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ClinicalTrials.gov public records Last synced Nov 15, 2026, 4:41 AM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 625–648 of 2,615 matching trials from the live ClinicalTrials.gov search.

Filters: Condition: Sleep-Wake Disorders Clear all

Conditions: Sleep Disordered Breathing, Obstructive Sleep Apnea, Central Sleep Apnea
Interventions: Not listed
Lead sponsor: Cleveland Medical Devices Inc; Industry
Eligibility: Not listed
Enrollment: 146 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2007 – 2010
U.S. locations: 2
States / cities: Baltimore, Maryland • Cleveland, Ohio

Conditions: Sleep Disturbance, Craving, Cortisol; Hypersecretion
Interventions: Suvorexant 20 mg; Drug
Lead sponsor: Milton S. Hershey Medical Center; Other
Eligibility: 21 Years to 64 Years
Enrollment: 28 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2023
U.S. locations: 1
States / cities: Wernersville, Pennsylvania

Conditions: Delirium in the Intensive Care Unit, Sleep Quality in Adult ICU Patients, Agitation Associated With Critical Illness, Anxiety Acute
Interventions: Virtual reality (VR) therapy; Behavioral
Lead sponsor: Milton S. Hershey Medical Center; Other
Eligibility: Not listed
Enrollment: 20 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026
U.S. locations: 1
States / cities: Hershey, Pennsylvania

Conditions: Restless Legs Syndrome
Interventions: Rotigotine, Placebo; Drug · Other
Lead sponsor: UCB Pharma; Industry
Eligibility: 18 Years to 75 Years
Enrollment: 150 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2013
U.S. locations: 18
States / cities: Birmingham, Alabama • Jasper, Alabama • Gilbert, Arizona + 15 more

Conditions: Obstructive Sleep Apnea
Interventions: Paroxetine, 5HTP; Drug
Lead sponsor: US Department of Veterans Affairs; Federal
Eligibility: 16 Years to 60 Years
Healthy volunteers: Accepts healthy volunteers
Timeline: 2000 – 2003
U.S. locations: 1
States / cities: Gainesville, Florida

Conditions: Insomnia, Sleep, Sleep Disturbance, Sleep Disorder, Sleep Hygiene, Sleep Initiation and Maintenance Disorders
Interventions: Full Sleep, Path to Better Sleep; Behavioral
Lead sponsor: Koko Home, Inc.; Industry
Eligibility: 18 Years and older
Enrollment: 200 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023 – 2024
U.S. locations: 1
States / cities: Redwood City, California

Conditions: Chronic Insomnia
Interventions: WatchPAT sleep monitor, CBT-i Coach mobile app; Device · Behavioral
Lead sponsor: VA Office of Research and Development; Federal
Eligibility: 21 Years to 65 Years
Enrollment: 38 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2016
U.S. locations: 1
States / cities: Bedford, Massachusetts

Conditions: Hyperandrogenism
Interventions: Blood sampling; Other
Lead sponsor: University of Virginia; Other
Eligibility: 8 Years to 15 Years · Female only
Enrollment: 90 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2008 – 2023
U.S. locations: 1
States / cities: Charlottesville, Virginia

Conditions: Insomnia, Mental Health Disorder, Substance Use Disorder
Interventions: Quetiapine, Trazodone; Drug
Lead sponsor: VA Connecticut Healthcare System; Federal
Eligibility: 18 Years and older
Enrollment: 1 participant
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2015
U.S. locations: 1
States / cities: West Haven, Connecticut

Conditions: Insomnia, Insomnia Chronic
Interventions: Zolpidem tartrate; Drug
Lead sponsor: University of Pennsylvania; Other
Eligibility: 40 Years to 85 Years
Enrollment: 197 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2024
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Obstructive Sleep Apnea (OSA)
Interventions: Positive airway pressure (PAP) therapy, Sleep dental device, Atomoxetine-oxybutynin; Device · Drug
Lead sponsor: Sairam Parthasarathy; Other
Eligibility: 18 Years and older
Enrollment: 2,400 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2032
U.S. locations: 4
States / cities: Tucson, Arizona • Redwood City, California • Miami, Florida + 1 more

Conditions: Blood Pressure, Hypertension, Elevated Blood Pressure, Sleep, Short Sleep Phenotype
Interventions: Sleep hygiene/extension intervention, Control care; Behavioral
Lead sponsor: Columbia University; Other
Eligibility: 18 Years and older
Enrollment: 66 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2024
U.S. locations: 1
States / cities: New York, New York

Conditions: Creutzfeldt-Jakob Disease
Interventions: Quinacrine, Placebo; Drug
Lead sponsor: University of California, San Francisco; Other
Eligibility: 18 Years and older
Enrollment: 69 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2005 – 2012
U.S. locations: 1
States / cities: San Francisco, California

Conditions: Sleep Disturbance
Interventions: Auricular acupuncture, Standard treatment; Device · Other
Lead sponsor: Paul Crawford; Federal
Eligibility: 18 Years and older
Enrollment: 180 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2026
U.S. locations: 1
States / cities: Nellis Air Force Base, Nevada

Conditions: Right to Left Shunt, Patent Foramen Ovale, Atrial Septal Defect
Interventions: Flow Detection System; Device
Lead sponsor: Cardiox Corporation; Industry
Eligibility: 18 Years and older
Enrollment: 141 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2015
U.S. locations: 8
States / cities: Phoenix, Arizona • Los Angeles, California • Aurora, Colorado + 5 more

