Older Suffering From Mandibular Fractures Registry

Outcomes Tracking in Unilateral Vocal Fold Paralysis (UVFP) and Atrophy After Medialization Laryngeal Surgery

Assessing the Efficacy and Safety fo DEXTENZA, Sustained Release Dexamethasone 0.4 mg Insert(s) for the Treatment of Pain, Inflammation, and Cystoid Macular Edema Following 27 Gauge Vitrectomy With Internal Limiting Membrane Peel for the Treatment of Retinal Edema Associated With Macular Pucker.