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ClinicalTrials.gov public records Last synced Oct 23, 2026, 7:56 PM EDT

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Showing 793–816 of 2,080 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Smoking Behavior Clear all
Completed Not applicable Interventional Accepts healthy volunteers

Relapse-Prevention Booklets as an Adjunct to a Tobacco Telephone Helpline("Quitline")

NCT01352000
View directory record Official record
Conditions
Smoking Cessation
Interventions
Smoking Cessation
Behavioral
Lead sponsor
H. Lee Moffitt Cancer Center and Research Institute
Other
Eligibility
18 Years and older
Enrollment
3,830 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2016
U.S. locations
1
States / cities
Tampa, Florida
Source: ClinicalTrials.gov public record
Updated Feb 23, 2017 · Synced Oct 23, 2026, 7:56 PM EDT
Completed Not applicable Interventional Results available

Effect of Different E-cigarette Cooling Flavors on Adults' Sensory Experience TCORS 3.0

NCT05932693
View directory record Official record
Conditions
E-Cig Use
Interventions
E-liquid coolant (WS-3, 0.05%), E-liquid coolant (WS-3, 0.1%), E-liquid coolant (WS-3, 0.5%), E-liquid coolant (WS-3, 1.0%), E-liquid coolant (WS-3, 2.0%), E-liquid coolant (menthol, 0.05%), E-liquid coolant (menthol, 0.1%), E-liquid coolant (menthol, 0.5%), E-liquid coolant (menthol, 1.0%), E-liquid coolant (menthol, 2.0%), E-liquid coolant (WS-23, 0.05%), E-liquid coolant (WS-23, 0.1%), E-liquid coolant (WS-23, 0.5%), E-liquid coolant (WS-23, 1.0%), E-liquid coolant (WS-23, 2.0%), E-liquid coolant (WS-23, 4.0%)
Other
Lead sponsor
Yale University
Other
Eligibility
18 Years and older
Enrollment
31 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Feb 18, 2026 · Synced Oct 23, 2026, 7:56 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Neuroimaging Attentional Impairment During Abstinence

NCT00692406
View directory record Official record
Conditions
Smoking
Interventions
Smoking Abstinence
Behavioral
Lead sponsor
Duke University
Other
Eligibility
18 Years to 50 Years
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2005 – 2009
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Mar 28, 2013 · Synced Oct 23, 2026, 7:56 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers Results available

Effects of Menthol in E-cigarettes on Smoking Behaviors

NCT04521647
View directory record Official record
Conditions
Nicotine Dependence
Interventions
Nicotine
Drug
Lead sponsor
Yale University
Other
Eligibility
21 Years to 65 Years
Enrollment
14 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Jun 16, 2026 · Synced Oct 23, 2026, 7:56 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Investigation of the Effects of Electronic Cigarettes on Vascular Health

NCT03041493
View directory record Official record
Conditions
Vascular Health
Interventions
Electronic cigarette, traditional cigarette, (sham cigarette) - no actual exposure to cigarettes
Behavioral
Lead sponsor
Memorial Sloan Kettering Cancer Center
Other
Eligibility
18 Years to 50 Years
Enrollment
12 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2021
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jun 18, 2021 · Synced Oct 23, 2026, 7:56 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Impact of Cigarette Pack Constituent Disclosures

NCT02785484
View directory record Official record
Conditions
Cigarette Smoking Behavior
Interventions
Label with constituent disclosure message, Label with litter message
Other
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
21 Years and older
Enrollment
784 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2017
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Jun 8, 2017 · Synced Oct 23, 2026, 7:56 PM EDT
Terminated Phase 4 Interventional Results available

Pilot Study of Nicotine Nasal Spray and Varenicline on Smoking in Methadone-Maintained Patients

NCT02147132
View directory record Official record
Conditions
Cigarette Smoking, Methadone Maintenance
Interventions
Nicotine Nasal Spray, Varenicline, Placebo Nasal Spray, Placebo Varenicline
Drug
Lead sponsor
University of Cincinnati
Other
Eligibility
18 Years and older
Enrollment
7 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2017
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Dec 5, 2018 · Synced Oct 23, 2026, 7:56 PM EDT
Completed Phase 2 Interventional Results available

18F-FSPG PET/CT in Imaging Patients With Newly Diagnosed Lung Cancer or Indeterminate Pulmonary Nodules

NCT02448225
View directory record Official record
Conditions
Lung Carcinoma, Solitary Pulmonary Nodule, Cigarette Smoking Behavior
Interventions
Computed Tomography, fluorodeoxyglucose F-18, Fluorine F 18 L-glutamate Derivative BAY94-9392, Laboratory Biomarker Analysis, Positron Emission Tomography, Positron Emission Tomography (PET)
Procedure · Radiation · Drug + 1 more
Lead sponsor
Vanderbilt-Ingram Cancer Center
Other
Eligibility
40 Years to 80 Years
Enrollment
46 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2022
U.S. locations
2
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Oct 19, 2022 · Synced Oct 23, 2026, 7:56 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers Results available

