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ClinicalTrials.gov public records Last synced Nov 4, 2026, 9:41 PM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 1–24 of 141 matching trials from the live ClinicalTrials.gov search.

Filters: Condition: Smoker Lung Clear all

Conditions: Smoking Cessation
Interventions: Nicotine Patches, Telephone Counseling, Brief Hospital Counseling; Drug · Behavioral
Lead sponsor: University of California, San Diego; Other
Eligibility: 18 Years and older
Enrollment: 1,270 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2014
U.S. locations: 6
States / cities: Chula Vista, California • Davis, California • La Jolla, California + 1 more

Conditions: Cigarette Smoker, Current Smoker, Former Smoker, Multiple Pulmonary Nodules, Pulmonary Nodule
Interventions: Computed Tomography, Fludeoxyglucose F-18, Fluorine F 18 L-glutamate Derivative BAY94-9392, Positron Emission Tomography (PET/CT); Diagnostic Test · Drug
Lead sponsor: Andrei Iagaru; Other
Eligibility: 45 Years and older
Enrollment: 15 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2021
U.S. locations: 1
States / cities: Palo Alto, California

Conditions: Asthma, Smoking Cessation
Interventions: PAM, PAM-Enhanced/Asthma Counseling Phone Calls, Follow-Up Phone Calls - Child Wellness Topic; Behavioral
Lead sponsor: The Miriam Hospital; Other
Eligibility: 18 Years and older
Enrollment: 573 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2005 – 2011
U.S. locations: 5
States / cities: Fall River, Massachusetts • Pawtucket, Rhode Island • Providence, Rhode Island + 1 more

Conditions: Pulmonary Disease, Chronic Obstructive (COPD), Cognitive Impairment
Interventions: Neuropsychological Assessment, Spirometry, Arterial Blood Gas, Diffusion Capacity of the Lung for Carbon Monoxide, 6 Minute Walk Test, Systemic Vascular Measures, Blood Biomarkers, Symptom Questionnaire Measures, Brain MRI; Behavioral · Procedure · Diagnostic Test + 1 more
Lead sponsor: Karin Hoth; Other
Eligibility: 30 Years to 85 Years
Enrollment: 170 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017 – 2025
U.S. locations: 1
States / cities: Iowa City, Iowa

Conditions: Non-Small Cell Lung Cancer
Interventions: Bortezomib, Acyclovir; Drug
Lead sponsor: Memorial Sloan Kettering Cancer Center; Other
Eligibility: 18 Years and older
Enrollment: 17 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2019
U.S. locations: 5
States / cities: Basking Ridge, New Jersey • Commack, New York • New York, New York + 2 more

Conditions: Asthma
Interventions: Cessation Counseling; Behavioral
Lead sponsor: Children's Hospital Medical Center, Cincinnati; Other
Eligibility: Not listed
Enrollment: 230 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2016
U.S. locations: 1
States / cities: Cincinnati, Ohio

Conditions: Lung Carcinoma
Interventions: Nicotine Replacement; Drug
Lead sponsor: M.D. Anderson Cancer Center; Other
Eligibility: 50 Years to 80 Years
Enrollment: 135 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2026
U.S. locations: 1
States / cities: Houston, Texas

Conditions: Chronic Obstructive Pulmonary Disease (COPD)
Interventions: Beclomethasone; Drug
Lead sponsor: Weill Medical College of Cornell University; Other
Eligibility: 18 Years and older
Enrollment: 24 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2010 – 2014
U.S. locations: 1
States / cities: New York, New York

Conditions: Smoking, Lung Cancer
Interventions: Best Practice, Nicotine Patch, Quality-of-Life Assessment, Questionnaire Administration, Tobacco Cessation Counseling; Other · Drug
Lead sponsor: M.D. Anderson Cancer Center; Other
Eligibility: 55 Years to 77 Years
Enrollment: 358 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2020 – 2027
U.S. locations: 3
States / cities: Galveston, Texas • Houston, Texas • Tyler, Texas

Conditions: Lung Cancer
Interventions: celecoxib, placebo; Drug · Other
Lead sponsor: University of California, Los Angeles; Other
Eligibility: 45 Years and older
Enrollment: 112 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2002 – 2009
U.S. locations: 1
States / cities: Los Angeles, California

Conditions: Lung Cancer, Non-small Cell Lung Cancer, Bronchioloalveolar Cancer
Interventions: Gefitinib; Drug
Lead sponsor: Memorial Sloan Kettering Cancer Center; Other
Eligibility: 18 Years and older
Enrollment: 65 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2004 – 2010
U.S. locations: 1
States / cities: New York, New York

Conditions: Lung Cancer
Interventions: Biosensor Platform; Diagnostic Test
Lead sponsor: Thomas Jefferson University; Other
Eligibility: 18 Years and older
Enrollment: 87 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2028
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Tobacco Use Disorder
Interventions: Not listed
Lead sponsor: National Institute on Drug Abuse (NIDA); NIH
Eligibility: 55 Years to 74 Years
Enrollment: 72 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2005 – 2007
U.S. locations: 1
States / cities: Minneapolis, Minnesota

Conditions: Non-small Cell Lung Cancer
Interventions: Pralatrexate, Erlotinib, Vitamin B12, Folic Acid; Drug · Dietary Supplement
Lead sponsor: Spectrum Pharmaceuticals, Inc; Industry
Eligibility: 18 Years and older
Enrollment: 201 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2010
U.S. locations: 15
States / cities: Bakersfield, California • San Diego, California • Port Saint Lucie, Florida + 12 more

