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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Smokers Clear all
Completed No phase listed Observational Results available

Brain Nicotine Receptor Density in Veteran Smokers

NCT01721473
View directory record Official record
Conditions
Positron Emission Tomography
Interventions
positron emission tomography scan
Other
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years to 65 Years
Enrollment
184 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2016
U.S. locations
2
States / cities
San Diego, California • West Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Oct 6, 2019 · Synced Jun 25, 2026, 11:54 PM EDT
Completed Not applicable Interventional

APPSPIRE App in Preventing Students From Smoking

NCT01967082
View directory record Official record
Conditions
Cigarette Smoker, Current Every Day Smoker, Student
Interventions
APPSPIRE, Focus Group, Survey Administration
Behavioral · Other
Lead sponsor
M.D. Anderson Cancer Center
Other
Eligibility
18 Years to 24 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2020
U.S. locations
2
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jan 13, 2020 · Synced Jun 25, 2026, 11:54 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

CSD201004: An Actual Use Study of P10 and P13 Nicotine Pouches Among U.S. Adult Smokers

NCT05184920
View directory record Official record
Conditions
Smoking, Tobacco Use, Tobacco Smoking
Interventions
P1012919 nicotine pouch, P1012915 nicotine pouch, P1012914 nicotine pouch, P1013315 nicotine pouch, P1013119 nicotine pouch, P1013218 nicotine pouch, P1012818 nicotine pouch, P1312915 nicotine pouch, P1312914 nicotine pouch, P1313015 nicotine pouch, P1313314 nicotine pouch, P1312815 nicotine pouch
Other
Lead sponsor
RAI Services Company
Industry
Eligibility
21 Years to 60 Years
Enrollment
1,105 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022
U.S. locations
10
States / cities
Phoenix, Arizona • Atlanta, Georgia • Chicago, Illinois + 7 more
Source: ClinicalTrials.gov public record
Updated Jun 26, 2022 · Synced Jun 25, 2026, 11:54 PM EDT
Completed Phase 2 Interventional

Erlotinib and Green Tea Extract (Polyphenon® E) in Preventing Cancer Recurrence in Former Smokers Who Have Undergone Surgery for Bladder Cancer

NCT00088946
View directory record Official record
Conditions
Bladder Cancer
Interventions
Polyphenon E, erlotinib hydrochloride, Erlotinib placebo, Polyphenon E
Dietary Supplement · Drug · Other
Lead sponsor
Jonsson Comprehensive Cancer Center
Other
Eligibility
18 Years and older
Enrollment
17 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2006
U.S. locations
5
States / cities
Phoenix, Arizona • Los Angeles, California • Santa Monica, California + 1 more
Source: ClinicalTrials.gov public record
Updated Jul 30, 2020 · Synced Jun 25, 2026, 11:54 PM EDT
Completed Phase 4 Interventional

Bupropion for Hospitalized Smokers With Acute Cardiovascular Disease

NCT00181818
View directory record Official record
Conditions
Smoking, Myocardial Infarction, Unstable Angina, Cardiovascular Disease
Interventions
bupropion SR (sustained-release)
Drug
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years and older
Enrollment
248 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
1999 – 2003
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Sep 15, 2005 · Synced Jun 25, 2026, 11:54 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effects of Nature Exposure on Smoking Behavior

NCT03716440
View directory record Official record
Conditions
Tobacco Smoking
Interventions
Nature exposure, Non-nature exposure
Other
Lead sponsor
University of Montana
Other
Eligibility
Not listed
Enrollment
42 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018
U.S. locations
1
States / cities
Missoula, Montana
Source: ClinicalTrials.gov public record
Updated Oct 29, 2018 · Synced Jun 25, 2026, 11:54 PM EDT
Completed Not applicable Interventional Results available

Varenicline or Nicotine Patch and Nicotine Gum in Helping Smokers in a Methadone Treatment Program Stop Smoking

NCT00790569
View directory record Official record
Conditions
Bladder Cancer, Cervical Cancer, Esophageal Cancer, Gastric Cancer, Head and Neck Cancer, Kidney Cancer, Leukemia, Liver Cancer, Lung Cancer, Pancreatic Cancer, Tobacco Use Disorder
Interventions
nicotine, varenicline, placebo
Drug · Other
Lead sponsor
Butler Hospital
Other
Eligibility
18 Years to 120 Years
Enrollment
315 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2012
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Jun 5, 2018 · Synced Jun 25, 2026, 11:54 PM EDT
Recruiting Phase 4 Interventional