A Study to Assess the Safety, Tolerability and Pharmacokinetics of AZD4041 in Healthy Volunteers

NCT04076540
View directory record Official record
Conditions
Smoking Cessation
Interventions
AZD4041, Placebo
Drug
Lead sponsor
AstraZeneca
Industry
Eligibility
18 Years to 65 Years
Enrollment
48 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2022
U.S. locations
2
States / cities
Las Vegas, Nevada • Austin, Texas
Source: ClinicalTrials.gov public record
Updated Jul 17, 2024 · Synced Oct 23, 2026, 7:56 PM EDT
Recruiting Not applicable Interventional

Effects of Tax Proposals and Cigarette Availability on Tobacco Purchasing

NCT07142668
View directory record Official record
Conditions
Cigarette Smoking
Interventions
Harm Reduction Tax - Normal Nicotine Cigarettes Available, Harm Reduction Tax - Normal Nicotine Cigarettes Not Available, Modified Risk Tobacco Product Tax - Normal Nicotine Cigarettes Available, Modified Risk Tobacco Product Tax - Normal Nicotine Cigarettes Not Available, Nicotine Content Tax - Normal Nicotine Cigarettes Available, Nicotine Content Tax - Normal Nicotine Cigarettes Not Available, Tobacco Parity Tax - Normal Nicotine Cigarettes Available, Tobacco Parity Tax - Normal Nicotine Cigarettes Not Available
Behavioral
Lead sponsor
Virginia Polytechnic Institute and State University
Other
Eligibility
21 Years and older
Enrollment
316 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
2
States / cities
Buffalo, New York • Roanoke, Virginia
Source: ClinicalTrials.gov public record
Updated May 19, 2026 · Synced Oct 23, 2026, 7:56 PM EDT
Completed No phase listed Observational

Nicotine Reinforcement and Smoking-Cue Reactivity: Association With Genetic Polymorphisms

NCT01505725
View directory record Official record
Conditions
Nicotine Dependence
Interventions
Not listed
Lead sponsor
National Institute on Drug Abuse (NIDA)
NIH
Eligibility
18 Years to 64 Years
Enrollment
92 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2013
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Apr 5, 2018 · Synced Oct 23, 2026, 7:56 PM EDT
Completed Phase 3 Interventional Accepts healthy volunteers Results available

Impact of Very Low Nicotine Content Cigarettes in a Complex Marketplace

NCT03272685
View directory record Official record
Conditions
Tobacco Smoking, Nicotine Dependence
Interventions
Very Low Nicotine Content Cigarettes, Normal Nicotine Content Cigarettes
Drug
Lead sponsor
University of Minnesota
Other
Eligibility
21 Years and older
Enrollment
799 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2023
U.S. locations
6
States / cities
San Francisco, California • Minneapolis, Minnesota • Durham, North Carolina + 3 more
Source: ClinicalTrials.gov public record
Updated Aug 20, 2024 · Synced Oct 23, 2026, 7:56 PM EDT
Completed Phase 2 Interventional Results available

Evaluation of the Nicotine Lozenge in Relief of Provoked Acute Craving

NCT01466361
View directory record Official record
Conditions
Smoking, Smoking Cessation
Interventions
Nicotine lower dose, Nicotine higher dose, Placebo
Drug
Lead sponsor
GlaxoSmithKline
Industry
Eligibility
18 Years and older
Enrollment
187 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010
U.S. locations
1
States / cities
Burbank, California
Source: ClinicalTrials.gov public record
Updated Aug 28, 2019 · Synced Oct 23, 2026, 7:56 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Interventions to Help More Low-income Smokers Quit

NCT04311983
View directory record Official record
Conditions
Tobacco Use Cessation, Smoking Behaviors, Health Disparity
Interventions
Tobacco Quitline, Smoke Free Home
Behavioral
Lead sponsor
Washington University School of Medicine
Other
Eligibility
21 Years and older
Enrollment
1,973 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2023
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Oct 10, 2024 · Synced Oct 23, 2026, 7:56 PM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Secondhand Effects of Hookah (i.e., Waterpipe) Smoke and Aerosol

NCT04661683
View directory record Official record
Conditions
Hookah Smoking, Secondhand Aerosol, Vascular Stiffness, Vaping
Interventions
Combustible Hookah Smoke, Electronic Hookah Aerosol, Clean Room Air
Other
Lead sponsor
University of California, Los Angeles
Other
Eligibility
21 Years to 49 Years
Enrollment
12 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2027
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Apr 22, 2026 · Synced Oct 23, 2026, 7:56 PM EDT
Recruiting Not applicable Interventional