Conditions: Bladder Cancer, Cervical Cancer, Esophageal Cancer, Gastric Cancer, Head and Neck Cancer, Kidney Cancer, Leukemia, Liver Cancer, Lung Cancer, Pancreatic Cancer, Tobacco Use Disorder
Interventions: nicotine, varenicline, placebo; Drug · Other
Lead sponsor: Butler Hospital; Other
Eligibility: 18 Years to 120 Years
Enrollment: 315 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2012
U.S. locations: 1
States / cities: Providence, Rhode Island

Conditions: Lung Carcinoma
Interventions: Iloprost, Placebo Administration, Quality-of-Life Assessment, Questionnaire Administration; Drug · Other
Lead sponsor: National Cancer Institute (NCI); NIH
Eligibility: 18 Years to 85 Years
Enrollment: 34 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2023
U.S. locations: 2
States / cities: Aurora, Colorado • Denver, Colorado

Conditions: Lung Cancer
Interventions: celecoxib; Drug
Lead sponsor: Jonsson Comprehensive Cancer Center; Other
Eligibility: 45 Years and older
Enrollment: 21 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2001 – 2009
U.S. locations: 1
States / cities: Los Angeles, California

Conditions: Smoking
Interventions: Brussel Sprouts, Deuterated Phenanthrene; Other · Drug
Lead sponsor: Masonic Cancer Center, University of Minnesota; Other
Eligibility: 18 Years to 99 Years
Enrollment: 39 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2016 – 2021
U.S. locations: 1
States / cities: Minneapolis, Minnesota

Conditions: Bladder Cancer, Cervical Cancer, Esophageal Cancer, Gastric Cancer, Head and Neck Cancer, Kidney Cancer, Leukemia, Liver Cancer, Lung Cancer, Pancreatic Cancer, Tobacco Use Disorder
Interventions: zinc oxide; Dietary Supplement
Lead sponsor: Wake Forest University Health Sciences; Other
Eligibility: 21 Years to 120 Years
Enrollment: 61 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2003 – 2015
U.S. locations: 1
States / cities: Winston-Salem, North Carolina

Conditions: Lung Cancer
Interventions: questionnaire administration, computed tomography, evaluation of cancer risk factors, study of high risk factors; Other · Procedure
Lead sponsor: University of Nebraska; Other
Eligibility: 19 Years to 120 Years
Enrollment: 100 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2005 – 2012
U.S. locations: 1
States / cities: Omaha, Nebraska

Conditions: Bronchial Dysplasia, Tobacco Smoking, History of Non-Small Cell Lung Cancer, History of Head and Neck Cancer
Interventions: Nivolumab; Drug
Lead sponsor: University of Colorado, Denver; Other
Eligibility: 18 Years to 80 Years
Enrollment: 19 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2026
U.S. locations: 2
States / cities: Aurora, Colorado • Denver, Colorado

Conditions: Pulmonary Disease
Interventions: Institutional standard of care, Biosamples of airway and blood; Other
Lead sponsor: Boston University; Other
Eligibility: 46 Years and older
Enrollment: 85 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2026
U.S. locations: 19
States / cities: Birmingham, Alabama • Los Angeles, California • San Diego, California + 13 more

Conditions: COPD, Smoking, Lung Disorder
Interventions: Not listed
Lead sponsor: Weill Medical College of Cornell University; Other
Eligibility: 18 Years and older
Enrollment: 111 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2014 – 2024
U.S. locations: 1
States / cities: New York, New York

Conditions: Lung Cancer, Tobacco Use Disorder
Interventions: phenethyl isothiocyanate, placebo; Drug · Other
Lead sponsor: University of Minnesota; Other
Eligibility: 21 Years to 70 Years
Enrollment: 107 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2013
U.S. locations: 1
States / cities: Minneapolis, Minnesota

Search by objective public record fields.

Smoking Cessation in Hospitalized Smokers

18F-FSPG PET/CT in Diagnosing Early Lung Cancer in Patients With Lung Nodules

Sustaining Smoking Cessation in Smokers With Kids With Asthma

COPD-Related Physiology and the Brain

Bortezomib in KRAS-Mutant Non-Small Cell Lung Cancer in Never Smokers or Those With KRAS G12D

Exploring a Cessation Intervention for Smokers

Risk and Benefits of Electronic Cigarettes to Older Smokers at High Risk for Lung Cancer

Effect of Inhaled Steroids on Gene Expression in the Lungs - 2

Centralized Lung Cancer EARly Detection Among Smokers (CLEAR Study)

Celecoxib in Preventing Lung Cancer in Former Heavy Smokers

Phase II Trial to Correlate Radiographic Response Induced By Gefitinib With Mutations in the Protein-Tyrosine Kinase Domain of the EGF Receptor Gene

Lung Cancer Detection in Never Smokers Using Urine Volatile Organic Compound (VOCs)

Assessing the Variability Over Time of Tobacco Carcinogen Biomarkers in Smokers - 2

Study of Pralatrexate vs. Erlotinib for Non-Small Cell Lung Cancer After at Least 1 Prior Platinum-based Treatment

Varenicline or Nicotine Patch and Nicotine Gum in Helping Smokers in a Methadone Treatment Program Stop Smoking

Iloprost in Preventing Lung Cancer in Former Smokers

Celecoxib in Preventing Non-Small Cell Lung Cancer in Tobacco Smokers

Glucobrassicin-Brussel Sprout Effect on D10 Phe Metabolism

Zinc Supplements in Lowering Cadmium Levels in Smokers

CT Scans in Screening for Lung Cancer in Current and Former Smokers

Nivolumab for the Reversal of Squamous Dysplasia in High Risk Current and Former Smokers

DECAMP 1 PLUS: Prediction of Lung Cancer Using Noninvasive Biomarkers

Defective FGFR2 Signaling in the Small Airway Basal Progenitor Cells in COPD

Phenethyl Isothiocyanate in Preventing Lung Cancer in Smokers