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ClinicalTrials.gov public records Last synced Oct 20, 2026, 8:12 PM EDT

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Showing 25–48 of 2,080 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Smoking Behavior Clear all
Completed Phase 1 Interventional Accepts healthy volunteers Results available

Effects of Menthol in E-cigarettes on Smoking Behaviors

NCT04521647
View directory record Official record
Conditions
Nicotine Dependence
Interventions
Nicotine
Drug
Lead sponsor
Yale University
Other
Eligibility
21 Years to 65 Years
Enrollment
14 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Jun 16, 2026 · Synced Oct 20, 2026, 8:12 PM EDT
Completed Not applicable Interventional

Interventions to Help Smoking Parents of Inpatients Reduce Exposure (INSPIRE)

NCT02281864
View directory record Official record
Conditions
Tobacco Use Cessation, Second Hand Tobacco Smoke
Interventions
Smoking Cessation Intervention Bundle, Control Group: Quitline
Behavioral · Other
Lead sponsor
University of Colorado, Denver
Other
Eligibility
Up to 80 Years
Enrollment
600 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2022
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Jan 31, 2023 · Synced Oct 20, 2026, 8:12 PM EDT
Completed Phase 4 Interventional

Timing of Smoking Intervention in Alcohol Treatment (Nicotine Patch)

NCT00000444
View directory record Official record
Conditions
Alcoholism, Smoking
Interventions
nicotine replacement patch
Drug
Lead sponsor
Minneapolis Veterans Affairs Medical Center
Federal
Eligibility
21 Years to 75 Years
Enrollment
500 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
1997 – 2004
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Feb 11, 2011 · Synced Oct 20, 2026, 8:12 PM EDT
Completed Not applicable Interventional Results available

Financial Incentives for Smoking Cessation Among Mothers

NCT05740098
View directory record Official record
Conditions
Cigarette Smoking
Interventions
Best Practices, Financial Incentives, Nicotine Replacement Therapy
Behavioral · Drug
Lead sponsor
University of Vermont
Other
Eligibility
18 Years and older · Female only
Enrollment
198 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2020
U.S. locations
1
States / cities
Burlington, Vermont
Source: ClinicalTrials.gov public record
Updated Jul 28, 2023 · Synced Oct 20, 2026, 8:12 PM EDT
Recruiting Phase 2 Interventional

GLP-1 Receptor Agonists to Decrease Ethanol and CVD Risk in HIV

NCT07221214
View directory record Official record
Conditions
HIV, Alcohol, Smoking Cigarette, Cardiovascular Disease Prevention
Interventions
Semaglutide (Rybelsus®), Placebo
Drug
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
18 Years to 89 Years
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2030
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated May 26, 2026 · Synced Oct 20, 2026, 8:12 PM EDT
Not yet recruiting Not applicable Interventional Accepts healthy volunteers

ChatGPT-Supported Text Messaging Program for Smoking Cessation

NCT07079306
View directory record Official record
Conditions
Smoking Cessation
Interventions
BeFree+Bot, BeFree
Behavioral
Lead sponsor
George Washington University
Other
Eligibility
18 Years and older
Enrollment
180 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2027
U.S. locations
1
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated Oct 14, 2026 · Synced Oct 20, 2026, 8:12 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

An Alternative Dosing Schedule of Varenicline for Smoking Cessation

NCT00835900
View directory record Official record
Conditions
Smoking Cessation
Interventions
varenicline, placebo
Drug
Lead sponsor
Roswell Park Cancer Institute
Other
Eligibility
18 Years to 65 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2015
U.S. locations
1
States / cities
Buffalo, New York
Source: ClinicalTrials.gov public record
Updated May 30, 2017 · Synced Oct 20, 2026, 8:12 PM EDT
Completed Not applicable Interventional

A Peer Navigator Model to Improve Quit Attempts and Smoking Cessation Rates Among HIV-positive Smokers

NCT04327921
View directory record Official record
Conditions
HIV
Interventions
Peer navigation social support for smoking cessation, Standard Condition
Behavioral
Lead sponsor
Brown University
Other
Eligibility
18 Years and older
Enrollment
66 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Mar 2, 2022 · Synced Oct 20, 2026, 8:12 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Way to Quit - Comparative Efficacy, Acceptance and Effectiveness of Health Incentive Structures