Conditions: Perceived Stress, Anxiety, Sleep Disturbance
Interventions: "Calm" is a mindfulness meditation mobile app; Other
Lead sponsor: University of Arizona; Other
Eligibility: 18 Years to 99 Years · Female only
Enrollment: 101 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2020
U.S. locations: 1
States / cities: Phoenix, Arizona

Conditions: Cardiovascular Diseases
Interventions: Nutrition, Exercise, Stress Management Counseling, usual care; Behavioral · Other
Lead sponsor: University of Pittsburgh; Other
Eligibility: 45 Years to 75 Years
Enrollment: 2,000 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2003 – 2029
U.S. locations: 1
States / cities: Pittsburgh, Pennsylvania

Conditions: Sleep Apnea, Obstructive
Interventions: Dexmedetomidine, Propofol; Drug
Lead sponsor: Children's Hospital Medical Center, Cincinnati; Other
Eligibility: 12 Months to 25 Years
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2011
U.S. locations: 1
States / cities: Cincinnati, Ohio

Conditions: Insomnia Disorder
Interventions: Lemborexant 5 mg, Lemborexant 10 mg, Lemborexant-matched placebo., Flurazepam 30 mg; Drug
Lead sponsor: Eisai Inc.; Industry
Eligibility: 18 Years to 99 Years
Enrollment: 69 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2015
U.S. locations: 2
States / cities: Atlanta, Georgia • Crestview Hills, Kentucky

Conditions: REM Sleep Behavior Disorder
Interventions: Adalimumab, Placebo; Drug
Lead sponsor: Yale University; Other
Eligibility: 50 Years to 80 Years
Enrollment: 108 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2030
U.S. locations: 17
States / cities: Los Angeles, California • Aurora, Colorado • North Haven, Connecticut + 13 more

Conditions: Sleep Apnea, Age
Interventions: 1) hyperventilation via noninvasive positive pressure ventilation 2) multiple trials of episodic hypoxia; Other
Lead sponsor: VA Office of Research and Development; Federal
Eligibility: 18 Years to 89 Years
Enrollment: 92 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2008 – 2015
U.S. locations: 1
States / cities: Detroit, Michigan

Conditions: Sleep Initiation and Maintenance Disorders
Interventions: Eplivanserin (SR46349); Drug
Lead sponsor: Sanofi; Industry
Eligibility: 6 Years to 17 Years
Enrollment: 41 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009
U.S. locations: 1
States / cities: Bridgewater, New Jersey

Conditions: Sleep, Sleep Disturbance, Insufficient Sleep
Interventions: Sleep Promotion Program; Behavioral
Lead sponsor: University of Pittsburgh; Other
Eligibility: 12 Years and older
Enrollment: 16 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2025
U.S. locations: 1
States / cities: Pittsburgh, Pennsylvania

Conditions: Insomnia, Depression, Posttraumatic Stress Disorder, Suicidal Ideation
Interventions: CBT-I, TAU; Behavioral · Other
Lead sponsor: VA Office of Research and Development; Federal
Eligibility: 18 Years to 70 Years
Enrollment: 54 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2016
U.S. locations: 1
States / cities: Syracuse, New York

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Pre-operative Polysomnography Assessment of Cardiac Surgery Inpatients

The Efficacy of Suvorexant in Treatment of Patients With Substance Use Disorder and Insomnia: A Pilot Open Trial

Virtual Reality to Reduce Anxiety, Agitation and Delirium in Critically Ill Patients

Rotigotine Effect on All-day Functioning and Quality of Life in Subjects With Moderate to Severe Restless Legs Syndrome (RLS)

Serotonin and the Upper Airway in Obstructive Sleep Apnea

Online Insomnia Treatment Program

Mobile Sleep Intervention for OEF, OIF and OND Veterans

Sleep-wake Changes of Luteinizing Hormone Frequency in Pubertal Girls With and Without High Testosterone

Comparison of Quetiapine and Trazodone Treatment for Insomnia in Dually Diagnosed Veterans

Partial Reinforcement II: Three Approaches to Maintenance Therapy for Chronic Insomnia

A Comparative Effectiveness Study of Positive Airway Pressure (PAP) Therapy, Dental Device, and Atomoxetine-Oxybutynin for Treatment of Obstructive Sleep Apnea in Adults

Sleep Duration and Blood Pressure During Sleep

CJD (Creutzfeldt-Jakob Disease) Quinacrine Study

Auricular Acupuncture for Sleep Disturbances

Right to Left Cardiac Shunt Detection

Effects of Using Mobile App on Perceived Stress During COVID-19 Pandemic

Novel Strategies for Reducing Heart Disease Risk Disparities

Dexmedetomidine and Propofol in Children With History of Obstructive Sleep Apnea

Study to Evaluate the Effect of 2 Dosage Strengths of Lemborexant (E2006) on a Multiple Sleep Latency Test in Participants With Insomnia Disorder

An Exploratory Study of the Potential for Rational Immune System Manipulation to Prevent Emergence of Synucleinopathy Manifestations in Persons With REM Sleep Behavior Disorder (RBD)

Determinants of Age Related Breathing Instability During Non-Rapid-Eye-Movement (NREM) Sleep

Single Dose Safety, Tolerability, Pharmacokinetic and Pharmacodynamic Evaluation of Eplivanserin in Children With Insomnia

Sleep Promotion Program Primary Care (SPP PC) Open Trial

Adjunctive Brief Behavioral Treatment of Insomnia (BBTI) for Sleep Intervention (SI)