Remote Smoking Cessation in Hospitalized Cardiac Patients

NCT05738408
View directory record Official record
Conditions
Smoking Cessation
Interventions
Financial Incentives (FI) and Nicotine Replacement Therapy (NRT)
Behavioral
Lead sponsor
University of Vermont Medical Center
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
1
States / cities
Burlington, Vermont
Source: ClinicalTrials.gov public record
Updated Jan 20, 2025 · Synced Oct 23, 2026, 7:56 PM EDT
Recruiting Not applicable Interventional

Effects of E-cigs vs Pouches on Cigarette Smoking and Addiction

NCT06077240
View directory record Official record
Conditions
Smoking, Smoking Behaviors, Nicotine Dependence
Interventions
E-cigarette with 2.4% Nicotine with Menthol and Tobacco Flavors, E-cigarette with 2.4% Nicotine with Tobacco Flavor Only, E-cigarette with 5% Nicotine with Menthol and Tobacco Flavors, E-cigarette with 5% Nicotine with Tobacco Flavor Only, Tobacco Pouches with 3mg Nicotine with Menthol and Tobacco Flavors, Tobacco Pouches with 3mg Nicotine with Tobacco Flavor Only, Tobacco Pouches with 6mg Nicotine with Menthol and Tobacco Flavors, Tobacco Pouches with 6mg Nicotine with Tobacco Flavor Only
Behavioral
Lead sponsor
Yale University
Other
Eligibility
21 Years and older
Enrollment
256 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2028
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Mar 19, 2026 · Synced Oct 23, 2026, 7:56 PM EDT
Recruiting Not applicable Interventional

Behavioral Intervention for Youth to Promote Vaping Cessation

NCT06765291
View directory record Official record
Conditions
Vaping, Vaping Teens, Nicotine Dependence
Interventions
QuitVaping, This is Quitting (TIQ)
Behavioral
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
14 Years to 19 Years
Enrollment
400 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2029
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 7, 2026 · Synced Oct 23, 2026, 7:56 PM EDT
Completed Phase 2 Interventional Results available

Varenicline and Smoking Cessation in Schizophrenia

NCT01111149
View directory record Official record
Conditions
Schizophrenia, Smoking Cessation
Interventions
Sugar Pill, Varenicline, Bupropion HCl
Other · Drug
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years to 75 Years
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2012
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Jul 17, 2014 · Synced Oct 23, 2026, 7:56 PM EDT
Not yet recruiting Early Phase 1 Interventional Accepts healthy volunteers

Lung Health and Breath Biomarkers: Acute Effects of Inhaled Cannabis

NCT07694466
View directory record Official record
Conditions
Cannabis Use, Tobacco, Biomarkers
Interventions
Cannabis (THC), Tobacco Cigarette
Drug
Lead sponsor
Hannah Harris
Other
Eligibility
18 Years to 55 Years
Enrollment
12 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2027
U.S. locations
1
States / cities
Lexington, Kentucky
Source: ClinicalTrials.gov public record
Updated Oct 6, 2026 · Synced Oct 23, 2026, 7:56 PM EDT
Completed Phase 3 Interventional Results available

Behavioral Activation Intervention, Reward Processing, and Youth Smoking Cessation

NCT01351766
View directory record Official record
Conditions
Smoking
Interventions
Transdermal Nicotine Patch
Drug
Lead sponsor
University of Maryland, College Park
Other
Eligibility
18 Years to 21 Years
Enrollment
39 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2013
U.S. locations
1
States / cities
College Park, Maryland
Source: ClinicalTrials.gov public record
Updated May 18, 2022 · Synced Oct 23, 2026, 7:56 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Enhancing Smoking Cessation Via Telehealth Options in Primary Care

NCT05493254
View directory record Official record
Conditions
Smoking Cessation
Interventions
Smoking cessation e-visit, Treatment As Usual
Behavioral
Lead sponsor
Medical University of South Carolina
Other
Eligibility
18 Years and older
Enrollment
672 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2026
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Mar 5, 2026 · Synced Oct 23, 2026, 7:56 PM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers Results available

Responses to E-Cigarette Advertising

NCT04249219
View directory record Official record
Conditions
E-Cig Use
Interventions
Viewing e-cigarette ads
Other
Lead sponsor
University of Massachusetts, Worcester
Other
Eligibility
18 Years to 26 Years
Enrollment
62 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
Worcester, Massachusetts
Source: ClinicalTrials.gov public record
Updated Sep 8, 2023 · Synced Oct 23, 2026, 7:56 PM EDT
Completed Not applicable Interventional Results available

Impact of E-cigarette Characteristics on Reinforcement and Tobacco Use Patterns

NCT03844672
View directory record Official record
Conditions
Smoking, Tobacco Use
Interventions
Low Power, High Power, Low Concentration, High Concentration
Behavioral
Lead sponsor
Medical University of South Carolina
Other
Eligibility
21 Years and older
Enrollment
93 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2023
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Oct 24, 2024 · Synced Oct 23, 2026, 7:56 PM EDT