Using Multiphase Optimization Strategy (MOST) to Optimize a Cost-effective, Sustainable and Scalable Smoking Cessation Package for Smokers in HIV Clinical Care

NCT06598397
View directory record Official record
Conditions
Human Immunodeficiency Virus (HIV), Smoking Cessation
Interventions
Motivational Interviewing (MI) Counseling, Peer Mentoring, Skills-based Text Messaging, Combination NRT
Behavioral · Drug
Lead sponsor
New York University
Other
Eligibility
18 Years and older
Enrollment
500 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2028
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Apr 12, 2026 · Synced Jun 25, 2026, 11:54 PM EDT
Completed Phase 2 Interventional

Celecoxib in Preventing Non-Small Cell Lung Cancer in Tobacco Smokers

NCT00020878
View directory record Official record
Conditions
Lung Cancer
Interventions
celecoxib
Drug
Lead sponsor
Jonsson Comprehensive Cancer Center
Other
Eligibility
45 Years and older
Enrollment
21 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2001 – 2009
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Aug 2, 2020 · Synced Jun 25, 2026, 11:54 PM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Are Smokers Switching to Vaping at Lower Risk for Cancer? (Electronic Cigarettes and Cancer Risk)

NCT03750825
View directory record Official record
Conditions
Cigarette Smoking
Interventions
NIDA Standard Research E-cigarette (SREC)
Device
Lead sponsor
University of Southern California
Other
Eligibility
22 Years to 55 Years
Enrollment
150 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2028
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Aug 5, 2025 · Synced Jun 25, 2026, 11:54 PM EDT
Completed No phase listed Observational

Vanguard Study for Head and Neck Cancer or Non-Small Cell Lung Cancer (NSCLC) Patients

NCT00352391
View directory record Official record
Conditions
Head and Neck Cancer, Lung Cancer
Interventions
Assessments
Other
Lead sponsor
M.D. Anderson Cancer Center
Other
Eligibility
18 Years and older
Enrollment
54 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2016
U.S. locations
3
States / cities
Fort Gordon, Georgia • Johnstown, Pennsylvania • Houston, Texas
Source: ClinicalTrials.gov public record
Updated Feb 2, 2016 · Synced Jun 25, 2026, 11:54 PM EDT
Completed Phase 3 Interventional

Safety Study of Cytisinicline in Adult Combustible and/or E-cigarette Smokers

NCT06435221
View directory record Official record
Conditions
Smoking Cessation, Vaping Cessation
Interventions
Cytisinicline
Drug
Lead sponsor
Achieve Life Sciences
Industry
Eligibility
18 Years and older
Enrollment
479 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
29
States / cities
Mobile, Alabama • Tempe, Arizona • Little Rock, Arkansas + 26 more
Source: ClinicalTrials.gov public record
Updated Nov 25, 2025 · Synced Jun 25, 2026, 11:54 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

A Pilot Study to Evaluate the Efficacy and Safety of Ariva® Silver Wintergreen in Healthy Smokers

NCT01337817
View directory record Official record
Conditions
Tobacco Use Disorder, Smoking
Interventions
Ariva Silver Wintergreen, Ariva Wintergreen
Other
Lead sponsor
Star Scientific, Inc
Industry
Eligibility
23 Years to 72 Years
Enrollment
37 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009
U.S. locations
1
States / cities
Martinsburg, West Virginia
Source: ClinicalTrials.gov public record
Updated Oct 23, 2014 · Synced Jun 25, 2026, 11:54 PM EDT
Not yet recruiting Early Phase 1 Interventional

Psilocybin as a Treatment for Chronic Pain in Smokers

NCT07118332
View directory record Official record
Conditions
Smokers With Chronic Pain
Interventions
Psilocybin (drug)
Drug
Lead sponsor
Yale University
Other
Eligibility
21 Years to 65 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
West Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Jun 8, 2026 · Synced Jun 25, 2026, 11:54 PM EDT
Completed Not applicable Interventional

Effects of Choice Bundling on Valuation of Delayed Gains and Losses in Cigarette Smokers

NCT05110716
View directory record Official record
Conditions
Cigarette Smoking
Interventions
Bundle-size 1, Bundle-size 3, Bundle-size 9
Behavioral
Lead sponsor
Virginia Polytechnic Institute and State University
Other
Eligibility
21 Years and older
Enrollment
308 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021
U.S. locations
1
States / cities
Roanoke, Virginia
Source: ClinicalTrials.gov public record
Updated Jan 23, 2025 · Synced Jun 25, 2026, 11:54 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Tobacco Pilot Study for Low Income Smokers