NCT01526265
View directory record Official record
Conditions
Tobacco Use Disorder
Interventions
Usual Care, Individual Rewards, Fixed Deposits, Competitive Deposits (Pari-Mutuel), Collaborative Rewards
Behavioral
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years and older
Enrollment
2,185 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2015
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 12, 2016 · Synced Oct 20, 2026, 8:12 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Evaluation of Environmental Emissions From Electronic Cigarettes and Tobacco-Burning Cigarettes

NCT02185898
View directory record Official record
Conditions
Smoking
Interventions
Leading U.S. non-menthol cigarette, Leading U.S. menthol cigarette, Electronic cigarette #1, Electronic cigarette #2, Electronic cigarette #3, U.S. Market-sample electronic cigarettes
Other
Lead sponsor
R.J. Reynolds Vapor Company
Industry
Eligibility
21 Years to 99 Years
Enrollment
71 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2015
U.S. locations
1
States / cities
Stockbridge, Georgia
Source: ClinicalTrials.gov public record
Updated Jun 1, 2018 · Synced Oct 20, 2026, 8:12 PM EDT
Completed Not applicable Interventional

Influencer E-Cigarette and Cannabis Marketing: a Survey-Based Experiment Among Adolescents

NCT06919263
View directory record Official record
Conditions
Electronic Nicotine Delivery Systems
Interventions
Influencer marketing
Behavioral
Lead sponsor
University of Southern California
Other
Eligibility
16 Years to 17 Years
Enrollment
1,462 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Apr 9, 2025 · Synced Oct 20, 2026, 8:12 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Financial Incentives to Reduce Pediatric Tobacco Smoke Exposures

NCT03099811
View directory record Official record
Conditions
Asthma, Incentives, Tobacco Smoking
Interventions
Incentive plan, Smoking cessation
Behavioral
Lead sponsor
Johns Hopkins University
Other
Eligibility
2 Years to 12 Years
Enrollment
147 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Nov 20, 2018 · Synced Oct 20, 2026, 8:12 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Implementation of Genomics in Substance Use Disorder Treatment

NCT04768114
View directory record Official record
Conditions
Tobacco Use Disorder, Smoking Cessation, Tobacco Use Cessation
Interventions
Genetically-Informed RiskProfile, Brief Cessation Advice
Behavioral · Other
Lead sponsor
Washington University School of Medicine
Other
Eligibility
18 Years and older
Enrollment
148 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Jan 3, 2024 · Synced Oct 20, 2026, 8:12 PM EDT
Completed Not applicable Interventional

Personalized Intervention Program: Tobacco Treatment for Patients at Risk for Lung Cancer (PIP)

NCT02658032
View directory record Official record
Conditions
Smoking Cessation, Biofeedback
Interventions
personalized cessation care, bio feedback, standard care
Behavioral · Other
Lead sponsor
Yale University
Other
Eligibility
50 Years and older
Enrollment
276 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2020
U.S. locations
2
States / cities
New Haven, Connecticut • Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Apr 21, 2023 · Synced Oct 20, 2026, 8:12 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Sensory Perception of Sweet Flavors in E-Cigarette

NCT03332953
View directory record Official record
Conditions
Smoking
Interventions
E-cigarettes with varying concentrations of nicotine & flavor
Other
Lead sponsor
Oregon State University
Other
Eligibility
18 Years to 35 Years
Enrollment
19 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018
U.S. locations
1
States / cities
Corvallis, Oregon
Source: ClinicalTrials.gov public record
Updated Oct 11, 2019 · Synced Oct 20, 2026, 8:12 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers Results available

Brain Imaging in Tobacco Smokers During a Quit Attempt

NCT04055467
View directory record Official record
Conditions
Tobacco Use Disorder, Tobacco Smoking
Interventions
[F18]-ASEM (3-(1,4-diazabicyclo[3.2.2]nonan-4-yl)-6-[18F]fluorodibenzo[b,d]thiophene 5,5-dioxide), Contingency Management
Drug · Behavioral
Lead sponsor
Johns Hopkins University
Other
Eligibility
21 Years to 50 Years
Enrollment
15 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2022
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Aug 6, 2024 · Synced Oct 20, 2026, 8:12 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Nicotine Receptor Density & Response to Nicotine Patch: Pt 2 Extended Treatment

NCT02676375
View directory record Official record
Conditions
Smoking Cessation, Schizophrenia
Interventions
Combination Bupropion + NRTs, Extended Treatment, Home Visits & Calls, Monotherapy
Drug · Other
Lead sponsor
Brentwood Biomedical Research Institute
Other
Eligibility
21 Years and older
Enrollment
42 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2016
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Jul 30, 2019 · Synced Oct 20, 2026, 8:12 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Effects of Hookah (Waterpipe) Smoking on Blood Vessel Function

NCT03616002
View directory record Official record
Conditions
Hookah Smoking
Interventions
Hookah smoking
Other
Lead sponsor
Cedars-Sinai Medical Center
Other
Eligibility
18 Years to 29 Years
Enrollment
58 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2020
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Feb 4, 2021 · Synced Oct 20, 2026, 8:12 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers

Effect of Behavioral Training on Physiological Responses to Smoking Cues, Affect and Cortisol

NCT01362101
View directory record Official record
Conditions
Smokers
Interventions
Mindfulness behavioral intervention (MT),cognitive behavioral intervention (CBT)
Behavioral
Lead sponsor
A. Eden Evins
Other
Eligibility
18 Years to 65 Years
Enrollment
56 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2012
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 11, 2013 · Synced Oct 20, 2026, 8:12 PM EDT
Completed Not applicable Interventional Results available

Strategies to Connect Patients at Federally Qualified Health Clinics With Evidence Based Tobacco Cessation Treatment

NCT03900767
View directory record Official record
Conditions
Current Smoker, Tobacco Smoking, Tobacco Use
Interventions
Ask-Advise-Connect (AAC), Text Messaging (TM), Motivation And Problem-Solving (MAPS), Quitline
Other · Behavioral
Lead sponsor
University of Utah
Other
Eligibility
18 Years and older
Enrollment
12,009 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Sep 8, 2026 · Synced Oct 20, 2026, 8:12 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Innovative Smartphone Application of a New Behavioral Method to Quit Smoking: Pilot Trial (Smart Quit)

NCT01812070
View directory record Official record
Conditions
Smoking
Interventions
ACT, CBT
Behavioral
Lead sponsor
Fred Hutchinson Cancer Center
Other
Eligibility
18 Years and older
Enrollment
196 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Mar 6, 2015 · Synced Oct 20, 2026, 8:12 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Characterization of Nicotine Exposure and Urge-to-Smoke Following Use of Electronic and Conventional Cigarettes

NCT02210754
View directory record Official record
Conditions
Smoking
Interventions
blu™ Classic Tobacco rechargeable (2.4% nicotine, glycerin vehicle), blu™ Classic Tobacco rechargeable (2.4% nicotine, glycerin/PG vehicle), blu™ Magnificent Menthol rechargeable (2.4% nicotine, glycerin vehicle), blu™ Classic Tobacco rechargeable (1.6% nicotine, glycerin vehicle), blu™ Classic Tobacco rechargeable (1.6% nicotine, glycerin/PG vehicle), Marlboro Cigarette
Other
Lead sponsor
Lorillard Tobacco Company
Industry
Eligibility
21 Years to 65 Years
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014
U.S. locations
1
States / cities
Lincoln, Nebraska
Source: ClinicalTrials.gov public record
Updated Aug 7, 2014 · Synced Oct 20, 2026, 8:12 PM EDT
Completed Not applicable Interventional

Proactive Care Coordination for Cancer Survivors Who Smoke

NCT02723656
View directory record Official record
Conditions
Cancer
Interventions
Online Referral NYS Quitline, Tobacco cessation counseling and coordination of cessation medications
Behavioral
Lead sponsor
NYU Langone Health
Other
Eligibility
18 Years and older
Enrollment
581 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2018
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Dec 11, 2018 · Synced Oct 20, 2026, 8:12 PM EDT
Terminated Phase 4 Interventional Accepts healthy volunteers

Testing Pharmacological Therapies for Pregnant Smokers

NCT00224419
View directory record Official record
Conditions
Smoking, Pregnancy
Interventions
Motivational interviewing for smoking cessation, Cognitive behaviors therapy, CBT + NRT
Behavioral · Drug
Lead sponsor
Duke University
Other
Eligibility
18 Years and older · Female only
Enrollment
181 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
Started 2003
U.S. locations
2
States / cities
Durham, North Carolina • Fayetteville, North Carolina
Source: ClinicalTrials.gov public record
Updated Jul 21, 2014 · Synced Oct 20, 2026, 8:12 PM EDT