NCT03017092
View directory record Official record
Conditions
Tobacco Use Disorder
Interventions
Tablet-guided tobacco intervention
Behavioral
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017
U.S. locations
1
States / cities
Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated Dec 25, 2019 · Synced Jun 25, 2026, 11:54 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Enhancing Quitline Services for African American Smokers

NCT03064971
View directory record Official record
Conditions
Tobacco Use Cessation
Interventions
Standard Care, smoking cessation DVD, PTF DVD
Behavioral
Lead sponsor
Case Comprehensive Cancer Center
Other
Eligibility
18 Years and older
Enrollment
1,050 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2020
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Aug 18, 2020 · Synced Jun 25, 2026, 11:54 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Cigarette Smoke and Susceptibility to Influenza Infection

NCT00448617
View directory record Official record
Conditions
Healthy
Interventions
Not listed
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years to 35 Years
Enrollment
138 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2011
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated May 28, 2015 · Synced Jun 25, 2026, 11:54 PM EDT
Withdrawn Phase 4 Interventional

Effects of Varenicline in Heavy Drinking Smokers

NCT02488889
View directory record Official record
Conditions
Cigarette Smoking, Alcohol Consumption
Interventions
Varenicline, Placebo pill (for varenicline), Alcohol, placebo beverage (for alcohol)
Drug
Lead sponsor
University of California, Los Angeles
Other
Eligibility
21 Years to 55 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated May 31, 2018 · Synced Jun 25, 2026, 11:54 PM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Physical Activity in Promoting Smoking Cessation in African Americans

NCT01915810
View directory record Official record
Conditions
Current Smoker, Healthy Subject
Interventions
Exercise Intervention, Laboratory Biomarker Analysis, Nicotine Patch, Questionnaire Administration, Tobacco Cessation Counseling
Behavioral · Other · Drug
Lead sponsor
M.D. Anderson Cancer Center
Other
Eligibility
21 Years to 65 Years
Enrollment
45 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2027
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jan 29, 2026 · Synced Jun 25, 2026, 11:54 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Motivating Quitline Use Among Smokers in Treatment for Substance Use Disorders

NCT01882673
View directory record Official record
Conditions
Smoking Cessation
Interventions
Brief Computer Motivational Interviewing for Smoking Cessation, Nutrition Control
Behavioral
Lead sponsor
Butler Hospital
Other
Eligibility
18 Years to 70 Years
Enrollment
76 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2014
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Jul 19, 2016 · Synced Jun 25, 2026, 11:54 PM EDT
Completed Not applicable Interventional Results available

A Pilot Randomized Controlled Trial of Financial Incentives, Text Messaging, and Usual Care for Homeless Smokers

NCT02565381
View directory record Official record
Conditions
Smoking
Interventions
Transdermal nicotine patch, In-person smoking cessation counseling, Contingent financial rewards for smoking abstinence, Text messages to support smoking abstinence
Drug · Behavioral
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years and older
Enrollment
83 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 13, 2017 · Synced Jun 25, 2026, 11:54 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Pilot Study to Evaluate the Safety and Efficacy of Ariva® Silver Wintergreen in Reducing Cigarette Craving in Smokers

NCT01337830
View directory record Official record
Conditions
Tobacco Use Disorder, Smoking
Interventions
Ariva® Silver Wintergreen, Silver Wintergreen
Other
Lead sponsor
Star Scientific, Inc
Industry
Eligibility
23 Years to 72 Years
Enrollment
111 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010
U.S. locations
1
States / cities
Martinsburg, West Virginia
Source: ClinicalTrials.gov public record
Updated Oct 23, 2014 · Synced Jun 25, 2026, 11:54 PM EDT
Completed Not applicable Interventional Results available

Enhancing a High School Based Smoking Cessation Program

NCT01145001
View directory record Official record
Conditions
Nicotine Dependence
Interventions
Cognitive Behavioural Therapy, Contingency Management, Nicotine Transdermal Patch
Behavioral · Drug
Lead sponsor
Yale University
Other
Eligibility
14 Years to 19 Years
Enrollment
154 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2015
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Dec 28, 2016 · Synced Jun 25, 2026, 11:54 PM EDT